plasmodium berghei

Summary

Summary: A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.

Top Publications

  1. Straschil U, Talman A, Ferguson D, Bunting K, Xu Z, Bailes E, et al. The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS ONE. 2010;5:e12901 pubmed publisher
    ..Here, we characterise a Plasmodium PF16 homologue using reverse genetics in the mouse malaria parasite Plasmodium berghei. PF16 is a conserved Armadillo-repeat protein that regulates flagellar structure and motility in organisms ..
  2. Friesen J, Matuschewski K. Comparative efficacy of pre-erythrocytic whole organism vaccine strategies against the malaria parasite. Vaccine. 2011;29:7002-8 pubmed publisher
    ..we systematically compared the protective efficacy of different whole-organism vaccination approaches in the Plasmodium berghei/C57bl/6 rodent malaria model...
  3. Oliveira G, Lieberman J, Barillas Mury C. Epithelial nitration by a peroxidase/NOX5 system mediates mosquito antiplasmodial immunity. Science. 2012;335:856-9 pubmed publisher
  4. Mesfin A, Giday M, Animut A, Teklehaymanot T. Ethnobotanical study of antimalarial plants in Shinile District, Somali Region, Ethiopia, and in vivo evaluation of selected ones against Plasmodium berghei. J Ethnopharmacol. 2012;139:221-7 pubmed publisher
    ..eastern Ethiopia, and evaluated selected medicinal plants for their antiplasmodial activities against Plasmodium berghei. The study was conducted in four kebeles of Shinile District, Somali Region, Ethiopia...
  5. Pfander C, Anar B, Schwach F, Otto T, Brochet M, Volkmann K, et al. A scalable pipeline for highly effective genetic modification of a malaria parasite. Nat Methods. 2011;8:1078-82 pubmed publisher
    ..We overcame these roadblocks by creating a high-integrity library of Plasmodium berghei genomic DNA (>77% A+T content) in a bacteriophage N15-based vector that can be modified efficiently using ..
  6. Goodman A, Forbes E, Williams A, Douglas A, de Cassan S, Bauza K, et al. The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment. Sci Rep. 2013;3:1706 pubmed publisher
    ..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum. ..
  7. Giovannini D, Spath S, Lacroix C, Perazzi A, Bargieri D, Lagal V, et al. Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa. Cell Host Microbe. 2011;10:591-602 pubmed publisher
    ..Here we find that, in Plasmodium berghei, while both AMA1 and RON4 are important for merozoite invasion of erythrocytes, only RON4 is required for ..
  8. Ejigiri I, Ragheb D, Pino P, Coppi A, Bennett B, Soldati Favre D, et al. Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity. PLoS Pathog. 2012;8:e1002725 pubmed publisher
  9. Kenthirapalan S, Waters A, Matuschewski K, Kooij T. Flow cytometry-assisted rapid isolation of recombinant Plasmodium berghei parasites exemplified by functional analysis of aquaglyceroporin. Int J Parasitol. 2012;42:1185-92 pubmed publisher
    The most critical bottleneck in the generation of recombinant Plasmodium berghei parasites is the mandatory in vivo cloning step following successful genetic manipulation...

More Information

Publications86

  1. Guttery D, Poulin B, Ferguson D, Szoor B, Wickstead B, Carroll P, et al. A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog. 2012;8:e1002948 pubmed publisher
    ..Here, we use reverse genetics in the rodent malaria model, Plasmodium berghei, to examine the role of a unique protein phosphatase containing kelch-like domains (termed PPKL) from a ..
  2. Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, et al. Identification of a new chemical class of antimalarials. J Infect Dis. 2012;206:735-43 pubmed publisher
    ..ACT-213615 is orally bioavailable in mice, exhibits activity in the murine Plasmodium berghei model and efficacy comparable to that of the reference drug chloroquine in the recently established P...
  3. Fonager J, Pasini E, Braks J, Klop O, Ramesar J, Remarque E, et al. Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo. J Exp Med. 2012;209:93-107 pubmed publisher
    ..Irbc of the rodent parasite Plasmodium berghei ANKA sequester in a fashion analogous to P. falciparum by adhering to the host receptor CD36...
  4. Rodrigues Duarte L, de Moraes L, Barboza R, Marinho C, Franke Fayard B, Janse C, et al. Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57BL/6 mouse. Malar J. 2012;11:231 pubmed publisher
    ..A murine model of experimental PM using BALB/c mice infected with Plasmodium berghei ANKA was recently established, but there is need for additional PM models with different parasite/host ..
