plasmodium cynomolgi

Summary

Summary: A protozoan parasite that occurs naturally in the macaque. It is similar to PLASMODIUM VIVAX and produces a type of malaria similar to vivax malaria (MALARIA, VIVAX). This species has been found to give rise to both natural and experimental human infections.

Top Publications

  1. Wengelnik K, Vidal V, Ancelin M, Cathiard A, Morgat J, Kocken C, et al. A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science. 2002;295:1311-4 pubmed
    ..falciparum and P. cynomolgi...
  2. Puri S, Dutta G. Plasmodium cynomolgi: gametocytocidal activity of the anti-malarial compound CDRI 80/53 (elubaquine) in rhesus monkeys. Exp Parasitol. 2005;111:8-13 pubmed
    ..new enamine analogue of primaquine, elubaquine (compound CDRI 80/53, bulaquine), has been evaluated against Plasmodium cynomolgi B in rhesus monkeys...
  3. Corcoran K, Hansukjariya P, Sattabongkot J, Ngampochjana M, Edstein M, Smith C, et al. Causal prophylactic and radical curative activity of WR182393 (a guanylhydrazone) against Plasmodium cynomolgi in Macaca mulatta. Am J Trop Med Hyg. 1993;49:473-7 pubmed
    ..as part of an effort to evaluate alternatives to primaquine in the rhesus monkey (Macaca mulatta)/Plasmodium cynomolgi test model. The drug was suspended in dimethylsulfoxide for intramuscular (im) injection...
  4. Puri S, Dutta G, Levy H, Maheshwari R. Poly ICLC inhibits Plasmodium cynomolgi B malaria infection in rhesus monkeys. J Interferon Cytokine Res. 1996;16:49-52 pubmed
    ..04 x 10(5)-0.70 x 10(6) sporozoites) of Plasmodium cynomolgi B in the rhesus monkey, completely abolished the infectivity of sporozoites...
  5. Zheng L, Wang S, Romans P, Zhao H, Luna C, Benedict M. Quantitative trait loci in Anopheles gambiae controlling the encapsulation response against Plasmodium cynomolgi Ceylon. BMC Genet. 2003;4:16 pubmed
    ..cynomolgi B, a simian malaria originating in Malaysia...
  6. Li Q, Ruan Z, Zhang H, Peng N, Zhao S, Qin L, et al. Characterization of peripheral blood T lymphocyte subsets in Chinese rhesus macaques with repeated or long-term infection with Plasmodium cynomolgi. Parasitol Res. 2012;110:961-9 pubmed publisher
    ..the profile of T cells in malaria immunity, we infected Chinese rhesus macaques with the malaria parasite (Plasmodium cynomolgi) and examined the dynamics of T cell subsets. Both repeated and long-term infections were involved...
  7. Crews Oyen A, Kumar V, Collins F. Association of two esterase genes, a chromosomal inversion, and susceptibility to Plasmodium cynomolgi in the African malaria vector Anopheles gambiae. Am J Trop Med Hyg. 1993;49:341-7 pubmed
    ..strain of the malaria vector Anopheles gambiae to encapsulate the early oocysts of the malaria parasite Plasmodium cynomolgi B has previously been shown to be genetically linked to specific esterase phenotypes...
  8. Voorberg van der Wel A, Zeeman A, van Amsterdam S, van den Berg A, Klooster E, Iwanaga S, et al. Transgenic fluorescent Plasmodium cynomolgi liver stages enable live imaging and purification of Malaria hypnozoite-forms. PLoS ONE. 2013;8:e54888 pubmed publisher
    ..The fluorescently-tagged parasites in combination with FACS-purification open new avenues for a wide range of studies for analysing hypnozoite biology and reactivation...
  9. Deye G, Gettayacamin M, Hansukjariya P, Im Erbsin R, Sattabongkot J, Rothstein Y, et al. Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances. Am J Trop Med Hyg. 2012;86:931-5 pubmed publisher
    ..The rhesus macaque-P. cynomolgi model remains a useful tool for screening drugs with anti-hypnozoite activity. Tinidazole and pyrazinamide require further investigation as agents to enable dose reduction of primaquine...

