plasmodium vivax

Summary

Summary: A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.

Top Publications

  1. Russell B, Malleret B, Suwanarusk R, Anthony C, Kanlaya S, Lau Y, et al. Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity. Antimicrob Agents Chemother. 2013;57:5170-4 pubmed publisher
    ..develop and validate a simple, field-optimized protocol using SYBR green and dihydroethidium for the accurate and objective determination of antimalarial drug sensitivity in freshly isolated Plasmodium vivax and Plasmodium falciparum.
  2. Teixeira L, Tararam C, Lasaro M, Camacho A, Ersching J, Leal M, et al. Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents. Infect Immun. 2014;82:793-807 pubmed publisher
    b>Plasmodium vivax is the most widespread and the second most prevalent malaria-causing species in the world. Current measures used to control the transmission of this disease would benefit from the development of an efficacious vaccine...
  3. Barber B, William T, Grigg M, Menon J, Auburn S, Marfurt J, et al. A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy. Clin Infect Dis. 2013;56:383-97 pubmed publisher
    ..We compared risk, spectrum, and outcome of severe disease from P. knowlesi, Plasmodium falciparum, and Plasmodium vivax and outcomes following introduction of protocols for early referral and intravenous artesunate for all severe ..
  4. Sampath S, Carrico C, Janes J, Gurumoorthy S, Gibson C, Melcher M, et al. Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development. PLoS Pathog. 2013;9:e1003420 pubmed publisher
    ..Here this approach was used to investigate the binding interaction of Plasmodium vivax Duffy Binding Protein (PvDBP) and the Duffy Antigen Receptor for Chemokines (DARC) and to evaluate if glycan-..
  5. Molina D, Finney O, Arevalo Herrera M, Herrera S, Felgner P, Gardner M, et al. Plasmodium vivax pre-erythrocytic-stage antigen discovery: exploiting naturally acquired humoral responses. Am J Trop Med Hyg. 2012;87:460-9 pubmed publisher
    The development of pre-erythrocytic Plasmodium vivax vaccines is hindered by the lack of in vitro culture systems or experimental rodent models...
  6. Arango E, Samuel R, Agudelo O, Carmona Fonseca J, Maestre A, Yanow S. Molecular detection of malaria at delivery reveals a high frequency of submicroscopic infections and associated placental damage in pregnant women from northwest Colombia. Am J Trop Med Hyg. 2013;89:178-83 pubmed publisher
    ..These data prompt a re-examination of the local epidemiology of malaria using molecular diagnostics to establish the clinical relevance of submicroscopic infections during pregnancy as well as their consequences for mothers and newborns...
  7. Borlon C, Russell B, Sriprawat K, Suwanarusk R, Erhart A, Renia L, et al. Cryopreserved Plasmodium vivax and cord blood reticulocytes can be used for invasion and short term culture. Int J Parasitol. 2012;42:155-60 pubmed publisher
    ..vivax culture. In addition, this model could be used for testing vaccine candidates as well as for studying invasion-specific molecular mechanisms. ..
  8. Hwang J, Alemayehu B, Reithinger R, Tekleyohannes S, Takele Teshi -, Birhanu S, et al. In vivo efficacy of artemether-lumefantrine and chloroquine against Plasmodium vivax: a randomized open label trial in central Ethiopia. PLoS ONE. 2013;8:e63433 pubmed publisher
    ..In Ethiopia, chloroquine (CQ) without primaquine is the first-line treatment for Plasmodium vivax in malarious areas, but artemether-lumefantrine (AL) is also commonly used...
  9. Espinosa D, Yadava A, Angov E, Maurizio P, Ockenhouse C, Zavala F. Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy. Infect Immun. 2013;81:2882-7 pubmed publisher
    The development of vaccine candidates against Plasmodium vivax-the most geographically widespread human malaria species-is challenged by technical difficulties, such as the lack of in vitro culture systems and availability of animal ..

More Information

Publications99

  1. Añez A, Navarro Costa D, Yucra O, Garnica C, Melgar V, Moscoso M, et al. [Therapeutic response of Plasmodium vivax to chloroquine in Bolivia]. Biomedica. 2012;32:527-35 pubmed publisher
    Knowledge of the therapeutic efficacy of chloroquine for Plasmodium vivax infections improves the capacity for surveillance of anti-malarial drug resistance...
  2. Barber B, William T, Grigg M, Yeo T, Anstey N. Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi. Malar J. 2013;12:8 pubmed publisher
    ..Species misidentification by microscopy has been reported in areas co-endemic for vivax and falciparum malaria, and may be more frequent in regions where Plasmodium knowlesi also commonly occurs...
