plasmodium chabaudi

Summary

Summary: A protozoan parasite of rodents transmitted by the mosquito Anopheles stephensi.

Top Publications

  1. Bell A, de Roode J, Sim D, Read A. Within-host competition in genetically diverse malaria infections: parasite virulence and competitive success. Evolution. 2006;60:1358-71 pubmed
    ..polymerase chain reaction protocols to determine the pairwise competitiveness of genetically divergent Plasmodium chabaudi clones that represent a wide range of innate virulences in their rodent host...
  2. Ferguson H, Mackinnon M, Chan B, Read A. Mosquito mortality and the evolution of malaria virulence. Evolution. 2003;57:2792-804 pubmed
  3. Wargo A, de Roode J, Huijben S, Drew D, Read A. Transmission stage investment of malaria parasites in response to in-host competition. Proc Biol Sci. 2007;274:2629-38 pubmed
    ..We developed and used a clone-specific, stage-specific, quantitative PCR protocol to quantify Plasmodium chabaudi replication and transmission stage densities in mixed-clone infections...
  4. Mohan K, Stevenson M. Dyserythropoiesis and severe anaemia associated with malaria correlate with deficient interleukin-12 production. Br J Haematol. 1998;103:942-9 pubmed
    ..b>Plasmodium chabaudi AS susceptible A/J mice experience severe and fatal anaemia whereas resistant C57BL/6 (B6) mice survive ..
  5. Burns J, Flaherty P, Nanavati P, Weidanz W. Protection against Plasmodium chabaudi malaria induced by immunization with apical membrane antigen 1 and merozoite surface protein 1 in the absence of gamma interferon or interleukin-4. Infect Immun. 2004;72:5605-12 pubmed
    ..Immunologically intact or selected immunologic knockout mice were immunized with purified recombinant Plasmodium chabaudi AMA-1 (PcAMA-1) and/or the 42-kDa C-terminal processing fragment of P. chabaudi MSP-1 (MSP-1(42))...
  6. Hunt P, Martinelli A, Fawcett R, Carlton J, Carter R, Walliker D. Gene synteny and chloroquine resistance in Plasmodium chabaudi. Mol Biochem Parasitol. 2004;136:157-64 pubmed
    Chloroquine resistance in the rodent malaria parasite Plasmodium chabaudi has been shown to be caused by a gene on chromosome 11, and is not linked to orthologues of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) or ..
  7. Martinelli A, Hunt P, Fawcett R, Cravo P, Walliker D, Carter R. An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi. Malar J. 2005;4:11 pubmed
    b>Plasmodium chabaudi chabaudi can be considered as a rodent model of human malaria parasites in the genetic analysis of important characters such as drug resistance and immunity...
  8. Mackinnon M, Gandon S, Read A. Virulence evolution in response to vaccination: the case of malaria. Vaccine. 2008;26 Suppl 3:C42-52 pubmed
    ..We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered. ..
  9. Langhorne J, Cross C, Seixas E, Li C, von der Weid T. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc Natl Acad Sci U S A. 1998;95:1730-4 pubmed
    B cell knockout mice are unable to clear a primary erythrocytic infection of Plasmodium chabaudi chabaudi...

More Information

Publications102 found, 100 shown here

  1. Timms R, Colegrave N, Chan B, Read A. The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi. Parasitology. 2001;123:1-11 pubmed
    ..were designed to look at the relationship between infective dose and disease severity using 2 clones of Plasmodium chabaudi that differ in virulence...
  2. Cravo P, Carlton J, Hunt P, Bisoni L, Padua R, Walliker D. Genetics of mefloquine resistance in the rodent malaria parasite Plasmodium chabaudi. Antimicrob Agents Chemother. 2003;47:709-18 pubmed
    ..Using the rodent malaria model Plasmodium chabaudi, we investigated the role of the orthologue of this gene, pcmdr1, in a stable mefloquine-resistant mutant, ..
  3. Weidanz W, LaFleur G, Brown A, Burns J, Gramaglia I, van der Heyde H. Gammadelta T cells but not NK cells are essential for cell-mediated immunity against Plasmodium chabaudi malaria. Infect Immun. 2010;78:4331-40 pubmed publisher
    Blood-stage Plasmodium chabaudi infections are suppressed by antibody-mediated immunity and/or cell-mediated immunity (CMI)...
