vacuolar sorting protein vps15


Summary: A 150 kDa protein serine-threonine kinase that is found as a regulatory subunit of the class III phosphatidylinositol 3-kinases. The protein is believed to play an important role in the regulation of vesicular trafficking with the cell.

Top Publications

  1. Stjepanovic G, Baskaran S, Lin M, Hurley J. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex. Mol Cell. 2017;67:528-534.e3 pubmed publisher
    ..This pinpoints the dislodging and tethering of the VPS34 catalytic domain, and its regulation by VPS15, as a master allosteric switch in autophagy induction. ..