blastocystis

Summary

Summary: A genus of protozoa of the suborder BLASTOCYSTINA. It was first classified as a yeast but further studies have shown it to be a protozoan.

Top Publications

  1. Ozyurt M, Kurt O, Mølbak K, Nielsen H, Haznedaroglu T, Stensvold C. Molecular epidemiology of Blastocystis infections in Turkey. Parasitol Int. 2008;57:300-6 pubmed publisher
    b>Blastocystis is a very common unicellular intestinal parasite of ubiquitous occurrence...
  2. Tan K. New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev. 2008;21:639-65 pubmed publisher
    b>Blastocystis is an unusual enteric protozoan parasite of humans and many animals. It has a worldwide distribution and is often the most commonly isolated organism in parasitological surveys...
  3. Puthia M, Sio S, Lu J, Tan K. Blastocystis ratti induces contact-independent apoptosis, F-actin rearrangement, and barrier function disruption in IEC-6 cells. Infect Immun. 2006;74:4114-23 pubmed
    b>Blastocystis is an enteric protozoan purportedly associated with numerous clinical cases of diarrhea, flatulence, vomiting, and other gastrointestinal symptoms...
  4. Moosavi A, Haghighi A, Mojarad E, Zayeri F, Alebouyeh M, Khazan H, et al. Genetic variability of Blastocystis sp. isolated from symptomatic and asymptomatic individuals in Iran. Parasitol Res. 2012;111:2311-5 pubmed publisher
    b>Blastocystis is an unusual enteric protozoan parasite of humans and many animals whose pathogenic potential is still controversial...
  5. Santin M, Gomez Munoz M, Solano Aguilar G, Fayer R. Development of a new PCR protocol to detect and subtype Blastocystis spp. from humans and animals. Parasitol Res. 2011;109:205-12 pubmed publisher
    b>Blastocystis spp. is commonly found in the feces of humans worldwide. Infection has been reported as asymptomatic, acute symptomatic, and chronic symptomatic...
  6. Mirza H, Tan K. Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity. Parasitol Res. 2009;104:355-61 pubmed publisher
    b>Blastocystis is an enteric protistan parasite of zoonotic potential and poorly understood pathogenesis...
  7. Tan T, Tan P, Sharma R, Sugnaseelan S, Suresh K. Genetic diversity of caprine Blastocystis from Peninsular Malaysia. Parasitol Res. 2013;112:85-9 pubmed publisher
    b>Blastocystis sp. is a common intestinal parasite found in humans and animals. The possibility of zoonotic transmission to humans from livestock especially goats led us to investigate the genetic diversity of caprine Blastocystis sp...
  8. Tsaousis A, Ollagnier de Choudens S, Gentekaki E, Long S, Gaston D, Stechmann A, et al. Evolution of Fe/S cluster biogenesis in the anaerobic parasite Blastocystis. Proc Natl Acad Sci U S A. 2012;109:10426-31 pubmed publisher
    ..Here we show that the anaerobic human protozoan parasite Blastocystis, in addition to possessing ISC and iron/sulfur assembly systems, expresses a fused version of the SufC and SufB ..
  9. Stensvold C, Arendrup M, Jespersgaard C, Mølbak K, Nielsen H. Detecting Blastocystis using parasitologic and DNA-based methods: a comparative study. Diagn Microbiol Infect Dis. 2007;59:303-7 pubmed
    Few studies have targeted the relative performance of diagnostic methods used for the detection of Blastocystis, a unicellular organism often present in fecal specimens from individuals with and without gastrointestinal symptoms...

More Information

Publications107 found, 100 shown here

  1. Stensvold C, Christiansen D, Olsen K, Nielsen H. Blastocystis sp. subtype 4 is common in Danish Blastocystis-positive patients presenting with acute diarrhea. Am J Trop Med Hyg. 2011;84:883-5 pubmed publisher
    Fecal samples from 444 Danish patients presenting with acute diarrhea were tested for Blastocystis and positive samples were subtyped to investigate the prevalence and subtype distribution of Blastocystis in this patient group...
  2. Bart A, Wentink Bonnema E, Gilis H, Verhaar N, Wassenaar C, van Vugt M, et al. Diagnosis and subtype analysis of Blastocystis sp. in 442 patients in a hospital setting in the Netherlands. BMC Infect Dis. 2013;13:389 pubmed publisher
    b>Blastocystis sp. are among the most commonly observed intestinal parasites in routine clinical parasitology. Blastocystis in humans consists of at least 9 genetic subtypes...
  3. Vogelberg C, Stensvold C, Monecke S, Ditzen A, Stopsack K, Heinrich Gräfe U, et al. Blastocystis sp. subtype 2 detection during recurrence of gastrointestinal and urticarial symptoms. Parasitol Int. 2010;59:469-71 pubmed publisher
    b>Blastocystis is a common unicellular intestinal parasite in humans. Its clinical relevance is still subject to discussion with numerous conflicting reports on its ability to cause disease...