  4. Wunderlich F, Dkhil M, Mehnert L, Braun J, El Khadragy M, Borsch E, et al. Testosterone responsiveness of spleen and liver in female lymphotoxin beta receptor-deficient mice resistant to blood-stage malaria. Microbes Infect. 2005;7:399-409 pubmed
    ..however, we find that female LTbetaR-deficient mice are even more resistant to blood stages of Plasmodium chabaudi malaria than wild-type C57BL/6 mice...
  5. Pattaradilokrat S, Cheesman S, Carter R. Linkage group selection: towards identifying genes controlling strain specific protective immunity in malaria. PLoS ONE. 2007;2:e857 pubmed
    ..Selection, to locate the target(s) of Strain Specific Protective Immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi. In a previous such analysis using the progeny of a genetic cross between P. c...
  6. Malu D, Bélanger B, Desautels F, Kelendji K, Dalko E, Sanchez Dardon J, et al. Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice. J Immunol. 2011;186:6271-9 pubmed publisher
    ..production by CD4(+) T cells is pivotal to resolve murine malaria and that secretion of MIF is induced by Plasmodium chabaudi adami parasites, we investigated the effect of MIF deficiency on the infection with this pathogen...
  7. Mackinnon M, Read A. Immunity promotes virulence evolution in a malaria model. PLoS Biol. 2004;2:E230 pubmed
    ..Using the mouse malaria model, Plasmodium chabaudi, we experimentally tested whether immune pressure promotes the evolution of more virulent pathogens by ..
  8. Graham A, Lamb T, Read A, Allen J. Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency. J Infect Dis. 2005;191:410-21 pubmed
    ..Using rodent models of lymphatic filariasis (Litomosoides sigmodontis) and noncerebral malaria (clone AS Plasmodium chabaudi chabaudi), we quantified disease severity, parasitemia, and polyclonal splenic immune responses in BALB/c ..
  9. Min oo G, Fortin A, Pitari G, Tam M, Stevenson M, Gros P. Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. J Exp Med. 2007;204:511-24 pubmed
    ..74) that regulates the blood-stage replication of Plasmodium chabaudi AS independently of Pklr...
  10. Helmby H, Kullberg M, Troye Blomberg M. Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infections. Infect Immun. 1998;66:5167-74 pubmed
    ..Protection and elimination of blood-stage Plasmodium chabaudi chabaudi AS in resistant mice are characterized by a sequential activation of CD4(+) Th1 and Th2 cells...
  11. Krucken J, Stamm O, Schmitt Wrede H, Mincheva A, Lichter P, Wunderlich F. Spleen-specific expression of the malaria-inducible intronless mouse gene imap38. J Biol Chem. 1999;274:24383-91 pubmed
    We characterize the mouse gene imap38 and its inducibility by Plasmodium chabaudi malaria among different lymphoid tissues and mouse strains of different H-2 complex and non-H-2 background...
  12. Rivero A, Ferguson H. The energetic budget of Anopheles stephensi infected with Plasmodium chabaudi: is energy depletion a mechanism for virulence?. Proc Biol Sci. 2003;270:1365-71 pubmed
    ..Mosquitoes infected with Plasmodium chabaudi were expected to have less energetic resources than uninfected mosquitoes, and energy levels were predicted ..
  13. Langhorne J, Albano F, Hensmann M, Sanni L, Cadman E, Voisine C, et al. Dendritic cells, pro-inflammatory responses, and antigen presentation in a rodent malaria infection. Immunol Rev. 2004;201:35-47 pubmed
    An infection of mice with Plasmodium chabaudi is characterized by a rapid and marked inflammatory response with a rapid but regulated production of interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (..
  14. Li C, Corraliza I, Langhorne J. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun. 1999;67:4435-42 pubmed
    Infection of interleukin-10 (IL-10)-nonexpressing (IL-10(-/-)) mice with Plasmodium chabaudi chabaudi (AS) leads to exacerbated pathology in female mice and death in a proportion of them...
