plasmodium yoelii

Summary

Summary: A species of PLASMODIUM causing malaria in rodents.

Top Publications

  1. Imai T, Shen J, Chou B, Duan X, Tu L, Tetsutani K, et al. Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. Eur J Immunol. 2010;40:1053-61 pubmed publisher
    ..found that CD8(+) T cells contribute to protective immunity against infection with blood-stage parasites of Plasmodium yoelii. Infection of C57BL/6 mice with P...
  2. Zhang J, Huang F, Xu W, Song P, Duan J, Yang S, et al. Plasmodium yoelii: correlation of up-regulated prophenoloxidase and phenoloxidases with melanization induced by the antimalarial, nitroquine. Exp Parasitol. 2008;118:308-14 pubmed
  3. Witkowski B, Lelièvre J, Nicolau Travers M, Iriart X, Njomnang Soh P, Bousejra Elgarah F, et al. Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. PLoS ONE. 2012;7:e32620 pubmed publisher
    ..Such considerations appear crucial in the current context of early artemisinin resistance in Asia. ..
  4. Grüber A, Manimekalai M, Balakrishna A, Hunke C, Jeyakanthan J, Preiser P, et al. Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii. PLoS ONE. 2010;5:e9146 pubmed publisher
    ..A 94 kDa region named Nucleotide-Binding Domain 94 (NBD94) of Plasmodium yoelii YM, representative of the putative nucleotide binding region of RH, has been demonstrated to bind ATP and ..
  5. Chen G, Feng H, Liu J, Qi Z, Wu Y, Guo S, et al. Characterization of immune responses to single or mixed infections with P. yoelii 17XL and P. chabaudi AS in different strains of mice. Parasitol Int. 2010;59:400-6 pubmed publisher
    The outcome of Plasmodium yoelii 17XL (P...
  6. Zheng W, Wang Q, Feng H, Liu J, Meng H, Cao Y. CD4+CD25+Foxp3+ regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium yoelii infection in susceptible BALB/c mice. Folia Parasitol (Praha). 2009;56:242-50 pubmed
    ..Experimental data suggest that the death of Plasmodium yoelii 17XL (Py 17XL) susceptible BALB/c mice results from the suppression of Th1 immune response mediated by CD4+..
  7. Charrin S, Yalaoui S, Bartosch B, Cocquerel L, Franetich J, Boucheix C, et al. The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. J Biol Chem. 2009;284:31572-8 pubmed publisher
    ..We have previously reported that CD81 is required on hepatocytes for infection by Plasmodium falciparum and Plasmodium yoelii sporozoites. CD81 belongs to the tetraspanin superfamily of transmembrane proteins...
  8. Qi Y, Zhu F, Li J, Fu Y, Pattaradilokrat S, Hong L, et al. Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses. Exp Parasitol. 2013;133:44-50 pubmed publisher
    ..the factors that might influence the chances of obtaining RP from a genetic cross and showed that different Plasmodium yoelii strains/subspecies/clones had unique abilities in producing oocysts in a mosquito midgut...
  9. Hafalla J, Cockburn I, Zavala F. Protective and pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol. 2006;28:15-24 pubmed
    ..Once again, the relevance of these results to human disease is one of the primary questions facing workers in this field. ..

More Information

Publications98

  1. Roy S, Hartl D. Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number. Genome Res. 2006;16:750-6 pubmed
    ..compared intron positions in conserved regions of 3479 orthologous gene pairs from Plasmodium falciparum and Plasmodium yoelii, which likely diverged >or=100 million years ago (Mya)...
  2. Roux C, Butler B, Chau J, Paixao T, Cheung K, Santos R, et al. Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice. Infect Immun. 2010;78:1520-7 pubmed publisher
    ..we established a model for oral Salmonella enterica serotype Typhimurium challenge in mice infected with Plasmodium yoelii nigeriensis. Initial characterization of this model showed that 5 days after coinoculation, P...
  3. Wykes M, Zhou Y, Liu X, Good M. Plasmodium yoelii can ablate vaccine-induced long-term protection in mice. J Immunol. 2005;175:2510-6 pubmed
    ..Our study demonstrates a novel mechanism by which Plasmodium ablates immunological memory of vaccines, which would leave the host immuno-compromised. ..