More Information

Publications83

  1. Bhardwaj D, Hora B, Singh N, Puri S, Lalitha P, Rupa P, et al. Immunogenicity and protective efficacy of three DNA vaccines encoding pre-erythrocytic- and erythrocytic-stage antigens of Plasmodium cynomolgi in rhesus monkeys. FEMS Immunol Med Microbiol. 2002;34:33-43 pubmed
    ..the erythrocytic stage, and the thrombospondin-related adhesive protein from the pre-erythrocytic stage of Plasmodium cynomolgi in rhesus monkeys...
  2. Zheng L, Cornel A, Wang R, Erfle H, Voss H, Ansorge W, et al. Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B. Science. 1997;276:425-8 pubmed
    ..Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control...
  3. Waters A, Higgins D, McCutchan T. Evolutionary relatedness of some primate models of Plasmodium. Mol Biol Evol. 1993;10:914-23 pubmed
    ..b>Plasmodium cynomolgi is used extensively as a model for the human parasite, P. vivax, and P...
  4. Okenu D, Meyer E, Puckett T, Rosas Acosta G, Barnwell J, Galinski M. The reticulocyte binding proteins of Plasmodium cynomolgi: a model system for studies of P. vivax. Mol Biochem Parasitol. 2005;143:116-20 pubmed
  5. Romans P, Black W, Sakai R, Gwadz R. Linkage of a gene causing malaria refractoriness to Diphenol oxidase-A2 on chromosome 3 of Anopheles gambiae. Am J Trop Med Hyg. 1999;60:22-9 pubmed
    ..in one or more of these genes, we performed genetic crosses to determine whether a previously identified Plasmodium cynomolgi Ceylon refractoriness gene, Pif-C, is linked to Dox-A2...
  6. Song P, Malhotra P, Tuteja N, Chauhan V. RNA helicase-related genes of Plasmodium falciparum and Plasmodium cynomolgi. Biochem Biophys Res Commun. 1999;255:312-6 pubmed
    ..Further characterization of these helicases may also help in designing parasite-specific inhibitors/drugs which specifically inhibit the parasite's growth without affecting the host...
  7. Collins W, Sullivan J, Nace D, Williams T, Williams A, Barnwell J. Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse. J Parasitol. 2009;95:349-52 pubmed publisher
    Forty-four splenectomized Aotus nancymaae monkeys were infected with 6 different strains of Plasmodium cynomolgi, 11 via trophozoites and 33 via sporozoites...
  8. Dow G, Gettayacamin M, Hansukjariya P, Imerbsin R, Komcharoen S, Sattabongkot J, et al. Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). Malar J. 2011;10:212 pubmed publisher
    ..Combination with other antimalarials may mitigate these concerns...
  9. Akinyi S, Hanssen E, Meyer E, Jiang J, Korir C, Singh B, et al. A 95 kDa protein of Plasmodium vivax and P. cynomolgi visualized by three-dimensional tomography in the caveola-vesicle complexes (Schüffner's dots) of infected erythrocytes is a member of the PHIST family. Mol Microbiol. 2012;84:816-31 pubmed publisher
    ..This suggests that PHIST/CVC-81(95) is essential for survival of these malaria parasites...
  10. Tachibana S, Sullivan S, Kawai S, Nakamura S, Kim H, Goto N, et al. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nat Genet. 2012;44:1051-5 pubmed publisher
    ..The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax...
  11. Collins W, Warren M, Galland G. Studies on infections with the Berok strain of Plasmodium cynomolgi in monkeys and mosquitoes. J Parasitol. 1999;85:268-72 pubmed
    Infections with the Berok strain of Plasmodium cynomolgi were induced in Macaca mulatta, Macaca fascicularis, Macaca nemestrina, Aotus lemurinus griseimembra, Aotus azarae boliviensis, and Saimiri boliviensis monkeys...
