tetrahymena pyriformis


Summary: A species of ciliate protozoa used extensively in genetic research.

Top Publications

  1. Xue Y, Li H, Ung C, Yap C, Chen Y. Classification of a diverse set of Tetrahymena pyriformis toxicity chemical compounds from molecular descriptors by statistical learning methods. Chem Res Toxicol. 2006;19:1030-9 pubmed
    Toxicity of various compounds has been measured in many studies by their toxic effects against Tetrahymena pyriformis. Efforts have also been made to use computational quantitative structure-activity relationship (QSAR) and statistical ..
  2. Ellison C, Cronin M, Madden J, Schultz T. Definition of the structural domain of the baseline non-polar narcosis model for Tetrahymena pyriformis. SAR QSAR Environ Res. 2008;19:751-83 pubmed publisher
    ..relationship (QSAR) for the toxicity (log IGC(50)(-1)) of classic non-polar narcotics to Tetrahymena pyriformis, and subsequently use this model to define the domain of applicability for baseline narcosis...
  3. Kohidai L, Vakkuri O, Keresztesi M, Leppäluoto J, Csaba G. Melatonin in the unicellular Tetrahymena pyriformis: effects of different lighting conditions. Cell Biochem Funct. 2002;20:269-72 pubmed
    Melatonin content in the cellular fraction and medium of Tetrahymena pyriformis GL cultures was measured at different time points of light and dark exposures...
  4. Shi J, Ma C, Xu B, Zhang H, Yu C. Effect of light on toxicity of nanosilver to Tetrahymena pyriformis. Environ Toxicol Chem. 2012;31:1630-8 pubmed publisher
    ..The aim of the present study was to elucidate the influence of light on the toxicity of AgNPs to Tetrahymena pyriformis. Silver nanoparticles, which were synthesized by reduction of silver nitrate with sodium borohydride, ..
  5. Bonnet J, Bonnemoy F, Dusser M, Bohatier J. Assessment of the potential toxicity of herbicides and their degradation products to nontarget cells using two microorganisms, the bacteria Vibrio fischeri and the ciliate Tetrahymena pyriformis. Environ Toxicol. 2007;22:78-91 pubmed
    ..cells was assessed using two microorganisms frequently used in ecotoxicology, Vibrio fischeri and Tetrahymena pyriformis. Toxicity assays involved the Microtox test, the T...
  6. Bonnet J, Bonnemoy F, Dusser M, Bohatier J. Toxicity assessment of the herbicides sulcotrione and mesotrione toward two reference environmental microorganisms: Tetrahymena pyriformis and Vibrio fischeri. Arch Environ Contam Toxicol. 2008;55:576-83 pubmed publisher
    ..assessed using representative environmental microorganisms frequently used in ecotoxicology: the eukaryote Tetrahymena pyriformis and the prokaryote Vibrio fischeri...
  7. Cronin M, Schultz T. Development of quantitative structure-activity relationships for the toxicity of aromatic compounds to Tetrahymena pyriformis: comparative assessment of the methodologies. Chem Res Toxicol. 2001;14:1284-95 pubmed
    ..quantitative structure-activity relationships (QSARs) for the toxicity of 268 aromatic compounds in the Tetrahymena pyriformis growth inhibition assay...
  8. Kahn I, Sild S, Maran U. Modeling the toxicity of chemicals to Tetrahymena pyriformis using heuristic multilinear regression and heuristic back-propagation neural networks. J Chem Inf Model. 2007;47:2271-9 pubmed
    During the last years, considerable effort has been devoted to model the toxicity of chemicals to Tetrahymena pyriformis for medium and large sized data sets using various artificial neural network (ANN) techniques...
  9. Cronin M, Aptula A, Duffy J, Netzeva T, Rowe P, Valkova I, et al. Comparative assessment of methods to develop QSARs for the prediction of the toxicity of phenols to Tetrahymena pyriformis. Chemosphere. 2002;49:1201-21 pubmed
    ..structure-activity relationships (QSARs) for the toxicity of 200 phenols to the ciliated protozoan Tetrahymena pyriformis, and the validation of the QSARs using a test set of a further 50 compounds, are reported...

More Information


  1. Bonnet J, Dusser M, Bohatier J, Laffosse J. Cytotoxicity assessment of three therapeutic agents, cyclosporin-A, cisplatin and doxorubicin, with the ciliated protozoan Tetrahymena pyriformis. Res Microbiol. 2003;154:375-85 pubmed
    ..agents was determined using bioassays performed with a unicellular eukaryote, the ciliated protozoan Tetrahymena pyriformis. For this purpose we used the population growth impairment test and the non-specific esterase activities ..
