neospora

Summary

Summary: A genus of protozoan parasites of the subclass COCCIDIA. Its species are parasitic in dogs, cattle, goats, and sheep, among others. N. caninum, a species that mainly infects dogs, is intracellular in neural and other cells of the body, multiplies by endodyogeny, has no parasitophorous vacuole, and has numerous rhoptries. It is known to cause lesions in many tissues, especially the brain and spinal cord as well as abortion in the expectant mother.

Top Publications

  1. Strohbusch M, Muller N, Hemphill A, Greif G, Gottstein B. NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. Parasitology. 2008;135:1065-73 pubmed publisher
    The treatment of Neospora caninum infection in the bovine host is still at an experimental stage. In contrast to the in vivo situation, a wide range of compounds have been intensively investigated in cell-culture-based assays...
  2. Bishop S, King J, Windsor P, Reichel M, Ellis J, Slapeta J. The first report of ovine cerebral neosporosis and evaluation of Neospora caninum prevalence in sheep in New South Wales. Vet Parasitol. 2010;170:137-42 pubmed publisher
    Presence of Neospora caninum DNA was detected in the brain and spinal cord of an adult Merino sheep suspected of dying with acute non-suppurative meningoencephalitis and mild to moderate non-suppurative myelitis...
  3. Behrendt J, Taubert A, Zahner H, Hermosilla C. Studies on synchronous egress of coccidian parasites (Neospora caninum, Toxoplasma gondii, Eimeria bovis) from bovine endothelial host cells mediated by calcium ionophore A23187. Vet Res Commun. 2008;32:325-32 pubmed
    b>Neospora caninum, Toxoplasma gondii and Eimeria bovis are coccidian parasites of veterinary importance. Tachyzoites of N. caninum and T. gondii and sporozoites of E...
  4. Basso W, Schares S, Minke L, Bärwald A, Maksimov A, Peters M, et al. Microsatellite typing and avidity analysis suggest a common source of infection in herds with epidemic Neospora caninum-associated bovine abortion. Vet Parasitol. 2010;173:24-31 pubmed publisher
    ..Two different abortion patterns associated with Neospora caninum infection have been observed in cattle herds: endemic and epidemic abortion outbreaks...
  5. Aguado Martínez A, Ortega Mora L, Alvarez Garcia G, Rodríguez Marco S, Risco Castillo V, Marugán Hernández V, et al. Stage-specific expression of Nc SAG4 as a marker of chronic Neospora caninum infection in a mouse model. Parasitology. 2009;136:757-64 pubmed publisher
    b>Neospora caninum infection persists throughout the life of its intermediate host due to the conversion of tachyzoites to slowly dividing bradyzoites that encyst in the brain. This event results in persistent N...
  6. Feng X, Zhang N, Tuo W. Neospora caninum tachyzoite- and antigen-stimulated cytokine production by bone marrow-derived dendritic cells and spleen cells of naive BALB/c mice. J Parasitol. 2010;96:717-23 pubmed publisher
    b>Neospora caninum is an intracellular protozoan pathogen that causes abortion in cattle...
  7. Ghalmi F, China B, Kaidi R, Losson B. Neospora caninum is associated with abortion in Algerian cattle. J Parasitol. 2011;97:1121-4 pubmed publisher
    b>Neospora caninum is a major cause of abortion in cattle worldwide. However, little information is available for Algeria...
  8. Carvalho J, Alves C, Cardoso M, Mota C, Barbosa B, Ferro E, et al. Differential susceptibility of human trophoblastic (BeWo) and uterine cervical (HeLa) cells to Neospora caninum infection. Int J Parasitol. 2010;40:1629-37 pubmed publisher
    b>Neospora caninum is an apicomplexan parasite, closely related to Toxoplasma gondii, and causes abortion and congenital neosporosis in cattle worldwide...
  9. Rojo Montejo S, Collantes Fernandez E, Rodríguez Marcos S, Pérez Zaballos F, López Pérez I, Prenafeta A, et al. Comparative efficacy of immunization with inactivated whole tachyzoites versus a tachyzoite-bradyzoite mixture against neosporosis in mice. Parasitology. 2011;138:1372-83 pubmed publisher
    The worldwide economic impact of Neospora caninum infection has caused the development of effective vaccines to become one of the main goals in the field of neosporosis research...

More Information

Publications105 found, 100 shown here

  1. Basso W, Herrmann D, Conraths F, Pantchev N, Vrhovec M, Schares G. First isolation of Neospora caninum from the faeces of a dog from Portugal. Vet Parasitol. 2009;159:162-6 pubmed publisher
    We report the in vitro isolation of Neospora caninum from the faeces of a naturally infected 8-year-old male stray boxer from Portugal...
  2. Goodswen S, Kennedy P, Ellis J. A review of the infection, genetics, and evolution of Neospora caninum: from the past to the present. Infect Genet Evol. 2013;13:133-50 pubmed publisher
    This paper is a review of current knowledge on Neospora caninum in the context of other apicomplexan parasites and with an emphasis on: life cycle, disease, epidemiology, immunity, control and treatment, evolution, genomes, and biological ..
  3. Ribeiro D, Freitas M, Cardoso M, Pajuaba A, Silva N, Mineo T, et al. CpG-ODN combined with Neospora caninum lysate, but not with excreted-secreted antigen, enhances protection against infection in mice. Vaccine. 2009;27:2570-9 pubmed publisher
    ..This study aimed to evaluate the potential of CpG-ODN combined with Neospora lysate antigen (NLA) or excreted-secreted antigen (NcESA) to induce protective immune response against Neospora ..