  4. Scanlan P. Blastocystis: past pitfalls and future perspectives. Trends Parasitol. 2012;28:327-34 pubmed publisher
    b>Blastocystis is a genetically heterogeneous protist found in the intestinal tract (IT) of many vertebrates, and although it is implicated in a variety of human intestinal disorders, data regarding the clinical relevance of Blastocystis is ..
  5. Menounos P, Spanakos G, Tegos N, Vassalos C, Papadopoulou C, Vakalis N. Direct detection of Blastocystis sp. in human faecal samples and subtype assignment using single strand conformational polymorphism and sequencing. Mol Cell Probes. 2008;22:24-9 pubmed
    b>Blastocystis is an anaerobic parasitic microorganism, which has been found in the intestinal tract of many vertebrates including humans. Recently, members of Blastocystis sp...
  6. Mirza H, Wu Z, Teo J, Tan K. Statin pleiotropy prevents rho kinase-mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases. Cell Microbiol. 2012;14:1474-84 pubmed publisher
    b>Blastocystis is an enteric parasite that causes acute and chronic intestinal infections, often non-responsive to conventional antibiotics...
  7. Anuar T, Ghani M, Azreen S, Salleh F, Moktar N. Blastocystis infection in Malaysia: evidence of waterborne and human-to-human transmissions among the Proto-Malay, Negrito and Senoi tribes of Orang Asli. Parasit Vectors. 2013;6:40 pubmed publisher
    b>Blastocystis has been described as the most common intestinal parasite in humans and has an increased impact on public health. However, the transmission of this parasite has not been conclusively determined.
  8. Whipps C, Boorom K, Bermudez L, Kent M. Molecular characterization of Blastocystis species in Oregon identifies multiple subtypes. Parasitol Res. 2010;106:827-32 pubmed publisher
    The association of Blastocystis species infections with gastrointestinal symptoms in humans is clouded by the variable presentation of disease and multiple lineages of the parasite that can infect humans and other animals...
  9. Puthia M, Lu J, Tan K. Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner. Eukaryot Cell. 2008;7:435-43 pubmed
    b>Blastocystis is a ubiquitous enteric protozoan found in the intestinal tracts of humans and a wide range of animals...
  10. Scanlan P, Stensvold C. Blastocystis: getting to grips with our guileful guest. Trends Parasitol. 2013;29:523-9 pubmed publisher
    b>Blastocystis, a common single-celled intestinal parasite of humans and animals, continues to puzzle clinical microbiologists, gastroenterologists, and general practitioners who are still unsure of the clinical significance of the organism...
  11. Tan T, Ong S, Suresh K. Genetic variability of Blastocystis sp. isolates obtained from cancer and HIV/AIDS patients. Parasitol Res. 2009;105:1283-6 pubmed publisher
    This represents the first study to determine the genetic diversity of Blastocystis sp. among cancer and HIV/AIDS patients. Forty Blastocystis sp...
  12. Petrášová J, Uzlikova M, Kostka M, Petrzelkova K, Huffman M, Modry D. Diversity and host specificity of Blastocystis in syntopic primates on Rubondo Island, Tanzania. Int J Parasitol. 2011;41:1113-20 pubmed publisher
    ..b>Blastocystis was detected using standard microscopy, together with PCR-based determination and the prevalence and subtype ..
  13. Stenzel D, Boreham P. Virus-like particles in Blastocystis sp. from simian faecal material. Int J Parasitol. 1997;27:345-8 pubmed
    Virus-like particles were observed in the cytoplasm of Blastocystis sp. found in fresh faecal material from 2 monkeys (Macaca fascicularis)...
  14. Stensvold C, Arendrup M, Nielsen H, Bada A, Thorsen S. Symptomatic infection with Blastocystis sp. subtype 8 successfully treated with trimethoprim-sulfamethoxazole. Ann Trop Med Parasitol. 2008;102:271-4 pubmed publisher
  15. Katsarou Katsari A, Vassalos C, Tzanetou K, Spanakos G, Papadopoulou C, Vakalis N. Acute urticaria associated with amoeboid forms of Blastocystis sp. subtype 3. Acta Derm Venereol. 2008;88:80-1 pubmed publisher
  16. Iguchi A, Yoshikawa H, Yamada M, Kimata I, Arizono N. Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis sp. strain RN94-9. Parasitol Res. 2009;105:135-40 pubmed publisher
    b>Blastocystis hominis is a zoonotic intestinal protozoan parasite whose pathogenic potential is still controversial. The aim of the present study was to clarify the pathogenicity of Blastocystis parasites in rats...
  17. Thathaisong U, Siripattanapipong S, Mungthin M, Pipatsatitpong D, Tan ariya P, Naaglor T, et al. Identification of Blastocystis subtype 1 variants in the Home for Girls, Bangkok, Thailand. Am J Trop Med Hyg. 2013;88:352-8 pubmed publisher
    A cross-sectional study of Blastocystis infection was conducted to evaluate the prevalence, risk factors, and subtypes of Blastocystis at the Home for Girls, Bangkok, Thailand in November 2008. Of 370 stool samples, 118 (31...