  12. Praba Egge A, Montenegro S, Cogswell F, Hopper T, James M. Cytokine responses during acute simian Plasmodium cynomolgi and Plasmodium knowlesi infections. Am J Trop Med Hyg. 2002;67:586-96 pubmed
    ..b>Plasmodium cynomolgi (P. vivax-like) and P. knowlesi (P...
  13. Puri S, Dutta G. Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys. Acta Trop. 2003;86:35-40 pubmed
    ..vivax relapses was evaluated for blood schizontocidal activity against two simian malaria infections namely Plasmodium cynomolgi B and Plasmodium fragile in rhesus monkeys. Treatment with WR 238605 at a dose of 3...
  14. Wijayalath W, Cheesman S, Rajakaruna J, Handunnetti S, Carter R, Pathirana P. Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey. Parasite Immunol. 2008;30:630-6 pubmed publisher
    We have conducted experiments to test the induction of strain-specific protective immunity against Plasmodium cynomolgi infections in toque monkeys...
  15. Corredor V, Enea V. The small ribosomal subunit RNA isoforms in Plasmodium cynomolgi. Genetics. 1994;136:857-65 pubmed
    We report the isolation, characterization and analysis of the small subunit rRNA genes in Plasmodium cynomolgi (Ceylon)...
  16. Yang C, Collins W, Millet P. Immunologic characterization of Plasmodium vivax antigens using Plasmodium cynomolgi liver stage-primed immune sera. Am J Trop Med Hyg. 1994;51:365-71 pubmed
    ..of a rhesus monkey (Macaca mulatta) with inactivated liver stages of the simian malaria parasite Plasmodium cynomolgi (B strain) produced high antibody titers against sporozoites, liver stages, and blood stages of P...
  17. Kocken C, Remarque E, Dubbeld M, Wein S, van der Wel A, Verburgh R, et al. Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria. Antimicrob Agents Chemother. 2009;53:421-7 pubmed publisher
    ..We have used asexual erythrocytic Plasmodium cynomolgi infections of rhesus macaques to model Plasmodium vivax during preclinical development of compounds ..
  18. Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, et al. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. Mol Biochem Parasitol. 2007;156:74-9 pubmed
    ..vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages...
  19. Shanks G, Edstein M, Chedester A, Smith C, Corcoran K, Ngampochjana M, et al. Proguanil plus sulfamethoxazole is not causally prophylactic in the Macaca mulatta--Plasmodium cynomolgi model. Am J Trop Med Hyg. 1994;50:641-5 pubmed
    ..combination was investigated using a rhesus monkey model (Macaca mulatta infected with Plasmodium cynomolgi) to determine whether causal prophylaxis could be achieved...
  20. Gorman M, Cornel A, Collins F, Paskewitz S. A shared genetic mechanism for melanotic encapsulation of CM-Sephadex beads and a malaria parasite, Plasmodium cynomolgi B, in the mosquito, Anopheles gambiae. Exp Parasitol. 1996;84:380-6 pubmed
    ..Backcross progeny were given a blood meal containing infective Plasmodium cynomolgi B, and the parasites were allowed to develop for 6-7 days, at which time the infected mosquitoes were ..
  21. Klein T, Harrison B, Dixon S, Burge J. Comparative susceptibility of Southeast Asian Anopheles mosquitoes to the simian malaria parasite Plasmodium cynomolgi. J Am Mosq Control Assoc. 1991;7:481-7 pubmed
    Seven Anopheles species/isolates were compared with Anopheles dirus (control) for susceptibility to Plasmodium cynomolgi B strain. The mean numbers of oocysts in paired replicates of An. dirus and An...
  22. Dutta S, Kaushal D, Ware L, Puri S, Kaushal N, Narula A, et al. Merozoite surface protein 1 of Plasmodium vivax induces a protective response against Plasmodium cynomolgi challenge in rhesus monkeys. Infect Immun. 2005;73:5936-44 pubmed
    ..The soluble and refolded forms of PcMSP-1(42) and PvMSP-1(42) proteins also appeared to have a similar partially protective effect...