  4. Ishih A, Kawakami C, Todoroki A, Hirai H, Ohori K, Kobayashi F. Outcome of primary lethal and nonlethal Plasmodium yoelii malaria infection in BALB/c and IFN-? receptor-deficient mice following chloroquine treatment. Parasitol Res. 2013;112:773-80 pubmed publisher
    ..wild-type (WT) mice, with or without chloroquine (CQ) treatment, were infected intraperitoneally with Plasmodium yoelii 17XL (lethal) and P...
  5. Kebaier C, Voza T, Vanderberg J. Kinetics of mosquito-injected Plasmodium sporozoites in mice: fewer sporozoites are injected into sporozoite-immunized mice. PLoS Pathog. 2009;5:e1000399 pubmed publisher
  6. Mikolajczak S, Jacobs Lorena V, MacKellar D, Camargo N, Kappe S. L-FABP is a critical host factor for successful malaria liver stage development. Int J Parasitol. 2007;37:483-9 pubmed
    ..This is the first identified direct liver stage-host cell protein interaction, providing a possible explanation for the importance of UIS3 in liver infection. ..
  7. Dwivedi V, Khan A, Vasco A, Fatima N, Soni V, Dangi A, et al. Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice. Pharm Res. 2008;25:2312-9 pubmed publisher
    ..therapy comprising of immunomodulator picroliv and antimalarial chloroquine against drug resistant Plasmodium yoelii (P. yoelii) infection in BALB/c mice...
  8. Ono T, Tadakuma T, Rodriguez A. Plasmodium yoelii yoelii 17XNL constitutively expressing GFP throughout the life cycle. Exp Parasitol. 2007;115:310-3 pubmed
    b>Plasmodium yoelii is a rodent parasite commonly used as a model to study malaria infection...
  9. Ma S, Zheng L, Liu Y, Guo S, Feng H, Chen G, et al. Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice. Exp Parasitol. 2007;116:266-72 pubmed
    ..BALB/c and DBA/2 mice were infected by Plasmodium yoelii 17XNL and 17XL strains, respectively, and then treated with different doses of antimalarial drugs: ..
  10. Vaughan A, O Neill M, Tarun A, Camargo N, Phuong T, Aly A, et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol. 2009;11:506-20 pubmed publisher
    ..This was confirmed by knockout of FabZ, another critical FAS II enzyme. However, FAS II-deficient Plasmodium yoelii liver stages failed to form exo-erythrocytic merozoites, the invasive stage that first initiates blood stage ..
  11. Soulard V, Roland J, Sellier C, Gruner A, Leite de Moraes M, Franetich J, et al. Primary infection of C57BL/6 mice with Plasmodium yoelii induces a heterogeneous response of NKT cells. Infect Immun. 2007;75:2511-22 pubmed
    ..We characterized the NKT cell response induced in C57BL/6 mice during a primary infection with Plasmodium yoelii sporozoites. We observed a heterogeneous NKT cell response that differed between liver and spleen...
  12. Yalaoui S, Zougbédé S, Charrin S, Silvie O, Arduise C, Farhati K, et al. Hepatocyte permissiveness to Plasmodium infection is conveyed by a short and structurally conserved region of the CD81 large extracellular domain. PLoS Pathog. 2008;4:e1000010 pubmed publisher
  13. Wong K, Rodriguez A. Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells. J Immunol. 2008;180:716-26 pubmed
    ..During a Plasmodium yoelii infection, these regulatory CD11clowCD45RBhigh DCs become the prevalent CD11c-expressing cells in the spleen,..
  14. Cunningham D, Fonager J, Jarra W, Carret C, Preiser P, Langhorne J. Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?. PLoS ONE. 2009;4:e4285 pubmed publisher
    ..Individual parasites of the rodent malaria Plasmodium yoelii, selected by micromanipulation, transcribe only 1 to 3 different pir (yir) suggesting tight transcriptional ..
  15. Hisaeda H, Hamano S, Mitoma Obata C, Tetsutani K, Imai T, Waldmann H, et al. Resistance of regulatory T cells to glucocorticoid-induced [corrected] TNFR family-related protein (GITR) during Plasmodium yoelii infection. Eur J Immunol. 2005;35:3516-24 pubmed
    CD4+ T cells are the major effector T cells against blood-stage Plasmodium yoelii infection. On the other hand, the lethal strain of P...