  18. Yoshikawa H, Abe N, Wu Z. PCR-based identification of zoonotic isolates of Blastocystis from mammals and birds. Microbiology. 2004;150:1147-51 pubmed
    The genotype of Blastocystis isolated from humans and animals is highly polymorphic...
  19. Jones M, Whipps C, Ganac R, Hudson N, Boorom K, Boroom K. Association of Blastocystis subtype 3 and 1 with patients from an Oregon community presenting with chronic gastrointestinal illness. Parasitol Res. 2009;104:341-5 pubmed publisher
    ..Using a real-time LightCycler PCR assay we detected Blastocystis in nine patients from a metropolitan area of Corvallis, Oregon who presented with diarrhea, abdominal pain, ..
  20. Stensvold C, Ahmed U, Andersen L, Nielsen H. Development and evaluation of a genus-specific, probe-based, internal-process-controlled real-time PCR assay for sensitive and specific detection of Blastocystis spp. J Clin Microbiol. 2012;50:1847-51 pubmed publisher
    b>Blastocystis is a common intestinal parasite of unsettled clinical significance, which is not easily detected by standard parasitological methods...
  21. Thathaisong U, Worapong J, Mungthin M, Tan ariya P, Viputtigul K, Sudatis A, et al. Blastocystis isolates from a pig and a horse are closely related to Blastocystis hominis. J Clin Microbiol. 2003;41:967-75 pubmed
    b>Blastocystis has a widespread distribution in a variety of animals, which is a potential source of infection for humans...
  22. Noël C, Dufernez F, Gerbod D, Edgcomb V, Delgado Viscogliosi P, Ho L, et al. Molecular phylogenies of Blastocystis isolates from different hosts: implications for genetic diversity, identification of species, and zoonosis. J Clin Microbiol. 2005;43:348-55 pubmed
    Small-subunit (SSU) rRNA gene sequences were obtained by PCR from 12 Blastocystis isolates from humans, rats, and reptiles for which elongation factor 1alpha (EF-1alpha) gene sequences are already available...
  23. Graczyk T, Shiff C, Tamang L, Munsaka F, Beitin A, Moss W. The association of Blastocystis hominis and Endolimax nana with diarrheal stools in Zambian school-age children. Parasitol Res. 2005;98:38-43 pubmed
    ..5%) were diarrhetic. The overall prevalence of Endolimax nana, Schistosoma haematobium, Blastocystis hominis, Giardia lamblia, Cryptosporidium parvum, Encephalitozoon intestinalis, and Strongyloides stercoralis ..
  24. Stensvold C, Nielsen H, Mølbak K, Smith H. Pursuing the clinical significance of Blastocystis--diagnostic limitations. Trends Parasitol. 2009;25:23-9 pubmed publisher
    The clinical significance of one of the most prevalent single-celled intestinal parasites worldwide, Blastocystis, remains unsettled...
  25. Stensvold C, Smith H, Nagel R, Olsen K, Traub R. Eradication of Blastocystis carriage with antimicrobials: reality or delusion?. J Clin Gastroenterol. 2010;44:85-90 pubmed publisher
    ..and is also traditionally considered first-line therapy in cases where there is a requirement to treat Blastocystis, a common protist of disputable clinical significance...
  26. Puthia M, Vaithilingam A, Lu J, Tan K. Degradation of human secretory immunoglobulin A by Blastocystis. Parasitol Res. 2005;97:386-9 pubmed
    ..To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to ..
  27. Boorom K. Is this recently characterized gastrointestinal pathogen responsible for rising rates of inflammatory bowel disease (IBD) and IBD associated autism in Europe and the United States in the 1990s?. Med Hypotheses. 2007;69:652-9 pubmed
    In 2006, a pathogenic variant of the common intestinal organism Blastocystis was discovered in patients who were experiencing chronic gastrointestinal symptoms. Most species of Blastocystis inhabit humans with no symptoms...
  28. Alfellani M, Stensvold C, Vidal Lapiedra A, Onuoha E, Fagbenro Beyioku A, Clark C. Variable geographic distribution of Blastocystis subtypes and its potential implications. Acta Trop. 2013;126:11-8 pubmed publisher
    b>Blastocystis is a common intestinal micro-eukaryote found in both humans and non-human hosts and known to be genetically very diverse. It has been divided into numerous subtypes (STs), nine of which have been identified in humans to date...
  29. Arisue N, Hashimoto T, Yoshikawa H, Nakamura Y, Nakamura G, Nakamura F, et al. Phylogenetic position of Blastocystis hominis and of stramenopiles inferred from multiple molecular sequence data. J Eukaryot Microbiol. 2002;49:42-53 pubmed
    b>Blastocystis hominis, a parasite of the human intestine, has recently been positioned within stramenopiles by the small subunit rRNA phylogeny...