  15. Scorza T, Grubb K, Cambos M, Santamaria C, Tshikudi Malu D, Spithill T. Vaccination with a Plasmodium chabaudi adami multivalent DNA vaccine cross-protects A/J mice against challenge with P. c. adami DK and virulent Plasmodium chabaudi chabaudi AS parasites. Int J Parasitol. 2008;38:819-27 pubmed
    ..a 30K multivalent DNA vaccine has been evaluated in susceptible A/J mice (H-2a) against infection with the Plasmodium chabaudi adami DK strain and a virulent parasite subspecies, Plasmodium chabaudi chabaudi AS...
  16. Stephens R, Culleton R, Lamb T. The contribution of Plasmodium chabaudi to our understanding of malaria. Trends Parasitol. 2012;28:73-82 pubmed publisher
    ..We outline here the parallels between the Plasmodium chabaudi mouse model of malaria and human malaria. We will highlight the contribution of P...
  17. Seixas E, Cross C, Quin S, Langhorne J. Direct activation of dendritic cells by the malaria parasite, Plasmodium chabaudi chabaudi. Eur J Immunol. 2001;31:2970-8 pubmed
    A primary infection of mice with Plasmodium chabaudi chabaudi (AS) is characterized by a rapid and marked inflammatory response. Typically, IL-12, TNF-alpha and IFN-gamma are produced in the spleen, and are transiently present in plasma...
  18. Stephens R, Albano F, Quin S, Pascal B, Harrison V, Stockinger B, et al. Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance. Blood. 2005;106:1676-84 pubmed
    ..carrying a TCR specific for an epitope of the merozoite surface protein 1 (MSP-1) of the malaria parasite, Plasmodium chabaudi. In adoptive transfer experiments, malaria-specific CD4(+) T cells expand and produce interferon gamma (IFN-..
  19. Grech K, Watt K, Read A. Host-parasite interactions for virulence and resistance in a malaria model system. J Evol Biol. 2006;19:1620-30 pubmed
    ..host-by-parasite interactions in a medically relevant vertebrate disease model: the rodent malaria parasite Plasmodium chabaudi in laboratory mice...
  20. Cadman E, Abdallah A, Voisine C, Sponaas A, Corran P, Lamb T, et al. Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity. Infect Immun. 2008;76:3924-31 pubmed publisher
    ..Immunization of mice with chicken gamma globulin 2 weeks prior to acute Plasmodium chabaudi infection did not affect the quantity or avidity of the immunoglobulin G antibody response to this antigen...
  21. Voisine C, Mastelic B, Sponaas A, Langhorne J. Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria. Int J Parasitol. 2010;40:711-9 pubmed publisher
    ..We have investigated pDC in a Plasmodium chabaudi infection in mice...
  22. Feng H, Zhu X, Qi Z, Wang Q, Wang G, Pan Y, et al. Transient attenuated Foxp3 expression on CD4? T cells treated with 7D4 mAb contributes to the control of parasite burden in DBA?/?2 mice infected with lethal Plasmodium chabaudi chabaudi AS. Scand J Immunol. 2012;75:46-53 pubmed publisher
    ..anti-CD25 mAb (7D4 clone) treatment affects Foxp3 expression in CD4(+) T cells in DBA/2 mice infected with Plasmodium chabaudi chabaudi AS (P. c. chabaudi AS). We found that DBA/2 mice succumbed to P. c...
  23. Buckling A, Read A. The effect of partial host immunity on the transmission of malaria parasites. Proc Biol Sci. 2001;268:2325-30 pubmed
    ..were carried out to determine the effect of partial host immunity against the rodent malaria parasite Plasmodium chabaudi on the transmission success of the parasite...
  24. Langhorne J, Quin S, Sanni L. Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology. Chem Immunol. 2002;80:204-28 pubmed
  25. Ferreira I, Nogueira F, Borges S, Do Rosario V, Cravo P. Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?. Mol Biochem Parasitol. 2004;136:43-50 pubmed
    ..Using an in silico/PCR combined approach, we have isolated from Plasmodium chabaudi, full sequences of five Plasmodium falciparum gene orthologues involved in GSH metabolism: the gamma-..
  26. Nduati E, Ng D, Ndungu F, Gardner P, Urban B, Langhorne J. Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice. PLoS ONE. 2010;5:e15007 pubmed publisher
    ..or bone marrow, we have investigated these components of the humoral response in PBMC using a model of Plasmodium chabaudi blood-stage infections in C57BL/6 mice...