  3. Barber B, William T, Grigg M, Piera K, Yeo T, Anstey N. Evaluation of the sensitivity of a pLDH-based and an aldolase-based rapid diagnostic test for diagnosis of uncomplicated and severe malaria caused by PCR-confirmed Plasmodium knowlesi, Plasmodium falciparum, and Plasmodium vivax. J Clin Microbiol. 2013;51:1118-23 pubmed publisher
    ..knowlesi. More sensitive RDTs are needed in regions of P. knowlesi endemicity...
  4. Jangpatarapongsa K, Xia H, Fang Q, Hu K, Yuan Y, Peng M, et al. Immunity to malaria in Plasmodium vivax infection: a study in central China. PLoS ONE. 2012;7:e45971 pubmed publisher
    ..falciparum antigens. Although the magnitude of the response was only half that measured after stimulation with P. vivax antigens, the matter of cross-antigenic stimulation is of great interest. ..
  5. Bahia A, Oliveira J, Kubota M, Araújo H, Lima J, Ríos Velásquez C, et al. The role of reactive oxygen species in Anopheles aquasalis response to Plasmodium vivax infection. PLoS ONE. 2013;8:e57014 pubmed publisher
    ..The mosquito Anopheles aquasalis is an important vector of Plasmodium vivax, the main human malaria parasite in the Americas...
  6. Cheng Y, Wang Y, Ito D, Kong D, Ha K, Chen J, et al. The Plasmodium vivax merozoite surface protein 1 paralog is a novel erythrocyte-binding ligand of P. vivax. Infect Immun. 2013;81:1585-95 pubmed publisher
    Merozoite surface protein 1 of Plasmodium vivax (PvMSP1), a glycosylphosphatidylinositol-anchored protein (GPI-AP), is a malaria vaccine candidate for P. vivax. The paralog of PvMSP1, named P...
  7. Lopez A, Ortiz A, Coello J, Sosa Ochoa W, Torres R, Banegas E, et al. Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras. Malar J. 2012;11:391 pubmed publisher
    ..Five molecular markers were analysed to determine the genotypes of Plasmodium vivax and Plasmodium falciparum from endemic areas in Honduras...
  8. Senn N, Rarau P, Stanisic D, Robinson L, Barnadas C, Manong D, et al. Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial. PLoS Med. 2012;9:e1001195 pubmed publisher
    ..IPTi using a long half-life drug combination is efficacious for the prevention of malaria and anemia in infants living in a region highly endemic for both Pf and Pv. ..
  9. Prajapati S, Kumari P, Singh O. Molecular analysis of reticulocyte binding protein-2 gene in Plasmodium vivax isolates from India. BMC Microbiol. 2012;12:243 pubmed publisher
    b>Plasmodium vivax reticulocyte binding protein-2 (PvRBP-2) is a promising candidate for development of vaccine against parasite...
  10. Yeom J, Jun G, Kim J, Lee W, Shin E, Chang K, et al. Status of Plasmodium vivax malaria in the Republic of Korea, 2008-2009: decrease followed by resurgence. Trans R Soc Trop Med Hyg. 2012;106:429-36 pubmed publisher
    The number of Plasmodium vivax malaria cases in the Republic of Korea (ROK) in 2008 was 1009, a 54.2% decrease on the previous year. It then resurged to 1317 cases in 2009 (30.5% increase on 2008)...
  11. Zimmerman P, Ferreira M, Howes R, Mercereau Puijalon O. Red blood cell polymorphism and susceptibility to Plasmodium vivax. Adv Parasitol. 2013;81:27-76 pubmed publisher
    Resistance to Plasmodium vivax blood-stage infection has been widely recognised to result from absence of the Duffy (Fy) blood group from the surface of red blood cells (RBCs) in individuals of African descent...
  12. Dias S, Wickramarachchi T, Sahabandu I, Escalante A, Udagama P. Population genetic structure of the Plasmodium vivax circumsporozoite protein (Pvcsp) in Sri Lanka. Gene. 2013;518:381-7 pubmed publisher
    ..Population genetics of Plasmodium vivax parasites accurately describe transmission dynamics of the parasites and evaluation of malaria control ..
  13. Neafsey D, Galinsky K, Jiang R, Young L, Sykes S, Saif S, et al. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genet. 2012;44:1046-50 pubmed publisher
    ..vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen. ..
  14. Taylor J, Pacheco M, Bacon D, Beg M, Machado R, Fairhurst R, et al. The evolutionary history of Plasmodium vivax as inferred from mitochondrial genomes: parasite genetic diversity in the Americas. Mol Biol Evol. 2013;30:2050-64 pubmed publisher
    b>Plasmodium vivax is the most prevalent human malaria parasite in the Americas...
  15. Kim J, Kim H, Na B, Kim Y, Sohn Y, Kim H, et al. Estimating the malaria transmission of Plasmodium vivax based on serodiagnosis. Malar J. 2012;11:257 pubmed publisher
    b>Plasmodium vivax re-emerged in 1993 and has now become a major public health problem during the summer season in South Korea...