  30. Hoevers J, Snowden K. Analysis of the ITS region and partial ssu and lsu rRNA genes of Blastocystis and Proteromonas lacertae. Parasitology. 2005;131:187-96 pubmed
    b>Blastocystis is a common single-celled enteric parasite found in a large variety of hosts...
  31. Grabensteiner E, Hess M. PCR for the identification and differentiation of Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis spp. Vet Parasitol. 2006;142:223-30 pubmed
    ..flagellates: Histomonas meleagridis and Tetratrichomonas gallinarum as well as the protozoan microorganism: Blastocystis spp...
  32. Parkar U, Traub R, Kumar S, Mungthin M, Vitali S, Leelayoova S, et al. Direct characterization of Blastocystis from faeces by PCR and evidence of zoonotic potential. Parasitology. 2007;134:359-67 pubmed
    In vitro propagation followed by PCR, and a PCR-based method capable of the direct detection of Blastocystis in faeces were utilized to detect Blastocystis from various hosts in Australia, including primates and their handlers from the ..
  33. Stechmann A, Hamblin K, Perez Brocal V, Gaston D, Richmond G, van der Giezen M, et al. Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes. Curr Biol. 2008;18:580-5 pubmed publisher
    b>Blastocystis is a unicellular stramenopile of controversial pathogenicity in humans. Although it is a strict anaerobe, Blastocystis has mitochondrion-like organelles with cristae, a transmembrane potential and DNA...
  34. Hamblin K, Standley D, Rogers M, Stechmann A, Roger A, Maytum R, et al. Localization and nucleotide specificity of Blastocystis succinyl-CoA synthetase. Mol Microbiol. 2008;68:1395-405 pubmed publisher
    The anaerobic lifestyle of the intestinal parasite Blastocystis raises questions about the biochemistry and function of its mitochondria-like organelles...
  35. Jimenez Gonzalez D, Martínez Flores W, Reyes Gordillo J, Ramirez Miranda M, Arroyo Escalante S, Romero Valdovinos M, et al. Blastocystis infection is associated with irritable bowel syndrome in a Mexican patient population. Parasitol Res. 2012;110:1269-75 pubmed publisher
    In recent times, some common "non-pathogenic" parasites, such as Blastocystis and Dientamoeba fragilis, have been associated to the aetiology of irritable bowel syndrome (IBS), while host pro-inflammatory cytokine gene ..
  36. Lee I, Tan T, Tan P, Nanthiney D, Biraj M, Surendra K, et al. Predominance of Blastocystis sp. subtype 4 in rural communities, Nepal. Parasitol Res. 2012;110:1553-62 pubmed publisher
    b>Blastocystis sp. is a common intestinal parasite. To date, there have been sporadic and scanty studies on Blastocystis sp. carried out in rural communities in Nepal. We surveyed the prevalence of Blastocystis sp...
  37. Wang W, Cuttell L, Bielefeldt Ohmann H, Inpankaew T, Owen H, Traub R. Diversity of Blastocystis subtypes in dogs in different geographical settings. Parasit Vectors. 2013;6:215 pubmed publisher
    b>Blastocystis is a ubiquitous, globally distributed intestinal protist infecting humans and a wide range of animals. Several studies have shown that Blastocystis is a potentially zoonotic parasite...
  38. Yan Y, Su S, Ye J, Lai X, Lai R, Liao H, et al. Blastocystis sp. subtype 5: a possibly zoonotic genotype. Parasitol Res. 2007;101:1527-32 pubmed
    b>Blastocystis has a widespread distribution in a variety of animals, which is a potential source of infection for humans. Previous studies show that Blastocystis sp...
  39. Grabensteiner E, Liebhart D, Arshad N, Hess M. Antiprotozoal activities determined in vitro and in vivo of certain plant extracts against Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis sp. Parasitol Res. 2008;103:1257-64 pubmed publisher
    ..their in vitro activities against clonal cultures of Histomonas meleagridis, Tetratrichomonas gallinarum, and Blastocystis sp. Ethanolic extracts of thyme, saw palmetto, grape seed, and pumpkin fruit proved to be most efficacious...
  40. Stensvold C, Alfellani M, Nørskov Lauritsen S, Prip K, Victory E, Maddox C, et al. Subtype distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype. Int J Parasitol. 2009;39:473-9 pubmed publisher
    b>Blastocystis isolates from 56 Danish synanthropic and zoo animals, 62 primates primarily from United Kingdom (UK) collections and 16 UK primate handlers were subtyped by PCR, sequencing and phylogenetic analysis...
  41. Forsell J, Granlund M, Stensvold C, Clark C, Clark G, Evengard B. Subtype analysis of Blastocystis isolates in Swedish patients. Eur J Clin Microbiol Infect Dis. 2012;31:1689-96 pubmed publisher
    b>Blastocystis is a genetically diverse and widespread intestinal parasite of animals and humans with controversial pathogenic potential. At least nine subtypes of Blastocystis have been found in humans...
