aurora kinases

Summary

Summary: A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.

Top Publications

  1. Khodjakov A, Pines J. Centromere tension: a divisive issue. Nat Cell Biol. 2010;12:919-23 pubmed publisher
  2. Zhao X, Toyooka T, Ibuki Y. Silver nanoparticle-induced phosphorylation of histone H3 at serine 10 is due to dynamic changes in actin filaments and the activation of Aurora kinases. Toxicol Lett. 2017;276:39-47 pubmed publisher
    ..These results suggest that Ag ions released from AgNPs incorporated into inner cells changed the dynamics of actin filaments, and this was followed by the activation of AURKs, leading to the induction of p-H3S10. ..
  3. Janczyk P, Skorupka K, Tooley J, Matson D, Kestner C, WEST T, et al. Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores. Dev Cell. 2017;41:438-449.e4 pubmed publisher
  4. Ferguson F, Doctor Z, Chaikuad A, Sim T, Kim N, Knapp S, et al. Characterization of a highly selective inhibitor of the Aurora kinases. Bioorg Med Chem Lett. 2017;27:4405-4408 pubmed publisher
    b>Aurora kinases play an essential role in mitosis and cell cycle regulation. In recent years Aurora kinases have proved popular cancer targets and many inhibitors have been developed...
  5. Borisa A, Bhatt H. A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies. Eur J Med Chem. 2017;140:1-19 pubmed publisher
    ..We reported details of small molecules, specifically inhibiting all 3 types of Aurora kinases, which includes extensive literature search in various database like various scientific journals, patents, ..
  6. Pollard J, Mortimore M. Discovery and development of aurora kinase inhibitors as anticancer agents. J Med Chem. 2009;52:2629-51 pubmed publisher
  7. Lane S, Morgan S, Wu T, Collins J, Merriman J, Elinati E, et al. DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes. Development. 2017;144:3475-3486 pubmed publisher
    ..Therefore, mouse oocytes have a unique ability to sense DNA damage rapidly by activating the checkpoint at their kinetochores. ..