  23. Guan J, Wang X, Smith K, Ager A, Gettayacamin M, Kyle D, et al. Malaria causal prophylactic activity of imidazolidinedione derivatives. J Med Chem. 2007;50:6226-31 pubmed
    ..Three compounds were further tested for causal prophylactic activity in Rhesus monkeys infected with Plasmodium cynomolgi sporozoites, and all showed a delay in patency from 13 to 40 days at 30 mg/kg/day x 3 days by IM dosing...
  24. Tang Y, Joyner C, Cabrera Mora M, Saney C, Lapp S, Nural M, et al. Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malar J. 2017;16:384 pubmed publisher
    ..biology to evaluate the transcriptional and alterations in cell populations in the bone marrow during Plasmodium cynomolgi infection of rhesus macaques (a model of Plasmodium vivax malaria) that may affect erythropoiesis...
  25. Biagini G, Fisher N, Shone A, Mubaraki M, Srivastava A, Hill A, et al. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proc Natl Acad Sci U S A. 2012;109:8298-303 pubmed publisher
    ..Several analogs also display activity against liver-stage parasites (Plasmodium cynomolgi) as well as transmission-blocking properties...
  26. Li Y, Qin L, Peng N, Liu G, Zhao S, He Z, et al. Antimalarial effects of human immunodeficiency virus protease inhibitors in rhesus macaques. Antimicrob Agents Chemother. 2011;55:3039-42 pubmed publisher
    ..Indinavir effectively suppressed the growth of Plasmodium cynomolgi and Plasmodium knowlesi in vivo after a 7- or 3-day treatment, respectively, with clinically relevant doses,..
  27. Zhang J, Lin B, Pan Y, Zheng H, Tang W, Chen Y, et al. [Studies on the establishment of malarial animal model of short-term relapse. I. Asynchronous growth of exoerythrocytic schizonts of Plasmodium cynomolgi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10:176-8 pubmed
    A monkey was infected with sporozoites of Plasmodium cynomolgi from Vietnam. Parasitemia was detected on the 8th day with a starting density of 17/100 white blood cells...
  28. Wijayalath W, Cheesman S, Tanabe K, Handunnetti S, Carter R, Pathirana S. Strain-specific protective effect of the immunity induced by live malarial sporozoites under chloroquine cover. PLoS ONE. 2012;7:e45861 pubmed publisher
    ..of live sporozoite-induced immunity using two genetically and immunologically different strains of Plasmodium cynomolgi, Pc746 and PcCeylon, in toque monkeys...
  29. Singh P, Singh S, Dhawan V, Haq W, Mathur K, Dutta G, et al. Enkephalins-modulation of Plasmodium cynomolgi antigens-induced colony-stimulating factors elaboration by macrophages. J Biol Regul Homeost Agents. 1991;5:142-6 pubmed
    ..Methionine-enkephalin (M-Enk) and its analogue compound 82/205 (10(-5) and 10(-6) M) inhibited elaboration of Plasmodium cynomolgi total antigens soluble in culture medium (P.c...
  30. Maeno Y. Molecular epidemiology of mosquitoes for the transmission of forest malaria in south-central Vietnam. Trop Med Health. 2017;45:27 pubmed publisher
    Human infection caused by non-human primate malarial parasites, such as Plasmodium knowlesi and Plasmodium cynomolgi, occurs naturally in Southeast Asian countries, including Vietnam...
  31. Edstein M, Corcoran K, Shanks G, Ngampochjana M, Hansukjariya P, Sattabongkot J, et al. Evaluation of WR250417 (a proguanil analog) for causal prophylactic activity in the Plasmodium cynomolgi-Macaca mulatta model. Am J Trop Med Hyg. 1994;50:181-6 pubmed
    The Plasmodium cynomolgi-Macaca mulatta model has been used to test the antimalarial activity of new drugs for both radical cure and casual prophylaxis...
  32. Kamboj K, Puri S, Katiyar J, Dutta G. In-vitro cultivation of exoerythrocytic stages of Plasmodium cynomolgi in hepatocytes of Macaca radiata. Indian J Malariol. 1996;33:67-73 pubmed
    ..from bonet monkey (Macaca radiata) obtained by perfusion of a liver biopsy were infected in-vitro with Plasmodium cynomolgi bastianellii sporozoites raised in Anopheles stephensi...
