nucleoside diphosphate kinase

Summary

Summary: An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside diphosphate, e.g., UDP, to form ADP and UTP. Many nucleoside diphosphates can act as acceptor, while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC 2.7.4.6.

Top Publications

  1. Kandeel M, Miyamoto T, Kitade Y. Bioinformatics, enzymologic properties, and comprehensive tracking of Plasmodium falciparum nucleoside diphosphate kinase. Biol Pharm Bull. 2009;32:1321-7 pubmed
    The gene encoding for nucleoside diphosphate kinase from Plasmodium falciparum was obtained by polymerase chain reaction (PCR) and expressed in Escherichia coli...
  2. Braun S, Mauch C, Boukamp P, Werner S. Novel roles of NM23 proteins in skin homeostasis, repair and disease. Oncogene. 2007;26:532-42 pubmed
    ..In a search for KGF-regulated genes, we identified the gene encoding the nucleoside diphosphate kinase NM23-H1...
  3. Niitsu N, Nakamine H, Okamoto M, Akamatsu H, Honma Y, Higashihara M, et al. Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma. Br J Haematol. 2003;123:621-30 pubmed
    ..The nm23-H1 protein can be an important prognostic factor in the lymphomas studied here. New treatments that target nm23 overexpression could be developed as a result of nm23-HI production by lymphoma cells. ..
  4. Wang N, Yoshida Y, Hasunuma K. Catalase-1 (CAT-1) and nucleoside diphosphate kinase-1 (NDK-1) play an important role in protecting conidial viability under light stress in Neurospora crassa. Mol Genet Genomics. 2007;278:235-42 pubmed
    ..in protecting conidial viability in Neurospora crassa, and interacted with a light signal transducer, nucleoside diphosphate kinase-1 (NDK-1)...
  5. Miranda M, Canepa G, Bouvier L, Pereira C. Trypanosoma cruzi nucleoside diphosphate kinase 1 ( TcNDPK1) has a broad nuclease activity. Parasitology. 2008;135:1661-6 pubmed publisher
    Here, we present the characterization of a trypanosomatid nucleoside diphosphate kinase (TcNDPK1) exhibiting nuclease activity. This is the first identification of a NDPK with this property in trypanosomatid organisms...
  6. Postel E. Multiple biochemical activities of NM23/NDP kinase in gene regulation. J Bioenerg Biomembr. 2003;35:31-40 pubmed
  7. Valenti D, Vacca R, de Pinto M, De Gara L, Marra E, Passarella S. In the early phase of programmed cell death in Tobacco Bright Yellow 2 cells the mitochondrial adenine nucleotide translocator, adenylate kinase and nucleoside diphosphate kinase are impaired in a reactive oxygen species-dependent manner. Biochim Biophys Acta. 2007;1767:66-78 pubmed
    ..7.4.3) and nucleoside diphosphate kinase (NDPK; EC 2.7.4.6) are inhibited in a non-competitive-like manner...
  8. Bennett S, Chen C, Mosbaugh D. Escherichia coli nucleoside diphosphate kinase does not act as a uracil-processing DNA repair nuclease. Proc Natl Acad Sci U S A. 2004;101:6391-6 pubmed
    Escherichia coli nucleoside diphosphate kinase (Ndk) catalyzes ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the cognate diphosphate precursor...
  9. Kimura N, Shimada N, Ishijima Y, Fukuda M, Takagi Y, Ishikawa N. Nucleoside diphosphate kinases in mammalian signal transduction systems: recent development and perspective. J Bioenerg Biomembr. 2003;35:41-7 pubmed
    ..Consequently, we propose a hypothesis that NDP kinases might act like a molecular switch to determine the cell fate toward proliferation or differentiation in response to environmental signals. ..

More Information

Publications80

  1. Muimo R, Crawford R, Mehta A. Nucleoside diphosphate kinase A as a controller of AMP-kinase in airway epithelia. J Bioenerg Biomembr. 2006;38:181-7 pubmed
    ..Thus we propose a novel paradigm in NDPK-A function by suggesting that AMP-kinase can be regulated by NDPK-A, independently of AMP. ..
  2. Lutz S, Mura R, Hippe H, Tiefenbacher C, Niroomand F. Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. Br J Pharmacol. 2003;140:1019-26 pubmed
    1. Receptor-independent activation of heterotrimeric G proteins by plasma membrane-associated nucleoside diphosphate kinase (NDPK) has been demonstrated in vivo, and elevated levels of NDPK were found in purified sarcolemmal membranes of ..