  4. Dion S, Germon S, Guiton R, Ducournau C, Dimier Poisson I. Functional activation of T cells by dendritic cells and macrophages exposed to the intracellular parasite Neospora caninum. Int J Parasitol. 2011;41:685-95 pubmed publisher
    b>Neospora caninum is an intracellular protozoan pathogen that causes abortion in cattle. We studied how the interaction between murine conventional dendritic cells or macrophages and N...
  5. Thomasson D, Wright E, Hughes J, Dodd N, Cox A, Boyce K, et al. Prevalence and co-infection of Toxoplasma gondii and Neospora caninum in Apodemus sylvaticus in an area relatively free of cats. Parasitology. 2011;138:1117-23 pubmed publisher
    ..The prevalences of the related parasite, Neospora caninum were found to be low in both populations (A. sylvaticus: 3·39% (95% CI: 0·12%-6·66%); M...
  6. Collantes Fernandez E, Arrighi R, Alvarez Garcia G, Weidner J, Regidor Cerrillo J, Boothroyd J, et al. Infected dendritic cells facilitate systemic dissemination and transplacental passage of the obligate intracellular parasite Neospora caninum in mice. PLoS ONE. 2012;7:e32123 pubmed publisher
    The obligate intracellular parasite Neospora caninum disseminates across the placenta and the blood-brain barrier, to reach sites where it causes severe pathology or establishes chronic persistent infections. The mechanisms used by N...
  7. Rojo Montejo S, Collantes Fernandez E, Regidor Cerrillo J, Alvarez Garcia G, Marugán Hernández V, Pedraza Díaz S, et al. Isolation and characterization of a bovine isolate of Neospora caninum with low virulence. Vet Parasitol. 2009;159:7-16 pubmed publisher
    b>Neospora caninum tachyzoites were isolated from the brain of an asymptomatic naturally infected calf with precolostral-specific antibodies. The new isolate, named Nc-Spain 1H, was identified as a member of the N...
  8. Reichel M, Ellis J. Neospora caninum--how close are we to development of an efficacious vaccine that prevents abortion in cattle?. Int J Parasitol. 2009;39:1173-87 pubmed publisher
    b>Neospora caninum is a protozoan parasite that causes abortion in cattle around the world...
  9. Strohbusch M, Muller N, Hemphill A, Margos M, Grandgirard D, Leib S, et al. Neospora caninum and bone marrow-derived dendritic cells: parasite survival, proliferation, and induction of cytokine expression. Parasite Immunol. 2009;31:366-72 pubmed publisher
    ..We exploratively addressed invasion and survival ability of Neospora caninum, a parasite causing abortion in cattle, in mouse bone marrow DCs (BMDCs), and respective cytokine ..
  10. Rojo Montejo S, Collantes Fernandez E, López Pérez I, Risco Castillo V, Prenafeta A, Ortega Mora L. Evaluation of the protection conferred by a naturally attenuated Neospora caninum isolate against congenital and cerebral neosporosis in mice. Vet Res. 2012;43:62 pubmed publisher
    The parasite Neospora caninum is an important abortifacient agent in cattle worldwide. At present, the development of an effective and safe vaccine against bovine neosporosis is of great relevance. Recently, a new isolate of N...
  11. Caspe S, Moore D, Leunda M, Cano D, Lischinsky L, Regidor Cerrillo J, et al. The Neospora caninum-Spain 7 isolate induces placental damage, fetal death and abortion in cattle when inoculated in early gestation. Vet Parasitol. 2012;189:171-81 pubmed publisher
    The Nc-Spain 7 isolate of Neospora caninum, which was newly obtained from an asymptomatic congenitally infected calf, demonstrated a similar virulence as Nc-1 strain in mouse models...
  12. Ueno T, Gonçalves V, Heinemann M, Dilli T, Akimoto B, de Souza S, et al. Prevalence of Toxoplasma gondii and Neospora caninum infections in sheep from Federal District, central region of Brazil. Trop Anim Health Prod. 2009;41:547-52 pubmed publisher
    ..using sera diluted 1:64 and 1:50 as cut-off values for the detection of antibodies against Toxoplasma gondii and Neospora caninum, respectively. The observed prevalence for T. gondii infection was 38.22% (26.81%<CI 0.95<49...
  13. King J, Jenkins D, Ellis J, Fleming P, Windsor P, Slapeta J. Implications of wild dog ecology on the sylvatic and domestic life cycle of Neospora caninum in Australia. Vet J. 2011;188:24-33 pubmed publisher
    b>Neospora caninum is transmitted either transplacentally or horizontally by ingestion of tissue cysts present in tissues or oocysts shed by dogs. Neosporosis is a significant disease, causing cattle abortion at 5-7 months of pregnancy...
  14. Eiras C, Arnaiz I, Alvarez Garcia G, Ortega Mora L, Sanjuánl M, Yus E, et al. Neospora caninum seroprevalence in dairy and beef cattle from the northwest region of Spain, Galicia. Prev Vet Med. 2011;98:128-32 pubmed publisher
    Herd and individual animal seroprevalence for Neospora caninum (N. caninum) in dairy, beef and mixed cattle were obtained in all populations within the Galician Farmer Sanitary Defence Associations (ADSG) in 2004...