  16. Adhikari M, Ranjitkar S, Schousboe M, Alifrangis M, Imwong M, Bhatta D, et al. Genetic diversity of plasmodium vivax merozoite surface protein-3alpha (Pvmsp-3alpha) gene in Jhapa District of Nepal. Southeast Asian J Trop Med Public Health. 2012;43:280-6 pubmed
    In Nepal, Plasmodium vivax accounts for approximately 80-90% of the malaria cases, but limited studies have been conducted on the genetic diversity of this parasite population...
  17. Kim J, Ji S, Goo Y, Na B, Pyo H, Lee H, et al. Comparison of rapid diagnostic tests for the detection of Plasmodium vivax malaria in South Korea. PLoS ONE. 2013;8:e64353 pubmed publisher
    South Korea is one of many countries with endemic Plasmodium vivax malaria. Here we report the evaluation of four rapid diagnostic tests (RDTs) for diagnosis of this disease. A total of 253 subjects were enrolled in the study...
  18. Pinzón M, Pineda J, Rosso F, Shinchi M, Bonilla Abadía F. Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia. Asian Pac J Trop Med. 2013;6:413-5 pubmed publisher
    Complicated malaria is usually due to Plasmodium falciparum. Nevertheless, Plasmodium vivax is infrequently related with life-threatening complications...
  19. Cucunubá Z, Guerra A, Rivera J, Nicholls R. Comparison of asymptomatic Plasmodium spp. infection in two malaria-endemic Colombian locations. Trans R Soc Trop Med Hyg. 2013;107:129-36 pubmed publisher
    ..2-7.7), 6.6% (95% CI 3.8-10.6%) in Tierralta and 3.4% (95% CI 1.5-6.6%) in Tumaco. Plasmodium vivax was predominant in Tierralta, P. falciparum in Tumaco. The main associated factors were male sex (aOR 2...
  20. Abeles S, Chuquiyauri R, Tong C, Vinetz J. Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon. Am J Trop Med Hyg. 2013;88:1130-7 pubmed publisher
    ..This study tested the hypothesis that pro- or anti-inflammatory cytokines are associated with transmission of Plasmodium vivax to Anopheles darlingi mosquitoes in experimental infection. Blood from adults with acute, non-severe P...
  21. Auburn S, Marfurt J, Maslen G, Campino S, Ruano Rubio V, Manske M, et al. Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing. PLoS ONE. 2013;8:e53160 pubmed publisher
    Whole genome sequencing (WGS) of Plasmodium vivax is problematic due to the reliance on clinical isolates which are generally low in parasitaemia and sample volume...
  22. Foley D, Klein T, Kim H, Kim M, Wilkerson R, Harrison G, et al. Synchronous peaks in trap catches of malaria-infected mosquito species at Daeseongdong, a border village between North and South Korea. J Vector Ecol. 2012;37:29-36 pubmed publisher
    ..Molecular techniques were used to identify Anopheles to species and for detection of Plasmodium vivax sporozoites in their head and thorax. Trap catches showed concordant peaks of Anopheles belenrae and An...
  23. Endeshaw T, Graves P, Ayele B, Mosher A, Gebre T, Ayalew F, et al. Performance of local light microscopy and the ParaScreen Pan/Pf rapid diagnostic test to detect malaria in health centers in Northwest Ethiopia. PLoS ONE. 2012;7:e33014 pubmed publisher
    ..Deficiencies in RDT use at some health centers must be rectified before universal replacement of good routine microscopy with RDTs. Maintenance and strengthening of good quality microscopy remains a priority at health center level. ..
  24. HESTER J, Chan E, Menard D, Mercereau Puijalon O, Barnwell J, Zimmerman P, et al. De novo assembly of a field isolate genome reveals novel Plasmodium vivax erythrocyte invasion genes. PLoS Negl Trop Dis. 2013;7:e2569 pubmed publisher
    Recent sequencing of Plasmodium vivax field isolates and monkey-adapted strains enabled characterization of SNPs throughout the genome. These analyses relied on mapping short reads onto the P...
  25. Chamchod F, Beier J. Modeling Plasmodium vivax: relapses, treatment, seasonality, and G6PD deficiency. J Theor Biol. 2013;316:25-34 pubmed publisher
    b>Plasmodium vivax (P. vivax) is one of the most important human malaria species that is geographically widely endemic and causes social and economic burden globally...
  26. Chenet S, Pacheco M, Bacon D, Collins W, Barnwell J, Escalante A. The evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (MSP-9), in Plasmodium vivax and closely related species. Infect Genet Evol. 2013;20:239-48 pubmed publisher
    ..Plasmodium knowlesi, Plasmodium inui, Plasmodium simiovale, Plasmodium fieldi, Plasmodium cynomolgi and Plasmodium vivax and evaluated the signature of natural selection in all MSP-9 orthologs...
