Genomes and Genes
Summary: A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 188.8.131.52.
- Cheng T, Chen S, Huang C, Fu Y, Yu J, Cheng C, et al. Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility. Int J Cancer. 2005;113:345-53 pubmed
- Falany C, Wheeler J, Oh T, Falany J. Steroid sulfation by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 1994;48:369-75 pubmed
- Wang Y, Spitz M, Tsou A, Zhang K, Makan N, Wu X. Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis. Lung Cancer. 2002;35:137-42 pubmed..74, 95% CI: 1.08-2.29) and heavy smokers (OR=1.45, 95% CI: 1.05-2.00). Our results support the hypothesis that a genetic polymorphism in the SULT1A1 gene may be associated with increased lung cancer risk. ..
- Gulyaeva L, Mikhailova O, PustyInyak V, Kim I, Gerasimov A, Krasilnikov S, et al. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Adv Exp Med Biol. 2008;617:359-66 pubmed publisher..In conclusion, these results support the hypothesis that susceptibility gene alleles of estrogen-metabolizing enzymes may differentially influence risk for woman hormone-dependent cancers. ..
- Pachouri S, Sobti R, Kaur P, Singh J, Gupta S. Impact of polymorphism in sulfotransferase gene on the risk of lung cancer. Cancer Genet Cytogenet. 2006;171:39-43 pubmed..78, P = 0.000002) or AA (OR = 3.9, 95% CI = 1.99-7.81, P = 0.0002), and lung cancer. The present study indicates that the SULT1A1 genotype may play an important role in the risk of developing lung cancer, especially in cigarette smokers. ..
- Tiemersma E, Bunschoten A, Kok F, Glatt H, de Boer S, Kampman E. Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. Int J Cancer. 2004;108:97-103 pubmed..We conclude that smoking increases risk of colorectal adenomas and that SULT1A1 and NAT2 only modestly modify this association. ..
- Thomae B, Rifki O, Theobald M, Eckloff B, Wieben E, Weinshilboum R. Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism. J Neurochem. 2003;87:809-19 pubmed..These observations raise the possibility of ethnic-specific inherited alterations in catecholamine sulfation in humans. ..
- Lu J, Li H, Liu M, Zhang J, Li M, An X, et al. Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005;335:417-23 pubmed..On the other hand, residue Asp86 appeared to be critical to the Mn2+-stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3, in addition to a supporting role in the stereoselectivity and sulfating activity. ..
- Tang D, Rundle A, Mooney L, Cho S, Schnabel F, Estabrook A, et al. Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study. Breast Cancer Res Treat. 2003;78:217-22 pubmed..Contrary to our hypothesis PAH-DNA adduct levels in breast tissue were not associated with SULT1A1 genotype. Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk. ..
- Nowell S, Ratnasinghe D, Ambrosone C, Williams S, Teague Ross T, Trimble L, et al. Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians. Cancer Epidemiol Biomarkers Prev. 2004;13:270-6 pubmed..These results indicate that variations in SULT1A1 activity contributes to prostate cancer risk and the magnitude of the association may differ by ethnicity and be modified by meat consumption. ..
- Hebbring S, Adjei A, Baer J, Jenkins G, Zhang J, Cunningham J, et al. Human SULT1A1 gene: copy number differences and functional implications. Hum Mol Genet. 2007;16:463-70 pubmed..0001). Overall, these observations have obvious implications for the effectiveness of SULT1A1 as a drug and hormone metabolizing enzyme and its potential role as a risk factor for disease. ..
- Wood T, Aksoy I, Aksoy S, Weinshilboum R. Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. Biochem Biophys Res Commun. 1994;198:1119-27 pubmed..The cloning of a cDNA for human liver TL PST represents an important step toward understanding the molecular basis for the regulation of this enzyme in humans. ..
- Arslan S, Silig Y, Pinarbasi H. An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population. Cell Biochem Funct. 2009;27:211-5 pubmed publisher..027) and other types of cancer (p = 0.037), except SMCC (p = 0.854). ..
- Saintot M, Malaveille C, Hautefeuille A, Gerber M. Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk. Int J Cancer. 2003;107:652-7 pubmed..e., 4-hydroxy-estradiol) among smokers. Our study showed that gene polymorphisms of CYP1B1 and SULT1A1 induce an individual susceptibility to breast cancer among current smokers. ..
- Koike H, Nakazato H, Ohtake N, Matsui H, Okugi H, Shibata Y, et al. Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population. Int Urol Nephrol. 2008;40:947-51 pubmed publisher..These findings suggested that genetic polymorphism of SULT1A1 might not be involved in genetic susceptibility to prostate cancer. ..