  16. Perkins S, Sarkar I, Carter R. The phylogeny of rodent malaria parasites: simultaneous analysis across three genomes. Infect Genet Evol. 2007;7:74-83 pubmed
    ..species native to African thicket rats (Plasmodium berghei, Plasmodium chabaudi, Plasmodium vinckei, and Plasmodium yoelii) and one from a porcupine (Plasmodium atheruri) using DNA sequence data collected from seven genes from each ..
  17. Sedegah M, Weiss W, Hoffman S. Cross-protection between attenuated Plasmodium berghei and P. yoelii sporozoites. Parasite Immunol. 2007;29:559-65 pubmed
    ..berghei, but no protection against P. yoelii. The cross-protection data in BALB/c mice support testing a human vaccine based on attenuated PfSPZ for its efficacy against P. vivax...
  18. Wijayalath W, Danner R, Kleschenko Y, Majji S, Villasante E, Richie T, et al. HLA class II (DR0401) molecules induce Foxp3+ regulatory T cell suppression of B cells in Plasmodium yoelii strain 17XNL malaria. Infect Immun. 2014;82:286-97 pubmed publisher
    Unlike human malaria parasites that induce persistent infection, some rodent malaria parasites, like Plasmodium yoelii strain 17XNL (Py17XNL), induce a transient (self-curing) malaria infection...
  19. Tarun A, Baer K, Dumpit R, Gray S, Lejarcegui N, Frevert U, et al. Quantitative isolation and in vivo imaging of malaria parasite liver stages. Int J Parasitol. 2006;36:1283-93 pubmed
    ..Here, we present green fluorescent protein (GFP)-tagged Plasmodium yoelii rodent malaria parasite liver infections in BALB/c mice as an excellent quantitative model for the live ..
  20. Frischknecht F, Martin B, Thiery I, Bourgouin C, Menard R. Using green fluorescent malaria parasites to screen for permissive vector mosquitoes. Malar J. 2006;5:23 pubmed
    The Plasmodium species that infect rodents, particularly Plasmodium berghei and Plasmodium yoelii, are useful to investigate host-parasite interactions...
  21. Labaied M, Harupa A, Dumpit R, Coppens I, Mikolajczak S, Kappe S. Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection. Infect Immun. 2007;75:3758-68 pubmed
    ..Here, we generated p52/p36-deficient Plasmodium yoelii parasites by the simultaneous deletion of both genes using a single genetic manipulation...
  22. Douradinha B, van Dijk M, Ataide R, van Gemert G, Thompson J, Franetich J, et al. Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection. Int J Parasitol. 2007;37:1511-9 pubmed
    ..to a lesser extent, p36p(-)-sporozoites inhibits parasite intrahepatic development in mice challenged with Plasmodium yoelii sporozoites...
  23. Medica D, Sinnis P. Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes. Infect Immun. 2005;73:4363-9 pubmed
  24. Jaramillo Gutierrez G, Rodrigues J, Ndikuyeze G, Povelones M, Molina Cruz A, Barillas Mury C. Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes. BMC Microbiol. 2009;9:154 pubmed publisher
    ..The interactions between highly compatible animal models of malaria, such as P. yoelii (17XNL)-An. stephensi (Nijmegen Sda500), is more similar to that of P. falciparum (3D7)-An. gambiae (G3). ..
  25. Morrot A, Cockburn I, Overstreet M, Rodriguez D, Zavala F. Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression. Infect Immun. 2006;74:2495-7 pubmed
    CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against ..
  26. Pal Bhowmick I, Vora H, Jarori G. Sub-cellular localization and post-translational modifications of the Plasmodium yoelii enolase suggest moonlighting functions. Malar J. 2007;6:45 pubmed
    ..functions was examined by investigating its sub-cellular distribution in the murine malarial parasite, Plasmodium yoelii. Cellular extracts of P...
  27. Ma C, Harrison P, Wang L, Coppel R. Automated estimation of parasitaemia of Plasmodium yoelii-infected mice by digital image analysis of Giemsa-stained thin blood smears. Malar J. 2010;9:348 pubmed publisher
    ..This programme has been validated for use in estimation of parasitemia in mouse infection by Plasmodium yoelii and used to monitor parasitaemia on a daily basis for an entire challenge infection...