  3. Moon H, Lee B, Choi G, Shin D, Prasad D, Lee O, et al. NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. Proc Natl Acad Sci U S A. 2003;100:358-63 pubmed
    ..Thus, AtNDPK2 appears to play a previously uncharacterized regulatory role in H(2)O(2)-mediated MAPK signaling in plants. ..
  4. Cho S, Shin S, Kim K, Kim Y, Eun M, Cho B. Enhanced expression of a gene encoding a nucleoside diphosphate kinase 1 (OsNDPK1) in rice plants upon infection with bacterial pathogens. Mol Cells. 2004;18:390-5 pubmed
    ..OsNDPK1 gene expression was also strongly induced in response to exposure to salicylic acid, jasmonic acid, and abscisic acid, although the level of transcripts and their pattern of expression depended on the inducer...
  5. Verslues P, Batelli G, Grillo S, Agius F, Kim Y, Zhu J, et al. Interaction of SOS2 with nucleoside diphosphate kinase 2 and catalases reveals a point of connection between salt stress and H2O2 signaling in Arabidopsis thaliana. Mol Cell Biol. 2007;27:7771-80 pubmed
    ..SOS2 was found to interact with the H2O2 signaling protein nucleoside diphosphate kinase 2 (NDPK2) and to inhibit its autophosphorylation activity...
  6. Yoshida Y, Ogura Y, Hasunuma K. Interaction of nucleoside diphosphate kinase and catalases for stress and light responses in Neurospora crassa. FEBS Lett. 2006;580:3282-6 pubmed publisher
    b>Nucleoside diphosphate kinase (NDK) is an ubiquitous enzyme with the function of a signal transducer. In Neurospora crassa, an ndk-1(P72H) mutant carrying the point mutation Pro72His was isolated...
  7. Chopra P, Koduri H, Singh R, Koul A, Ghildiyal M, Sharma K, et al. Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases. FEBS Lett. 2004;571:212-6 pubmed
    ..b>Nucleoside diphosphate kinase (Ndk) was identified as this culture supernatant protein that stimulated in vitro GTP hydrolysis by ..
  8. Wieland T. Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers: consequences on G protein activation and stability. Naunyn Schmiedebergs Arch Pharmacol. 2007;374:373-83 pubmed
    ..In addition, the transfer of high energetic phosphate by nucleoside diphosphate kinase (NDPK) and/or the beta subunit of G proteins (Gbeta) can induce G protein activation...
  9. Hippe H, Luedde M, Lutz S, Koehler H, Eschenhagen T, Frey N, et al. Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circ Res. 2007;100:1191-9 pubmed
    ..alpha subunits can be activated by a phosphate transfer via a plasma membrane-associated complex of nucleoside diphosphate kinase B (NDPK B) and G protein betagamma-dimers (Gbetagamma)...
  10. Yonezawa Y, Tokunaga H, Ishibashi M, Taura S, Tokunaga M. Cloning, expression, and efficient purification in Escherichia coli of a halophilic nucleoside diphosphate kinase from the moderate halophile Halomonas sp. #593. Protein Expr Purif. 2003;27:128-33 pubmed
    ..In this report, we describe cloning of the ndk gene of nucleoside diphosphate kinase from a moderately halophilic eubacterium and overexpression of the protein in E...
  11. Lee B, Yoshida Y, Hasunuma K. Nucleoside diphosphate kinase-1 regulates hyphal development via the transcriptional regulation of catalase in Neurospora crassa. FEBS Lett. 2009;583:3291-5 pubmed publisher
    A nucleoside diphosphate kinase-1-disrupted (ndk-1(RIP-1)) mutant was observed to be defective in aerial hyphal and conidial development. In this study, two types of hyphae, fine and thick, were observed in wild-type (Wt) strains...
  12. Dar H, Chakraborti P. Intermolecular phosphotransfer is crucial for efficient catalytic activity of nucleoside diphosphate kinase. Biochem J. 2010;430:539-49 pubmed publisher
    NDK (nucleoside diphosphate kinase) is primarily involved in maintaining cellular nucleotide pools in both prokaryotes and eukaryotes...