  33. Akter R, Vythilingam I, Khaw L, Qvist R, Lim Y, Sitam F, et al. Simian malaria in wild macaques: first report from Hulu Selangor district, Selangor, Malaysia. Malar J. 2015;14:386 pubmed publisher
    ..knowlesi, Plasmodium inui, Plasmodium cynomolgi, Plasmodium fieldi, and Plasmodium coatneyi. All five species of simian malaria parasites were detected...
  34. Gorman M, Paskewitz S. A genetic study of a melanization response to Sephadex beads in Plasmodium-refractory and -susceptible strains of Anopheles gambiae. Am J Trop Med Hyg. 1997;56:446-51 pubmed
    ..No linkage with either marker was detected. The pattern of inheritance of the melanizing phenotype is similar to that of the refractory phenotype of Pif-B; therefore, the genetic basis of the two responses may be the same. ..
  35. Ouattara M, Wein S, Calas M, Hoang Y, Vial H, Escale R. Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives. Bioorg Med Chem Lett. 2007;17:593-6 pubmed
    ..The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration. ..
  36. Collins W, Warren M, Sullivan J, Galland G, Nace D, Williams A, et al. Studies on two strains of Plasmodium cynomolgi in New World and Old World monkeys and mosquitoes. J Parasitol. 2005;91:280-3 pubmed
    Infections that cause the Gombak and Smithsonian strains of Plasmodium cynomolgi were induced in Macaca mulatta, Aotus lemurinus griseimembra, Aotus nancymai, and Saimiri boliviensis monkeys. Transmission of the Gombak strain to Aotus spp...
  37. Zhang J, Lin B, Pan Y, Zheng H, Tang W, Chen Y, et al. [Studies on the establishment of malarial animal model of short-term relapse. IV. Short-term relapse in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1993;11:244-7 pubmed
    ..the experimental design, when the parasitemia was detected in rhesus monkeys infected with sporozoites of Plasmodium cynomolgi, a combined therapy of pyronaridine 6 mg/kg body weight, artemether 10 mg/kg and chloroquine 20 mg/kg once ..
  38. Siner A, Liew S, Kadir K, Mohamad D, Thomas F, Zulkarnaen M, et al. Correction to: Absence of Plasmodium inui and Plasmodium cynomolgi, but detection of Plasmodium knowlesi and Plasmodium vivax infections in asymptomatic humans in the Betong division of Sarawak, Malaysian Borneo. Malar J. 2017;16:445 pubmed publisher
    ..After publication of the article [1], it has been brought to our attention that two of the labels on Figure 4 have transposed. The labels "S-type SSU rRNA" and "A-type SSU rRNA" should be in opposite places. ..
  39. Saxena N, Murthy P. Hydrolytic enzyme activity in rhesus monkey placenta during early gestational malaria: histochemical studies. J Vector Borne Dis. 2005;42:135-40 pubmed
    ..Present study dealing with hydrolytic enzymes in early gestational placenta of rhesus monkeys during Plasmodium cynomolgi infection was anticipated to provide a better insight into the functional impairment of this organ during ..
  40. Tang Y, Joyner C, Cabrera Mora M, Saney C, Lapp S, Nural M, et al. Correction to: Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques. Malar J. 2017;16:486 pubmed publisher
    ..1, including some cited in the figure's key. The correct version of the figure is shown below and has now been updated in the original article. ..
  41. Siner A, Liew S, Kadir K, Mohamad D, Thomas F, Zulkarnaen M, et al. Absence of Plasmodium inui and Plasmodium cynomolgi, but detection of Plasmodium knowlesi and Plasmodium vivax infections in asymptomatic humans in the Betong division of Sarawak, Malaysian Borneo. Malar J. 2017;16:417 pubmed publisher
    ..for Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Plasmodium knowlesi, Plasmodium cynomolgi and Plasmodium inui. Blood films of samples positive by PCR were also examined by microscopy...