  15. Ellis J, Miller C, Quinn H, Ryce C, Reichel M. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine. 2008;26:5989-96 pubmed publisher
    Abortion, resulting from infections by the parasite Neospora caninum, is a major cause of economic loss to both the dairy and beef industries of cattle-producing countries of the world...
  16. Kamga Waladjo A, Gbati O, Kone P, Lapo R, Chatagnon G, Bakou S, et al. Seroprevalence of Neospora caninum antibodies and its consequences for reproductive parameters in dairy cows from Dakar-Senegal, West Africa. Trop Anim Health Prod. 2010;42:953-9 pubmed publisher
    The aim of this study was to determine the seroprevalence of Neospora caninum antibodies and its effects on reproductive parameters in cows in intensive dairy herds in Dakar...
  17. Cabezón O, Millan J, Gomis M, Dubey J, Ferroglio E, Almeria S. Kennel dogs as sentinels of Leishmania infantum, Toxoplasma gondii, and Neospora caninum in Majorca Island, Spain. Parasitol Res. 2010;107:1505-8 pubmed publisher
    ..Spain) for evidence of infection with three protozoan parasites: Leishmania infantum, Toxoplasma gondii, and Neospora caninum. Exposure to L. infantum was found in 56.3% of 48 dogs (37.5% by Western blot, 43.8% by PCR)...
  18. Bartley P, Wright S, Maley S, Macaldowie C, Nath M, Hamilton C, et al. Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation. Vet Res. 2012;43:38 pubmed publisher
    ..Peripheral blood mononuclear cell (PBMC) responses to Neospora antigen and foetal viability were assessed throughout the experiment...
  19. Nishimura M, Kohara J, Hiasa J, Muroi Y, Yokoyama N, Kida K, et al. Tissue distribution of Neospora caninum in experimentally infected cattle. Clin Vaccine Immunol. 2013;20:309-12 pubmed publisher
    Histopathology and quantitative PCR (qPCR) were used to determine the tissue distribution of Neospora caninum in calves at 80 days postinfection. Our findings revealed that the most appropriate brain areas for researching N...
  20. Kubota N, Sakata Y, Miyazaki N, Itamoto K, Bannai H, Nishikawa Y, et al. Serological survey of Neospora caninum infection among dogs in Japan through species-specific ELISA. J Vet Med Sci. 2008;70:869-72 pubmed
    A seroepidemiological survey of Neospora caninum infection among dogs in Japan was conducted using species-specific enzyme-linked immunosorbent assay with recombinant surface antigen (Nc-SAG1t). Among 1,206 dogs examined, 126 dogs (10...
  21. Bartova E, Sedlak K, Literak I. Toxoplasma gondii and Neospora caninum antibodies in sheep in the Czech Republic. Vet Parasitol. 2009;161:131-2 pubmed publisher
    ..serum from 547 sheep coming from nine farms was examined for antibodies against parasites Toxoplasma gondii and Neospora caninum by screening ELISA. Antibodies against T...
  22. Alkurashi M, Eastick F, Kuchipudi S, Rauch C, Madouasse A, Zhu X, et al. Influence of culture medium pH on internalization, growth and phenotypic plasticity of Neospora caninum. Vet Parasitol. 2011;177:267-74 pubmed publisher
    b>Neospora caninum, a strictly intracellular protozoan, is a major leading cause of parasite-induced abortion in cattle. A widely held view of N...
  23. Beck H, Blake D, Dardé M, Felger I, Pedraza Díaz S, Regidor Cerrillo J, et al. Molecular approaches to diversity of populations of apicomplexan parasites. Int J Parasitol. 2009;39:175-89 pubmed publisher
    ..Cryptosporidium spp., Toxoplasma gondii, Neospora caninum, Theileria spp. and Plasmodium spp...
  24. Panadero R, Painceira A, Lopez C, Vazquez L, Paz A, Diaz P, et al. Seroprevalence of Toxoplasma gondii and Neospora caninum in wild and domestic ruminants sharing pastures in Galicia (Northwest Spain). Res Vet Sci. 2010;88:111-5 pubmed publisher
    The prevalence of antibodies to the protozoan parasites Toxoplasma gondii and Neospora caninum were investigated by the direct agglutination test (DAT) and cELISA, respectively, in 160 roe deer (Capreolus capreolus), 177 sheep and 178 ..
  25. Dangoudoubiyam S, Oliveira J, Víquez C, Gomez Garcia A, Gonzalez O, Romero J, et al. Detection of antibodies against Sarcocystis neurona, Neospora spp., and Toxoplasma gondii in horses from Costa Rica. J Parasitol. 2011;97:522-4 pubmed publisher
    ..from Costa Rica, Central America, were examined for the presence of antibodies against Sarcocystis neurona, Neospora spp...
  26. Barratt J, Al Qassab S, Reichel M, Ellis J. The development and evaluation of a nested PCR assay for detection of Neospora caninum and Hammondia heydorni in feral mouse tissues. Mol Cell Probes. 2008;22:228-33 pubmed publisher
    The development of a novel nested polymerase chain reaction is described and used for detecting the presence of Neospora caninum and Hammondia heydorni DNA in DNA extracted from feral rodent tissues...
  27. Vanleeuwen J, Haddad J, Dohoo I, Keefe G, Tiwari A, Scott H. Risk factors associated with Neospora caninum seropositivity in randomly sampled Canadian dairy cows and herds. Prev Vet Med. 2010;93:129-38 pubmed publisher
    Our objective was to determine cow- and herd-level risk factors associated with seropositivity for Neospora caninum in a large number of randomly selected Canadian dairy herds, controlling for important confounding variables and co-..