  42. Tan K. Blastocystis in humans and animals: new insights using modern methodologies. Vet Parasitol. 2004;126:121-44 pubmed
    Among the waterborne protozoan parasites of medical and veterinary importance, Blastocystis is perhaps one of the less well-understood...
  43. Suresh K, Smith H, Tan T. Viable blastocystis cysts in Scottish and Malaysian sewage samples. Appl Environ Microbiol. 2005;71:5619-20 pubmed
    b>Blastocystis cysts were detected in 38% (47/123) (37 Scottish, 17 Malaysian) of sewage treatment works. Fifty percent of influents (29% Scottish, 76% Malaysian) and 28% of effluents (9% Scottish, 60% Malaysian) contained viable cysts...
  44. Poirier P, Wawrzyniak I, Albert A, El Alaoui H, Delbac F, Livrelli V. Development and evaluation of a real-time PCR assay for detection and quantification of blastocystis parasites in human stool samples: prospective study of patients with hematological malignancies. J Clin Microbiol. 2011;49:975-83 pubmed publisher
    b>Blastocystis anaerobic parasites are widespread worldwide in the digestive tract of many animal species, including humans...
  45. Stensvold C, Alfellani M, Clark C. Levels of genetic diversity vary dramatically between Blastocystis subtypes. Infect Genet Evol. 2012;12:263-73 pubmed publisher
    b>Blastocystis is a common single-celled parasite of humans and other animals comprising at least 13 genetically distinct small subunit ribosomal RNA lineages (subtypes (STs))...
  46. Stensvold C. Comparison of sequencing (barcode region) and sequence-tagged-site PCR for Blastocystis subtyping. J Clin Microbiol. 2013;51:190-4 pubmed publisher
    b>Blastocystis is the most common nonfungal microeukaryote of the human intestinal tract and comprises numerous subtypes (STs), nine of which have been found in humans (ST1 to ST9)...
  47. Wang W, Owen H, Traub R, Cuttell L, Inpankaew T, Bielefeldt Ohmann H. Molecular epidemiology of Blastocystis in pigs and their in-contact humans in Southeast Queensland, Australia, and Cambodia. Vet Parasitol. 2014;203:264-9 pubmed publisher
    b>Blastocystis, an intestinal protist commonly found in humans and animals worldwide, has been implicated by some as a causative agent in irritable bowel syndrome in humans...
  48. Govind S, Khairul A, Smith H. Multiple reproductive processes in Blastocystis. Trends Parasitol. 2002;18:528 pubmed
  49. Wu B, Yin J, Texier C, Roussel M, Tan K. Blastocystis legumain is localized on the cell surface, and specific inhibition of its activity implicates a pro-survival role for the enzyme. J Biol Chem. 2010;285:1790-8 pubmed publisher
    ..that a surface-reactive monoclonal antibody (mAb) 1D5 could induce multiple PCD pathways in the protozoan Blastocystis. In this study, we identified, by two-dimensional gel electrophoresis and mass spectrometry, the target of mAb ..
  50. Souppart L, Moussa H, Cian A, Sanciu G, Poirier P, El Alaoui H, et al. Subtype analysis of Blastocystis isolates from symptomatic patients in Egypt. Parasitol Res. 2010;106:505-11 pubmed publisher
    b>Blastocystis sp. has been described as the most common intestinal parasite in humans and has an increased impact in public health...
  51. Tsaousis A, Gaston D, Stechmann A, Walker P, Lithgow T, Roger A. A functional Tom70 in the human parasite Blastocystis sp.: implications for the evolution of the mitochondrial import apparatus. Mol Biol Evol. 2011;28:781-91 pubmed publisher
    ..We have identified a tom70 gene in the human parasitic anaerobic stramenopile Blastocystis sp. that is neither an animal nor a fungus...
  52. Dogruman Al F, Simsek Z, Boorom K, Ekici E, Sahin M, Tuncer C, et al. Comparison of methods for detection of Blastocystis infection in routinely submitted stool samples, and also in IBS/IBD Patients in Ankara, Turkey. PLoS ONE. 2010;5:e15484 pubmed publisher
    This study compared diagnostic methods for identifying Blastocystis in stool samples, and evaluated the frequency of detection of Blastocystis in patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
  53. Long S, Changmai P, Tsaousis A, Skalicky T, Verner Z, Wen Y, et al. Stage-specific requirement for Isa1 and Isa2 proteins in the mitochondrion of Trypanosoma brucei and heterologous rescue by human and Blastocystis orthologues. Mol Microbiol. 2011;81:1403-18 pubmed publisher
    ..The Isa2 orthologue of the anaerobic protist Blastocystis partially rescued the growth and enzymatic activities of TbIsa1/2 knock-down...
  54. Abdulsalam A, Ithoi I, Al Mekhlafi H, Khan A, Ahmed A, Surin J, et al. Prevalence, predictors and clinical significance of Blastocystis sp. in Sebha, Libya. Parasit Vectors. 2013;6:86 pubmed publisher
    b>Blastocystis sp. has a worldwide distribution and is often the most common human intestinal protozoan reported in children and adults in developing countries. The clinical relevance of Blastocystis sp. remains controversial...