  13. Bosnar M, de Gunzburg J, Bago R, Brecevic L, Weber I, Pavelic J. Subcellular localization of A and B Nm23/NDPK subunits. Exp Cell Res. 2004;298:275-84 pubmed
    The human Nm23-H1/NDPK A and Nm23-H2/NDPK B encode for two subunits of nucleoside diphosphate kinase--a ubiquitous enzyme that transfers the terminal phosphates from ATP to (d)NDPs...
  14. Kumar P, Verma A, Saini A, Chopra P, Chakraborti P, Singh Y, et al. Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction. Nucleic Acids Res. 2005;33:2707-14 pubmed
    The reason for secretion of nucleoside diphosphate kinase (NdK), an enzyme involved in maintaining the cellular pool of nucleoside triphosphates in both prokaryotes and eukaryotes, by Mycobacterium tuberculosis is intriguing...
  15. Lombardi D, Mileo A. Protein interactions provide new insight into Nm23/nucleoside diphosphate kinase functions. J Bioenerg Biomembr. 2003;35:67-71 pubmed
    ..The findings herein summarized provide new and intriguing suggestions for a more extensive understanding of the biological functions of the Nm23 proteins. ..
  16. Chen Y, Morera S, Mocan J, Lascu I, Janin J. X-ray structure of Mycobacterium tuberculosis nucleoside diphosphate kinase. Proteins. 2002;47:556-7 pubmed
  17. Miller J, Funchain P, Clendenin W, Huang T, Nguyen A, Wolff E, et al. Escherichia coli strains (ndk) lacking nucleoside diphosphate kinase are powerful mutators for base substitutions and frameshifts in mismatch-repair-deficient strains. Genetics. 2002;162:5-13 pubmed
  18. Amutha B, Pain D. Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial intermembrane space. Biochem J. 2003;370:805-15 pubmed
    b>Nucleoside diphosphate kinase (NDPK) is a highly conserved multifunctional enzyme...
  19. Epand R, Schlattner U, Wallimann T, Lacombe M, Epand R. Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes. Biophys J. 2007;92:126-37 pubmed
    This study provides evidence of a novel function for mitochondrial creatine kinase (MtCK) and nucleoside diphosphate kinase (NDPK-D)...
  20. Chopra P, Singh A, Koul A, Ramachandran S, Drlica K, Tyagi A, et al. Cytotoxic activity of nucleoside diphosphate kinase secreted from Mycobacterium tuberculosis. Eur J Biochem. 2003;270:625-34 pubmed
    ..A component of these enzymes is nucleoside diphosphate kinase (Ndk). The ndk gene was cloned from M. tuberculosis H37Rv and expressed in Escherichia coli...
  21. Shen R, Olcott M, Kim J, Rajagopal I, Mathews C. Escherichia coli nucleoside diphosphate kinase interactions with T4 phage proteins of deoxyribonucleotide synthesis and possible regulatory functions. J Biol Chem. 2004;279:32225-32 pubmed publisher
    In both prokaryotic and eukaryotic organisms, nucleoside diphosphate kinase is a multifunctional protein, with well defined functions in ribo- and deoxyribonucleoside triphosphate biosynthesis and more recently described functions in ..
  22. Kowluru A. Defective protein histidine phosphorylation in islets from the Goto-Kakizaki diabetic rat. Am J Physiol Endocrinol Metab. 2003;285:E498-503 pubmed
    ..g., nucleoside diphosphate kinase and succinyl thiokinase) in insulin secretion from the islet beta-cell (Kowluru A...
  23. Schneider B, Norda A, Karlsson A, Veron M, Deville Bonne D. Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase. Protein Sci. 2002;11:1648-56 pubmed
    ..For the first time, the true equilibrium dissociation constants of NDP for the analog of the phosphoenzyme are determined in the absence of phosphotransfer, allowing a better understanding of the catalytic mechanism of the enzyme. ..
  24. Mizrahi A, Molshanski Mor S, Weinbaum C, Zheng Y, Hirshberg M, Pick E. Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. J Biol Chem. 2005;280:3802-11 pubmed
    ..oxidase activation is explained by ATP serving as a gamma-phosphoryl donor for a membrane-localized nucleoside diphosphate kinase (NDPK), converting GDP to GTP...
  25. Niitsu N, Nakamine H, Okamoto M, Akamatsu H, Higashihara M, Honma Y, et al. Clinical significance of intracytoplasmic nm23-H1 expression in diffuse large B-cell lymphoma. Clin Cancer Res. 2004;10:2482-90 pubmed
    ..We suggest that nm23-H1 expression is a prognostic factor for DLBCL, and that it is as important as serum nm23-H1, both of which are useful for planning a treatment strategy. ..