  28. Arora K, Srivastava A. Antimalarial efficacy of methylene blue and menadione and their effect on glutathione metabolism of Plasmodium yoelii-infected albino mice. Parasitol Res. 2005;97:521-6 pubmed
    b>Plasmodium yoelii infection caused significant decline in the hepatic and splenic glutathione content and the activities of the key enzymes, that is, glutamate cysteine ligase (EC 6.3.2.2) and glutathione reductase (EC 1.8.1...
  29. Ophorst O, Radosevic K, Havenga M, Pau M, Holterman L, Berkhout B, et al. Immunogenicity and protection of a recombinant human adenovirus serotype 35-based malaria vaccine against Plasmodium yoelii in mice. Infect Immun. 2006;74:313-20 pubmed
    ..5 (rAd5) as a malaria vaccine carrier in preclinical models, we evaluated the potency of rAd35 coding for Plasmodium yoelii circumsporozoite protein (rAd35PyCS)...
  30. Mauduit M, Tewari R, Depinay N, Kayibanda M, Lallemand E, Chavatte J, et al. Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infect Immun. 2010;78:2182-8 pubmed publisher
    ..we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-..
  31. Williams C, Azad A. Transcriptional analysis of the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium yoelii. PLoS ONE. 2010;5:e10267 pubmed publisher
    ..liver stage parasites collected either 24 hours (24hrLS) or 48 hours (48hrLS) after mice were infected with Plasmodium yoelii. Our results revealed 1100 Plasmodium genes that were differentially expressed in one or more constituents ..
  32. Ogun S, Howell S, Taylor H, Holder A. A member of the py235 gene family of Plasmodium yoelii encodes an erythrocyte binding protein recognised by a protective monoclonal antibody. Mol Biochem Parasitol. 2006;147:140-3 pubmed
  33. Zheng W, Wang Q, Liu Y, Liu J, Feng H, Wu J, et al. Distinct host-related dendritic cell responses during the early stage of Plasmodium yoelii infection in susceptible and resistant mice. Parasite Immunol. 2010;32:324-34 pubmed publisher
    ..by dendritic cells (DCs), we compared their phenotype and function during the early stages of infection with Plasmodium yoelii 17XL (P.y 17XL) strain in susceptible (BALB/c) and resistant (DBA/2) mice...
  34. Putrianti E, Silvie O, Kordes M, Borrmann S, Matuschewski K. Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites. J Infect Dis. 2009;199:899-903 pubmed
    ..Pharmacological inhibition of liver-stage parasites in the rodent malaria model offers a potential fast track toward development of a vaccine that targets parasites in preerythrocytic stages...
  35. Pattaradilokrat S, Culleton R, Cheesman S, Carter R. Gene encoding erythrocyte binding ligand linked to blood stage multiplication rate phenotype in Plasmodium yoelii yoelii. Proc Natl Acad Sci U S A. 2009;106:7161-6 pubmed publisher
    ..The rodent malaria parasite Plasmodium yoelii yoelii has strains with marked differences in multiplication rate and pathogenicity in the blood...
  36. Wang Q, Liu Y, Liu J, Chen G, Zheng W, Wang J, et al. Plasmodium yoelii: assessment of production and role of nitric oxide during the early stages of infection in susceptible and resistant mice. Exp Parasitol. 2009;121:268-73 pubmed publisher
    ..In this study, we used two strains of mice infected with Plasmodium yoelii 17XL in order to assess the NO production profile and its possible role during the early stage of malaria ..
  37. Baer K, Roosevelt M, Clarkson A, Van Rooijen N, Schnieder T, Frevert U. Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver. Cell Microbiol. 2007;9:397-412 pubmed
    ..Together these data provide strong support for the hypothesis that Kupffer cells are the portal for sporozoites to hepatocytes and critical for the onset of a malaria infection...
  38. Wong K, Zhou A, Rodriguez A. Protective immunity induced by daily bites from irradiated mosquitoes infected with Plasmodium yoelii. Parasite Immunol. 2008;30:482-6 pubmed publisher
    ..Using irradiated mosquitoes infected with Plasmodium yoelii 17XNL, we tested whether daily bites from a few mosquitoes can induce a protective immune response in mice...