- Hildebrandt M, Salavaggione O, Martin Y, Flynn H, Jalal S, Wieben E, et al. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. Biochem Biophys Res Commun. 2004;321:870-8 pubmed..The duplication of SULT1A3 will have to be taken into account in future efforts to understand individual variation in SULT1A3 activity or properties. ..
- Han D, Zhou X, Hu M, Wang C, Xie W, Tan X, et al. Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women. Toxicol Lett. 2004;150:167-77 pubmed..Our findings suggest that the SULT1A1 His allele was positively associated with the risk of breast cancer in Chinese women. And there was interaction between SULT1A1 polymorphism and related exposure factors. ..
- Langsenlehner U, Krippl P, Renner W, Yazdani Biuki B, Eder T, Wolf G, et al. Genetic variants of the sulfotransferase 1A1 and breast cancer risk. Breast Cancer Res Treat. 2004;87:19-22 pubmed..002). We conclude that the SULT1A1 R213H polymorphism is not a general risk factor for breast cancer, but may be involved in lymph node metastazing in breast cancer patients. ..
- Zheng L, Wang Y, Schabath M, Grossman H, Wu X. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Cancer Lett. 2003;202:61-9 pubmed..Further studies are warranted to elucidate the function of this SULT1A1 polymorphism with regard to organ specificity, gene-environment interactions, and the gender-related difference we observed. ..
- Chacko P, Rajan B, Mathew B, Joseph T, Pillai M. CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer. Breast Cancer. 2004;11:380-8 pubmed..Such genotype analysis resulting in a high-risk profile holds considerable promise for individualizing screening, diagnosis and therapeutic intervention in breast cancer. ..
- Ma B, Shou M, Schrag M. Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003;31:1300-5 pubmed..4%, v/v) was reduced to <15% for all solvents examined. Thus, it is recommended that ethanol is used as the preferred solvent vehicle and that incubations with expressed enzyme contain >12 microg/ml total protein. ..
- Wegman P, Vainikka L, Stal O, Nordenskjold B, Skoog L, Rutqvist L, et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res. 2005;7:R284-90 pubmed..However, results are in contradiction to prior hypotheses and the present sample size is relatively small. Findings therefore need to be confirmed in a larger cohort. ..
- Dandara C, Li D, Walther G, Parker M. Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus. Carcinogenesis. 2006;27:791-7 pubmed..The genotype results show that SULT1A1*2/*2 genotype is associated with increased risk for OC among subjects exposed to tobacco-smoke-related carcinogens. ..
- Wilborn T, Comer K, Dooley T, Reardon I, Heinrikson R, Falany C. Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase. Mol Pharmacol. 1993;43:70-7 pubmed..Characterization of P-PST at the molecular level provides insight into the structure and heterogeneity of this major class of drug-metabolizing enzymes. ..
- Yasuda S, Idell S, Fu J, Carter G, Snow R, Liu M. Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs. Toxicol Appl Pharmacol. 2007;221:13-20 pubmed..By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds. ..
- Wong C, Liyou N, Leggett B, Young J, Johnson A, McManus M. Association of the SULT1A1 R213H polymorphism with colorectal cancer. Clin Exp Pharmacol Physiol. 2002;29:754-8 pubmed..4. From this study, we conclude that the SULT1A1 R213H polymorphism is not linked with colorectal cancer in this elderly Australian population. ..
- Muckel E, Frandsen H, Glatt H. Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines. Food Chem Toxicol. 2002;40:1063-8 pubmed..Therefore, both O-acetylation and O-sulfonation by human enzymes have to be regarded as important determinants for HA genotoxicity in humans. ..
- Nowell S, Ahn J, Rae J, Scheys J, Trovato A, Sweeney C, et al. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat. 2005;91:249-58 pubmed..These studies indicate that genetic variation in Phase II conjugating enzymes can influence the efficacy of tamoxifen therapy for breast cancer. ..
- Pereira W, Paiva A, Queiroz J, Toma L, Dietrich C, Nader H, et al. Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer. Cancer Genet Cytogenet. 2005;160:55-60 pubmed..This decrease was more significant in cancer patients. The frequency of the SULT1A1( *)2 allele was increased in the myeloma group (odds ratio=0.53). These data suggest a functional role for the SULT1A1 gene polymorphism in cancer. ..
- Lilla C, Risch A, Kropp S, Chang Claude J. SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study. Breast Cancer Res. 2005;7:R229-37 pubmed..In combination with NAT2 fast acetylator status, however, the SULT1A1*1/*1 genotype might increase breast cancer risk in women exposed to tobacco smoke. ..