  28. Almeria S, Serrano B, Yaniz J, Darwich L, Lopez Gatius F. Cytokine gene expression profiles in peripheral blood mononuclear cells from Neospora caninum naturally infected dams throughout gestation. Vet Parasitol. 2012;183:237-43 pubmed publisher
    b>Neospora caninum is a major cause of abortion in cattle but it is not known why some infected animals suffer abortion while others do not. An essential role in protective immunity against N...
  29. Leon A, Richard E, Fortier C, Laugier C, Fortier G, Pronost S. Molecular detection of Coxiella burnetii and Neospora caninum in equine aborted foetuses and neonates. Prev Vet Med. 2012;104:179-83 pubmed publisher
    ..Among others, Chlamydophila abortus (1 case), Coxiella burnetii (6 cases) and Neospora caninum (3 cases) were detected by real-time PCR; one of these samples being co-infected by N. caninum and C...
  30. Orozco M, Morales E, Salmeron F. Characterization of the inflammatory response in the uteri of cows infected naturally by Neospora caninum. J Comp Pathol. 2013;148:148-56 pubmed publisher
    ..Experimental studies of Neospora caninum-infected cattle have been performed, but little is known about the in-utero inflammatory response...
  31. Liu J, Cai J, Zhang W, Liu Q, Chen D, Han J, et al. Seroepidemiology of Neospora caninum and Toxoplasma gondii infection in yaks (Bos grunniens) in Qinghai, China. Vet Parasitol. 2008;152:330-2 pubmed publisher
    b>Neospora caninum is a protozoan parasite and is closely related to Toxoplasma gondii, but they are antigenically different. N. caninum and T...
  32. Al Qassab S, Reichel M, Ellis J. A second generation multiplex PCR for typing strains of Neospora caninum using six DNA targets. Mol Cell Probes. 2010;24:20-6 pubmed publisher
    Genetic diversity of Neospora caninum was investigated through a study of repetitive sequences found in the genome of this species...
  33. Asmare K, Regassa F, Robertson L, Martin A, Skjerve E. Reproductive disorders in relation to Neospora caninum, Brucella spp. and bovine viral diarrhoea virus serostatus in breeding and dairy farms of central and southern Ethiopia. Epidemiol Infect. 2013;141:1772-80 pubmed publisher
    ..This study investigated whether bovine viral diarrhoea virus (BVDV), Brucella spp., and Neospora caninum are associated with abortion and/or stillbirth in dairy cattle in Ethiopia...
  34. Marugán Hernández V, Ortega Mora L, Aguado Martínez A, Alvarez Garcia G. Genetic manipulation of Neospora caninum to express the bradyzoite-specific protein NcSAG4 in tachyzoites. Parasitology. 2011;138:472-80 pubmed publisher
    b>Neospora caninum is an apicomplexan parasite and the aetiological agent of bovine neosporosis, one of the main causes of reproductive failure worldwide. We have generated 2 independent transgenic knock-in clones, Nc-1SAG4c1...
  35. Innes E. The host-parasite relationship in pregnant cattle infected with Neospora caninum. Parasitology. 2007;134:1903-10 pubmed
    The protozoan parasite Neospora caninum is an important cause of reproductive disease in cattle worldwide...
  36. Regidor Cerrillo J, Gomez Bautista M, Pereira Bueno J, Aduriz G, Navarro Lozano V, Risco Castillo V, et al. Isolation and genetic characterization of Neospora caninum from asymptomatic calves in Spain. Parasitology. 2008;135:1651-9 pubmed publisher
    b>Neospora caninum is a cyst-forming parasite that causes abortion in cattle. Despite this parasite's ubiquitous distribution and wide host range, the number of N. caninum isolates obtained to date is limited...
  37. Rojo Montejo S, Collantes Fernandez E, Blanco Murcia J, Rodriguez Bertos A, Risco Castillo V, Ortega Mora L. Experimental infection with a low virulence isolate of Neospora caninum at 70 days gestation in cattle did not result in foetopathy. Vet Res. 2009;40:49 pubmed publisher
    The Nc-Spain 1H isolate of Neospora caninum, which was newly obtained from the brain of a congenitally asymptomatic infected calf, demonstrated a reduced in vitro tachyzoite yield and viability rate, as well as low virulence in mouse ..
  38. Yakhchali M, Javadi S, Morshedi A. Prevalence of antibodies to Neospora caninum in stray dogs of Urmia, Iran. Parasitol Res. 2010;106:1455-8 pubmed publisher
    To investigate anti-Neospora caninum antibodies in stray dogs living in Urmia city, 135 blood samples were collected. Serum samples were screened for detection of anti-N...
  39. Vanleeuwen J, Greenwood S, Clark F, Acorn A, Markham F, McCarron J, et al. Monensin use against Neospora caninum challenge in dairy cattle. Vet Parasitol. 2011;175:372-6 pubmed publisher
    ..The extracted DNA from whole blood was tested for the Nc-5 gene fragment of Neospora caninum using a quantitative real time polymerase chain reaction. Serum was tested for antibodies to N...
  40. Rosbottom A, Gibney H, Kaiser P, Hartley C, Smith R, Robinson R, et al. Up regulation of the maternal immune response in the placenta of cattle naturally infected with Neospora caninum. PLoS ONE. 2011;6:e15799 pubmed publisher
    b>Neospora caninum is an intracellular protozoan parasite which is a major cause of abortion in cattle worldwide...