  39. Butler N, Schmidt N, Vaughan A, Aly A, Kappe S, Harty J. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe. 2011;9:451-62 pubmed publisher
  40. Cockburn I, Chen Y, Overstreet M, Lees J, Van Rooijen N, Farber D, et al. Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog. 2010;6:e1000877 pubmed publisher
    ..Together these data show that the optimal development of protective CD8+ T cell immunity against malaria liver stages is dependent upon the prolonged presentation of sporozoite-derived antigen...
  41. Chakravarty S, Cockburn I, Kuk S, Overstreet M, Sacci J, Zavala F. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med. 2007;13:1035-41 pubmed
    ..Using a model mimicking natural infection by Plasmodium yoelii, we delineated early events governing the development of protective CD8(+) T-cell responses to the ..
  42. Moneriz C, Marín García P, Bautista J, Diez A, Puyet A. Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice. Malar J. 2011;10:103 pubmed publisher
    ..anti-malarial activity of maslinic acid (MA), a natural triterpene which has been previously shown to exert a parasitostatic action on Plasmodium falciparum cultures, was analysed in vivo by using the Plasmodium yoelii 17XL murine model.
  43. Haque A, Best S, Unosson K, Amante F, de Labastida F, Anstey N, et al. Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria. J Immunol. 2011;186:6148-56 pubmed publisher
    ..Thus, an interdependent relationship between parasite burden and CD8(+) T cells dictates the onset of perforin/GzmB-mediated ECM...
  44. Wipasa J, Xu H, Liu X, Hirunpetcharat C, Stowers A, Good M. Effect of Plasmodium yoelii exposure on vaccination with the 19-kilodalton carboxyl terminus of merozoite surface protein 1 and vice versa and implications for the application of a human malaria vaccine. Infect Immun. 2009;77:817-24 pubmed publisher
    ..the antibody response that develops following exposure to the malaria vaccine candidate homologue Plasmodium yoelii MSP1(19) in mice that had previously experienced malaria infection and vice versa...
  45. Pattaradilokrat S, Cheesman S, Carter R. Congenicity and genetic polymorphism in cloned lines derived from a single isolate of a rodent malaria parasite. Mol Biochem Parasitol. 2008;157:244-7 pubmed
    Many of the most commonly studied lines of the rodent malaria parasite Plasmodium yoelii yoelii originated from a single parasite isolate designated 17X...
  46. Miller J, Harupa A, Kappe S, Mikolajczak S. Plasmodium yoelii macrophage migration inhibitory factor is necessary for efficient liver-stage development. Infect Immun. 2012;80:1399-407 pubmed publisher
    ..In this study, we characterized the MIF homologue of Plasmodium yoelii throughout the life cycle, with emphasis on preerythrocytic stages. P...
  47. Kumar A, Kumar K, Korde R, Puri S, Malhotra P, Singh Chauhan V. Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential. Infect Immun. 2007;75:2026-34 pubmed
    ..and its role in invasion, we analyzed the immunogenicity of falcipain-1 in mice, followed by heterologous challenge with Plasmodium yoelii sporozoites. Our results suggest a possible role of falcipain-1 in merozoite invasion.
  48. Shi Q, Cernetich A, Daly T, Galvan G, Vaidya A, Bergman L, et al. Alteration in host cell tropism limits the efficacy of immunization with a surface protein of malaria merozoites. Infect Immun. 2005;73:6363-71 pubmed
    Immunization with Plasmodium yoelii merozoite surface protein-8 (PyMSP-8) has been shown to protect mice against lethal P. yoelii 17XL malaria. Here we demonstrate that PyMSP-8-specific antibodies preferentially suppress P...
  49. Chattopadhyay R, Conteh S, Li M, James E, Epstein J, Hoffman S. The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine. Vaccine. 2009;27:3675-80 pubmed publisher
    ..This was studied in the Plasmodium yoelii rodent model system. Exposure to 100 Gy completely attenuated P. yoelii sporozoites (PySPZ)...
  50. Stoyanov C, Boscardin S, Deroubaix S, Barba Spaeth G, Franco D, Nussenzweig R, et al. Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii. Vaccine. 2010;28:4644-52 pubmed publisher
    ..was genetically altered to express the circumsporozoite protein (CSP) from the murine malarial parasite Plasmodium yoelii. Reconstituted recombinant virus was viable and exhibited robust CSP expression...