- Nagar S, Walther S, Blanchard R. Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation. Mol Pharmacol. 2006;69:2084-92 pubmed..These differences are potentially critical for understanding interindividual variability in drug response and toxicity, as well as cancer risk and incidence. ..
- Zhu X, Veronese M, Iocco P, McManus M. cDNA cloning and expression of a new form of human aryl sulfotransferase. Int J Biochem Cell Biol. 1996;28:565-71 pubmed
- Glatt H, Boeing H, Engelke C, Ma L, Kuhlow A, Pabel U, et al. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutat Res. 2001;482:27-40 pubmed..Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls. ..
- Yang G, Gao Y, Cai Q, Shu X, Cheng J, Zheng W. Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones. Breast Cancer Res Treat. 2005;94:63-70 pubmed..These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk. ..
- Raftogianis R, Wood T, Otterness D, Van Loon J, Weinshilboum R. Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype. Biochem Biophys Res Commun. 1997;239:298-304 pubmed..The allele frequency of SULT1A1*2 in a randomly selected population sample of 150 Caucasian blood donors was 0.31 (31%), indicating that approximately 9% of this population would be homozygous for that allele. ..
- Wang Z, Fu Y, Tang C, Lu S, Chu W. SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls. Breast Cancer Res Treat. 2010;122:193-8 pubmed publisher..03, 95% CI = 1.00-4.41, P (heterogeneity) = 0.62). Taken together, this meta-analysis suggests that the SULT1A1 R213H may be a low-penetrant risk factor for developing breast cancer in Asian population. ..
- Kotnis A, Kannan S, Sarin R, Mulherkar R. Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk. Br J Cancer. 2008;99:1340-7 pubmed publisher..92, 95% CI: 0.71, 1.18). Thus risk for different cancers in distinct ethnic groups could be modulated by interaction between genetic variants and different endogenous and exogenous carcinogens. ..
- Carlini E, Raftogianis R, Wood T, Jin F, Zheng W, Rebbeck T, et al. Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. Pharmacogenetics. 2001;11:57-68 pubmed..001). These observations represent a step towards determining the possible functional implications for individual variations in sulfate conjugation of common genetic polymorphisms for SULT1A1 and SULT1A2. ..
- Richard K, Hume R, Kaptein E, Stanley E, Visser T, Coughtrie M. Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain. J Clin Endocrinol Metab. 2001;86:2734-42 pubmed
- Jones A, Hagen M, Coughtrie M, Roberts R, Glatt H. Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form. Biochem Biophys Res Commun. 1995;208:855-62 pubmed
- Coughtrie M, Gilissen R, Shek B, Strange R, Fryer A, Jones P, et al. Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochem J. 1999;337 ( Pt 1):45-9 pubmed
- Ozawa S, Shimizu M, Katoh T, Miyajima A, Ohno Y, Matsumoto Y, et al. Sulfating-activity and stability of cDNA-expressed allozymes of human phenol sulfotransferase, ST1A3*1 ((213)Arg) and ST1A3*2 ((213)His), both of which exist in Japanese as well as Caucasians. J Biochem. 1999;126:271-7 pubmed..Protein instability and ST1A3 gene regulation may be both involved in the polymorphism of p-nitrophenol sulfation in human tissues. ..
- Sipilä J, Hood A, Coughtrie M, Taskinen J. CoMFA modeling of enzyme kinetics: K(m) values for sulfation of diverse phenolic substrates by human catecholamine sulfotransferase SULT1A3. J Chem Inf Comput Sci. 2003;43:1563-9 pubmed..624. These predictive QSAR models will provide us information about the factors that affect substrate binding at the active site of human catecholamine sulfotransferase SULT1A3. ..
- Seth P, Lunetta K, Bell D, Gray H, Nasser S, Rhei E, et al. Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. Cancer Res. 2000;60:6859-63 pubmed..The large number of environmental mutagens and carcinogens activated by sulfotransferases and the high frequency of the SULT1A1*1 allele in human populations warrants additional studies to address the role of SULT genes in human cancer. ..
- Yeh C, Yen G. Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity. J Agric Food Chem. 2003;51:1474-9 pubmed..71, p < 0.01; and r = 0.66, p < 0.01). These observations suggest that antioxidant phenolic acids might alter sulfate conjugation. ..
- Honma W, Shimada M, Sasano H, Ozawa S, Miyata M, Nagata K, et al. Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver. Drug Metab Dispos. 2002;30:944-9 pubmed..These findings suggest that accumulation of unmetabolized troglitazone causes the cytotoxicity in the hepatoma cells and may be responsible for toxicity in human liver. ..