  5. Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler E, et al. The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med. 2012;9:e1001169 pubmed publisher
    ..This study might reveal the potential of life-cycle-wide analyses of drugs for other pathogens with complex life cycles. ..
  6. Lacrue A, Saenz F, Cross R, Udenze K, Monastyrskyi A, Stein S, et al. 4(1H)-Quinolones with liver stage activity against Plasmodium berghei. Antimicrob Agents Chemother. 2013;57:417-24 pubmed publisher
    ..In this study, a transgenic Plasmodium berghei parasite (1052Cl1; PbGFP-Luc(con)) that expresses luciferase was used to assess the anti-liver stage ..
  7. Currà C, Pace T, Franke Fayard B, Picci L, Bertuccini L, Ponzi M. Erythrocyte remodeling in Plasmodium berghei infection: the contribution of SEP family members. Traffic. 2012;13:388-99 pubmed publisher
    ..We show here that members of the rodent Plasmodium berghei family are components of the parasitophorous vacuole membrane (PVM), which surrounds the parasite throughout ..
  8. Masuda Suganuma H, Usui M, Fukumoto S, Inoue N, Kawazu S. Mitochondrial peroxidase TPx-2 is not essential in the blood and insect stages of Plasmodium berghei. Parasit Vectors. 2012;5:252 pubmed publisher
    ..is expressed in the mitochondria, by disrupting the TPx-2 gene (pbtpx-2) of the rodent malaria parasite Plasmodium berghei. ..
  9. Oliveira Lima O, Bernardes D, Xavier Pinto M, Esteves Arantes R, Carvalho Tavares J. Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection. Microbes Infect. 2013;15:903-10 pubmed publisher
    Infection of mice with Plasmodium berghei NK65 represents a well-recognized malaria model in which infection is accompanied by an intense hepatic inflammatory response...
  10. Okokon J, Nwafor P, Andrew U. Antimalarial and analgesic activities of ethanolic leaf extract of Panicum maximum. Asian Pac J Trop Med. 2011;4:442-6 pubmed publisher
    ..96 mg/kg) of Panicum maximum were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity against chemical and heat-induced pains...
  11. Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, et al. IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages. Eur J Immunol. 2013;43:2696-706 pubmed publisher
    ..Here, we show that IL-23 is produced during infection with Plasmodium berghei NK65. Mice deficient in IL-23 (p19KO) had higher parasitemia and died earlier than wild-type (WT) controls...
  12. Silva Filho J, Souza M, Ferreira Dasilva C, Silva L, Costa M, Padua T, et al. Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE. 2013;8:e62999 pubmed publisher
    ..T cells activated by Plasmodium berghei ANKA antigens showed 6-fold enhance in AT? levels in comparison with naive cells...
  13. Hughes G, VEGA RODRIGUEZ J, Xue P, Rasgon J. Wolbachia strain wAlbB enhances infection by the rodent malaria parasite Plasmodium berghei in Anopheles gambiae mosquitoes. Appl Environ Microbiol. 2012;78:1491-5 pubmed publisher
    ..and wMelPop from Drosophila melanogaster, on the vector competence of Anopheles gambiae challenged with Plasmodium berghei. We show that the wAlbB strain significantly increases P...
  14. Palomo J, Fauconnier M, Coquard L, Gilles M, Meme S, Szeremeta F, et al. Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol. 2013;43:2683-95 pubmed publisher
    ..Although T-cell activation and type II IFN-? are required for Plasmodium berghei ANKA (PbA)-induced murine experimental cerebral malaria (ECM), the role of type I IFN-?/? in ECM development ..
  15. Villegas Mendez A, de Souza J, Murungi L, Hafalla J, Shaw T, Greig R, et al. Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection. J Immunol. 2011;187:2885-97 pubmed publisher
    IFN-? and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection...
  16. Panchal D, Govindasamy K, Rana A, Bhanot P. Improved Plasmodium berghei lines for conditional mutagenesis. Mol Biochem Parasitol. 2012;184:52-4 pubmed publisher
    Conditional mutagenesis is a powerful tool for genetic analysis in Plasmodium berghei. It allows the study of proteins that function both during the parasite's pre-erythocytic and erythrocytic development...