  27. Chenet S, Schneider K, Villegas L, Escalante A. Local population structure of Plasmodium: impact on malaria control and elimination. Malar J. 2012;11:412 pubmed publisher
    ..b>Plasmodium vivax samples collected in Tumeremo, Venezuela, between March 2003 and November 2004 were analysed...
  28. Kim J, Nandy A, Maji A, Addy M, Dondorp A, Day N, et al. Genotyping of Plasmodium vivax reveals both short and long latency relapse patterns in Kolkata. PLoS ONE. 2012;7:e39645 pubmed publisher
    The Plasmodium vivax that was once prevalent in temperate climatic zones typically had an interval between primary infection and first relapse of 7-10 months, whereas in tropical areas P...
  29. Vargas Rodríguez R, da Silva Bastos M, Menezes M, Orjuela Sánchez P, Ferreira M. Single-nucleotide polymorphism and copy number variation of the multidrug resistance-1 locus of Plasmodium vivax: local and global patterns. Am J Trop Med Hyg. 2012;87:813-21 pubmed publisher
    Emerging resistance to chloroquine (CQ) poses a major challenge for Plasmodium vivax malaria control, and nucleotide substitutions and copy number variation in the P...
  30. Dzakah E, Kang K, Ni C, Wang H, Wu P, Tang S, et al. Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China. Malar J. 2013;12:199 pubmed publisher
    ..The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections ..
  31. Costa J, Zanchi F, Rodrigues F, Honda E, Katsuragawa T, Pereira D, et al. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax. Mem Inst Oswaldo Cruz. 2013;108:98-105 pubmed
    ..However, sera of Plasmodium vivax patients from the same Amazon area, in particular from asymptomatic vivax parasite carriers, reacted strongly ..
  32. Mendonça V, Queiroz A, Lopes F, Andrade B, Barral Netto M. Networking the host immune response in Plasmodium vivax malaria. Malar J. 2013;12:69 pubmed publisher
    b>Plasmodium vivax malaria clinical outcomes are a consequence of the interaction of multiple parasite, environmental and host factors...
  33. Mueller I, Galinski M, Tsuboi T, Arevalo Herrera M, Collins W, King C. Natural acquisition of immunity to Plasmodium vivax: epidemiological observations and potential targets. Adv Parasitol. 2013;81:77-131 pubmed publisher
    Population studies show that individuals acquire immunity to Plasmodium vivax more quickly than Plasmodium falciparum irrespective of overall transmission intensity, resulting in the peak burden of P. vivax malaria in younger age groups...
  34. Bouillon A, Giganti D, Benedet C, Gorgette O, Petres S, Crublet E, et al. In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound. J Biol Chem. 2013;288:18561-73 pubmed publisher
    ..development of new antimalarials that target novel steps in the life cycle of Plasmodium falciparum and Plasmodium vivax. The essential subtilisin-like serine protease SUB1 of Plasmodium merozoites plays a dual role in egress from ..
  35. Prugnolle F, Rougeron V, Becquart P, Berry A, Makanga B, Rahola N, et al. Diversity, host switching and evolution of Plasmodium vivax infecting African great apes. Proc Natl Acad Sci U S A. 2013;110:8123-8 pubmed publisher
    b>Plasmodium vivax is considered to be absent from Central and West Africa because of the protective effect of Duffy negativity...
  36. Lança E, Magalhães B, Vitor Silva S, Siqueira A, Benzecry S, Alexandre M, et al. Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. PLoS ONE. 2012;7:e35406 pubmed publisher
    b>Plasmodium vivax is responsible for a significant proportion of malaria cases worldwide and is increasingly reported as a cause of severe disease...
  37. Chittoria A, Mohanty S, Jaiswal Y, Das A. Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India. PLoS ONE. 2012;7:e45219 pubmed publisher
    The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs...
  38. Wright M, Clough B, Rackham M, Rangachari K, Brannigan J, Grainger M, et al. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014;6:112-21 pubmed publisher
    ..Our studies provide the basis for the development of new antimalarials targeting N-myristoyltransferase. ..
  39. Gonzalez Ceron L, Martinez Barnetche J, Montero Solís C, Santillan F, Soto A, Rodriguez M, et al. Molecular epidemiology of Plasmodium vivax in Latin America: polymorphism and evolutionary relationships of the circumsporozoite gene. Malar J. 2013;12:243 pubmed publisher
    The origins and dispersal of Plasmodium vivax to its current worldwide distribution remains controversial. Although progress on P...