  2. Stefanidou M, Chatziioannou A, Livaditou A, Rellaki A, Alevisopoulos G, Spiliopoulou H, et al. DNA toxicity of cocaine hydrochloride and cocaine freebase by means of DNA image analysis on Tetrahymena pyriformis. Biol Pharm Bull. 2002;25:332-4 pubmed
    An assay for computerized scoring of the DNA content of the protozoan Tetrahymena pyriformis has been used for the detection of toxic responses to cocaine, since DNA is responsible for the replication of the genetic material and also ..
  3. Thurman J, Parry J, Hill P, Laybourn Parry J. The filter-feeding ciliates Colpidium striatum and Tetrahymena pyriformis display selective feeding behaviours in the presence of mixed, equally-sized, bacterial prey. Protist. 2010;161:577-88 pubmed publisher
    ..Colpidium striatum selected K. aerogenes over K. ozaenae which itself was selected over E. coli. Tetrahymena pyriformis showed no selectivity between K. aerogenes and E. coli but K. aerogenes was selected over K...
  4. Schultz T, Sparfkin C, Aptula A. Reactivity-based toxicity modelling of five-membered heterocyclic compounds: application to Tetrahymena pyriformis. SAR QSAR Environ Res. 2010;21:681-91 pubmed publisher
    ..thiol and acute aquatic toxicity assays using glutathione (GSH) as a model nucleophile and the ciliate Tetrahymena pyriformis, respectively...
  5. Fu C, Miao W. Cloning and characterization of a new multi-stress inducible metallothionein gene in Tetrahymena pyriformis. Protist. 2006;157:193-203 pubmed
    ..metallothionein (MT) gene isoform has been cloned and characterized from the ciliate Tetrahymena pyriformis. Both the 5'- and 3'-UT regions of the Tp-MT2 gene are very different from the previously reported Tp-MT1 ..
  6. Schnare M, Heinonen T, Young P, Gray M. A discontinuous small subunit ribosomal RNA in Tetrahymena pyriformis mitochondria. J Biol Chem. 1986;261:5187-93 pubmed
    We show here that in the mitochondria of Tetrahymena pyriformis, the small subunit (SSU) rRNA is discontinuous, being comprised of two separate components which we term "alpha" (a novel low molecular weight RNA, approximately ..
  7. Zhang Y, Yang J, Yin X, Yang S, Zhu Y. Arsenate toxicity and stress responses in the freshwater ciliate Tetrahymena pyriformis. Eur J Protistol. 2012;48:227-36 pubmed publisher
    ..Herein, we investigated the cell stress responses of the freshwater ciliate Tetrahymena pyriformis to arsenate toxicity. An acute toxicity assay revealed an 18-h EC(50) arsenate concentration of ca...
  8. Domènech J, Bofill R, Tinti A, Torreggiani A, Atrian S, Capdevila M. Comparative insight into the Zn(II)-, Cd(II)- and Cu(I)-binding features of the protozoan Tetrahymena pyriformis MT1 metallothionein. Biochim Biophys Acta. 2008;1784:693-704 pubmed publisher
    b>Tetrahymena pyriformis MT1 (TpyMT1) is a model among ciliate metallothioneins (MTs)...
  9. Su L, Fu L, He J, Qin W, Sheng L, Abraham M, et al. Comparison of Tetrahymena pyriformis toxicity based on hydrophobicity, polarity, ionization and reactivity of class-based compounds. SAR QSAR Environ Res. 2012;23:537-52 pubmed publisher
    ..the toxicities of 970 hydrophobic, polar and ionizable, nitro substituted and ?,?-unsaturated compounds to Tetrahymena pyriformis was classified into different groups based on the structure and substituted functional groups...
  10. Joachimiak E, Pucciarelli S, Barchetta S, Ballarini P, Kaczanowska J, Miceli C. Cell cycle-dependent expression of gamma-tubulin in the amicronuclear ciliate Tetrahymena pyriformis. Protist. 2007;158:39-50 pubmed
    ..This study deals with the characterization of gamma-tubulin in the amicronuclear ciliate Tetrahymena pyriformis. Sequence analysis revealed some specific substitutions in nucleotide-binding loops characteristic of the ..
