proto oncogene proteins c yes


Summary: Members of the src-family tyrosine kinases that are activated during the transition from G2 PHASE to M PHASE of the CELL CYCLE. It is highly homologous to PROTO-ONCOGENE PROTEIN PP60(C-SRC).

Top Publications

  1. Gregersen L, Jacobsen A, Frankel L, Wen J, Krogh A, Lund A. MicroRNA-145 targets YES and STAT1 in colon cancer cells. PLoS ONE. 2010;5:e8836 pubmed publisher
    ..The study identifies and validates new cancer-relevant direct targets of miR-145 in colon cancer cells and hereby adds important mechanistic understanding of the tumor-suppressive functions of miR-145. ..
  2. Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, et al. Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J Cell Sci. 2009;122:965-75 pubmed publisher
  3. Varrin Doyer M, Vincent P, Cavagna S, Auvergnon N, Noraz N, Rogemond V, et al. Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem. 2009;284:13265-76 pubmed publisher
    ..In addition to providing a novel mechanism for T lymphocyte motility, our findings reveal CRMP2 as a transducer of chemokine signaling. ..
  4. Matteucci E, Bendinelli P, Desiderio M. Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells. Carcinogenesis. 2009;30:937-45 pubmed publisher
    ..Wwox/Met system can be suggested as a potential target to impair breast carcinoma progression. ..
  5. Tournaviti S, Pietro E, Terjung S, Schafmeier T, Wegehingel S, Ritzerfeld J, et al. Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins. Traffic. 2009;10:1047-60 pubmed publisher
    ..We provide evidence that a cycle of phosphorylation and dephosphorylation may also be involved in intracellular targeting of other SH4 proteins such as the Src kinase Yes. ..
  6. Nayak R, Kearns M, Spielman R, Cheung V. Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. Genome Res. 2009;19:1953-62 pubmed publisher
    ..Therefore, our analysis of gene coexpression networks offers information on the role of human genes in normal and disease processes. ..
  7. Rahman M, Senga T, Ito S, Hyodo T, Hasegawa H, Hamaguchi M. S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion. J Biol Chem. 2010;285:3806-14 pubmed publisher
    ..These results identify a novel signaling pathway that links NO and Src family kinases to cancer cell invasion and metastasis. ..
  8. Sekigawa M, Kunoh T, Wada S, Mukai Y, Ohshima K, Ohta S, et al. Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals. J Biomol Screen. 2010;15:368-78 pubmed publisher
    ..The actions of one group are exerted through direct interactions with the human proteins, whereas those of the other group are mediated through interactions with chaperones. ..
  9. Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, et al. Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity. Circ Res. 2010;106:1839-48 pubmed publisher
    ..These data suggest that cell adhesion to extracellular matrix induces a downstream signaling using the tyrosine kinase receptor VEGFR-3 as scaffold. ..

More Information


  1. Le Lay S, Li Q, Proschogo N, Rodriguez M, Gunaratnam K, Cartland S, et al. Caveolin-1-dependent and -independent membrane domains. J Lipid Res. 2009;50:1609-20 pubmed publisher
    ..In contrast, the abundance of ordered domains in adherent cells is reduced in Cav1(-/-) compared with WT MEFs, suggesting that cell architecture is critical in maintaining Cav1-induced lipid rafts...
  2. Chen S, Khanna R, Bessette D, Samayawardhena L, Pallen C. Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration. Am J Physiol Cell Physiol. 2009;297:C133-9 pubmed publisher
  3. Lin Y, Huang J, Kan H, Frisbee J, Yu H. Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases. J Biol Chem. 2009;284:30433-40 pubmed publisher
    ..In conclusion, we demonstrate a novel mechanism using three endogenous Src kinases to rescue a trafficking defective HCN4 mutant channel (D553N) by enhancing the tyrosine phosphorylation of the mutant channel protein. ..
  4. Baranova L, Emelyanova V, Volotovski I. Role of the Yes and Csk tyrosine kinases in the development of a pathological state in the human retina. Mol Biol Rep. 2010;37:2727-33 pubmed publisher
  5. Konecny G, Glas R, Dering J, Manivong K, Qi J, Finn R, et al. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer. 2009;101:1699-708 pubmed publisher
    ..These data provide a clear biological rationale to test dasatinib as a single agent or in combination with chemotherapy in patients with ovarian cancer. ..
  6. Kubo T, Kuroda Y, Kokubu A, Hosoda F, Arai Y, Hiraoka N, et al. Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer. Pancreas. 2009;38:e200-6 pubmed publisher
    ..Our genome-wide resequencing approach revealed novel oncogenic pathways in pancreatic cancers. ..
  7. Lee J, Pyon J, Kim D, Lee S, Nam H, Kim C, et al. Elevated c-Src and c-Yes expression in malignant skin cancers. J Exp Clin Cancer Res. 2010;29:116 pubmed publisher
    ..Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis. c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers. ..