  40. Kang J, Ju H, Kang Y, Lee D, Moon S, Sohn W, et al. Genetic polymorphism and natural selection in the C-terminal 42?kDa region of merozoite surface protein-1 among Plasmodium vivax Korean isolates. Malar J. 2012;11:206 pubmed publisher
    The carboxy-terminal 42?kDa region of Plasmodium vivax merozoite surface protein-1 (PvMSP-1??) is a leading candidate antigen for blood stage vaccine development...
  41. Noulin F, Borlon C, Van den Eede P, Boel L, Verfaillie C, D Alessandro U, et al. Cryopreserved reticulocytes derived from hematopoietic stem cells can be invaded by cryopreserved Plasmodium vivax isolates. PLoS ONE. 2012;7:e40798 pubmed publisher
    The development of a system for the continuous culture of Plasmodium vivax in vitro would benefit from the use of reticulocytes derived from differentiated hematopoietic stem cells (HCS)...
  42. Magalhães B, Alexandre M, Siqueira A, Melo G, Gimaque J, Bastos M, et al. Clinical profile of concurrent dengue fever and Plasmodium vivax malaria in the Brazilian Amazon: case series of 11 hospitalized patients. Am J Trop Med Hyg. 2012;87:1119-24 pubmed publisher
    ..Eleven patients with concurrent dengue virus (DENV) and Plasmodium vivax infection are reported...
  43. Baird J. Evidence and implications of mortality associated with acute Plasmodium vivax malaria. Clin Microbiol Rev. 2013;26:36-57 pubmed publisher
    ..Humanity must rally substantial resources, intellect, and energy to counter this daunting but profound threat...
  44. Gupta P, Das A, Singh O, Ghosh S, Singh V. Assessing the genetic diversity of the vir genes in Indian Plasmodium vivax population. Acta Trop. 2012;124:133-9 pubmed publisher
    ..Detailed knowledge of the genetic variation among the vir genes will help in understanding the evolutionary aspects of vir genes and may also provide basis for understanding the disease chronicity...
  45. Marfurt J, Chalfein F, Prayoga P, Wabiser F, Wirjanata G, Sebayang B, et al. Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax. Antimicrob Agents Chemother. 2012;56:5258-63 pubmed publisher
    ..vivax. The high activity against drug-resistant strains of both Plasmodium species confirms these compounds to be promising candidates for future artemisinin-based combination therapy (ACT) regimens in regions of coendemicity...
  46. Orjuela Sánchez P, Sa J, Brandi M, Rodrigues P, Bastos M, Amaratunga C, et al. Higher microsatellite diversity in Plasmodium vivax than in sympatric Plasmodium falciparum populations in Pursat, Western Cambodia. Exp Parasitol. 2013;134:318-26 pubmed publisher
    Previous microsatellite analyses of sympatric populations of Plasmodium vivax and Plasmodium falciparum in Brazil revealed higher diversity in the former species...
  47. Gupta N, Sahoo S. Plasmodium vivax induced myocarditis: a rare case report. Indian J Med Microbiol. 2013;31:180-1 pubmed publisher
    ..However the plasmodium still continues to give surprises to all of us. In the similar context we report a case of Plasmodium vivax induced myocarditis in a 20 year old male and review the literature related to this rare entitiy.
  48. Kim T, Kim J, Na B, Lee W, Kim H, Youn S, et al. Decreasing incidence of Plasmodium vivax in the Republic of Korea during 2010-2012. Malar J. 2013;12:309 pubmed publisher
    After the re-emergence of Plasmodium vivax in 1993, a total of 31,254 cases of vivax malaria were reported between 1993-2012 in the Republic of Korea (ROK)...
  49. Piñeros J, Tobón Castaño A, Alvarez G, Portilla C, Blair S. Maternal clinical findings in malaria in pregnancy in a region of northwestern Colombia. Am J Trop Med Hyg. 2013;89:520-6 pubmed publisher
    ..0% (15 of 166) had severe malaria, of which 66.7% was caused by Plasmodium vivax and 33.3% by P. falciparum. Hepatic dysfunction was the main complication (9 of 15) observed...
  50. Liu X, Tao Z, Fang Q, Wang X, Zhang H, Stoute J, et al. A case of congenital plasmodium vivax malaria from a temperate region in Central China. Malar J. 2012;11:182 pubmed publisher
    In February 2011, a rare case of congenital Plasmodium vivax malaria was diagnosed in a temperate region of Central China. An infant developed intermittent fever 20 days after delivery...
  51. Bi Y, Yu W, Hu W, Lin H, Guo Y, Zhou X, et al. Impact of climate variability on Plasmodium vivax and Plasmodium falciparum malaria in Yunnan Province, China. Parasit Vectors. 2013;6:357 pubmed publisher
    ..This study aimed to identify the high risk area of malaria transmission in Yunnan Province, and to estimate the effects of climatic variability on the transmission of Plasmodium vivax and Plasmodium falciparum in the identified area.