  55. Alfellani M, Taner Mulla D, Jacob A, Imeede C, Yoshikawa H, Stensvold C, et al. Genetic diversity of blastocystis in livestock and zoo animals. Protist. 2013;164:497-509 pubmed publisher
    b>Blastocystis is a common unicellular anaerobic eukaryote that inhabits the large intestine of many animals worldwide, including humans...
  56. Sawangjaroen N, Sawangjaroen K. The effects of extracts from anti-diarrheic Thai medicinal plants on the in vitro growth of the intestinal protozoa parasite: Blastocystis hominis. J Ethnopharmacol. 2005;98:67-72 pubmed
    ..nut gall were tested against the in vitro growth of fresh isolates of the intestinal protozoan parasite, Blastocystis hominis. The extracts at concentrations that ranged from 62...
  57. Wong K, Ng G, Lin R, Yoshikawa H, Taylor M, Tan K. Predominance of subtype 3 among Blastocystis isolates from a major hospital in Singapore. Parasitol Res. 2008;102:663-70 pubmed
    b>Blastocystis is an enteric protozoan parasite commonly found in humans and animals. Phylogenetic and genotypic analyses have shown that Blastocystis exhibits extreme genetic diversity, and humans are host to a number of zoonotic isolates...
  58. Stensvold C, Lewis H, Hammerum A, Porsbo L, Nielsen S, Olsen K, et al. Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite. Epidemiol Infect. 2009;137:1655-63 pubmed publisher
    Two independent studies were conducted to describe symptoms and potential risk factors associated with Blastocystis infection. Isolates were subtyped by molecular analysis...
  59. Dogruman Al F, Yoshikawa H, Kustimur S, Balaban N. PCR-based subtyping of Blastocystis isolates from symptomatic and asymptomatic individuals in a major hospital in Ankara, Turkey. Parasitol Res. 2009;106:263-8 pubmed publisher
    ..Kinyoun's acid-fast stainings for parasitology examinations and with in vitro culture method for detection of Blastocystis. In a total of 203 stool samples tested, native Lugol's iodine and trichrome stainings could detect 12 (5...
  60. Yin J, Howe J, Tan K. Staurosporine-induced programmed cell death in Blastocystis occurs independently of caspases and cathepsins and is augmented by calpain inhibition. Microbiology. 2010;156:1284-93 pubmed publisher
    Previous studies have shown that the protozoan parasite Blastocystis exhibits apoptotic features with caspase-like activity upon exposure to a cytotoxic monoclonal antibody or the anti-parasitic drug metronidazole...
  61. Arisue N, Hashimoto T, Yoshikawa H. Sequence heterogeneity of the small subunit ribosomal RNA genes among blastocystis isolates. Parasitology. 2003;126:1-9 pubmed
    Genes encoding small subunit ribosomal RNA (SSUrRNA) of 16 Blastocystis isolates from humans and other animals were amplified by the polymerase chain reaction, and the corresponding fragments were cloned and sequenced...
  62. Rene B, Stensvold C, Badsberg J, Nielsen H. Subtype analysis of Blastocystis isolates from Blastocystis cyst excreting patients. Am J Trop Med Hyg. 2009;80:588-92 pubmed
    To determine the distribution of Blastocystis sp...
  63. Jantermtor S, Pinlaor P, Sawadpanich K, Pinlaor S, Sangka A, Wilailuckana C, et al. Subtype identification of Blastocystis spp. isolated from patients in a major hospital in northeastern Thailand. Parasitol Res. 2013;112:1781-6 pubmed publisher
    The present study is aimed to identify the prevalence of Blastocystis subtypes isolated from patients in a major hospital in northeastern Thailand...
  64. Li L, Zhou X, Du Z, Wang X, Wang L, Jiang J, et al. Molecular epidemiology of human Blastocystis in a village in Yunnan province, China. Parasitol Int. 2007;56:281-6 pubmed
    The purpose of this study was to improve our understanding of the molecular epidemiology of human Blastocystis, focusing on 239 randomly selected individuals in a single village in Yunnan province, China...
  65. Kostka M, Uzlikova M, Cepicka I, Flegr J. SlowFaster, a user-friendly program for slow-fast analysis and its application on phylogeny of Blastocystis. BMC Bioinformatics. 2008;9:341 pubmed publisher
    ..In several steps of increasing stringency, the slow-fast analysis omits the fastest substituting alignment positions from the analysed dataset and thus increases its signal/noise ratio...
  66. Vassalos C, Spanakos G, Vassalou E, Papadopoulou C, Vakalis N. Differences in clinical significance and morphologic features of Blastocystis sp subtype 3. Am J Clin Pathol. 2010;133:251-8 pubmed publisher
    b>Blastocystis is a polymorphic intestinal parasite that is common in humans. A total of 51 asymptomatic and symptomatic patients positive for Blastocystis only were included in the study...