  42. Bhardwaj D, Kushwaha A, Puri S, Herrera A, Singh N, Chauhan V. DNA prime-protein boost immunization in monkeys: efficacy of a novel construct containing functional domains of Plasmodium cynomolgi CS and TRAP. FEMS Immunol Med Microbiol. 2003;39:241-50 pubmed
    ..the N-terminus of thrombospondin-related adhesive protein and the C-terminus of circumsporozoite protein of Plasmodium cynomolgi. The vaccinated animals developed high titer antibodies against the chimeric antigen, the two components of ..
  43. Singh B, Simon Divis P. Orangutans not infected with Plasmodium vivax or P. cynomolgi, Indonesia. Emerg Infect Dis. 2009;15:1657-8 pubmed publisher
    After orangutans in Indonesia were reported as infected with Plasmodium cynomolgi and P. vivax, we conducted phylogenetic analyses of small subunit ribosomal RNA gene sequences of Plasmodium spp...
  44. Li P, Zhong H, Shi C, Li J, Zhang Y, Li C, et al. [Induction of protective immunity in rhesus monkey by inoculation with recombinant fusion protein of cholera toxin B subunit-multivalent epitopes of Plasmodium falciparum]. Sheng Wu Gong Cheng Xue Bao. 2004;20:516-9 pubmed
    ..The results demonstrated that the vaccine candidate could induce protective immune-responses in rhesus monkey against the challenge of P. cynomolgi. ..
  45. Mehrotra A, Dutta G. Role of fatty infiltration during malaria in rhesus monkey. Life Sci. 1994;54:1861-8 pubmed
    ..The parasite used in the study closely resembles the human parasite P. vivax. It has a defined prepatent period, can be cyclically passaged with ease and non fatal in nature...
  46. Zeeman A, der Wel A, Kocken C. Ex vivo culture of Plasmodium vivax and Plasmodium cynomolgi and in vitro culture of Plasmodium knowlesi blood stages. Methods Mol Biol. 2013;923:35-49 pubmed
    ..knowlesi as well as some techniques for synchronizing parasites. Cultured parasites can be used for a variety of purposes, e.g., for in vitro drug assays and antibody-mediated growth inhibition assays...
  47. Tuteja R, Malhotra P, Song P, Tuteja N, Chauhan V. Isolation and characterization of an eIF-4A homologue from Plasmodium cynomolgi. Mol Biochem Parasitol. 2002;124:79-83 pubmed
  48. Puri S, Singh N. Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. Exp Parasitol. 2000;94:8-14 pubmed
    ..chloroquine-resistant strain of Plasmodium yoelii nigeriensis (N-67) in Swiss mice and with simian parasite Plasmodium cynomolgi B in rhesus monkeys...
  49. Kosaisavee V, Suwanarusk R, Chua A, Kyle D, Malleret B, Zhang R, et al. Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. Blood. 2017;130:1357-1363 pubmed publisher
  50. Mehrotra A, Dutta G. Histochemical changes in host tissues from Plasmodium cynomolgi B infected rhesus monkey (Macaca mulatta). Indian J Exp Biol. 1996;34:155-8 pubmed
    b>Plasmodium cynomolgi B has been used to infect the rhesus monkey to study the histochemical changes (lipid infiltration, glycogen, protein, DNA and RNA) in liver, kidney and spleen during early (exoerythrocytic) and late (chronic) stages ..
  51. Tripathi R, Dutta G, Vishwakarma R. Gametocytocidal activity of alpha/beta arteether by the oral route of administration. Am J Trop Med Hyg. 1996;54:652-4 pubmed
    ..a mixture of alpha and beta enantioners) has been reported to possess gametocytocidal activity against Plasmodium cynomolgi B when the drug is given by the intramuscular route, but it would be preferable to use oral route therapy ..
  52. Chen L, Dai Z, Ma Z, Zheng X, Chen C. [Studies on residual antimalarial activity of tripynadine in mice and monkeys]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1993;11:190-4 pubmed
    ..However, the residual activity decreased evidently when the total dose was reduced to 100 mg/kg. In short, it seems that the residual antimalarial activity of tripynadine free base is slightly less than that of piperaquine in monkeys...