  52. Gething P, Elyazar I, Moyes C, Smith D, Battle K, Guerra C, et al. A long neglected world malaria map: Plasmodium vivax endemicity in 2010. PLoS Negl Trop Dis. 2012;6:e1814 pubmed publisher
    Current understanding of the spatial epidemiology and geographical distribution of Plasmodium vivax is far less developed than that for P. falciparum, representing a barrier to rational strategies for control and elimination...
  53. Garg S, Saxena V, Lumb V, Pakalapati D, Boopathi P, Subudhi A, et al. Novel mutations in the antifolate drug resistance marker genes among Plasmodium vivax isolates exhibiting severe manifestations. Exp Parasitol. 2012;132:410-6 pubmed publisher
    b>Plasmodium vivax is the predominant species of the human malaria parasite present in the Indian subcontinent. There have been recent reports on Chloroquine (CQ) resistance and severe manifestations shown by P...
  54. Rackham M, Brannigan J, Rangachari K, Meister S, Wilkinson A, Holder A, et al. Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). J Med Chem. 2014;57:2773-88 pubmed publisher
    ..These data further validate NMT as an exciting drug target in malaria and support 34c as an attractive tool for further optimization. ..
  55. Woyessa A, Deressa W, Ali A, Lindtjørn B. Prevalence of malaria infection in Butajira area, south-central Ethiopia. Malar J. 2012;11:84 pubmed publisher
    ..The objective of this study was to estimate malaria prevalence in highland areas of south-central Ethiopia, designated as the Butajira area...
  56. Koepfli C, Colborn K, Kiniboro B, Lin E, Speed T, Siba P, et al. A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children. PLoS Negl Trop Dis. 2013;7:e2403 pubmed publisher
    When both parasite species are co-endemic, Plasmodium vivax incidence peaks in younger children compared to P. falciparum...
  57. Ju H, Kang J, Moon S, Kim J, Lee H, Lin K, et al. Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates. Malar J. 2012;11:60 pubmed publisher
    b>Plasmodium vivax Duffy binding protein (PvDBP) plays an essential role in erythrocyte invasion and a potential asexual blood stage vaccine candidate antigen against P. vivax...
  58. Akinyi S, Hanssen E, Meyer E, Jiang J, Korir C, Singh B, et al. A 95 kDa protein of Plasmodium vivax and P. cynomolgi visualized by three-dimensional tomography in the caveola-vesicle complexes (Schüffner's dots) of infected erythrocytes is a member of the PHIST family. Mol Microbiol. 2012;84:816-31 pubmed publisher
    b>Plasmodium vivax and P. cynomolgi produce numerous caveola-vesicle complex (CVC) structures within the surface of the infected erythrocyte membrane...
  59. Tarning J, Chotsiri P, Jullien V, Rijken M, Bergstrand M, Cammas M, et al. Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy. Antimicrob Agents Chemother. 2012;56:5764-73 pubmed publisher
    Amodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria...
  60. Fowkes F, McGready R, Cross N, Hommel M, Simpson J, Elliott S, et al. New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women. J Infect Dis. 2012;206:1612-21 pubmed publisher
    How antimalarial antibodies are acquired and maintained during pregnancy and boosted after reinfection with Plasmodium falciparum and Plasmodium vivax is unknown.
  61. Schneider K, Escalante A. Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?. Malar J. 2013;12:15 pubmed publisher
    ..g. the emergence of drug resistance). In this investigation, the interactions between some fitness components and natural selection are explored...
  62. Shaikh S, Memon H, Iohano B, Shaikh A, Ahmed I, Baird J. Severe disease in children hospitalized with a diagnosis of Plasmodium vivax in south-eastern Pakistan. Malar J. 2012;11:144 pubmed publisher
    Infection by Plasmodium vivax has been considered rarely threatening to life, but recent studies challenge this notion...
  63. Menard D, Chan E, Benedet C, Ratsimbasoa A, Kim S, Chim P, et al. Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains. PLoS Negl Trop Dis. 2013;7:e2489 pubmed publisher
    b>Plasmodium vivax is the most prevalent human malaria parasite, causing serious public health problems in malaria-endemic countries...
  64. Costa F, Lopes S, Albrecht L, Ataide R, Siqueira A, Souza R, et al. On the pathogenesis of Plasmodium vivax malaria: perspectives from the Brazilian field. Int J Parasitol. 2012;42:1099-105 pubmed publisher
    Life-threatening Plasmodium vivax malaria cases, while uncommon, have been reported since the early 20th century. Unfortunately, the pathogenesis of these severe vivax malaria cases is still poorly understood...
  65. Battle K, Gething P, Elyazar I, Moyes C, Sinka M, Howes R, et al. The global public health significance of Plasmodium vivax. Adv Parasitol. 2012;80:1-111 pubmed publisher
    b>Plasmodium vivax occurs globally and thrives in both temperate and tropical climates...