  67. Mirza H, Teo J, Upcroft J, Tan K. A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities. Antimicrob Agents Chemother. 2011;55:637-48 pubmed publisher
    b>Blastocystis is an emerging protistan parasite of controversial pathogenesis...
  68. Malheiros A, Stensvold C, Clark C, Braga G, Shaw J. Short report: Molecular characterization of Blastocystis obtained from members of the indigenous Tapirapé ethnic group from the Brazilian Amazon region, Brazil. Am J Trop Med Hyg. 2011;85:1050-3 pubmed publisher
    ..Fecal DNAs from Blastocystis-positive samples were extracted, polymerase chain reaction amplified using Blastocystis-specific primers ..
  69. Fayer R, Santin M, Macarisin D. Detection of concurrent infection of dairy cattle with Blastocystis, Cryptosporidium, Giardia, and Enterocytozoon by molecular and microscopic methods. Parasitol Res. 2012;111:1349-55 pubmed publisher
    ..from 47 dairy cattle ranging in age from neonates to multiparous cows, 9, 10, 24, and 17 were positive for Blastocystis spp., Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi, respectively, as determined by PCR...
  70. Tan K, Ibrahim M, Ng G, Nasirudeen A, Ho L, Yap E, et al. Exposure of Blastocystis species to a cytotoxic monoclonal antibody. Parasitol Res. 2001;87:534-8 pubmed
    A recently described cytotoxic monoclonal antibody (mAb 1D5) raised against Blastocystis hominis isolate B, was tested for reactivity with 13 different isolates of Blastocystis...
  71. Yoshikawa H, Wu Z, Howe J, Hashimoto T, Geok Choo N, Tan K. Ultrastructural and phylogenetic studies on Blastocystis isolates from cockroaches. J Eukaryot Microbiol. 2007;54:33-7 pubmed
    Four Blastocystis isolates from cockroaches were established and these isolates were morphologically confirmed as Blastocystis organisms by light and/or electron microscopy...
  72. Rivera W. Phylogenetic analysis of Blastocystis isolates from animal and human hosts in the Philippines. Vet Parasitol. 2008;156:178-82 pubmed publisher
    To study the genetic diversity and cross-transmissibility of Blastocystis species in naturally infected hosts, 12 Blastocystis isolates from animal and human hosts in the Philippines were analyzed by sequencing the full-length small ..
  73. Lantsman Y, Tan K, Morada M, Yarlett N. Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7. Microbiology. 2008;154:2757-66 pubmed publisher
    A mitochondrion-like organelle (MLO) was isolated from isotonic homogenates of Blastocystis. The organelle sedimented at 5000 g for 10 min, and had an isopycnic density in sucrose of 1.2 g ml(-1)...
  74. Yoshikawa H, Wu Z, Pandey K, Pandey B, Sherchand J, Yanagi T, et al. Molecular characterization of Blastocystis isolates from children and rhesus monkeys in Kathmandu, Nepal. Vet Parasitol. 2009;160:295-300 pubmed publisher
    To investigate the possible transmission of Blastocystis organisms between local rhesus monkeys and children in Kathmandu, Nepal, we compared the subtype (ST) and sequence of Blastocystis isolates from children with gastrointestinal ..
  75. Parkar U, Traub R, Vitali S, Elliot A, Levecke B, Robertson I, et al. Molecular characterization of Blastocystis isolates from zoo animals and their animal-keepers. Vet Parasitol. 2010;169:8-17 pubmed publisher
    b>Blastocystis is an enteric protist and one of the most frequently reported parasitic infections in humans and a variety of animal hosts...
  76. Denoeud F, Roussel M, Noel B, Wawrzyniak I, Da Silva C, Diogon M, et al. Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite. Genome Biol. 2011;12:R29 pubmed publisher
    b>Blastocystis is a highly prevalent anaerobic eukaryotic parasite of humans and animals that is associated with various gastrointestinal and extraintestinal disorders...
  77. Abdulsalam A, Ithoi I, Al Mekhlafi H, Ahmed A, Surin J, Mak J. Drinking water is a significant predictor of Blastocystis infection among rural Malaysian primary schoolchildren. Parasitology. 2012;139:1014-20 pubmed publisher
    b>Blastocystis infection has a worldwide distribution especially among the disadvantaged population and immunocompromised subjects...
  78. Yoshikawa H, Morimoto K, Wu Z, Singh M, Hashimoto T. Problems in speciation in the genus Blastocystis. Trends Parasitol. 2004;20:251-5 pubmed
  79. Scicluna S, Tawari B, Clark C. DNA barcoding of blastocystis. Protist. 2006;157:77-85 pubmed
    We have developed a simple method for subtyping the intestinal protistan parasite Blastocystis using an approach equivalent to DNA barcoding in animals...
  80. Stensvold C, Suresh G, Tan K, Thompson R, Traub R, Viscogliosi E, et al. Terminology for Blastocystis subtypes--a consensus. Trends Parasitol. 2007;23:93-6 pubmed
    b>Blastocystis is a ubiquitous enteric protistan parasite that has extensive genetic diversity and infects humans and many other animals...