  26. Giraud M, Georgescauld F, Lascu I, Dautant A. Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP. J Bioenerg Biomembr. 2006;38:261-4 pubmed
    ..This suggests that the S120G mutation may affect an other protein property than NDP kinase activity. ..
  27. Dorion S, Matton D, Rivoal J. Characterization of a cytosolic nucleoside diphosphate kinase associated with cell division and growth in potato. Planta. 2006;224:108-24 pubmed
    ..These data suggest that NDPK1 plays a specific role in the supply of UTP during early growth of plant meristematic and provascular tissues. ..
  28. Lin X, Momany C, Momany M. SwoHp, a nucleoside diphosphate kinase, is essential in Aspergillus nidulans. Eukaryot Cell. 2003;2:1169-77 pubmed
  29. Kowluru A, Tannous M, Chen H. Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch Biochem Biophys. 2002;398:160-9 pubmed
    b>Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of terminal phosphates from nucleoside triphosphates to nucleoside diphosphates to yield nucleotide triphosphates...
  30. Hammargren J, Rosenquist S, Jansson C, Knorpp C. A novel connection between nucleotide and carbohydrate metabolism in mitochondria: sugar regulation of the Arabidopsis nucleoside diphosphate kinase 3a gene. Plant Cell Rep. 2008;27:529-34 pubmed
    ..In this study we investigated the impact of sucrose on the expression of the Arabidopsis thaliana Nucleoside Diphosphate Kinase gene family (NDPK, EC 2.7.4...
  31. Patel King R, Gorbatyuk O, Takebe S, King S. Flagellar radial spokes contain a Ca2+-stimulated nucleoside diphosphate kinase. Mol Biol Cell. 2004;15:3891-902 pubmed
    ..Here, we describe a novel nucleoside diphosphate kinase (NDK) from the Chlamydomonas flagellum...
  32. Sureka K, Sanyal S, Basu J, Kundu M. Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteria. Mol Microbiol. 2009;74:1187-97 pubmed publisher
    ..We present evidence that PPK2 does so by interacting with nucleoside diphosphate kinase (Ndk)...
  33. Ishikawa N, Shimada N, Takagi Y, Ishijima Y, Fukuda M, Kimura N. Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions. J Bioenerg Biomembr. 2003;35:7-18 pubmed
    ..In terms of this process, the transcription system would control another layer of gene expression: posttranscriptional (translational) regulation. ..
  34. Kolli B, Kostal J, Zaborina O, Chakrabarty A, Chang K. Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Mol Biochem Parasitol. 2008;158:163-75 pubmed publisher
    Leishmania amazonensis was found to release nucleoside diphosphate kinase (NdK)-a stable enzyme capable of decreasing extracellular ATP...
  35. Shen Y, Han Y, Kim J, Song P. Arabidopsis nucleoside diphosphate kinase-2 as a plant GTPase activating protein. BMB Rep. 2008;41:645-50 pubmed
    b>Nucleoside diphosphate kinase (NDPK) is involved in multiple signaling pathways in mammalian systems, including G-protein signaling...
  36. Postel E, Abramczyk B. Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nuclease. Proc Natl Acad Sci U S A. 2003;100:13247-52 pubmed
    Escherichia coli nucleoside diphosphate kinase (eNDK) is an XTP:XDP phosphotransferase that plays an important role in the regulation of cellular nucleoside triphosphate concentrations...
  37. Postel E, Abramczyk B, Gursky S, Xu Y. Structure-based mutational and functional analysis identify human NM23-H2 as a multifunctional enzyme. Biochemistry. 2002;41:6330-7 pubmed
    ..A model consistent with these observations is presented. ..
  38. Dorion S, Dumas F, Rivoal J. Autophosphorylation of Solanum chacoense cytosolic nucleoside diphosphate kinase on Ser117. J Exp Bot. 2006;57:4079-88 pubmed
    ..These findings provide evidence that autophosphorylation of cytosolic NDPK on Ser117 could constitute a regulatory mechanism for this important enzyme and that autophosphorylation of Ser117 is modulated by NDP availability. ..