  11. Tetko I, Sushko I, Pandey A, Zhu H, Tropsha A, Papa E, et al. Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: focusing on applicability domain and overfitting by variable selection. J Chem Inf Model. 2008;48:1733-46 pubmed publisher
    ..The developed models are available online at http://www.qspr.org site...
  12. Roberts D, Schultz T, Wolf E, Aptula A. Experimental reactivity parameters for toxicity modeling: application to the acute aquatic toxicity of SN2 electrophiles to Tetrahymena pyriformis. Chem Res Toxicol. 2010;23:228-34 pubmed publisher
    ..structure-activity relationship (QSAR) analysis correlating acute aquatic toxicity (IGC(50)) to Tetrahymena pyriformis with RC(50) values was carried out...
  13. Artemenko A, Muratov E, Kuz min V, Muratov N, Varlamova E, Kuz mina A, et al. QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action. SAR QSAR Environ Res. 2011;22:575-601 pubmed publisher
    ..explosives) tested for their toxicity (50% inhibition growth concentration, IGC??) against the ciliate Tetrahymena pyriformis. The dataset was divided into subsets according to putative mechanisms of toxicity...
  14. Pushkareva V, Ermolaeva S. Listeria monocytogenes virulence factor Listeriolysin O favors bacterial growth in co-culture with the ciliate Tetrahymena pyriformis, causes protozoan encystment and promotes bacterial survival inside cysts. BMC Microbiol. 2010;10:26 pubmed publisher
    ..In this study, we explored the potential of LLO to promote interactions between L. monocytogenes and the ubiquitous inhabitant of natural ecosystems bacteriovorous free-living ciliate Tetrahymena pyriformis.
  15. Strahl E, Gillaspy G, Falkinham J. Fluorescent acid-fast microscopy for measuring phagocytosis of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum by Tetrahymena pyriformis and their intracellular growth. Appl Environ Microbiol. 2001;67:4432-9 pubmed
    ..avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum in the ciliated phagocytic protozoan Tetrahymena pyriformis. There was a linear relationship between FAM and colony counts of M...
  16. Kar S, Harding A, Roy K, Popelier P. QSAR with quantum topological molecular similarity indices: toxicity of aromatic aldehydes to Tetrahymena pyriformis. SAR QSAR Environ Res. 2010;21:149-68 pubmed publisher
    ..relationship (QSAR) models for the toxicity of aldehydes to the ecologically important species Tetrahymena pyriformis. Quantum topological molecular similarity (QTMS) descriptors, along with the lipid-water partition ..
  17. Mekapati S, Hansch C. On the parametrization of the toxicity of organic chemicals to Tetrahymena pyriformis. The problem of establishing a uniform activity. J Chem Inf Comput Sci. 2002;42:956-61 pubmed
    ..A study of the action of a large set of phenols acting on Tetrahymena pyriformis made by Cronin and Schultz is analyzed to illustrate the problem.
  18. Barry R, Bowman E, McQueney M, Dunaway Mariano D. Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis. Biochem Biophys Res Commun. 1988;153:177-82 pubmed
    The biosynthetic reaction pathway leading to the natural product, 2-aminoethylphosphonate in Tetrahymena pyriformis has been elucidated. Incubation of [32P]PEP and [14C]PEP with T...
  19. Searcy D. Rapid hydrogen sulfide consumption by Tetrahymena pyriformis and its implications for the origin of mitochondria. Eur J Protistol. 2006;42:221-31 pubmed
    Although sulfide is typically regarded as toxic to eukaryotic cells, it is avidly consumed by Tetrahymena pyriformis. That was observed only when the sulfide concentration was kept below 1 microM...
  20. Piccinni E, Bertaggia D, Santovito G, Miceli C, Kraev A. Cadmium metallothionein gene of Tetrahymena pyriformis. Gene. 1999;234:51-9 pubmed
    A genomic sequence from Tetrahymena pyriformis, encoding a cadmium-induced metallothionein has been cloned...
  21. Kovacs P, Csaba G. Effect of drugs affecting microtubular assembly on microtubules, phospholipid synthesis and physiological indices (signalling, growth, motility and phagocytosis) in Tetrahymena pyriformis. Cell Biochem Funct. 2006;24:419-29 pubmed
    ..microtubular systems of Tetrahymena and also differently influence microtubule-dependent physiological processes. The latter are more dependent on microtubular dynamics than are changes in phospholipid signalling...