- Berger I, Guttman C, Amar D, Zarivach R, Aharoni A. The molecular basis for the broad substrate specificity of human sulfotransferase 1A1. PLoS ONE. 2011;6:e26794 pubmed publisher..Our combined approach highlights the dominant role of SULT1A1 structural flexibility in controlling the specificity and activity of this enzyme. ..
- Eagle K. Toxicological effects of red wine, orange juice, and other dietary SULT1A inhibitors via excess catecholamines. Food Chem Toxicol. 2012;50:2243-9 pubmed publisher..SULT1A inhibition may be a key contributor to cheese-induced migraines (via annatto), false positives in metanephrine testing, and the cardiovascular impacts of recreational alcohols...
- Sparks R, Ulrich C, Bigler J, Tworoger S, Yasui Y, Rajan K, et al. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Breast Cancer Res. 2004;6:R488-98 pubmed..003). The risk of ER- breast cancer tumors may vary by UGT or SULT genotype. Further, plasma estradiol and testosterone concentrations in breast cancer patients may differ depending on some UGT and SULT genotypes. ..
- Zhu X, Veronese M, Bernard C, Sansom L, McManus M. Identification of two human brain aryl sulfotransferase cDNAs. Biochem Biophys Res Commun. 1993;195:120-7 pubmed..In a human hepatocellular carcinoma the same band plus an extra larger band was also recognised. An intron of the gene encoding the 1424 bp cDNA was also identified. ..
- Glatt H, Pabel U, Meinl W, Frederiksen H, Frandsen H, Muckel E. Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes. Carcinogenesis. 2004;25:801-7 pubmed..Another minor activation pathway involved benzylic hydroxylation followed by sulpho conjugation by SULT1A1. ..
- Dajani R, Cleasby A, Neu M, Wonacott A, Jhoti H, Hood A, et al. X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity. J Biol Chem. 1999;274:37862-8 pubmed
- Sun X, Ahmadi A, Arbman G, Wallin A, Asklid D, Zhang H. Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival. World J Gastroenterol. 2005;11:6875-9 pubmed..03). Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients. ..
- Spink B, Katz B, Hussain M, Pang S, Connor S, Aldous K, et al. SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells. Carcinogenesis. 2000;21:1947-57 pubmed..These results show that SULT1A1 is an efficient and selective catalyst of 2-MeOE(2) sulfonation and, as such, may be important in modulating the anticarcinogenic effects of 2-MeOE(2) that have been described recently. ..
- Hung R, Boffetta P, Brennan P, Malaveille C, Hautefeuille A, Donato F, et al. GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer. 2004;110:598-604 pubmed..26 (95% CI = 1.06-9.95). SULT1A1 Arg213His polymorphism showed a marginal protective effect. These findings suggest that individual susceptibility to bladder cancer may be modulated by GSTM1, GSTT1 and NAT2 polymorphisms. ..
- Hempel N, Gamage N, Martin J, McManus M. Human cytosolic sulfotransferase SULT1A1. Int J Biochem Cell Biol. 2007;39:685-9 pubmed
- Nowell S, Sweeney C, Winters M, Stone A, Lang N, Hutchins L, et al. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. J Natl Cancer Inst. 2002;94:1635-40 pubmed..These data alternatively suggest that variability in the metabolism of tamoxifen may affect its efficacy. ..
- Bamber D, Fryer A, Strange R, Elder J, Deakin M, Rajagopal R, et al. Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics. 2001;11:679-85 pubmed..These results suggest that the high activity SULT1A1*1 allozyme protects against dietary and/or environmental chemicals involved in the pathogenesis of colorectal cancer. ..
- Murias M, Miksits M, Aust S, Spatzenegger M, Thalhammer T, Szekeres T, et al. Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition. Cancer Lett. 2008;261:172-82 pubmed
- Cook I, Wang T, Almo S, Kim J, Falany C, Leyh T. The gate that governs sulfotransferase selectivity. Biochemistry. 2013;52:415-24 pubmed publisher..Equilibrium and pre-steady-state binding studies confirm that SULT1A1 undergoes a nucleotide-induced isomerzation that controls substrate selection. ..