  17. Annoura T, Ploemen I, van Schaijk B, Sajid M, Vos M, van Gemert G, et al. Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates. Vaccine. 2012;30:2662-70 pubmed publisher
    ..on an approach for assessing adequacy of attenuation of genetically attenuated sporozoites in vivo using the Plasmodium berghei model of malaria and P. falciparum sporozoites cultured in primary human hepatocytes...
  18. Pfander C, Anar B, Brochet M, Rayner J, Billker O. Recombination-mediated genetic engineering of Plasmodium berghei DNA. Methods Mol Biol. 2013;923:127-38 pubmed
    DNA of Plasmodium berghei is difficult to manipulate in Escherichia coli by conventional restriction and ligation methods due to its high content of adenine and thymine (AT) nucleotides...
  19. Sebastian S, Brochet M, Collins M, Schwach F, Jones M, Goulding D, et al. A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe. 2012;12:9-19 pubmed publisher
    ..Using the rodent malaria parasite Plasmodium berghei, we show that CDPK1, which is known to be essential in the asexual blood stage of the parasite, is expressed ..
  20. Cockburn I, Tse S, Zavala F. CD8+ T cells eliminate liver-stage Plasmodium berghei parasites without detectable bystander effect. Infect Immun. 2014;82:1460-4 pubmed publisher
    ..this, we transferred antigen-specific effector CD8(+) T cells to mice that were then coinfected with two Plasmodium berghei strains, only one of which could be recognized directly by the transferred T cells...
  21. Hliscs M, Nahar C, Frischknecht F, Matuschewski K. Expression profiling of Plasmodium berghei HSP70 genes for generation of bright red fluorescent parasites. PLoS ONE. 2013;8:e72771 pubmed publisher
    ..In this study, we generated a red fluorescent line of the murine malarial parasite Plasmodium berghei. To allow constitutive and abundant expression of the mCherry protein we profiled expression of all members ..
  22. Xu J, HILLYER J, Coulibaly B, Sacko M, Dao A, Niare O, et al. Wild Anopheles funestus mosquito genotypes are permissive for infection with the rodent malaria parasite, Plasmodium berghei. PLoS ONE. 2013;8:e61181 pubmed publisher
    ..funestus genome sequence will provide currently lacking molecular tools to describe malaria parasite interactions in this mosquito, but previous reports suggested that A. funestus is not permissive for P. berghei development...
  23. Reis P, Estato V, da Silva T, D Avila J, Siqueira L, Assis E, et al. Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. PLoS Pathog. 2012;8:e1003099 pubmed publisher
    ..Six days after infection with Plasmodium berghei ANKA (PbA) mice displayed clear signs of CM and were treated with chloroquine, or chloroquine and lovastatin...
  24. Vathsala P, Dende C, Nagaraj V, Bhattacharya D, Das G, Rangarajan P, et al. Curcumin-arteether combination therapy of Plasmodium berghei-infected mice prevents recrudescence through immunomodulation. PLoS ONE. 2012;7:e29442 pubmed publisher
    ..In a parasite recrudescence model in mice infected with Plasmodium berghei (ANKA), a single dose of alpha,beta-arteether (ART) with three oral doses of curcumin prevented ..
  25. Mendes A, Awono Ambene P, Nsango S, Cohuet A, Fontenille D, Kafatos F, et al. Infection intensity-dependent responses of Anopheles gambiae to the African malaria parasite Plasmodium falciparum. Infect Immun. 2011;79:4708-15 pubmed publisher
    ..These responses are compared with those of mosquitoes infected with the rodent parasite Plasmodium berghei. We demonstrate that mosquito responses are largely dependent on the intensity of infection...
  26. Serghides L, Kim H, Lu Z, Kain D, Miller C, Francis R, et al. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS ONE. 2011;6:e27714 pubmed publisher
    ..100% survival in the artesunate plus iNO group, p?=?0.03). These data support the clinical investigation of inhaled nitric oxide as a novel adjunctive therapy in patients with severe malaria...
  27. Meister S, Plouffe D, Kuhen K, Bonamy G, Wu T, Barnes S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011;334:1372-7 pubmed publisher
    ..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
  28. Ghosh S, Sengupta A, Sharma S, Sonawat H. Multivariate modelling with (1)H NMR of pleural effusion in murine cerebral malaria. Malar J. 2011;10:330 pubmed publisher
    ..Immunological parameters have been assessed in pleural fluid in murine models; however there are no reports of characterization of metabolites present in pleural effusion...