  22. Schultz T, Netzeva T, Roberts D, Cronin M. Structure-toxicity relationships for the effects to Tetrahymena pyriformis of aliphatic, carbonyl-containing, alpha,beta-unsaturated chemicals. Chem Res Toxicol. 2005;18:330-41 pubmed
    ..Toxicity was assessed in the 2-day Tetrahymena pyriformis population growth impairment assay...
  23. Devillers J. Linear versus nonlinear QSAR modeling of the toxicity of phenol derivatives to Tetrahymena pyriformis. SAR QSAR Environ Res. 2004;15:237-49 pubmed
    ..derivatives for which the 50% growth inhibition concentration (IGC(50)) values to the ciliated protozoan Tetrahymena pyriformis were available...
  24. Enoch S, Cronin M, Schultz T, Madden J. An evaluation of global QSAR models for the prediction of the toxicity of phenols to Tetrahymena pyriformis. Chemosphere. 2008;71:1225-32 pubmed publisher
    ..global quantitative structure-activity relationships (QSARs) to predict the toxic potency of phenols to Tetrahymena pyriformis. The phenolic toxicity data set analysed is characterised by multiple mechanisms of toxic action...
  25. Zhu H, Tropsha A, Fourches D, Varnek A, Papa E, Gramatica P, et al. Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis. J Chem Inf Model. 2008;48:766-84 pubmed publisher
    ..toxicity data set containing 983 unique compounds tested in the same laboratory over a decade against Tetrahymena pyriformis. A modeling set including 644 compounds was selected randomly from the original set and distributed to all ..
  26. Bukharin O, Plotnikov A, Nemtseva N, Kovbyk L. [Histone-antihistone interactions in the Escherichia coli-Tetrahymena pyriformis association]. Mikrobiologiia. 2008;77:219-25 pubmed
    Using the Escherichia coli-Tetrahymena pyriformis system, we revealed the involvement of bacterial antihistone activity and protozoan histones in interactions between pro- and eukaryotic microorganisms...
  27. Nelson S, Cooper A, Taylor E, Salisbury V. Use of bioluminescent Escherichia coli O157:H7 to study intra-protozoan survival of bacteria within Tetrahymena pyriformis. FEMS Microbiol Lett. 2003;223:95-9 pubmed
    ..of the uptake and survival of bioluminescent Escherichia coli O157 within the freshwater ciliate Tetrahymena pyriformis. Constitutively bioluminescent E. coli O157 pLITE27 was cocultured with T...
  28. Frankel J, Nelsen E. The effects of supraoptimal temperatures on population growth and cortical patterning in Tetrahymena pyriformis and Tetrahymena thermophila: a comparison. J Eukaryot Microbiol. 2001;48:135-46 pubmed
    ..Both the initial spatial disorder and the failures in realignment are far more severe in T. pyriformis than in T. thermophila...
  29. Cronin M, Schultz T. Structure-toxicity relationships for three mechanisms of action of toxicity to Vibrio fischeri. Ecotoxicol Environ Saf. 1998;39:65-9 pubmed
    ..41, n = 19, s = 0.46, r2 = 0.892, F = 75.3]. In addition, an excellent correlation was found between Tetrahymena pyriformis [log(1/IGC50)] and V. fischeri. [log(1/IGC50) = 0.86(pT15)-0.25, n = 19, s = 0.25, r2 = 0...
  30. Rohr U, Weber S, Selenka F, Wilhelm M. Impact of silver and copper on the survival of amoebae and ciliated protozoa in vitro. Int J Hyg Environ Health. 2000;203:87-9 pubmed
    ..silver/copper combinations for inactivation of Hartmannella vermiformis amoebas and the ciliated protozoan Tetrahymena pyriformis in vitro was studied...
  31. Pasha F, Srivastava H, Singh P. Comparative QSAR study of phenol derivatives with the help of density functional theory. Bioorg Med Chem. 2005;13:6823-9 pubmed
    ..91 and cross-validation coefficient r(cv)2 0.88. This study is also helpful in determining the effect of any particular phenol derivative of this series over Tetrahymena pyriformis.
  32. Novotný C, Dias N, Kapanen A, Malachová K, Vandrovcova M, Itävaara M, et al. Comparative use of bacterial, algal and protozoan tests to study toxicity of azo- and anthraquinone dyes. Chemosphere. 2006;63:1436-42 pubmed
    ..3 (DB3)) were compared using bacterium Vibrio fischeri, microalga Selenastrum capricornutum and ciliate Tetrahymena pyriformis. The following respective endpoints were involved: acute toxicity measured as bacterial luminescence ..