  66. Douglas N, John G, von Seidlein L, Anstey N, Price R. Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria. Adv Parasitol. 2012;80:271-300 pubmed publisher
    Effective use of anti-malarial drugs is key to reducing the transmission potential of Plasmodium vivax. In patients presenting with symptomatic disease, treatment with potent and relatively slowly eliminated blood schizontocidal regimens ..
  67. Noulin F, Borlon C, Van den Abbeele J, D Alessandro U, Erhart A. 1912-2012: a century of research on Plasmodium vivax in vitro culture. Trends Parasitol. 2013;29:286-94 pubmed publisher
    The development of a continuous Plasmodium vivax blood cycle in vitro was first attempted 100 years ago. Since then, and despite the use of different methods, only short-term cultures have been achieved so far...
  68. Collins W. Origin of the St. Elizabeth strain of Plasmodium vivax. Am J Trop Med Hyg. 2013;88:726 pubmed publisher
    The St. Elizabeth strain of Plasmodium vivax originated in the South Carolina State Hospital instead of the St. Elizabeth Hospital in Washington, DC.
  69. Ding S, Ye R, Zhang D, Sun X, Zhou H, McCutchan T, et al. Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax. Sci Rep. 2013;3:1008 pubmed publisher
    ..to multi-drug therapy in a more predictable manner? We raise this question after analyzing over 500 Plasmodium vivax isolates collected from different, geographically isolated regions of China for sequence variation in and ..
  70. Kim J, Kim H, Shin H, Sohn Y, Kim H, Lee S, et al. Genetic variation of aldolase from Korean isolates of Plasmodium vivax and its usefulness in serodiagnosis. Malar J. 2012;11:159 pubmed publisher
    ..The genetic variation of Korean isolates was analysed and recombinant aldolase was evaluated as a serological antigen in Plasmodium vivax malaria.
  71. Givens M, Lin J, Lon C, Gosi P, Char M, Lanteri C, et al. Development of a capillary electrophoresis-based heteroduplex tracking assay to measure in-host genetic diversity of initial and recurrent Plasmodium vivax infections in Cambodia. J Clin Microbiol. 2014;52:298-301 pubmed publisher
    A heteroduplex tracking assay used to genotype Plasmodium vivax merozoite surface protein 1 was adapted to a capillary electrophoresis format, obviating the need for radiolabeled probes and allowing its use in settings where malaria is ..
  72. Kano F, Sanchez B, Sousa T, Tang M, Saliba J, Oliveira F, et al. Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well-consolidated settlement of the Amazon Region. Trop Med Int Health. 2012;17:989-1000 pubmed publisher
    To investigate risk factors associated with the acquisition of antibodies against Plasmodium vivax Duffy binding protein (PvDBP) - a leading malaria vaccine candidate - in a well-consolidated agricultural settlement of the Brazilian ..
  73. Mens P, Moers A, de Bes L, Flint J, Sak J, Keereecharoen L, et al. Development, validation and evaluation of a rapid PCR-nucleic acid lateral flow immuno-assay for the detection of Plasmodium and the differentiation between Plasmodium falciparum and Plasmodium vivax. Malar J. 2012;11:279 pubmed
    ..A PCR detecting the different Plasmodium species and differentiating between Plasmodium falciparum and Plasmodium vivax was developed and combined with a nucleic acid lateral flow immuno-assay (PCR-NALFIA) for amplicon detection...
  74. Lover A, Coker R. Quantifying effect of geographic location on epidemiology of Plasmodium vivax malaria. Emerg Infect Dis. 2013;19:1058-65 pubmed publisher
    Recent autochthonous transmission of Plasmodium vivax malaria in previously malaria-free temperate regions has generated renewed interest in the epidemiology of this disease...
  75. Culleton R, Carter R. African Plasmodium vivax: distribution and origins. Int J Parasitol. 2012;42:1091-7 pubmed publisher
    There is increasing evidence that the malaria parasite, Plasmodium vivax, is endemic in west and central Africa, a region from which it was previously thought to be almost completely absent due to the very high prevalence of the Duffy ..
  76. Pan J, Zhou S, Zheng X, Huang F, Wang D, Shen Y, et al. Vector capacity of Anopheles sinensis in malaria outbreak areas of central China. Parasit Vectors. 2012;5:136 pubmed publisher
    ..In order to understand the role of the vector in the transmission of malaria during the outbreak period, the vector capacity of An. sinensis in Huanghuai valley of central China was investigated...
  77. Price R, Auburn S, Marfurt J, Cheng Q. Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. Trends Parasitol. 2012;28:522-9 pubmed publisher
    In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance...