  41. Darwich L, Cabezón O, Echeverria I, Pabon M, Marco I, Molina Lopez R, et al. Presence of Toxoplasma gondii and Neospora caninum DNA in the brain of wild birds. Vet Parasitol. 2012;183:377-81 pubmed publisher
    ..gondii remains unknown. Neospora caninum, a closely related parasite to T...
  42. Hornok S, Edelhofer R, Joachim A, Farkas R, Berta K, Répási A, et al. Seroprevalence of Toxoplasma gondii and Neospora caninum infection of cats in Hungary. Acta Vet Hung. 2008;56:81-8 pubmed publisher
    ..were collected from 330 cats in Hungary in order to evaluate their seroconversion to Toxoplasma gondii and Neospora caninum using the indirect fluorescent antibody test (IFAT). The overall prevalence of toxoplasmosis was 47...
  43. Reiterová K, Spilovská S, Antolová D, Dubinsky P. Neospora caninum, potential cause of abortions in dairy cows: the current serological follow-up in Slovakia. Vet Parasitol. 2009;159:1-6 pubmed publisher
    ..of the rapid spread of neosporosis in herds throughout the world, our aim was to detect the prevalence of anti-Neospora antibodies in cows post-abortion (PA) (PA Group n=716) and in cows without any reproduction problems (Control ..
  44. Mineo T, Benevides L, Silva N, Silva J. Myeloid differentiation factor 88 is required for resistance to Neospora caninum infection. Vet Res. 2009;40:32 pubmed publisher
    b>Neospora caninum is an intracellular parasite that causes major economic impact on cattle raising farms, and infects a wide range of warm-blooded hosts worldwide...
  45. Wang C, Zhai Y, Zhao X, Tan Q, Chen J, Chen A, et al. [Preliminary application of PCR-based assay for the detection of Neospora caninum in bovine aborted fetus]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009;27:140-3 pubmed
    To establish a PCR diagnostic method based on Nc-5 gene of Neospora caninum, for being used to detect Neospora in brain tissues of bovine aborted fetus.
  46. Moore D, Echaide I, Verna A, Leunda M, Cano A, Pereyra S, et al. Immune response to Neospora caninum native antigens formulated with immune stimulating complexes in calves. Vet Parasitol. 2011;175:245-51 pubmed publisher
    The aim of this study was to compare the immune responses to live Neospora caninum tachyzoites and N. caninum native antigens formulated with immune stimulating complexes matrix (ISCOM-matrix) in calves...
  47. Marugán Hernández V, Alvarez Garcia G, Tomley F, Hemphill A, Regidor Cerrillo J, Ortega Mora L. Identification of novel rhoptry proteins in Neospora caninum by LC/MS-MS analysis of subcellular fractions. J Proteomics. 2011;74:629-42 pubmed publisher
    ..one rhoptry protein, NcROP2, has been identified and extensively characterized in the closely related parasite Neospora caninum, and this has showed immunoprotective properties...
  48. Coelho W, do Amarante A, Apolinário J, Coelho N, de Lima V, Perri S, et al. Seroepidemiology of Toxoplasma gondii, Neospora caninum, and Leishmania spp. infections and risk factors for cats from Brazil. Parasitol Res. 2011;109:1009-13 pubmed publisher
    The seroprevalence of infection by Toxoplasma gondii, Neospora caninum, and Leishmania spp. was detected through an indirect immunofluorescence in 70 cats from the Andradina Municipality, São Paulo State, Brazil. Anti-T...
  49. Monney T, Rütti D, Schorer M, Debache K, Grandgirard D, Leib S, et al. RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine. 2011;29:6967-75 pubmed publisher
    In order to achieve host cell entry, the apicomplexan parasite Neospora caninum relies on the contents of distinct organelles, named micronemes, rhoptries and dense granules, which are secreted at defined timepoints during and after host ..
  50. Li R, Tuo W. Neospora caninum: comparative gene expression profiling of Neospora caninum wild type and a temperature sensitive clone. Exp Parasitol. 2011;129:346-54 pubmed publisher
    ..expression profiles of a temperature-sensitive clone (NCts-8, relatively avirulent) and its wild type (NC-1) of Neospora caninum were characterized and compared using a high-density microarray with approximately 63,000 distinct ..
  51. Dong J, Otsuki T, Kato T, Park E. Development of a diagnostic method for neosporosis in cattle using recombinant Neospora caninum proteins. BMC Biotechnol. 2012;12:19 pubmed publisher
    Neosporosis is an infectious disease primarily of cattle and dogs, caused by intracellular parasite, Neospora caninum...
  52. Huang P, Liao M, Zhang H, Lee E, Nishikawa Y, Xuan X. Dense-granule protein NcGRA7, a new marker for the serodiagnosis of Neospora caninum infection in aborting cows. Clin Vaccine Immunol. 2007;14:1640-3 pubmed
    To investigate whether the production of an antigen-specific antibody is associated with Neospora caninum-induced bovine abortion, 62 serum samples were tested with an enzyme-linked immunosorbent assay using the recombinant antigens ..
  53. Dijkstra T, Lam T, Bartels C, Eysker M, Wouda W. Natural postnatal Neospora caninum infection in cattle can persist and lead to endogenous transplacental infection. Vet Parasitol. 2008;152:220-5 pubmed publisher
    ..5 years duration was done of a dairy herd that had experienced a mass seroconversion to Neospora caninum following a point source exposure shortly before the 17th of January 2000...