  33. Kojima H, Numata O. Enzymatic form and cytoskeletal form of bifunctional Tetrahymena 49kDa protein is regulated by phosphorylation. Zoolog Sci. 2002;19:37-42 pubmed
    ..With this dephosphorylation, the citrate synthase type isoforms obtained the ability to assemble 14-nm filaments. We propose that enzyme form and cytoskeletal form of 49kDa protein were maintained simply by phosphorylation. ..
  34. Manz W, Amann R, Szewzyk R, Szewzyk U, Stenström T, Hutzler P, et al. In situ identification of Legionellaceae using 16S rRNA-targeted oligonucleotide probes and confocal laser scanning microscopy. Microbiology. 1995;141 ( Pt 1):29-39 pubmed
    ..pneumophila within cells of the ciliated protozoan Tetrahymena pyriformis. Whole-cell probing with 16S rRNA-targeted oligonucleotides could, in the future, complement established ..
  35. Schultz T, Yarbrough J, Koss S. Identification of reactive toxicants: structure-activity relationships for amides. Cell Biol Toxicol. 2006;22:339-49 pubmed
    A diverse series of amides were evaluated for aquatic toxicity (IGC(50)) assessed in the Tetrahymena pyriformis population growth impairment assay and for reactivity (EC(50)) with the model soft nucleophile thiol in the form of the ..
  36. Ertürk M, Saçan M. First toxicity data of chlorophenols on marine alga Dunaliella tertiolecta: correlation of marine algal toxicity with hydrophobicity and interspecies toxicity relationships. Environ Toxicol Chem. 2012;31:1113-20 pubmed publisher
    ..data of chlorophenols with the previously published data on bacterium (Vibrio fischeri), protozoan (Tetrahymena pyriformis), daphnid (Daphnia magna), freshwater alga (Pseudokirchneriella subcapitata), and fish (Pimephales ..
  37. Schultz T, Cronin M, Netzeva T, Aptula A. Structure-toxicity relationships for aliphatic chemicals evaluated with Tetrahymena pyriformis. Chem Res Toxicol. 2002;15:1602-9 pubmed
    ..relationships were developed for the toxicity data of 500 aliphatic chemicals tested in the two-day Tetrahymena pyriformis population growth impairment assay...
  38. Schuurmann G, Aptula A, Kühne R, Ebert R. Stepwise discrimination between four modes of toxic action of phenols in the Tetrahymena pyriformis assay. Chem Res Toxicol. 2003;16:974-87 pubmed
    ..220 phenols with literature data on their toxicity and associated mode of action (MOA) toward the ciliate Tetrahymena pyriformis, a stepwise classification scheme was developed that allows the identification of four MOAs from molecular ..
  39. Shemarova I, Selivanova G, Vlasova T. [A cytophotometric study of the influence exerted by epidermal growth factor on RNA and protein synthesis in the ciliate Tetrahymena pyriformis]. Tsitologiia. 2004;46:993-5 pubmed
    The influence of EGF (10(-8) M) on RNA and protein synthesis in the ciliate Tetrahymena pyriformis was studied. It was found that EGF stimulated RNA and proteins synthesis in T. pyriformis within 3 h after addition of EGF.
  40. Denoncourt A, Paquet V, Charette S. Packaging of Mycobacterium smegmatis bacteria into fecal pellets by the ciliate Tetrahymena pyriformis. FEMS Microbiol Lett. 2017;: pubmed publisher
    ..The model bacterium Mycobacterium smegmatis survived digestion in food vacuoles of the ciliate Tetrahymena pyriformis and was included in expelled fecal pellets. LIVE/DEAD® staining confirmed that packaged M...
  41. Prikhodko E, Brailovskaya I, Korotkov S, Mokhova E. Features of mitochondrial energetics in living unicellular eukaryote Tetrahymena pyriformis. A model for study of mammalian intracellular adaptation. Biochemistry (Mosc). 2009;74:371-6 pubmed
    b>Tetrahymena pyriformis is used in diverse studies as a non-mammalian alternative due to their resemblance in many main metabolic cycles...
  42. Kovacs P, Csaba G. Comparison of the binding of anti-tubulin antibody and the fluorescent taxol derivative Flutax-1 to the microtubular system of Tetrahymena. Acta Biol Hung. 2006;57:323-9 pubmed
    ..anti-alpha-tubulin antibody and the fluorescent taxol derivative Flutax-1 in fixed and living Tetrahymena pyriformis GL, longitudinal microtubules, oral and somatic cilia, deep fibers, and contractile vacuole pores were ..