  53. Dembele L, Franetich J, Lorthiois A, Gego A, Zeeman A, Kocken C, et al. Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures. Nat Med. 2014;20:307-12 pubmed publisher
    ..models, principally Macaca rhesus and Macaca fascicularis, experimentally infected with the relapsing Plasmodium cynomolgi. Here, we present a protocol for long-term in vitro cultivation of P. cynomolgi-infected M...
  54. Gao Q, Tharavanij S, Khusmith S, Wang L, Looareesuwan S, Zhang W. Two-site pan-species monoclonal antibody ELISA for detection of blood stage malaria antigen. Southeast Asian J Trop Med Public Health. 1992;23:740-4 pubmed
    ..After two weeks treatment, 77.7% (14/18) of vivax malaria were still positive by this assay but with diminished level of reactivities [corrected]...
  55. Carter R, Mendis K. Immune responses against sexual stages of Plasmodium vivax during human malarial infections in Sri Lanka. Parassitologia. 1991;33:67-70 pubmed
    ..These factors are associated with paroxysm in non-immune individuals. In individuals from an endemic area with age-acquired anti-disease immunity clinical symptoms are mild and the parasite killing factors are not induced...
  56. Puri S, Dutta G. Differential sensitivity of the pre-erythrocytic stages of Plasmodium cynomolgi B to the prophylactic action of primaquine. Trop Med Parasitol. 1992;43:70-1 pubmed
    The sensitivity of the developing pre-erythrocytic stages of Plasmodium cynomolgi bastianelli to primaquine in single, two or three dose regimens administered at varying times during the incubation period has been investigated...
  57. Saxena N, Murthy P. Oxidoreductases in early gestational monkey placenta during maternal malarial infection: histochemical localisation. J Vector Borne Dis. 2007;44:116-21 pubmed
    ..study dealing with oxidoreductases in early gestational placenta during maternal malarial infection of Plasmodium cynomolgi bastianellii in rhesus monkeys was anticipated to provide a better insight into the functional impairment ..
  58. J Joyner C, Consortium T, Wood J, Moreno A, Garcia A, Galinski M. Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria. Am J Trop Med Hyg. 2017;97:548-555 pubmed publisher
    ..Here, the histopathological changes observed in a rhesus macaque with severe and complicated Plasmodium cynomolgi malaria are reported...
  59. Zhang J, Lin B, Pan Y, Zheng H, Fang Y. [Studies on the establishment of malarial animal model of short-term relapse. II. The phenomenon of sustained special ring form parasitemia in Plasmodium cynomolgi infection]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10:250-4 pubmed
    Our previous report that the EE merozites of Plasmodium cynomolgi from Vietnam continuously released from the liver to the blood circulation was further demonstrated in this report. Monkeys were given pyronaridine 24 mg/kg...
  60. Cubi R, Vembar S, Biton A, Franetich J, Bordessoulles M, Sossau D, et al. Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species. Cell Microbiol. 2017;19: pubmed publisher
    ..We developed a robust laser dissection microscopy protocol to isolate individual Plasmodium cynomolgi hypnozoites and schizonts from infected monkey hepatocytes and optimized RNA-seq analysis to obtain the ..
  61. Millet P, Grady K, Olsen M, Galland G, Sullivan J, Morris C, et al. Use of the rhesus monkey as an experimental model to test the degree of efficacy of an anti-sporozoite peptide malaria vaccine candidate combined with copolymer-based adjuvants. Am J Trop Med Hyg. 1995;52:328-35 pubmed
    ..monkeys with a synthetic peptide reproducing part of the repeated region of the circumsporozoite protein of Plasmodium cynomolgi. This peptide was conjugated to the carrier protein diphtheria toxoid and injected with four adjuvant ..
  62. Zhang J, Lin B, Pan Y, Zheng H, Fang Y. [Studies on the establishment of malarial animal model of short-term relapse. III. Combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1993;11:180-4 pubmed
    To establish a Plasmodium cynomolgi-monkey model of short-term relapse, different antimalarials have been used to inhibit recrudescence so as to elude the confusion between the two different onsets...