  54. Frössling J, Nødtvedt A, Lindberg A, Björkman C. Spatial analysis of Neospora caninum distribution in dairy cattle from Sweden. Geospat Health. 2008;3:39-45 pubmed
    The national herd prevalence and spatial distribution of Neospora caninum infected dairy herds in Sweden were investigated. The study was based on a bulk milk survey comprising samples from 2,978 herds...
  55. Dirikolu L, Yohn R, Garrett E, Chakkath T, Ferguson D. Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. J Vet Pharmacol Ther. 2009;32:280-8 pubmed publisher
    ..Toltrazuril sulfone may have clinical application in the treatment of Neospora. caninum and other protozoal infections in cattle...
  56. Garcia Ispierto I, Nogareda C, Yaniz J, Almeria S, Martínez Bello D, de Sousa N, et al. Neospora caninum and coxiella burnetii seropositivity are related to endocrine pattern changes during gestation in lactating dairy cows. Theriogenology. 2010;74:212-20 pubmed publisher
    ..Possible interactions with Neospora caninum were also explored. The study was performed on 58 gestating non-aborting cows...
  57. Serrano B, Almeria S, Garcia Ispierto I, Yaniz J, Abdelfattah Hassan A, Lopez Gatius F. Peripheral white blood cell counts throughout pregnancy in non-aborting Neospora caninum-seronegative and seropositive high-producing dairy cows in a Holstein Friesian herd. Res Vet Sci. 2011;90:457-62 pubmed publisher
    ..cell populations throughout pregnancy in a herd of high-producing dairy cows chronically infected or not with Neospora caninum. We examined 54 pregnant parous cows: 29 Neospora-seronegative and 25 Neospora-seropositive cows...
  58. Goździk K, Jakubek E, Bjorkman C, Bien J, Moskwa B, Cabaj W. Seroprevalence of Neospora caninum in free living and farmed red deer (Cervus elaphus) in Poland. Pol J Vet Sci. 2010;13:117-20 pubmed
    ..elaphus) from the Mazurian Lake District in north-east Poland were investigated for the presence of antibodies to Neospora caninum. A modified Neospora iscom-ELISA was used for initial screening...
  59. Shabbir M, Nazir M, Maqbool A, Lateef M, Shabbir M, Ahmad A, et al. Seroprevalence of Neospora caninum and Brucella abortus in dairy cattle herds with high abortion rates. J Parasitol. 2011;97:740-2 pubmed publisher
    The protozoan Neospora caninum and the bacterium Brucella abortus are well-recognized causes of abortion in dairy cattle...
  60. King J, McAllan B, Spielman D, Lindsay S, Hůrková Hofmannová L, Hartigan A, et al. Extensive production of Neospora caninum tissue cysts in a carnivorous marsupial succumbing to experimental neosporosis. Vet Res. 2011;42:75 pubmed publisher
    ..throughout the arid and semi-arid zones of Australia, show that this species can act as an intermediate host for Neospora caninum. In contrast to existing models that develop relatively few N...
  61. Benavides J, Katzer F, Maley S, Bartley P, Canton G, Palarea Albaladejo J, et al. High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestation. Vet Res. 2012;43:83 pubmed publisher
    ..This suggests that a change in the maternal immune response plays a crucial role in limiting the initial infection during the last term of pregnancy...
  62. Hemphill A, Debache K, Monney T, Schorer M, Guionaud C, Alaeddine F, et al. Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Front Biosci (Elite Ed). 2013;5:23-36 pubmed
    b>Neospora caninum is an apicomplexan parasite that is capable of infecting, a wide range of tissues...
  63. Gondim L, Abe Sandes K, Uzêda R, Silva M, Santos S, Mota R, et al. Toxoplasma gondii and Neospora caninum in sparrows (Passer domesticus) in the Northeast of Brazil. Vet Parasitol. 2010;168:121-4 pubmed publisher
    ..gondii infection in sparrows using serologic and molecular tests, and to investigate related parasites, such as Neospora caninum and Hammondia sp...
  64. Garosi L, Dawson A, Couturier J, Matiasek L, De Stefani A, Davies E, et al. Necrotizing cerebellitis and cerebellar atrophy caused by Neospora caninum infection: magnetic resonance imaging and clinicopathologic findings in seven dogs. J Vet Intern Med. 2010;24:571-8 pubmed publisher
    ..Adult dogs with neosporosis can develop a variety of neurologic signs. No area of predilection within the nervous system so far has been identified in adult dogs...
  65. Regidor Cerrillo J, Gomez Bautista M, del Pozo I, Jiménez Ruiz E, Aduriz G, Ortega Mora L. Influence of Neospora caninum intra-specific variability in the outcome of infection in a pregnant BALB/c mouse model. Vet Res. 2010;41:52 pubmed publisher
    ..However, the influence of Neospora caninum isolate itself has been poorly investigated...
  66. Sangster C, Bryant B, Campbell Ward M, King J, Slapeta J. Neosporosis in an aborted southern white rhinoceros (Ceratotherium simum simum) fetus. J Zoo Wildl Med. 2010;41:725-8 pubmed
    ..utilizing immunohistochemistry, polymerase chain reaction, and DNA sequencing identified the protozoan as Neospora caninum...