  43. Brandmaier S, Sahlin U, Tetko I, Oberg T. PLS-optimal: a stepwise D-optimal design based on latent variables. J Chem Inf Model. 2012;52:975-83 pubmed publisher
    ..This improvement is statistically significant, especially for the small number of compounds selected. ..
  44. Csaba G, Kovacs P, Pallinger E. Presence and localization of epidermal growth factor (EGF)- and EGF-receptor-like immunoreactivity in Tetrahymena. Cell Biol Int. 2004;28:491-6 pubmed
    ..The relationships between these observations and literary data on the effects of EGF in Tetrahymena are discussed. ..
  45. Rodríguez Sánchez N, Schultz T, Cronin M, Enoch S. Experimental verification of structural alerts for the protein binding of cyclic compounds acting as Michael acceptors. SAR QSAR Environ Res. 2013;24:963-77 pubmed publisher
    ..The accurate definition of the applicability domain for structural alerts within in silico profilers is important due to their use in chemical category in predictive and regulatory toxicology. ..
  46. Fourrat L, Iddar A, Valverde F, Serrano A, Soukri A. Effects of oxidative and nitrosative stress on Tetrahymena pyriformis glyceraldehyde-3-phosphate dehydrogenase. J Eukaryot Microbiol. 2007;54:338-46 pubmed
    ..To gain further insight into this regulatory process the model ciliated protozoan Tetrahymena pyriformis was chosen. Both reagents inhibited growth of T...
  47. Lajkó E, Szabo I, Andódy K, PUNGOR A, Mezo G, Kohidai L. Investigation on chemotactic drug targeting (chemotaxis and adhesion) inducer effect of GnRH-III derivatives in Tetrahymena and human leukemia cell line. J Pept Sci. 2013;19:46-58 pubmed publisher
    ..GnRHs (hGnRH-I, cGnRH-II, and lGnRH-III) and nine GnRH-III derivatives were evaluated in two model cells (Tetrahymena pyriformis and Mono Mac 6 human monocytes)...
  48. Tsao C, Gorovsky M. Different effects of Tetrahymena IFT172 domains on anterograde and retrograde intraflagellar transport. Mol Biol Cell. 2008;19:1450-61 pubmed publisher
    ..These results implicate different regions of Ift172p in different steps of the IFT process...
  49. Inazu A, Sato K, Nakayama T, Deyashiki Y, Hara A, Nozawa Y. Purification and characterization of a novel dimeric 20 alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis. Biochem J. 1994;297 ( Pt 1):195-200 pubmed
    b>Tetrahymena pyriformis was found to exhibit high NADPH-dependent 20-oxosteroid reductase activity that converted 17 alpha-hydroxyprogesterone into 17 alpha,20 alpha-dihydroxypregn-4-en-3-one...
  50. Csaba G, Kovacs P, Pallinger E. EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: a flow cytometric and confocal microscopic comparative analysis. Cell Biol Int. 2006;30:345-8 pubmed
    ..The results support earlier observations on the presence of these hormones in Tetrahymena and points to the advantage of EDAC fixation for demonstrating these hormones immunocytochemically. ..
  51. Csaba G, Kovacs P, Pallinger E. Hormonal interactions in Tetrahymena: effect of hormones on levels of epidermal growth factor (EGF). Cell Biol Int. 2005;29:301-5 pubmed
    ..This could be the basis of further evolution to the hormonal system of multicellulars...
  52. Searcy D, Peterson M. Hydrogen sulfide consumption measured at low steady state concentrations using a sulfidostat. Anal Biochem. 2004;324:269-75 pubmed
    ..The protozoan Tetrahymena pyriformis was used to demonstrate the apparatus; maximum sulfide consumption occurred near 0...
  53. Sinks G, Schultz T. Correlation of Tetrahymena and Pimephales toxicity: evaluation of 100 additional compounds. Environ Toxicol Chem. 2001;20:917-21 pubmed
    ..Toxicity values for the 96-h Pimephales promelas mortality assay (log[LC50(-1)]) and the 2-d Tetrahymena pyriformis growth assay (log[IGC50(-1)]) were compared. Each chemical was a priori assigned a mode of action...
  54. Csaba G, Pallinger E. How applicable is the general adaptation syndrome to the unicellular Tetrahymena?. Cell Biochem Funct. 2009;27:12-5 pubmed publisher
    ..It was concluded that the ancestor of Selye's General Adaptation Syndrome (GAS) can be found already at unicellular level, and this possibly has a life saving function...