  29. Montagna G, Buscaglia C, Münter S, Goosmann C, Frischknecht F, Brinkmann V, et al. Critical role for heat shock protein 20 (HSP20) in migration of malarial sporozoites. J Biol Chem. 2012;287:2410-22 pubmed publisher
    ..Our study also shows that fast locomotion of sporozoites is crucial during natural malaria transmission...
  30. Talman A, Lacroix C, Marques S, Blagborough A, Carzaniga R, Menard R, et al. PbGEST mediates malaria transmission to both mosquito and vertebrate host. Mol Microbiol. 2011;82:462-74 pubmed publisher
    ..We identified a Plasmodium berghei secreted protein (PBANKA_131270) that plays distinct roles in both the mammal-to-mosquito and the mosquito-..
  31. Iwanaga S, Kaneko I, Kato T, Yuda M. Identification of an AP2-family protein that is critical for malaria liver stage development. PLoS ONE. 2012;7:e47557 pubmed publisher
    ..In this study, we used the rodent malaria parasite Plasmodium berghei and showed that an AP2-family transcription factor, designated AP2-L, plays a critical role in the liver-..
  32. Lacroix C, Giovannini D, Combe A, Bargieri D, Spath S, Panchal D, et al. FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei. Nat Protoc. 2011;6:1412-28 pubmed publisher
    ..The protocol should allow the functional analysis of any essential protein in the sporozoite, liver stage or hepatic merozoite stages of rodent Plasmodium parasites...
  33. Ball E, Sambo M, Martins M, Trovoada M, Benchimol C, Costa J, et al. IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. J Immunol. 2013;190:5118-27 pubmed publisher
    ..Our findings prove that IFNAR1 signaling unleashes CD8(+) T cell effector capacity, which is vital for CM, and raises the hypothesis that the cohesive role of IFNAR1 in both human and mouse CM operates through CD8(+) T cell triggering...
  34. Souraud J, Briolant S, Dormoi J, Mosnier J, Savini H, Baret E, et al. Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model. Malar J. 2012;11:13 pubmed publisher
    ..Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine...
  35. Lo T, Coetzee M. Marked biological differences between insecticide resistant and susceptible strains of Anopheles funestus infected with the murine parasite Plasmodium berghei. Parasit Vectors. 2013;6:184 pubmed publisher
    ..funestus that were resistant and susceptible to pyrethroid insecticides, for their receptiveness to infection with Plasmodium berghei and compared development times with other vector species available in our laboratory.
  36. Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, et al. Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells. Eur J Immunol. 2013;43:693-704 pubmed publisher
    ..BALB/c mice were immunized by a heterologous prime/boost regimen against Plasmodium berghei CSP that induces a strong CD8(+) T-cell response and sterile protection, which is short-lived...
  37. Gbotosho G, Happi C, Woranola O, Abiodun O, Sowunmi A, Oduola A. Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune. Parasitol Res. 2012;110:895-9 pubmed publisher
    ..weight) of CFX in groups of 35 mice inoculated intraperitoneally with 10(7) chloroquine resistant strain Plasmodium berghei ANKA. Parasitological activity and survival of the animals were assessed over 21 days...
  38. Gitau E, Kokwaro G, Newton C, Ward S. Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry. Malar J. 2011;10:205 pubmed publisher
  39. Bopp S, Rodrigo E, González Páez G, Frazer M, Barnes S, Valim C, et al. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J. 2013;12:316 pubmed publisher
    ..As such, the identification of genetic loci associated with susceptibility or resistance may serve to modulate disease severity...
  40. Shi J, McIntosh R, Adame Gallegos J, Dehal P, van Egmond M, van de Winkel J, et al. The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19). BMC Biotechnol. 2011;11:77 pubmed publisher
    ..Although human serum immunoglobulin A (IgA) is the second most abundant class of antibody in the circulation, its contribution, if any, to protective responses against malaria is not clear...
  41. Zanini G, Martins Y, Cabrales P, Frangos J, Carvalho L. S-nitrosoglutathione prevents experimental cerebral malaria. J Neuroimmune Pharmacol. 2012;7:477-87 pubmed publisher
    Administration of the exogenous nitric oxide (NO) donor dipropylenetriamine-NONOate (DPTA-NO) to mice during Plasmodium berghei ANKA (PbA) infection largely prevents development of experimental cerebral malaria (ECM)...