  51. Ocana Morgner C, Wong K, Lega F, Dotor J, Borras Cuesta F, Rodriguez A. Role of TGF-beta and PGE2 in T cell responses during Plasmodium yoelii infection. Eur J Immunol. 2007;37:1562-74 pubmed
    ..Our findings suggest that the strong cytokine response induced by blood-stage P. yoelii infection affects host T cell responses, inhibiting protective CD8+ T cells against the liver-stage of the disease...
  52. Mout R, Xu Z, Wolf A, Jo Davisson V, Jarori G. Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii. Malar J. 2012;11:54 pubmed publisher
    ..In the process, a hypothesis was subsequently tested regarding the susceptibility of the cured animals to malaria reflected in an attenuated parasite load that may be evoked by a protective immune response in the host...
  53. Couper K, Blount D, Wilson M, Hafalla J, Belkaid Y, Kamanaka M, et al. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog. 2008;4:e1000004 pubmed publisher
    ..regulatory T cells do not significantly influence the outcome of infections with the lethal (17XL) strain of Plasmodium yoelii (PyL)...
  54. Noland G, Urban J, Fried B, Kumar N. Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice. Exp Parasitol. 2008;119:272-8 pubmed publisher
    ..We have previously reported exacerbation of normally non-lethal Plasmodium yoelii malaria in BALB/c mice chronically infected with the intestinal trematode Echinostoma caproni...
  55. Martin Jaular L, Ferrer M, Calvo M, Rosanas Urgell A, Kalko S, Graewe S, et al. Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape. Cell Microbiol. 2011;13:109-22 pubmed publisher
    ..resonance imaging of the mouse spleen in experimental infections with non-lethal (17X) and lethal (17XL) Plasmodium yoelii strains...
  56. Oliveira G, Kumar K, Calvo Calle J, Othoro C, Altszuler D, Nussenzweig V, et al. Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun. 2008;76:1200-6 pubmed
    ..immunity in protective immunity, we immunized beta2-microglobulin knockout (beta2M-/-) mice with irradiated Plasmodium yoelii or P. berghei sporozoites...
  57. Eslava I, Payares G, Pernia B, Holder A, Spencer L. Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii. Malar J. 2010;9:46 pubmed publisher
    ..Monoclonal antibodies (mAbs) specific for the C-terminus of MSP-1 from Plasmodium yoelii have been shown previously to provide protection against challenge infection when administered by passive ..
  58. Conteh S, Chattopadhyay R, Anderson C, Hoffman S. Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route. PLoS ONE. 2010;5:e8947 pubmed publisher
  59. Roland J, Soulard V, Sellier C, Drapier A, Di Santo J, Cazenave P, et al. NK cell responses to Plasmodium infection and control of intrahepatic parasite development. J Immunol. 2006;177:1229-39 pubmed
    ..We investigated the contribution of NK cells to the immune response to primary infection with Plasmodium yoelii sporozoites in C57BL/6 mice...
  60. Orengo J, Wong K, Ocana Morgner C, Rodriguez A. A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells. Malar J. 2008;7:254 pubmed publisher
    ..Plasmodium infects host erythrocytes causing the pathology of the disease. Plasmodium-infected erythrocytes can modulate the maturation of dendritic cells (DCs) and alter their capacity to activate T cells...
  61. Chen G, Liu J, Wang Q, Wu Y, Feng H, Zheng W, et al. Effects of CD4(+)CD25(+)Foxp3(+)regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice. Parasitology. 2009;136:1107-20 pubmed publisher
    The outcome of Plasmodium yoelii 17XL-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, respectively, depends largely on the establishment of effective pro-inflammatory type 1 responses during the early stages of ..
  62. Porter Kelley J, Dinglasan R, Alam U, Ndeta G, Sacci J, Azad A. Plasmodium yoelii: axenic development of the parasite mosquito stages. Exp Parasitol. 2006;112:99-108 pubmed
    ..Here, we show the complete axenic development of the parasite mosquito stages of Plasmodium yoelii. While we demonstrate that matrigel is not required for parasite development, soluble factors produced and ..
  63. Klotz C, Frevert U. Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells. Int J Parasitol. 2008;38:1639-50 pubmed publisher
    ..Stimulation of Plasmodium yoelii sporozoite-exposed Kupffer cells with lipopolysaccharide or IFN-gamma reveals down-modulation of TNF-alpha, ..