  27. Harris J, Bohr T, Stracener C, Landmesser M, Torres V, Mbugua A, et al. Sequential Plasmodium chabaudi and Plasmodium berghei infections provide a novel model of severe malarial anemia. Infect Immun. 2012;80:2997-3007 pubmed publisher
    ..This model is practical and reproducible, and its similarities with P. falciparum SMA in humans makes it an appealing system with which to study the pathogenesis of this condition and explore potential immunomodulatory interventions...
  28. Gadsby N, Lawrence R, Carter R. A study on pathogenicity and mosquito transmission success in the rodent malaria parasite Plasmodium chabaudi adami. Int J Parasitol. 2009;39:347-54 pubmed publisher
    ..to mosquitoes of blood infections in mice, of two strains, DS and DK, of the rodent malaria parasite Plasmodium chabaudi adami...
  29. Dkhil M. Apoptotic changes induced in mice splenic tissue due to malaria infection. J Microbiol Immunol Infect. 2009;42:13-8 pubmed
    ..of this study was to investigate the apoptotic changes in murine splenic tissue due to infection with Plasmodium chabaudi. Flow cytometric analysis was used to quantify normal and apoptotic spleen cells in P...
  30. Long G, Chan B, Allen J, Read A, Graham A. Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections. Parasitology. 2006;133:673-84 pubmed
    ..Here, primary infections with genetically distinct Plasmodium chabaudi chabaudi (P.c.c.) clones varied in the virulence and cytokine responses induced in female C57BL/6 mice...
  31. Cambos M, Belanger B, Jacques A, Roulet A, Scorza T. Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. Int J Parasitol. 2008;38:229-38 pubmed
    ..Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites, comparing the levels of parasitemia, inflammation and anaemia...
  32. Taylor P, Seixas E, Walport M, Langhorne J, Botto M. Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites. Infect Immun. 2001;69:3853-9 pubmed
    ..of the complement system on the progression and control of the erythrocyte stages of the malarial parasite Plasmodium chabaudi chabaudi...
  33. Wedekind C, Walker M, Little T. The course of malaria in mice: major histocompatibility complex (MHC) effects, but no general MHC heterozygote advantage in single-strain infections. Genetics. 2005;170:1427-30 pubmed
    ..However, the MHC heterozygotes did worse than expected from the average response of the homozygotes...
  34. Reece S, Thompson J. Transformation of the rodent malaria parasite Plasmodium chabaudi and generation of a stable fluorescent line PcGFPCON. Malar J. 2008;7:183 pubmed publisher
    The rodent malaria parasite Plasmodium chabaudi has proven of great value in the analysis of fundamental aspects of host-parasite-vector interactions implicated in disease pathology and parasite evolutionary ecology...
  35. Sánchez Torres L, Rodriguez Ropon A, Aguilar Medina M, Favila Castillo L. Mouse splenic CD4+ and CD8+ T cells undergo extensive apoptosis during a Plasmodium chabaudi chabaudi AS infection. Parasite Immunol. 2001;23:617-26 pubmed
    ..of apoptotic lymphocytes was studied in spleen cell suspensions taken from CB6F1 mice infected with Plasmodium chabaudi chabaudi AS. High levels of apoptotic cells were found, associated with high parasitaemias and splenomegaly...
  36. Gillman B, Batchelder J, Flaherty P, Weidanz W. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Infect Immun. 2004;72:6359-66 pubmed
    ..We now report that the time course shows that Plasmodium chabaudi parasitemia in NADPH oxidase KO (p47phox-/-) mice also was not exacerbated, suggesting a minimal role for ..
  37. Marques C, Rolão N, Centeno Lima S, Lousada H, Maia C, Campino L, et al. Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-gamma and interleukin-4 mRNA expression. Mem Inst Oswaldo Cruz. 2005;100:889-92 pubmed
    This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum...
  38. Lin E, Pappenfuss T, Tan R, Senyschyn D, Bahlo M, Speed T, et al. Mapping of the Plasmodium chabaudi resistance locus char2. Infect Immun. 2006;74:5814-9 pubmed
    Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines...