  42. Cruz L, Juliano M, Budu A, Juliano L, Holder A, Blackman M, et al. Extracellular ATP triggers proteolysis and cytosolic Ca²? rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. Malar J. 2012;11:69 pubmed publisher
    ..Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host...
  43. Hino A, Hirai M, Tanaka T, Watanabe Y, Matsuoka H, Kita K. Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei. J Biochem. 2012;152:259-68 pubmed publisher
    ..These results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production...
  44. Harris J, Bohr T, Stracener C, Landmesser M, Torres V, Mbugua A, et al. Sequential Plasmodium chabaudi and Plasmodium berghei infections provide a novel model of severe malarial anemia. Infect Immun. 2012;80:2997-3007 pubmed publisher
    ..This model is practical and reproducible, and its similarities with P. falciparum SMA in humans makes it an appealing system with which to study the pathogenesis of this condition and explore potential immunomodulatory interventions...
  45. Martins Y, Zanini G, Frangos J, Carvalho L. Efficacy of different nitric oxide-based strategies in preventing experimental cerebral malaria by Plasmodium berghei ANKA. PLoS ONE. 2012;7:e32048 pubmed publisher
    ..plays a role in the pathogenesis of human as well as of experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA (PbA)...
  46. Fauconnier M, Palomo J, Bourigault M, Meme S, Szeremeta F, Beloeil J, et al. IL-12R?2 is essential for the development of experimental cerebral malaria. J Immunol. 2012;188:1905-14 pubmed publisher
    A Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The role of pro-Th1 IL-12 in malaria is complex and controversial...
  47. Tamura T, Kimura K, Yuda M, Yui K. Prevention of experimental cerebral malaria by Flt3 ligand during infection with Plasmodium berghei ANKA. Infect Immun. 2011;79:3947-56 pubmed publisher
    ..of Flt3 ligand, a cytokine that induces dendritic cell production, in vivo on the course of infection with Plasmodium berghei ANKA...
  48. Wang M, Cao Y, Luo E, Zhang Y, Guo Y. Pre-existing Schistosoma japonicum infection alters the immune response to Plasmodium berghei infection in C57BL/6 mice. Malar J. 2013;12:322 pubmed publisher
    ..In the current study, distinct response profiles for splenic DCs and regulatory T cell (Treg) responses were assessed to evaluate the effects of a pre-existing Schistosoma japonicum infection on malaria infection...
  49. Aditya N, Chimote G, Gunalan K, Banerjee R, Patankar S, Madhusudhan B. Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice. Exp Parasitol. 2012;131:292-9 pubmed publisher
    ..liposomes alone and in combination with ?/? arteether when administered intravenously, was evaluated in Plasmodium berghei infected mice...
  50. Yerbanga R, Lucantoni L, Lupidi G, Dori G, Tepongning N, Nikiema J, et al. Antimalarial plant remedies from Burkina Faso: their potential for prophylactic use. J Ethnopharmacol. 2012;140:255-60 pubmed publisher
    ..Juss. (Meliaceae) are plant remedies of the folk medicine in Burkina Faso and are commonly used by traditional healers for the treatment of malaria...
  51. Deschermeier C, Hecht L, Bach F, Rützel K, Stanway R, Nagel A, et al. Mitochondrial lipoic acid scavenging is essential for Plasmodium berghei liver stage development. Cell Microbiol. 2012;14:416-30 pubmed publisher
    ..Here, we analyse the impact of lipoic acid scavenging on the development of Plasmodium berghei liver stage parasites. Treatment of P...
  52. Piva L, Tetlak P, Claser C, Karjalainen K, Renia L, Ruedl C. Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria. J Immunol. 2012;189:1128-32 pubmed publisher
    ..Specifically, we have analyzed the in vivo contribution of this DC subset in an experimental CM model using Plasmodium berghei, and we provide strong evidence that the absence of this DC subset resulted in complete resistance to ..
  53. Villegas Mendez A, Greig R, Shaw T, de Souza J, Gwyer Findlay E, Stumhofer J, et al. IFN-?-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain. J Immunol. 2012;189:968-79 pubmed publisher
    ..is well established that IFN-? is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-? during P...