  64. Chandele A, Mukerjee P, Das G, Ahmed R, Chauhan V. Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii. Immunology. 2011;132:273-86 pubmed publisher
    ..show that both CD8 and CD4 T cells robustly responded to an acute self-limiting blood-stage infection with Plasmodium yoelii. Similar to antigen-specific T cells, both CD8 and CD4 T cells showed dynamic expression of the surface ..
  65. Draper S, Moore A, Goodman A, Long C, Holder A, Gilbert S, et al. Effective induction of high-titer antibodies by viral vector vaccines. Nat Med. 2008;14:819-21 pubmed publisher
    ..Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
  66. Saiki E, Nagao K, Aonuma H, Fukumoto S, Xuan X, Bannai M, et al. Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii. Malar J. 2013;12:19 pubmed publisher
  67. Mikolajczak S, Aly A, Dumpit R, Vaughan A, Kappe S. An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model. Mol Biochem Parasitol. 2008;158:213-6 pubmed publisher
    In this report, we describe a cloning procedure for gene replacement by double homologous recombination in Plasmodium yoelii, which requires only one digestion and ligation step...
  68. Mahmoudi N, Garcia Domenech R, Galvez J, Farhati K, Franetich J, Sauerwein R, et al. New active drugs against liver stages of Plasmodium predicted by molecular topology. Antimicrob Agents Chemother. 2008;52:1215-20 pubmed publisher
    ..relationship (QSAR) study based on a database of 127 compounds previously tested against the liver stage of Plasmodium yoelii in order to develop a model capable of predicting the in vitro antimalarial activities of new compounds...
  69. Thorat S, Daly T, Bergman L, Burns J. Elevated levels of the Plasmodium yoelii homologue of macrophage migration inhibitory factor attenuate blood-stage malaria. Infect Immun. 2010;78:5151-62 pubmed publisher
    ..We used the Plasmodium yoelii murine model to study the potential role of parasite-encoded MIF in the pathogenesis of malaria...
  70. Ma C, Wang L, Webster D, Campbell A, Coppel R. Production, characterisation and immunogenicity of a plant-made Plasmodium antigen--the 19 kDa C-terminal fragment of Plasmodium yoelii merozoite surface protein 1. Appl Microbiol Biotechnol. 2012;94:151-61 pubmed publisher
    ..b>Plasmodium yoelii MSP1(19) (PyMSP1(19)) was produced in Nicotiana benthamiana using the MagnICON® deconstructed TMV-based ..
  71. Schmidt N, Butler N, Harty J. Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol. 2011;186:5873-84 pubmed publisher
    ..Thus, both Plasmodium species and strain-specific background genes in nonhematopoietic cells determine the threshold of memory CD8 T cells required for protection...
  72. Butler N, Schmidt N, Harty J. Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J Immunol. 2010;184:2528-38 pubmed publisher
    ..Our studies also show that the effector pathways that memory CD8 T cells use to eliminate liver stage infection are, in part, Plasmodium species specific...
  73. Herbas M, Ueta Y, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, et al. Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice. Malar J. 2010;9:101 pubmed publisher
    ..However, mechanisms of this Plasmodium inhibition, in addition to means by which to exploit this finding as a therapeutic strategy, remain unclear...
  74. Orengo J, Evans J, Bettiol E, Leliwa Sytek A, Day K, Rodriguez A. Plasmodium-induced inflammation by uric acid. PLoS Pathog. 2008;4:e1000013 pubmed publisher
    ..Identifying the mechanisms used by the parasite to induce the host inflammatory response is essential to develop urgently needed therapies against this disease...
  75. Wykes M, Liu X, Jiang S, Hirunpetcharat C, Good M. Systemic tumor necrosis factor generated during lethal Plasmodium infections impairs dendritic cell function. J Immunol. 2007;179:3982-7 pubmed
    ..This study shows that the systemic production of TNF-alpha contributes to poor DC function during lethal infections. These studies may explain, at least in part, immunosuppression that is associated with malaria...