  78. Faucher J, Bellanger A, Chirouze C, Hustache Mathieu L, Genton S, Hoen B. Primaquine for radical cure of Plasmodium vivax and Plasmodium ovale malaria: an observational survey (2008-2010). J Travel Med. 2013;20:134-6 pubmed publisher
    ..the French guidelines have promoted the systematic use of 30 mg/day of primaquine for the radical cure of Plasmodium vivax and Plamodium ovale infections...
  79. Eibach D, Ceron N, Krishnalall K, Carter K, Bonnot G, Bienvenu A, et al. Therapeutic efficacy of artemether-lumefantrine for Plasmodium vivax infections in a prospective study in Guyana. Malar J. 2012;11:347 pubmed publisher
    ..A worldwide increase of chloroquine resistance in Plasmodium vivax led to questioning of the current malaria treatment guidelines...
  80. Chotivanich K, Udomsangpetch R, Suwanarusk R, Pukrittayakamee S, Wilairatana P, Beeson J, et al. Plasmodium vivax adherence to placental glycosaminoglycans. PLoS ONE. 2012;7:e34509 pubmed publisher
    b>Plasmodium vivax infections seldom kill directly but do cause indirect mortality by reducing birth weight and causing abortion...
  81. Lima N, Bastos M, Ferreira M. Plasmodium vivax: reverse transcriptase real-time PCR for gametocyte detection and quantitation in clinical samples. Exp Parasitol. 2012;132:348-54 pubmed publisher
    The proportion of Plasmodium vivax-infected subjects that carry mature gametocytes, and thus are potentially infectious, remains poorly characterized in endemic settings...
  82. Sutanto I, Tjahjono B, Basri H, Taylor W, Putri F, Meilia R, et al. Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia. Antimicrob Agents Chemother. 2013;57:1128-35 pubmed publisher
    Radical cure of Plasmodium vivax infection applies blood schizontocidal therapy against the acute attack and hypnozoitocidal therapy against later relapse. Chloroquine and primaquine have been used for 60 years in this manner...
  83. Tachibana S, Sullivan S, Kawai S, Nakamura S, Kim H, Goto N, et al. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nat Genet. 2012;44:1051-5 pubmed publisher
    ..The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax...
  84. Garz n Ospina D, L pez C, Forero Rodr guez J, Patarroyo M. Genetic diversity and selection in three Plasmodium vivax merozoite surface protein 7 (Pvmsp-7) genes in a Colombian population. PLoS ONE. 2012;7:e45962 pubmed publisher
    ..Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine...
  85. Ntumngia F, King C, Adams J. Finding the sweet spots of inhibition: understanding the targets of a functional antibody against Plasmodium vivax Duffy binding protein. Int J Parasitol. 2012;42:1055-62 pubmed publisher
    b>Plasmodium vivax Duffy binding protein region II (DBPII) is an essential ligand for reticulocyte invasion, thereby making this molecule an attractive vaccine candidate against asexual blood-stage P. vivax...
  86. Baird K, Maguire J, Price R. Diagnosis and treatment of Plasmodium vivax malaria. Adv Parasitol. 2012;80:203-70 pubmed publisher
    Infection by Plasmodium vivax poses unique challenges for diagnosis and treatment...
  87. Kerlin D, Boyce K, Marfurt J, Simpson J, Kenangalem E, Cheng Q, et al. An analytical method for assessing stage-specific drug activity in Plasmodium vivax malaria: implications for ex vivo drug susceptibility testing. PLoS Negl Trop Dis. 2012;6:e1772 pubmed publisher
    ..The statistical methodology which has been developed also provides a novel means of detecting stage-specific drug activity for new antimalarials...
  88. Raghunandan J, Rajeshwari K, Dubey A, Singh T. Peripheral gangrene in an 18-month-old boy with Plasmodium vivax malaria. Paediatr Int Child Health. 2012;32:164-6 pubmed publisher
    ..There were gangrenous changes in the index and middle fingers of both hands. Plasmodium vivax was demonstrated in the peripheral blood smear but there was no evidence of disseminated intravascular ..
  89. Anstey N, Douglas N, Poespoprodjo J, Price R. Plasmodium vivax: clinical spectrum, risk factors and pathogenesis. Adv Parasitol. 2012;80:151-201 pubmed publisher
    ..Despite this, Plasmodium vivax was, and remains, responsible for major morbidity and significant mortality in vivax-endemic areas...
  90. Mourão L, Morais C, Bueno L, Jimenez M, Soares I, Fontes C, et al. Naturally acquired antibodies to Plasmodium vivax blood-stage vaccine candidates (PvMSP-1?? and PvMSP-3???????? and their relationship with hematological features in malaria patients from the Brazilian Amazon. Microbes Infect. 2012;14:730-9 pubmed publisher
    ..We investigated specific antibody responses against two Plasmodium vivax vaccine candidates, PvMSP-1?? and PvMSP-3????????...