elongation factor 2 kinase


Summary: A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.

Top Publications

  1. Lomonosova Y, Belova S, Mirzoev T, Kozlovskaya I, Shenkman B. Eukaryotic elongation factor 2 kinase activation in M. soleus under 14-day hindlimb unloading of rats. Dokl Biochem Biophys. 2017;474:165-167 pubmed publisher
    ..The level of eEF2 phosphorylation in group HU14 was 80%, whereas in the control is was 40%. The indices of eEF2k expression and protein content in group HU14 increased compared to group C. ..
  2. Deng Z, Luo P, Lai W, Song T, Peng J, Wei H. Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis. Biochem Biophys Res Commun. 2017;494:278-284 pubmed publisher
    ..It provided a new mechanism for myostatin regulating protein synthesis and treating muscle atrophy...

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