  39. Krucken J, Delic D, Pauen H, Wojtalla A, El Khadragy M, Dkhil M, et al. Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria. Malar J. 2009;8:54 pubmed publisher
    ..In order to evaluate if vaccination changes responses of the anti-malaria effectors spleen and liver to blood stage malaria, BALB/c mice succumbing to infection with Plasmodium chabaudi were compared to those surviving after vaccination.
  40. Gautret P, Voza T, Chabaud A, Landau I. Short-term effect of chloroquine on the infectivity of Plasmodium chabaudi gametocytes. Parasite. 2001;8:363-7 pubmed
    The short-term enhancing effect of chloroquine on gametocyte infectivity was investigated with Plasmodium chabaudi chabaudi, a synchronous parasite which is highly sensitive to chloroquine...
  41. de Roode J, Culleton R, Bell A, Read A. Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections. Malar J. 2004;3:33 pubmed
    ..Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance...
  42. Scorza T, Grubb K, Smooker P, Rainczuk A, Proll D, Spithill T. Induction of strain-transcending immunity against Plasmodium chabaudi adami malaria with a multiepitope DNA vaccine. Infect Immun. 2005;73:2974-85 pubmed
    ..We describe a multiepitope DNA vaccine, derived from a genomic Plasmodium chabaudi adami DS DNA expression library of 30,000 plasmids, which induces strain-transcending immunity in mice ..
  43. Wargo A, Randle N, Chan B, Thompson J, Read A, Babiker H. Plasmodium chabaudi: reverse transcription PCR for the detection and quantification of transmission stage malaria parasites. Exp Parasitol. 2006;112:13-20 pubmed
    ..chain reaction (RT-PCR) techniques to detect and quantify the transmission stages (gametocytes) of Plasmodium chabaudi malaria parasites...
  44. Clark K, Kulk N, Amante F, Haque A, Engwerda C. Lymphotoxin alpha and tumour necrosis factor are not required for control of parasite growth, but differentially regulate cytokine production during Plasmodium chabaudi chabaudi AS infection. Parasite Immunol. 2007;29:153-8 pubmed
    ..mice generated using donor bone marrow from these animals, to study the roles of these cytokines following Plasmodium chabaudi chabaudi AS infection. TNF and LTalpha were not required for the resolution of P...
  45. Long G, Chan B, Allen J, Read A, Graham A. Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection. Int J Parasitol. 2008;38:1073-81 pubmed publisher
    ..we investigated the effect TNFR1 blockade exerted on parasite transmission using the rodent malaria Plasmodium chabaudi chabaudi...
  46. Mideo N, Barclay V, Chan B, Savill N, Read A, Day T. Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria Plasmodium chabaudi. Am Nat. 2008;172:214-38 pubmed publisher
    ..g., resource abundance) in the dynamics of pathogenesis for the malaria species Plasmodium chabaudi in CD4+ T cell-depleted mice...
  47. Berretta F, St Pierre J, Piccirillo C, Stevenson M. IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol. 2011;186:4862-71 pubmed publisher
    ..investigate the role of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells in blood-stage malaria, we compared Plasmodium chabaudi AS infection in wild-type (WT) C57BL/6 and transgenic mice overexpressing the transcription factor Foxp3 (..
  48. Wiser M, Giraldo L, Schmitt Wrede H, Wunderlich F. Plasmodium chabaudi: immunogenicity of a highly antigenic glutamate-rich protein. Exp Parasitol. 1997;85:43-54 pubmed
    The immunogenicity of a 93-kDa Plasmodium chabaudi protein that contains glutamate-rich tandem repeats was investigated in this study...
  49. Carlton J, Mackinnon M, Walliker D. A chloroquine resistance locus in the rodent malaria parasite Plasmodium chabaudi. Mol Biochem Parasitol. 1998;93:57-72 pubmed
    We have located a possible chloroquine resistance locus in the genome of the rodent malaria parasite Plasmodium chabaudi. Two genetically distinct clones of the parasite were grown in vivo and allowed to undergo genetic crossing...
  50. Mota M, Jarra W, Hirst E, Patnaik P, Holder A. Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way. Infect Immun. 2000;68:4135-44 pubmed
    ..We have examined the rodent malaria parasite Plasmodium chabaudi chabaudi AS in mice as a potential model...