- Nowell S, Ambrosone C, Ozawa S, MacLeod S, Mrackova G, Williams S, et al. Relationship of phenol sulfotransferase activity (SULT1A1) genotype to sulfotransferase phenotype in platelet cytosol. Pharmacogenetics. 2000;10:789-97 pubmed..4 versus 0.4 pmol bound/mg DNA/20 min) than the SULT1A1*2 variant. A similar pattern was observed with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5b]pyridine (N-OH-PhIP) (4.6 versus 1.8 pmol bound/mg DNA/20 min). ..
- van den Hurk P, Kubiczak G, Lehmler H, James M. Hydroxylated polychlorinated biphenyls as inhibitors of the sulfation and glucuronidation of 3-hydroxy-benzo[a]pyrene. Environ Health Perspect. 2002;110:343-8 pubmed..Inhibition of glucuronosyltransferase by low concentrations of OH-PCBs has not been reported before and may have important consequences for the bioavailability, bioaccumulation, and toxicity of other phenolic environmental contaminants. ..
- Kim K, Lee S, Park P, Ha J, Park J. Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups. Eur J Clin Pharmacol. 2005;61:743-7 pubmed..8919, chi2 = 343.24, P = 0.0034). SULT1A1*2 and SULT1A2*2 are the major allelic variants in the Korean population, whereas the SULT1A1*3 and SULT1A2*3 alleles were not found. SULT1A1*2 and SULT1A2*2 are strongly linked. ..
- Nishimuta H, Ohtani H, Tsujimoto M, Ogura K, Hiratsuka A, Sawada Y. Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. Biopharm Drug Dispos. 2007;28:491-500 pubmed..In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists. ..
- Chen K, Fan C, Jin M, Song L, Xu H, He H, et al. [A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]. Zhonghua Zhong Liu Za Zhi. 2006;28:670-3 pubmed..This study suggests that SULT1A1 slow sulfation combined with higher intake of red meat may be associated with an elevated risk of rectal cancer. ..
- Gamage N, Duggleby R, Barnett A, Tresillian M, Latham C, Liyou N, et al. Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J Biol Chem. 2003;278:7655-62 pubmed..Thus the crystal structure of SULT1A1 provides the molecular basis for substrate inhibition and reveals the first clues as to how the enzyme sulfonates a wide variety of lipophilic compounds. ..
- Grabinski J, Smith L, Chisholm G, Drengler R, Rodriguez G, Lang A, et al. Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy. Breast Cancer Res Treat. 2006;95:13-6 pubmed..26). SULT1A1 genotype did not correlate with any prognostic or predictive markers associated with breast cancer. Future evaluations will assess the functional significance of this polymorphism on survival. ..
- Jerevall P, Ahmadi A, Bergman M, Stal O, Wingren S. Sulfotransferase1A1 and risk of postmenopausal breast cancer. Anticancer Res. 2005;25:2515-7 pubmed..e. neither of the alleles is associated with an increased risk of breast cancer in the present study. ..
- Ozawa S, Katoh T, Inatomi H, Imai H, Kuroda Y, Ichiba M, et al. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002;102:418-21 pubmed..Combined analyses of different alleles of carcinogenic aromatic amine-activating phase II enzymes were applied to urothelial cancer risk for the first time and showed the highest risk combination of ST1A3 and NAT2 alleles. ..
- Moreno V, Glatt H, Guino E, Fisher E, Meinl W, Navarro M, et al. Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer. Int J Cancer. 2005;113:683-6 pubmed
- Steiner M, Bastian M, Schulz W, Pulte T, Franke K, Röhring A, et al. Phenol sulphotransferase SULT1A1 polymorphism in prostate cancer: lack of association. Arch Toxicol. 2000;74:222-5 pubmed..7% vs 17.4%). Our study does not support the hypothesis that the phenol sulphotransferase variant allele SULT1A1*2 with a G/A transition at nucleotide 638 is a risk modifier for prostate cancer in the Caucasian population. ..
- Wang L, Lehmler H, Robertson L, James M. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem Biol Interact. 2006;159:235-46 pubmed
- Dajani R, Hood A, Coughtrie M. A single amino acid, glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3. Mol Pharmacol. 1998;54:942-8 pubmed..These experiments confirm the functional role of Glu146 in the selectivity of SULT1A3 for biogenic amines and suggest that this region is a key determinant of sulfotransferase substrate specificity. ..
- Rohn K, Cook I, Leyh T, KADLUBAR S, Falany C. Potent inhibition of human sulfotransferase 1A1 by 17?-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity. Drug Metab Dispos. 2012;40:1588-95 pubmed publisher..In conclusion, EE2 is a potent inhibitor, but not a substrate, of SULT1A1 at low nanomolar concentrations, indicating the possibility of drug-drug interactions during contraceptive therapy. ..