  55. Illyes E, Hudecz F, Kohidai L, Láng O, Szabo P, Sebestyen F. Synthesis of oligopeptides with the sequence SXWS and their chemotactic effects on a ciliated protozoan Tetrahymena pyriformis. J Pept Sci. 2002;8:13-22 pubmed
    ..properties with those of SEWS, which exhibits a prominent effect at 10(-12) M on a ciliated protozoan, Tetrahymena pyriformis, are described...
  56. Cronin M, Gregory B, Schultz T. Quantitative structure-activity analyses of nitrobenzene toxicity to Tetrahymena pyriformis. Chem Res Toxicol. 1998;11:902-8 pubmed
    Toxicity data for the 50% growth inhibitory concentration against Tetrahymena pyriformis (log (IGC50-1)) for 42 alkyl- and halogen-substituted nitro- and dinitrobenzenes were obtained experimentally...
  57. Csaba G, Kovacs P, Pallinger E. How does the unicellular Tetrahymena utilise the hormones that it produces? Paying a visit to the realm of atto-and zeptomolar concentrations. Cell Tissue Res. 2007;327:199-203 pubmed
    Changes in the hormone content of Tetrahymena pyriformis GL were investigated during histamine, serotonin or insulin treatment at concentrations of 10(-6)M to 10(-21)M for 30 min...
  58. Toropov A, Toropova A, Benfenati E, Manganaro A. QSAR modelling of the toxicity to Tetrahymena pyriformis by balance of correlations. Mol Divers. 2010;14:821-7 pubmed publisher
    ..Monte Carlo method) have shown that the statistical characteristics of the prediction for the toxicity to Tetrahymena pyriformis (the 50% growth inhibition concentration, IGC(50)) based on the balance of correlations are better than ..
  59. Ren S. Modeling the toxicity of aromatic compounds to tetrahymena pyriformis: the response surface methodology with nonlinear methods. J Chem Inf Comput Sci. 2003;43:1679-87 pubmed
    ..on multiple linear regression had previously been developed for the toxicity of aromatic chemicals to Tetrahymena pyriformis. However, a nonlinear relationship between toxicity and one of the molecular descriptors in the response ..
  60. Shpakov A, Derkach K, Uspenskaia Z, Shpakova E, Kuznetsova L, Plesneva S, et al. [Molecular mechanisms of regulatory action of adrenergic receptor agonists on functional activity of adenylyl cyclase signaling system of the ciliates Dileptus anser and Tetrahymena pyriformis]. Tsitologiia. 2004;46:317-25 pubmed
    ..earlier that agonists of adrenergic receptors (ARs) regulate AC activity of ciliates Dileptus anser and Tetrahymena pyriformis. The aim of this work was to study molecular mechanisms of AR ligand action on the functional activity of ..
  61. Melagraki G, Afantitis A, Makridima K, Sarimveis H, Igglessi Markopoulou O. Prediction of toxicity using a novel RBF neural network training methodology. J Mol Model. 2006;12:297-305 pubmed
    ..The dataset used consists of 221 phenols and their corresponding toxicity values to Tetrahymena pyriformis. Physicochemical parameters and molecular descriptors are used to provide input information to the models...
  62. Müller A, Wichmann G, Massolo L, Rehwagen M, Gräbsch C, Loffhagen N, et al. Cytotoxicity and oxidative stress caused by chemicals adsorbed on particulate matter. Environ Toxicol. 2006;21:457-63 pubmed
    ..processes caused by chemical compounds bound to PM of different size fractions were investigated in Tetrahymena pyriformis. The PM samplings were carried out using a high volume cascade impactor (6 size fractions between 10 ..
  63. Zhang X, Qin W, He J, Wen Y, Su L, Sheng L, et al. Discrimination of excess toxicity from narcotic effect: comparison of toxicity of class-based organic chemicals to Daphnia magna and Tetrahymena pyriformis. Chemosphere. 2013;93:397-407 pubmed publisher
    ..In this paper, the toxicity data of 758 chemicals to Daphnia magna and 993 chemicals to Tetrahymena pyriformis were used to investigate the excess toxicity...
  64. Shi J, Xu B, Sun X, Ma C, Yu C, Zhang H. Light induced toxicity reduction of silver nanoparticles to Tetrahymena Pyriformis: effect of particle size. Aquat Toxicol. 2013;132-133:53-60 pubmed publisher
    ..the particle size and the toxicity: small AgNPs (5-10nm) had higher toxicity than large AgNPs (15-25nm) to Tetrahymena pyriformis (T. pyriformis) under dark condition...