  67. Villalobos E, Furman K, Lara M, Cunha E, Finger M, Busch A, et al. Detection of Neospora sp. antibodies in cart horses from urban areas of Curitiba, Southern Brazil. Rev Bras Parasitol Vet. 2012;21:68-70 pubmed
    b>Neospora caninum is a protozoan parasite which affects dogs as definitive hosts and several mammalian species as intermediate hosts mainly causing abortions and central nervous system disorders...
  68. Langoni H, Matteucci G, Medici B, Camossi L, Richini Pereira V, Silva R. Detection and molecular analysis of Toxoplasma gondii and Neospora caninum from dogs with neurological disorders. Rev Soc Bras Med Trop. 2012;45:365-8 pubmed
    Toxoplasma gondii and Neospora caninum are related Apicomplexa parasites responsible for systemic diseases in many species of animals, including dogs.
  69. Debache K, Hemphill A. Differential effects of intranasal vaccination with recombinant NcPDI in different mouse models of Neospora caninum infection. Parasite Immunol. 2013;35:11-20 pubmed publisher
  70. Reichel M, Alejandra Ayanegui Alcérreca M, Gondim L, Ellis J. What is the global economic impact of Neospora caninum in cattle - the billion dollar question. Int J Parasitol. 2013;43:133-42 pubmed publisher
    b>Neospora caninum is regarded as one of the most important infectious causes of abortions in cattle worldwide, yet the global economic impact of the infection has not been established. A systematic review of the economic impact of N...
  71. Diakoua A, Anastasia D, Papadopoulos E, Elias P, Panousis N, Nikolaos P, et al. Toxoplasma gondii and Neospora caninum seroprevalence in dairy sheep and goats mixed stock farming. Vet Parasitol. 2013;198:387-90 pubmed publisher
    Toxoplasma and Neospora infections are important causes of abortions and economic losses in animal production...
  72. Pinitkiatisakul S, Mattsson J, Lunden A. Quantitative analysis of parasite DNA in the blood of immunized and naïve mice after infection with Neospora caninum. Parasitology. 2008;135:175-82 pubmed
    ..complexes (iscoms) containing recombinant NcSRS2, one of the immunodominant surface antigens of Neospora caninum. After challenge infection, blood was collected daily for 9 days...
  73. López Pérez I, Collantes Fernandez E, Aguado Martínez A, Rodriguez Bertos A, Ortega Mora L. Influence of Neospora caninum infection in BALB/c mice during pregnancy in post-natal development. Vet Parasitol. 2008;155:175-83 pubmed publisher
    The influence of Neospora caninum infection during pregnancy on the post-natal period has been poorly investigated. In a previous study, we suggested that infection with N...
  74. Dubey J, Stone D, Kwok O, Sharma R. Toxoplasma gondii and Neospora caninum antibodies in dogs from Grenada, West Indies. J Parasitol. 2008;94:750-1 pubmed publisher
    Toxoplasma gondii and Neospora caninum are structurally similar parasites with many common hosts. The prevalence of antibodies to T. gondii and N. caninum was determined in sera from dogs in Grenada, West Indies...
  75. Mineo T, Oliveira C, Gutierrez F, Silva J. Recognition by Toll-like receptor 2 induces antigen-presenting cell activation and Th1 programming during infection by Neospora caninum. Immunol Cell Biol. 2010;88:825-33 pubmed publisher
    b>Neospora caninum is an apicomplexan parasite responsible for major economic losses due to abortions in cattle...
  76. Wiengcharoen J, Thompson R, Nakthong C, Rattanakorn P, Sukthana Y. Transplacental transmission in cattle: is Toxoplasma gondii less potent than Neospora caninum?. Parasitol Res. 2011;108:1235-41 pubmed publisher
    We compared the transplacental-transmission ability of Toxoplasma gondii and Neospora caninum in cattle. One uninfected pregnant heifer served as control, while three were inoculated with N. caninum K9WA strain and four with T...
  77. Malmsten J, Jakubek E, Björkman C. Prevalence of antibodies against Toxoplasma gondii and Neospora caninum in moose (Alces alces) and roe deer (Capreolus capreolus) in Sweden. Vet Parasitol. 2011;177:275-80 pubmed publisher
    Toxoplasma gondii and Neospora caninum are two coccidian parasites with a worldwide distribution. T...
  78. Meerburg B, De Craeye S, Dierick K, Kijlstra A. Neospora caninum and Toxoplasma gondii in brain tissue of feral rodents and insectivores caught on farms in the Netherlands. Vet Parasitol. 2012;184:317-20 pubmed publisher
    We investigated the presence of both Neospora caninum and Toxoplasma gondii in 250 brain tissue samples from 9 species of feral rodents and insectivores caught on 10 organic farms in the Netherlands in 2004...
  79. Cóceres V, Alonso A, Alomar M, Corvi M. Rabbit antibodies against Toxoplasma Hsp20 are able to reduce parasite invasion and gliding motility in Toxoplasma gondii and parasite invasion in Neospora caninum. Exp Parasitol. 2012;132:274-81 pubmed publisher
    ..is present in different apicomplexan parasites, showing a high degree of conservation across the phylum, with Neospora caninum Hsp20 presenting an 82% identity to that of T. gondii. Hence rabbit anti-T...
