Summary: Sharp instruments used for puncturing or suturing.

Top Publications

  1. Choi Y, Lee J, Moon W, Cho S. Does the effect of acupuncture depend on needling sensation and manipulation?. Complement Ther Med. 2013;21:207-14 pubmed publisher
    ..It seems that needle rotation and acupuncture sensation play an important role in verifying the effect of acupuncture. ..
  2. Mai J, Yong J, Dixson H, Makris A, Aravindan A, Suranyi M, et al. Is bigger better? A retrospective analysis of native renal biopsies with 16 Gauge versus 18 Gauge automatic needles. Nephrology (Carlton). 2013;18:525-30 pubmed publisher
    ..Our study compares the sample adequacy and complication rates using 16 gauge (G) and 18 gauge (G) automatic needles on native kidney PRB...
  3. Lee J, Lee K, Choi E, Jang T, Jang K, Lee J, et al. A prospective, randomized trial comparing 25-gauge and 22-gauge needles for endoscopic ultrasound-guided fine needle aspiration of pancreatic masses. Scand J Gastroenterol. 2013;48:752-7 pubmed publisher
    ..2% with p = 0.004). 25G can be chosen in preference to 22G when performing pancreatic EUS-FNA because 25G was significantly superior to 22G in terms of manipulability and complications although both were effective for accurate diagnosis. ..
  4. Ghosh P, Pinninti R, Hammell D, Paudel K, Stinchcomb A. Development of a codrug approach for sustained drug delivery across microneedle-treated skin. J Pharm Sci. 2013;102:1458-67 pubmed publisher
    ..The skin concentration of DIC was high enough to keep the pores open in vivo in a hairless guinea pig model as demonstrated by day seven pore visualization studies. ..
  5. Song J, Kim Y, Lipatov A, Pearton M, Davis C, Yoo D, et al. Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice. Clin Vaccine Immunol. 2010;17:1381-9 pubmed publisher
    ..Microneedle vaccination in the skin with H5 VLPs represents a promising approach for a self-administered vaccine against viruses with pandemic potential...
  6. Ryan E, Garland M, Singh T, Bambury E, O Dea J, Migalska K, et al. Microneedle-mediated transdermal bacteriophage delivery. Eur J Pharm Sci. 2012;47:297-304 pubmed publisher
    ..Accordingly, bacteriophage-based therapeutics may now have an alternative route for systemic delivery. Once fully-investigated, this could lead to more widespread investigation of these interesting therapeutic viruses. ..
  7. Greenstein E, Passman R, Lin A, Knight B. Incidence of tissue coring during transseptal catheterization when using electrocautery and a standard transseptal needle. Circ Arrhythm Electrophysiol. 2012;5:341-4 pubmed publisher
    ..001). In an animal preparation, TSP at the level of the fossa ovalis using electrocautery and a standard open-ended Brockenbrough needle resulted in coring of the septal tissue in 35% of cases (33 of 96 punctures). ..
  8. Garland M, Caffarel Salvador E, Migalska K, Woolfson A, Donnelly R. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. J Control Release. 2012;159:52-9 pubmed publisher
    ..40%) for MN in combination with anodal ITP (p<0.001). As such, drug loaded soluble PMVE/MA MN arrays show promise for the electrically controlled transdermal delivery of biomacromolecules in a simple, one-step approach. ..
  9. Kim M, Jung B, Park J. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials. 2012;33:668-78 pubmed publisher
    ..However, they have limitations related to the difficulty of achieving separation of the needles into the skin...