  51. Mackinnon M, Read A. The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi. Parasitology. 2003;126:103-12 pubmed
    ..virulence, transmission rate, intrinsic growth rate and host recovery rate in the rodent malaria parasite, Plasmodium chabaudi. Groups of naïve and immunized mice were infected with 1 of 10 cloned lines of parasites and their ..
  52. Mackinnon M, Bell A, Read A. The effects of mosquito transmission and population bottlenecking on virulence, multiplication rate and rosetting in rodent malaria. Int J Parasitol. 2005;35:145-53 pubmed
  53. de Roode J, Helinski M, Anwar M, Read A. Dynamics of multiple infection and within-host competition in genetically diverse malaria infections. Am Nat. 2005;166:531-42 pubmed
    ..multiple infection in malaria, using two pairs of genetically distinct clones of the rodent malaria Plasmodium chabaudi in mice...
  54. Perkins S, Sarkar I, Carter R. The phylogeny of rodent malaria parasites: simultaneous analysis across three genomes. Infect Genet Evol. 2007;7:74-83 pubmed
    ..of rodent malaria parasites including four species native to African thicket rats (Plasmodium berghei, Plasmodium chabaudi, Plasmodium vinckei, and Plasmodium yoelii) and one from a porcupine (Plasmodium atheruri) using DNA ..
  55. Novo C, Martins T, Prata S, Lopes A, Armada A. Gene sequencing, modelling and immunolocalization of the protein disulfide isomerase from Plasmodium chabaudi. Int J Biol Macromol. 2009;45:399-406 pubmed publisher
    ..Most of the fatal cases are caused by Plasmodium falciparum. The rodent parasite Plasmodium chabaudi has been the model of choice in research due to its similarities to human malaria, including developmental ..
  56. Mackinnon M, Read A. Selection for high and low virulence in the malaria parasite Plasmodium chabaudi. Proc Biol Sci. 1999;266:741-8 pubmed
    ..Here we selected for high and low virulence within each of two clones of the rodent malaria parasite Plasmodium chabaudi on the basis of between-host differences in a surrogate measure of virulence--loss of live weight post-..
  57. Osa Y, Kobayashi S, Sato Y, Suzuki Y, Takino K, Takeuchi T, et al. Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi. J Med Chem. 2003;46:1948-56 pubmed
    For the purpose of developing chemosensitizers to reverse chloroquine (CQ) resistance in Plasmodium chabaudi in vivo, dibenzosuberanylpiperazine (1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine) (DSP) and its piperazin-1-yl ..
  58. Hensmann M, Li C, Moss C, Lindo V, Greer F, Watts C, et al. Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response. Eur J Immunol. 2004;34:639-648 pubmed publisher
    ..Although the reduced form of MSP1(19) does not induce protective antibodies, our data suggest that inclusion of unfolded protein may improve the efficacy of MSP1(19) as a vaccine...
  59. Mackinnon M, Read A. Virulence in malaria: an evolutionary viewpoint. Philos Trans R Soc Lond B Biol Sci. 2004;359:965-86 pubmed
    ..In this review, we summarize data from the laboratory rodent malaria model, Plasmodium chabaudi, and field data on the human malaria parasite, P...
  60. Long G, Chan B, Allen J, Read A, Graham A. Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites. BMC Evol Biol. 2008;8:128 pubmed publisher
    ..Here we studied the effects of immunopathology on infection-induced host mortality rate and lifetime transmission potential - key components of parasite fitness - using the rodent malaria model, Plasmodium chabaudi chabaudi.
  61. Ing R, Stevenson M. Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice. Infect Immun. 2009;77:770-82 pubmed publisher
    ..chabaudi AS infection and provide in vivo evidence for the importance of this interaction in IFN-gamma-dependent immunity to malaria...
  62. Sponaas A, Freitas do Rosario A, Voisine C, Mastelic B, Thompson J, Koernig S, et al. Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria. Blood. 2009;114:5522-31 pubmed publisher
    ..During Plasmodium chabaudi infection in mice, a population of CD11b(high)Ly6C(+) monocytes are generated in bone marrow, most of which ..