  80. Zanet S, Palese V, Trisciuoglio A, Cantón Alonso C, Ferroglio E. Encephalitozoon cuniculi, Toxoplasma gondii and Neospora caninum infection in invasive Eastern Cottontail Rabbits Sylvilagus floridanus in Northwestern Italy. Vet Parasitol. 2013;197:682-4 pubmed publisher
    ..floridanus were examined by PCR for Encephalitozoon cuniculi, Toxoplasma gondii and Neospora caninum. DNA of E. cuniculi was found with a prevalence of 9.72% (CI 95% 0.058-0.156). T. gondii and N...
  81. Sánchez G, Banda R, Sahagun R, Ledesma M, Morales S. Comparison between immunohistochemistry and two PCR methods for detection of Neospora caninum in formalin-fixed and paraffin-embedded brain tissue of bovine fetuses. Vet Parasitol. 2009;164:328-32 pubmed publisher
    ..In 29 out of 48 brains (60.4%), microscopic lesions consistent with Neospora infection were observed, and 21 of the 29 cases (72.41%) were positive for IHC...
  82. Yildiz K, Kul O, Babur C, Kilic S, Gazyagci A, Celebi B, et al. Seroprevalence of Neospora caninum in dairy cattle ranches with high abortion rate: special emphasis to serologic co-existence with Toxoplasma gondii, Brucella abortus and Listeria monocytogenes. Vet Parasitol. 2009;164:306-10 pubmed publisher
    The aim of this study was to determine seroprevalence of Neospora caninum in dairy cattle ranches with higher abortion rates and co-existence of Neospora caninum, Toxoplasma gondii, Brucella abortus, and Listeria monocytogenes antibodies...
  83. Millan J, Cabezón O, Pabón M, Dubey J, Almeria S. Seroprevalence of Toxoplasma gondii and Neospora caninum in feral cats (Felis silvestris catus) in Majorca, Balearic Islands, Spain. Vet Parasitol. 2009;165:323-6 pubmed publisher
    ..Antibodies to T. gondii and Neospora caninum were determined in serum samples from 59 feral cats (Felis silvestris catus) captured in baited traps ..
  84. Williams D, Hartley C, Bjorkman C, Trees A. Endogenous and exogenous transplacental transmission of Neospora caninum - how the route of transmission impacts on epidemiology and control of disease. Parasitology. 2009;136:1895-900 pubmed publisher
    Vertical transmission of the protozoan parasite, Neospora caninum is highly efficient and can take two forms - endogenous transplacental transmission resulting from activation of the quiescent bradyzoite stage during pregnancy or ..
  85. Pinheiro A, Costa S, Freire S, Ribeiro C, Tardy M, El Bachá R, et al. Neospora caninum: early immune response of rat mixed glial cultures after tachyzoites infection. Exp Parasitol. 2010;124:442-7 pubmed publisher
    b>Neospora caninum causes neurologic disease in dogs and abortion in cattle. Little is known about the immune response of the CNS against this protozoan...
  86. Goździk K, Wrzesień R, Wielgosz Ostolska A, Bien J, Kozak Ljunggren M, Cabaj W. Prevalence of antibodies against Neospora caninum in dogs from urban areas in Central Poland. Parasitol Res. 2011;108:991-6 pubmed publisher
    b>Neospora caninum is a protozoan parasite which causes abortion in cattle as well as reproduction problems and neurological disorders in dogs...
  87. Marugán Hernández V, Ortega Mora L, Aguado Martínez A, Jimenez Ruiz E, Alvarez Garcia G. Transgenic Neospora caninum strains constitutively expressing the bradyzoite NcSAG4 protein proved to be safe and conferred significant levels of protection against vertical transmission when used as live vaccines in mice. Vaccine. 2011;29:7867-74 pubmed publisher
    ..At present, there is no effective treatment or vaccine to prevent vertical transmission or abortion associated with Neospora caninum infection in cattle...
  88. Weston J, Heuer C, Williamson N. Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle. Prev Vet Med. 2012;103:136-44 pubmed publisher
    A clinical trial was undertaken to assess the efficacy of Bovilis(®) Neoguard, a killed Neospora caninum tachyzoite vaccine on 5 commercial dairy farms in New Zealand with a history of Neospora-associated abortion...
  89. Moreno B, Collantes Fernandez E, Villa A, Navarro A, Regidor Cerrillo J, Ortega Mora L. Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Vet Parasitol. 2012;187:312-8 pubmed publisher
    b>Neospora caninum and Toxoplasma gondii are closely related cyst-forming apicomplexan parasites identified as important causes of reproductive failure in cattle and small ruminants, respectively...
  90. Srinivasan S, Mueller J, Suana A, Hemphill A. Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. J Parasitol. 2007;93:1046-55 pubmed publisher
    NcMIC4 is a Neospora caninum microneme protein that has been isolated and purified on the basis of its unique lactose-binding properties...
  91. Phelps E, Sweeney K, Blader I. Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor. Infect Immun. 2008;76:4703-12 pubmed publisher
    ..activated in Toxoplasma-infected cells but not in cells infected with the closely related apicomplexan parasite Neospora caninum...
  92. Cabral A, Camargo C, Galleti N, Okuda L, Pituco E, Fava C. Diagnosis of Neospora caninum in bovine fetuses by histology, immunohistochemistry, and nested-PCR. Rev Bras Parasitol Vet. 2009;18:14-9 pubmed
    b>Neospora caninum, a cause of abortion and stillbirth in cattle, was studied by histology, immunohistochemistry, and nested-PCR, using primers from the Nc5 region of the genomic DNA (PCR PLUS) and primers from the ITS1 region of the ..