More Information


  1. Zhou K, Fang J, Wang X, Wang Y, Hong Y, Liu J, et al. Characterization of de qi with electroacupuncture at acupoints with different properties. J Altern Complement Med. 2011;17:1007-13 pubmed publisher
    ..Fullness, numbness, and soreness were the most common and obvious sensations associated with electroacupuncture. The difference of sensation intensities may be associated with different nerve innervations. ..
  2. Park J, Akazawa M, Ahn J, Beckman Harned S, Lin F, Lee K, et al. Acupuncture sensation during ultrasound guided acupuncture needling. Acupunct Med. 2011;29:257-65 pubmed publisher
    ..Furthermore, the new methodology has been proven feasible. A further study with an objective measurement is warranted. ..
  3. Salih N, Bäumler P, Simang M, Irnich D. Deqi sensations without cutaneous sensory input: results of an RCT. BMC Complement Altern Med. 2010;10:81 pubmed publisher
    ..However, further research is required to understand mechanisms underlying deqi. ..
  4. Stewart J, Srivastava S, Fung A, Mahmoud T, Telander D, Hariprasad S, et al. Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study. Ocul Immunol Inflamm. 2011;19:32-8 pubmed publisher
    To determine the incidence of bacterial contamination of needles used for intravitreal injections.
  5. Mikolajewska P, Donnelly R, Garland M, Morrow D, Singh T, Iani V, et al. Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. Pharm Res. 2010;27:2213-20 pubmed publisher
    ..MNs are a promising tool for improving the efficiency of topical PDT by improving the cutaneous delivery of ALA and MAL, without increase in side effects. ..
  6. Bronnec F, Bouillaguet S, Machtou P. Ex vivo assessment of irrigant penetration and renewal during the final irrigation regimen. Int Endod J. 2010;43:663-72 pubmed publisher
    ..To assess irrigant penetration in curved canals after shaping procedures ex vivo...
  7. Shen Y, Gao Y, Qian W, Ruse N, Zhou X, Wu H, et al. Three-dimensional numeric simulation of root canal irrigant flow with different irrigation needles. J Endod. 2010;36:884-9 pubmed publisher
    ..The purpose of this study was to investigate, by using computational fluid dynamics (CFD), the effect of needle tip design on irrigant flow pattern...
  8. Benham A, Phillips G, Johnson M. An experimental study on the self-report of acupuncture needle sensation during deep needling with bi-directional rotation. Acupunct Med. 2010;28:16-20 pubmed publisher
    Traditionally, acupuncturists manipulate needles to enhance sensations referred to as de qi or 'acupuncture needle sensation'. Acupuncture needle sensations are complex and quantifying the experience has been difficult...
  9. Gill H, Soderholm J, Prausnitz M, Sallberg M. Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther. 2010;17:811-4 pubmed publisher
    ..However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery...
  10. Gittard S, Ovsianikov A, Monteiro Riviere N, Lusk J, Morel P, Minghetti P, et al. Fabrication of polymer microneedles using a two-photon polymerization and micromolding process. J Diabetes Sci Technol. 2009;3:304-11 pubmed
  11. Constantin A, Brisson M, Kwan J, Proulx F. Percutaneous US-guided renal biopsy: a retrospective study comparing the 16-gauge end-cut and 14-gauge side-notch needles. J Vasc Interv Radiol. 2010;21:357-61 pubmed publisher
    Assess glomerular yield and safety profile of two different types of needles for percutaneous ultrasound-guided kidney biopsy...
  12. Qiu X, Lu S. [Discussion on reinforcing-reducing manipulations of acupuncture in Internal Classic]. Zhongguo Zhen Jiu. 2009;29:850-3 pubmed
    ..Mastering the reinforcing-reducing manipulations of acupuncture in Internal Classic will contribute to the improvement of therapeutic effects in clinical practice. ..
  13. Kim Y, Quan F, Yoo D, Compans R, Kang S, Prausnitz M. Improved influenza vaccination in the skin using vaccine coated microneedles. Vaccine. 2009;27:6932-8 pubmed publisher
    ..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines. ..
  14. Donnelly R, Morrow D, Singh T, Migalska K, McCarron P, O Mahony C, et al. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev Ind Pharm. 2009;35:1242-54 pubmed publisher
    ..It is hoped that we have illustrated conclusively the difficulties inherent in the processing and storage of carbohydrate-based dissolving MNs and that those in the industry will now follow alternative approaches. ..
  15. Stawicki S, Evans D, Cipolla J, Seamon M, Lukaszczyk J, Prosciak M, et al. Retained surgical foreign bodies: a comprehensive review of risks and preventive strategies. Scand J Surg. 2009;98:8-17 pubmed
    ..The authors also explore the relationship between RSFB and surgical training with emphasis on education in early recognition, prevention, and focus on team-oriented training strategies...