  81. Li L, Zhang X, Lv S, Zhang L, Yoshikawa H, Wu Z, et al. Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China. Parasitol Res. 2007;102:83-90 pubmed
    The prevalence and geographical distribution of the intestinal protozoa Blastocystis in humans across China is unknown, and the relative importance of different subtypes has yet to be investigated...
  82. Stensvold C, Arendrup M, Nielsen H, Mølbak K. [Blastocystis--an enigmatic parasite]. Ugeskr Laeger. 2009;171:2388-90 pubmed
    b>Blastocystis can be isolated from roughly 25% of patients suspected of intestinal parasitosis...
  83. Roberts T, Stark D, Harkness J, Ellis J. Subtype distribution of Blastocystis isolates identified in a Sydney population and pathogenic potential of Blastocystis. Eur J Clin Microbiol Infect Dis. 2013;32:335-43 pubmed publisher
    b>Blastocystis is one of the most common enteric parasites present in humans. There is still much uncertainty about the pathogenic potential of this parasite, and it was suggested that its pathogenicity could be subtype-related...
  84. El Safadi D, Meloni D, Poirier P, Osman M, Cian A, Gaayeb L, et al. Molecular epidemiology of Blastocystis in Lebanon and correlation between subtype 1 and gastrointestinal symptoms. Am J Trop Med Hyg. 2013;88:1203-6 pubmed publisher
    b>Blastocystis is the most common eukaryotic parasite in the intestinal tract of humans...
  85. Alfellani M, Jacob A, Perea N, Krecek R, Taner Mulla D, Verweij J, et al. Diversity and distribution of Blastocystis sp. subtypes in non-human primates. Parasitology. 2013;140:966-71 pubmed publisher
    b>Blastocystis SSU-rDNA sequence data from 317 captive and free-living non-human primates (NHPs) representing 30 genera of apes, Old and New World (OW and NW) monkeys and prosimians were analysed to investigate subtype (ST) and allele ..
  86. Kumarasamy V, Kuppusamy U, Samudi C, Kumar S. Blastocystis sp. subtype 3 triggers higher proliferation of human colorectal cancer cells, HCT116. Parasitol Res. 2013;112:3551-5 pubmed publisher
    b>Blastocystis sp. is a commonly found intestinal microorganism and was reported to cause many nonspecific gastrointestinal symptoms...
  87. Leelayoova S, Siripattanapipong S, Thathaisong U, Naaglor T, Taamasri P, Piyaraj P, et al. Drinking water: a possible source of Blastocystis spp. subtype 1 infection in schoolchildren of a rural community in central Thailand. Am J Trop Med Hyg. 2008;79:401-6 pubmed
    ..Of 675 stool samples, Blastocystis was identified with a prevalence of 18.9%. Genetic characterization of Blastocystis showed subtype 1 (77...
  88. Souppart L, Sanciu G, Cian A, Wawrzyniak I, Delbac F, Capron M, et al. Molecular epidemiology of human Blastocystis isolates in France. Parasitol Res. 2009;105:413-21 pubmed publisher
    b>Blastocystis sp. is the most common eukaryotic parasite in the intestinal tract of humans. Due to its strong impact in public health, in this study, we determined the frequency of different Blastocystis subtypes in patients in France...
  89. Mirza H, Wu Z, Kidwai F, Tan K. A metronidazole-resistant isolate of Blastocystis spp. is susceptible to nitric oxide and downregulates intestinal epithelial inducible nitric oxide synthase by a novel parasite survival mechanism. Infect Immun. 2011;79:5019-26 pubmed publisher
    b>Blastocystis, one of the most common parasites colonizing the human intestine, is an extracellular, noninvasive, luminal protozoan with controversial pathogenesis...
  90. Lee L, Chye T, Karmacharya B, Govind S. Blastocystis sp.: waterborne zoonotic organism, a possibility?. Parasit Vectors. 2012;5:130 pubmed publisher
    b>Blastocystis sp. is a common intestinal parasite found in faecal sample surveys. Several studies have implicated human-to-human, zoonotic and waterborne transmissions by Blastocystis sp...
  91. Roberts T, Stark D, Harkness J, Ellis J. Subtype distribution of Blastocystis isolates from a variety of animals from New South Wales, Australia. Vet Parasitol. 2013;196:85-9 pubmed publisher
    ..samples from 38 different species of animal from seven different locations were studied for the presence of Blastocystis. PCR analysis was completed on all samples and DNA sequence data from the rDNA were submitted to subtype ..
  92. Clark C, van der Giezen M, Alfellani M, Stensvold C. Recent developments in Blastocystis research. Adv Parasitol. 2013;82:1-32 pubmed publisher
    b>Blastocystis is a common parasite of the human large intestine but has an uncertain role in disease. In this review, we appraise the published evidence addressing this and its weaknesses...