nm23 nucleoside diphosphate kinases
Summary: A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathways that effect CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS. They are considered multifunctional proteins that interact with a variety of cellular proteins and have functions that are unrelated to their enzyme activity.
Fang M, Tao Y, Liu Z, Huang H, Lao M, Huang L, et al
. Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features. Biomed Res Int. 2017;2017:8047183 pubmed publisher
..Therefore, large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting GC progression. ..
Sheng Y, Xiong Y, Xu M, Kuang X, Wang D, Yang X. [Effect of Nm23-H1 Nuclear Localization on Proliferation of ?Human Lung Adenocarcinoma Cell Line A549]. Zhongguo Fei Ai Za Zhi. 2017;20:226-232 pubmed publisher
..000,1??????a549???g0?/g1??????35.69%???????28.28%?t=1.461, p=0.217?????????g2?/m??????58.7%??????31.30%?t=4.560, p=0.010???? nm23-h1?????a549????????????????g2?/m?????????????. ..
Yuan C, Xu X, Xu L, Sun M, Ni L, Liu Y, et al
. Low expression of nm23-H1 associates with poor survival of nasopharyngeal carcinoma patients: A prisma-compliant meta-analysis. Medicine (Baltimore). 2017;96:e7153 pubmed publisher
..The low expression of nm23-H1 is associated with poorer prognosis in patients with NPC, suggesting that it is a prognostic factor and potential biomarker for survival in NPC. ..
Saha D, Singh A, Hussain T, Srivastava V, Sengupta S, Kar A, et al
. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. J Biol Chem. 2017;292:15205-15215 pubmed publisher
..Together, our results support a mechanism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be targeted by tailored small molecules. ..
Parada Sanchez M, Chu E, Cox L, Undurty S, Standley J, Murray J, et al
. Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate. J Dent Res. 2017;96:1330-1338 pubmed publisher
..The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1/2 complex and thus the dynamic behavior of epithelia during lip/palate development. ..
Xu D, Aka J, Wang R, Lin S. 17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation. J Steroid Biochem Mol Biol. 2017;171:270-280 pubmed publisher
..We thus propose that 17?-HSD5 may not be a potent target for breast cancer treatment but its low expression could represent a poor prognosis factor. ..
Wang Y, Huang Z, Chen S, Wang C, Shan C, Yin Q, et al
. Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction. J Med Chem. 2017;60:6924-6941 pubmed publisher
..This work provides a new strategy to modulate c-MYC transcription for the development of selective anticancer drugs. ..