  54. Deligianni E, Morgan R, Bertuccini L, Wirth C, Silmon de Monerri N, Spanos L, et al. A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. Cell Microbiol. 2013;15:1438-55 pubmed publisher
    ..A mutant of Plasmodium berghei lacking PPLP2 displayed abnormal exflagellation; instead of each male gametocyte forming eight flagellated ..
  55. Chandel S, Bagai U, Vashishat N. Antiplasmodial activity of Xanthium strumarium against Plasmodium berghei-infected BALB/c mice. Parasitol Res. 2012;110:1179-83 pubmed publisher
    ..antiplasmodial activity of ethanolic leaves extract of traditional medicinal plant Xanthium strumarium in Plasmodium berghei-infected BALB/c mice along with phytochemical screening and acute toxicity test to support its traditional ..
  56. Mathias D, Plieskatt J, Armistead J, Bethony J, Abdul Majid K, McMillan A, et al. Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine. Infect Immun. 2012;80:1606-14 pubmed publisher
  57. Nganou Makamdop K, Ploemen I, Behet M, van Gemert G, Hermsen C, Roestenberg M, et al. Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization. Parasite Immunol. 2012;34:562-9 pubmed publisher
    ..Mice were immunized via either IV or ID route with Plasmodium berghei sporozoites in combination with chloroquine treatment (CPS) (allowing full liver stage development) or by ?-..
  58. Laurentino E, Taylor S, Mair G, Lasonder E, Bartfai R, Stunnenberg H, et al. Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Cell Microbiol. 2011;13:1956-74 pubmed publisher
    ..We identified a Plasmodium berghei protein, termed FACT-L, with homology to the SPT16 subunit of FACT...
  59. Ingmundson A, Nahar C, Brinkmann V, Lehmann M, Matuschewski K. The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells. Mol Microbiol. 2012;83:1229-43 pubmed publisher
    ..Here we characterize a novel Plasmodium berghei PEXEL/HT-containing protein, which we term IBIS1...
  60. Volkmann K, Pfander C, Burstroem C, Ahras M, Goulding D, Rayner J, et al. The alveolin IMC1h is required for normal ookinete and sporozoite motility behaviour and host colonisation in Plasmodium berghei. PLoS ONE. 2012;7:e41409 pubmed publisher
    ..In Plasmodium berghei, deletions of three alveolins, IMC1a, b, and h, each resulted in reduced mechanical strength and gliding ..
  61. Malleret B, Claser C, Ong A, Suwanarusk R, Sriprawat K, Howland S, et al. A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Sci Rep. 2011;1:118 pubmed publisher
    ..It also allows assessing the proportion of parasites at different developmental stages. Lastly, we demonstrate how this technique can be applied to antimalarial drug testing...
  62. Kooij T, Rauch M, Matuschewski K. Expansion of experimental genetics approaches for Plasmodium berghei with versatile transfection vectors. Mol Biochem Parasitol. 2012;185:19-26 pubmed publisher
    ..The murine malaria model parasite Plasmodium berghei is the genetically most amendable Plasmodium species and allows full access to the entire life cycle in vivo...
  63. Haussig J, Matuschewski K, Kooij T. Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. Mol Microbiol. 2011;81:1511-25 pubmed publisher
    ..Using targeted gene deletion in the rodent model malaria parasite Plasmodium berghei, we show that a Plasmodium-specific Apicoplast protein plays an important role for Liver Merozoite formation ..
  64. Ampawong S, Combes V, Hunt N, Radford J, Chan Ling T, Pongponratn E, et al. Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. Int J Clin Exp Pathol. 2011;4:566-74 pubmed
    ..If AQP4 changes are confirmed in human CM, it may represent a novel target for therapeutic intervention...
  65. Orr R, Philip N, Waters A. Improved negative selection protocol for Plasmodium berghei in the rodent malarial model. Malar J. 2012;11:103 pubmed publisher
    An improved methodology is presented here for transgenic Plasmodium berghei lines that express the negative selectable marker yFCU (a bifunctional protein that combines yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT))..
  66. Jambou R, El Assaad F, Combes V, Grau G. In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria. Malar J. 2011;10:346 pubmed publisher
    Infection with Plasmodium berghei is a widely used model of murine malaria and a powerful tool for reverse genetic and pathogenesis studies...
  67. Bongfen S, Rodrigue Gervais I, Berghout J, Torre S, Cingolani P, Wiltshire S, et al. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS ONE. 2012;7:e31012 pubmed publisher
    ..CM resistance in Jak3(W81R/+) heterozygotes occurs in presence of normal T, B and NK cell numbers. These findings highlight the pathological role of CD8(+) T cells and Jak3-dependent IFN-?-mediated Th1 responses in CM pathogenesis...