  63. Yap G, Stevenson M. Inhibition of in vitro erythropoiesis by soluble mediators in Plasmodium chabaudi AS malaria: lack of a major role for interleukin 1, tumor necrosis factor alpha, and gamma interferon. Infect Immun. 1994;62:357-62 pubmed
    ..splenic erythroid cells as an in vitro erythropoiesis model system, we demonstrate that spleen cells from Plasmodium chabaudi AS-infected C57BL/6 mice potently inhibited erythroid cell proliferation...
  64. Wunderlich G, Moura I, del Portillo H. Genetic immunization of BALB/c mice with a plasmid bearing the gene coding for a hybrid merozoite surface protein 1-hepatitis B virus surface protein fusion protects mice against lethal Plasmodium chabaudi chabaudi PC1 infection. Infect Immun. 2000;68:5839-45 pubmed
    The genetic immunization of rodents with a plasmid coding for a Plasmodium chabaudi merozoite surface protein 1 (C terminus)-hepatitis B virus surface fusion protein (pPcMSP1(19)-HBs) provided protection of mice against subsequent lethal ..
  65. Mackinnon M, Gaffney D, Read A. Virulence in rodent malaria: host genotype by parasite genotype interactions. Infect Genet Evol. 2002;1:287-96 pubmed
    ..mice of three genotypes (C57Bl/6J, CBA/Ca and DBA/2) with one of two parasite lines of the rodent malaria Plasmodium chabaudi. One of these parasite lines had been serially passaged through C57Bl/6J mice and had evolved higher ..
  66. Martínez Gómez F, Ixta Rodríguez O, Aguilar Figueroa B, Hernández Cruz R, Monroy Ostria A. Lactobaciilus casei ssp. rhamnosus enhances non specific protection against Plasmodium chabaudi AS in mice. Salud Publica Mex. 2006;48:498-503 pubmed
    To evaluate the capacity of Lactobacillus casei ssp. rhamnosus to enhance resistance against Plasmodium chabaudi chabaudi AS.
  67. Drew D, Reece S. Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections. Mol Biochem Parasitol. 2007;156:199-209 pubmed
    ..and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi infections...
  68. Antia R, Yates A, de Roode J. The dynamics of acute malaria infections. I. Effect of the parasite's red blood cell preference. Proc Biol Sci. 2008;275:1449-58 pubmed publisher
    ..of acute malaria infections and confronting it with experimental data from the rodent malaria parasite Plasmodium chabaudi. We show that the resource limitation model can explain the initial dynamics of infection of mice with ..
  69. Reece S, Drew D, Gardner A. Sex ratio adjustment and kin discrimination in malaria parasites. Nature. 2008;453:609-14 pubmed publisher
    ..Here we show that, as predicted by theory, sex ratio is an important fitness-determining trait and Plasmodium chabaudi parasites adjust their sex allocation in response to the presence of unrelated conspecifics...
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    The recombinant congenic mouse strains AcB55 and AcB61 are extremely resistant to malaria (Plasmodium chabaudi AS) despite the presence of susceptibility alleles at the known Char1/Char2 resistance loci...
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    ..We have used an F(11) advance intercross line (AIL) population of mice infected with Plasmodium chabaudi to identify additional mouse quantitative trait loci (QTL) for control of parasitaemia on Chrs 11 and 18, ..
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    ..This technique can be used in the mapping of genetic loci underlying phenotypic traits and in the evaluation of the effects of different alleles upon the reproductive success (fitness) of parasites...
  76. Stevenson M, Urban B. Antigen presentation and dendritic cell biology in malaria. Parasite Immunol. 2006;28:5-14 pubmed
    ..It is hoped that this review promotes more investigation among malariologists and immunologists alike on DCs and malaria...
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    Little is known about the function and regulation of splenic gammadelta T cells during chronic Plasmodium chabaudi malaria...
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    Artemisinin- and artesunate-resistant Plasmodium chabaudi mutants, AS-ART and AS-ATN, were previously selected from chloroquine-resistant clones AS-30CQ and AS-15CQ respectively...
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    While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia...
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    ..short-read whole-genome re-sequencing to determine the mutations in a clone of the rodent malaria parasite, Plasmodium chabaudi, which has altered susceptibility to both sulphadoxine and pyrimethamine...