  63. Kazim M, Puri S, Dutta G, Narasimham M. Evaluation of Ayush-64 for blood schizontocidal activity against rodent and simian malaria parasites. Indian J Malariol. 1991;28:255-8 pubmed
    ..berghei and P. yoelii nigeriensis in swiss mice and P. cynomolgi B and P. knowlesi in rhesus monkeys. No blood schizontocidal activity could be demonstrated against any of the four malaria parasites...
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    ..Additionally, ketotifen appeared to have some activity against relapse of Plasmodium cynomolgi infection in rhesus monkeys...
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    ..cynomolgi-infected hepatocytes. This first report of rIL-12-induced protection of primates against an infectious agent supports assessment of rhIL-12 for immunoprophylaxis of human malaria...
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    ..These data demonstrate that mimotopes selected from random repertoires do not necessarily represent structural equivalents of the original antigen but provide functional images that could replace it for vaccine development...
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    ..that a rhesus macaque that was chronically infected with Babesia microti was able to control infection with Plasmodium cynomolgi (a parasite of macaques with characteristics very similar to those of Plasmodium vivax) better than naïve ..
  68. Chitarra V, Holm I, Bentley G, Petres S, Longacre S. The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate. Mol Cell. 1999;3:457-64 pubmed
    ..In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed...
  69. Liu X, Wang X, Li Q, Kozar M, Melendez V, O Neil M, et al. Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives. J Med Chem. 2011;54:4523-35 pubmed publisher
    ..comparable to that of the commonly used clinical drugs in Rhesus monkeys infected with sporozoites of Plasmodium cynomolgi. The metabolic stability and metabolites profile indicated that the new deoxo-IZ derivatives (8) may act as ..
  70. Zhang L, Sathunuru R, Luong T, Melendez V, Kozar M, Lin A. New imidazolidinedione derivatives as antimalarial agents. Bioorg Med Chem. 2011;19:1541-9 pubmed publisher
    ..By oral, 9c showed only marginal activity in causal prophylactic and radical curative tests at 50 mg/kg/day×3 and 30 mg/kg/day×7 plus chloroquine 10 mg/kg for 7 days, respectively...
  71. Margout D, Bontemps N, Kocken C, Vial H, Bressolle F. Rapid resolution liquid chromatography-mass spectrometry determination of SAR97276 in monkey matrices. Pharmacokinetics in rhesus monkey infected by Plasmodium cynomolgi. J Pharm Biomed Anal. 2009;49:1266-71 pubmed publisher
    ..It was used to analyse samples taken during a pharmacokinetic/pharmacodynamic study carried out in infected Rhesus monkey by Plasmodium cynomolgi as part of the ongoing development of SAR97276.
  72. Benedict M, Hood Nowotny R, Howell P, Wilkins E. Methylparaben in Anopheles gambiae s.l. sugar meals increases longevity and malaria oocyst abundance but is not a preferred diet. J Insect Physiol. 2009;55:197-204 pubmed publisher
    ..Methylparaben effects on Plasmodium cynomolgi B oocyst formation and encapsulation were observed in a normal A...
  73. Zheng H, Zhu H, Ning B, Li X. [Molecular identification of naturally acquired Plasmodium knowlesi infection in a human case]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:273-6 pubmed
    ..To confirm the diagnosis of a human case with atypical vivax-malaria from Yunnan Province by molecular technique...
  74. Kaushal D, Kaushal N, Narula A, Kumar N, Puri S, Dutta S, et al. Biochemical and immunological characterization of E. coli expressed 42 kDa fragment of Plasmodium vivax and P. cynomolgi bastianelli merozoite surface protein-1. Indian J Biochem Biophys. 2007;44:429-36 pubmed
    ..These results suggested that the soluble and refolded forms of E. coli expressed P. vivax MSP-1(42) antigens were highly immunogenic and thus a viable candidate for vaccine studies...