  65. Carlsen L. A combined QSAR and partial order ranking approach to risk assessment. SAR QSAR Environ Res. 2006;17:133-46 pubmed
    ..Biodegradation estimates were adopted from the BioWin module of the EPI Suite. The population growth impairment of Tetrahymena pyriformis was used as a surrogate for fish lethality.
  66. Nam S, van Noort D, Yang Y, Park S. A biological sensor platform using a pneumatic-valve controlled microfluidic device containing Tetrahymena pyriformis. Lab Chip. 2007;7:638-40 pubmed
    ..actuated valves, generating a linear gradient of chemoeffectors to quantify the chemotactic response of Tetrahymena pyriformis, a freshwater ciliate...
  67. Gräbsch C, Wichmann G, Loffhagen N, Herbarth O, Muller A. Cytotoxicity assessment of gliotoxin and penicillic acid in Tetrahymena pyriformis. Environ Toxicol. 2006;21:111-7 pubmed
    ..Using Tetrahymena pyriformis, a single-cell organism well established as a suitable model for human respiratory epithelium-cell ..
  68. Schultz T, Yarbrough J, Woldemeskel M. Toxicity to Tetrahymena and abiotic thiol reactivity of aromatic isothiocyanates. Cell Biol Toxicol. 2005;21:181-9 pubmed
    ..77 [log (1/EC(50))] + 0.60; n = 12, s = 0.34, r(2) = 0.718, q(2) = 0.629, F = 26...
  69. Jiang L, Brady L, Tan J. Species diversity, invasion, and alternative community states in sequentially assembled communities. Am Nat. 2011;178:411-8 pubmed publisher
    ..We suggest that elucidating mechanisms regulating the strength of priority effects may help in understanding variation in diversity-invasion relationships among natural communities...
  70. Zahran E, Seo J, Noga E. The effect of adjuvant and microbial challenge on the expression of antimicrobial polypeptides in channel catfish (Ictalurus punctatus). Fish Shellfish Immunol. 2012;33:168-73 pubmed publisher
    ..Here we demonstrate that intraperitoneal injection of either Freund's complete adjuvant (FCA) or live Tetrahymena pyriformis (a parasitic ciliate) upregulated AMPP expression in channel catfish skin...
  71. Schultz T, Tucker V. Structure-toxicity relationships for the effects of N- and N,N'-alkyl thioureas to Tetrahymena pyriformis. Bull Environ Contam Toxicol. 2003;70:1251-8 pubmed
  72. Brunk C, Lee L, Tran A, Li J. Complete sequence of the mitochondrial genome of Tetrahymena thermophila and comparative methods for identifying highly divergent genes. Nucleic Acids Res. 2003;31:1673-82 pubmed
    ..genome of Tetrahymena thermophila has been determined and compared with the mitochondrial genome of Tetrahymena pyriformis. The sequence similarity clearly indicates homology of the entire T.thermophila and T...
  73. Salahinejad M, Ghasemi J. 3D-QSAR studies on the toxicity of substituted benzenes to Tetrahymena pyriformis: CoMFA, CoMSIA and VolSurf approaches. Ecotoxicol Environ Saf. 2014;105:128-34 pubmed publisher
    ..3D-QSAR) analysis were performed on the toxicity of a large set of substituted benzenes toward ciliate Tetrahymena pyriformis. The 3D-QSAR studies were carried out using comparative molecular ?eld analysis (CoMFA), comparative ..
  74. Kohidai L, Darvas Z, Csaba G. The effect of varying illumination on imprinting of Tetrahymena by insulin. Acta Microbiol Hung. 1987;34:179-85 pubmed
    b>Tetrahymena pyriformis cultures were imprinted with insulin. Hormone binding was reduced in the dark, but alternation of dark and light periods were in this respect more effective than the dark itself...
  75. Kovacs P, Pinter M. Effects of phosphoprotein phosphatase inhibitors (phenylarsine oxide and cantharidin) on Tetrahymena. Cell Biochem Funct. 2001;19:197-205 pubmed
    ..and glycolipids, and on the cytoskeletal elements (F-actin and tubulin containing structures) of Tetrahymena pyriformis. Both phosphatase inhibitors reduced the amount of incorporated 32P of the whole phospholipid content, but ..