  76. Tarun A, Dumpit R, Camargo N, Labaied M, Liu P, Takagi A, et al. Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. J Infect Dis. 2007;196:608-16 pubmed
    ..of genetically attenuated liver stages in vivo, we created deletions of the UIS3 and UIS4 loci in the Plasmodium yoelii rodent malaria model (Pyuis3[-] and Pyuis4[-]). The low 50% infectious dose of P...
  77. Narum D, Nguyen V, Zhang Y, Glen J, Shimp R, Lambert L, et al. Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection. Infect Immun. 2008;76:4876-82 pubmed publisher
    Previously, we identified a Plasmodium yoelii YM 140-kDa merozoite protein, designated PyP140, which formed a complex with apical membrane antigen 1 (AMA1)...
  78. Zhu X, Pan Y, Zheng L, Cui L, Cao Y. Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice. Malar J. 2012;11:49 pubmed publisher
    ..The aim of this study is to use the rodent malaria model Plasmodium yoelii 17XL (P...
  79. Xu L, Chaudhuri A. Plasmodium yoelii: a differential fluorescent technique using Acridine Orange to identify infected erythrocytes and reticulocytes in Duffy knockout mouse. Exp Parasitol. 2005;110:80-7 pubmed
    Both human malarial parasite Plasmodium vivax and mouse malaria parasite Plasmodium yoelii use Duffy protein as the receptor for invasion and they preferentially invade reticulocytes. Recently, it has been shown that P...
  80. Pei Y, Miller J, Lindner S, Vaughan A, Torii M, Kappe S. Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development. Cell Microbiol. 2013;15:1508-1526 pubmed publisher
    ..Here we further characterize the role of ICP?in vivo during infection with Plasmodium yoelii (Py) and Pf...
  81. Cernetich Ott A, Daly T, Vaidya A, Bergman L, Burns J. Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria. Malar J. 2012;11:265 pubmed publisher
    ..The aim of this study was to examine changes in gene expression of the rodent malaria parasite, Plasmodium yoelii 17X, while varying the in vivo setting of replication.
  82. Ogun S, Dumon Seignovert L, Marchand J, Holder A, Hill F. The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Infect Immun. 2008;76:3817-23 pubmed publisher
    ..b>Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in ..
  83. Shi X, Qin L, Liu G, Zhao S, Peng N, Chen X. Dynamic balance of pSTAT1 and pSTAT3 in C57BL/6 mice infected with lethal or nonlethal Plasmodium yoelii. Cell Mol Immunol. 2008;5:341-8 pubmed publisher
    ..of pSTAT1 and pSTAT3 in C57BL/6 mice infected with either a nonlethal (Py17XNL) or lethal (Py17XL) strain of Plasmodium yoelii. Both Py17XNL and Py17XL infections induced a maximum activation of STAT1 and STAT3 on the first day after ..
  84. Zhou L, Zhang Q, Zhang Y, Liu J, Cao Y. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses. Int Immunopharmacol. 2009;9:455-62 pubmed publisher
    ..We tested the effects of lentinan during blood-stage infection by Plasmodium yoelii 17XL (P.y17XL)...
  85. Hafalla J, Rai U, Morrot A, Bernal Rubio D, Zavala F, Rodriguez A. Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur J Immunol. 2006;36:1179-86 pubmed
    ..We propose that live parasites are not critical for the induction of memory T cell populations against the malaria liver stages...
  86. Tripathi R, Dhawan S, Dutta G. Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening. Parasitology. 2005;131:295-301 pubmed
    ..Instead of using a battery of resistant lines, a single MDR Plasmodium yoelii nigeriensis strain that shows a wide spectrum of drug resistance to high doses of chloroquine, mepacrine, ..
  87. Cramer J, Lepenies B, Kamena F, Holscher C, Freudenberg M, Burchard G, et al. MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection. Microbes Infect. 2008;10:1259-65 pubmed publisher
    ..We conclude that mainly IL-18/MyD88-dependent signalling but not TLR2/4/9-signalling is important for early parasite control in our model...
  88. Morrot A, Hafalla J, Cockburn I, Carvalho L, Zavala F. IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med. 2005;202:551-60 pubmed
    IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites...
  89. Sarfo B, Armah H, Irune I, Adjei A, Olver C, Singh S, et al. Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum. Malar J. 2005;4:63 pubmed
    ..A murine malaria model was utilized to evaluate the role of this chemokine and its receptors in malaria...