  82. Li C, Langhorne J. Tumor necrosis factor alpha p55 receptor is important for development of memory responses to blood-stage malaria infection. Infect Immun. 2000;68:5724-30 pubmed
    Tumor necrosis factor alpha (TNF-alpha) is associated with malarial pathology in both humans and mice. In Plasmodium chabaudi chabaudi (AS) infections, the production of TNF-alpha and reactive metabolites from macrophages are also ..
  83. Sardinha L, D Império Lima M, Alvarez J. Influence of the polyclonal activation induced by Plasmodium chabaudi on ongoing OVA-specific B- and T-cell responses. Scand J Immunol. 2002;56:408-16 pubmed
    Infection by Plasmodium chabaudi results in polyclonal activation, massive proliferation and differentiation of lymphocytes with parasite-unrelated specificities...
  84. Haydon D, Matthews L, Timms R, Colegrave N. Top-down or bottom-up regulation of intra-host blood-stage malaria: do malaria parasites most resemble the dynamics of prey or predator?. Proc Biol Sci. 2003;270:289-98 pubmed
    ..An immune response directed solely at merozoites required twice the level of activation of one directed at infected RBCs...
  85. de Roode J, Culleton R, Cheesman S, Carter R, Read A. Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections. Proc Biol Sci. 2004;271:1073-80 pubmed
    ..We infected laboratory mice with a mixture of two Plasmodium chabaudi clones: one virulent, the other avirulent...
  86. Martinelli A, Cheesman S, Hunt P, Culleton R, Raza A, Mackinnon M, et al. A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites. Proc Natl Acad Sci U S A. 2005;102:814-9 pubmed
    ..Two genetically distinct clones of the rodent malaria parasite Plasmodium chabaudi chabaudi, each of which induces an immunity in laboratory mice that is more protective against challenge ..
  87. Raberg L, de Roode J, Bell A, Stamou P, Gray D, Read A. The role of immune-mediated apparent competition in genetically diverse malaria infections. Am Nat. 2006;168:41-53 pubmed
    ..responses contribute to competition between clones in mixed infections of the rodent malaria parasite Plasmodium chabaudi. We studied single and mixed infections of a virulent and an avirulent clone and compared the extent of ..
  88. Cheesman S, Tanabe K, Sawai H, O Mahony E, Carter R. Strain-specific immunity may drive adaptive polymorphism in the merozoite surface protein 1 of the rodent malaria parasite Plasmodium chabaudi. Infect Genet Evol. 2009;9:248-55 pubmed publisher
    ..immunity (SSPI) exists between genetically distinct strains (cloned lines) of the rodent malaria parasite Plasmodium chabaudi chabaudi in mice [Cheesman, S., Raza, A., Carter, R., 2006...
  89. Helmby H. Gastrointestinal nematode infection exacerbates malaria-induced liver pathology. J Immunol. 2009;182:5663-71 pubmed publisher
    ..We have used the nonlethal malaria infection model of Plasmodium chabaudi AS in combination with the gastrointestinal nematode Heligmosomoides bakeri polygyrus to investigate the ..
  90. Spence P, Cunningham D, Jarra W, Lawton J, Langhorne J, Thompson J. Transformation of the rodent malaria parasite Plasmodium chabaudi. Nat Protoc. 2011;6:553-561 pubmed publisher
    The rodent malaria parasite Plasmodium chabaudi chabaudi shares many features with human malaria species, including P...
  91. Rosanas Urgell A, Martin Jaular L, Ricarte Filho J, Ferrer M, Kalko S, Kimura E, et al. Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS. Mem Inst Oswaldo Cruz. 2012;107:410-5 pubmed
    ..with the lethal and non-lethal Plasmodium yoelii strains 17XL and 17X, respectively, and the non-lethal Plasmodium chabaudi chabaudi AS strain...
  92. Martiney J, Sherry B, Metz C, Espinoza M, Ferrer A, Calandra T, et al. Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemia. Infect Immun. 2000;68:2259-67 pubmed
    ..chabaudi-infected mice with active disease, as compared to early disease, or of uninfected controls. In summary, the present results suggest that MIF may be a host-derived factor involved in the pathophysiology of malaria anemia...