  68. Pasini E, Braks J, Fonager J, Klop O, Aime E, Spaccapelo R, et al. Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins. Mol Cell Proteomics. 2013;12:426-48 pubmed publisher
    ..berghei parasites expressing chimeric P. berghei/P. falciparum proteins on the surface of rodent irbc, thereby opening new avenues for in vivo screening adjunct therapies that block sequestration...
  69. Espinosa D, Yadava A, Angov E, Maurizio P, Ockenhouse C, Zavala F. Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy. Infect Immun. 2013;81:2882-7 pubmed publisher
    ..We report the successful development and characterization of chimeric Plasmodium berghei parasites bearing the type I repeat region of P. vivax circumsporozoite protein (CSP). The P. berghei-P...
  70. Siden Kiamos I, Ganter M, Kunze A, Hliscs M, Steinbüchel M, Mendoza J, et al. Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes. Cell Microbiol. 2011;13:1996-2006 pubmed publisher
    ..By placing the corresponding Plasmodium berghei gene, PbMyoA, under the control of the apical membrane antigen 1 (AMA1) promoter, expression in blood stages ..
  71. Hernandez Romano J, Rodriguez M, Pando V, Torres Monzón J, Alvarado Delgado A, Lecona Valera A, et al. Conserved peptide sequences bind to actin and enolase on the surface of Plasmodium berghei ookinetes. Parasitology. 2011;138:1341-53 pubmed publisher
    ..study, using phage display, a consensus peptide sequence (PWWP) was identified in phages that bound to the Plasmodium berghei ookinete surface and, in selected phages, bound to actin and enolase in overlay assays with ookinete protein ..
  72. Boniface P, Pal A. Substantiation of the ethnopharmacological use of Conyza sumatrensis (Retz.) E.H.Walker in the treatment of malaria through in-vivo evaluation in Plasmodium berghei infected mice. J Ethnopharmacol. 2013;145:373-7 pubmed publisher
    ..Conyza sumatrensis is a plant which finds its use in treating malaria like fevers but lacks proper scientific validation. Our study has tried to address this gap by authenticating its traditional use for the treatment of malaria...
  73. Galizi R, Spano F, Giubilei M, Capuccini B, Magini A, Urbanelli L, et al. Evidence of tRNA cleavage in apicomplexan parasites: Half-tRNAs as new potential regulatory molecules of Toxoplasma gondii and Plasmodium berghei. Mol Biochem Parasitol. 2013;188:99-108 pubmed publisher
    ..apicomplexan parasites, Toxoplasma gondii, the agent of toxoplasmosis, and the rodent malaria parasite Plasmodium berghei. A low-scale molecular characterization of the small RNA fraction of T...
  74. Aldrich C, Magini A, Emiliani C, Dottorini T, Bistoni F, Crisanti A, et al. Roles of the amino terminal region and repeat region of the Plasmodium berghei circumsporozoite protein in parasite infectivity. PLoS ONE. 2012;7:e32524 pubmed publisher
    ..Rodent malaria Plasmodium berghei parasites, in which the endogenous CS gene has been replaced with the avian Plasmodium gallinaceum CS (PgCS) ..
  75. Sharma L, Kaur J, Shukla G. Role of oxidative stress and apoptosis in the placental pathology of Plasmodium berghei infected mice. PLoS ONE. 2012;7:e32694 pubmed publisher
    ..Experimentally, pregnant BALB/c mice were infected with Plasmodium berghei infected red blood cells on gestation day 10...
  76. de Oca M, Engwerda C, Haque A. Plasmodium berghei ANKA (PbA) infection of C57BL/6J mice: a model of severe malaria. Methods Mol Biol. 2013;1031:203-13 pubmed publisher
    ..the various clinical manifestations of severe malaria in humans, here we describe a detailed protocol for Plasmodium berghei ANKA infection of C57BL/6J mice...
  77. Mueller A, Behrends J, Hagens K, Mahlo J, Schaible U, Schneider B. Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model. PLoS ONE. 2012;7:e48110 pubmed publisher
    ..same host we established an experimental mouse model of co-infection between Mycobacterium tuberculosis and Plasmodium berghei NK65, a recently described model for MA-ARDS...