  39. Kowluru A, Veluthakal R, Kaetzel D. Regulatory roles for nm23/nucleoside diphosphate kinase-like enzymes in insulin secretion from the pancreatic islet beta cell. J Bioenerg Biomembr. 2006;38:227-32 pubmed
    ..We recently proposed that nm23/nucleoside diphosphate kinase (NDPK) catalyzes an alternate, non-receptor-dependent activation of islet endogenous G-proteins...
  40. Mocan I, Georgescauld F, Gonin P, Thoraval D, Cervoni L, Giartosio A, et al. Protein phosphorylation corrects the folding defect of the neuroblastoma (S120G) mutant of human nucleoside diphosphate kinase A/Nm23-H1. Biochem J. 2007;403:149-56 pubmed
    ..coli. Its renaturation stops at a folding intermediate and cannot be reactivated by ATP in vitro. The transfection of cells with this double mutant might be a good model to study the cellular effects of folding intermediates. ..
  41. Cuello F, Schulze R, Heemeyer F, Meyer H, Lutz S, Jakobs K, et al. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003;278:7220-6 pubmed
    ..Immunoblots, autophosphorylation, and enzymatic activity measurements demonstrated enriched nucleoside diphosphate kinase (NDPK) B in both preparations, together with residual Gbetagamma dimers...
  42. Kapetanovich L, Baughman C, Lee T. Nm23H2 facilitates coat protein complex II assembly and endoplasmic reticulum export in mammalian cells. Mol Biol Cell. 2005;16:835-48 pubmed
    ..The factor was purified and identified by mass spectrometry as Nm23H2, one of eight isoforms of nucleoside diphosphate kinase in mammalian cells...
  43. Allard L, Burkhard P, Lescuyer P, Burgess J, Walter N, Hochstrasser D, et al. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin Chem. 2005;51:2043-51 pubmed
    ..PARK7 and nucleoside diphosphate kinase A (NDKA) are increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, ..
  44. Almgren M, Henriksson K, Fujimoto J, Chang C. Nucleoside diphosphate kinase A/nm23-H1 promotes metastasis of NB69-derived human neuroblastoma. Mol Cancer Res. 2004;2:387-94 pubmed
    b>Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor in certain human tumors such as breast carcinoma...
  45. Shen Y, Kim J, Song P. Autophosphorylation of Arabidopsis nucleoside diphosphate kinase 2 occurs only on its active histidine residue. Biochemistry. 2006;45:1946-9 pubmed
    Arabidopsis nucleoside diphosphate kinase 2 (NDPK2) is a component in the phytochrome-mediated light signaling. In the present study, its autophosphorylation was investigated...
  46. Anderca M, Furuichi T, Pinontoan R, Muto S. Identification of a mitochondrial nucleoside diphosphate kinase from the green alga Dunaliella tertiolecta. Plant Cell Physiol. 2002;43:1276-84 pubmed
    ..Confocal microscopy on yeast cells expressing the recombinant protein revealed the specific mitochondrial localization of DtNDK1 labeled at the C-terminus with green fluorescent protein. ..
  47. Roymans D, Willems R, Van Blockstaele D, Slegers H. Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis. Clin Exp Metastasis. 2002;19:465-76 pubmed
  48. Bölter B, Sharma R, Soll J. Localisation of Arabidopsis NDPK2--revisited. Planta. 2007;226:1059-65 pubmed
    ..Plant nucleoside diphosphate kinase 2 (NDPK2) has been reported to be a component of the light-mediated signalling cascade and to interact ..
  49. Hammargren J, Salinas T, Maréchal Drouard L, Knorpp C. The pea mitochondrial nucleoside diphosphate kinase cleaves DNA and RNA. FEBS Lett. 2007;581:3507-11 pubmed
    ..ATP inhibits this nuclease activity, while ADP has no effect. Furthermore, studies on NDPK mutant proteins indicate that the nuclease- and the kinase-mechanisms are separate. ..
  50. Hippe H, Lutz S, Cuello F, Knorr K, Vogt A, Jakobs K, et al. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. J Biol Chem. 2003;278:7227-33 pubmed
    Formation of GTP by nucleoside diphosphate kinase (NDPK) can contribute to G protein activation in vitro...
  51. Kim S, Fountoulakis M, Cairns N, Lubec G. Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome. Biochem Biophys Res Commun. 2002;296:970-5 pubmed
    In brain, nucleoside diphosphate kinase (NDPK) and its coding gene, nm23, have been implicated to modulate neuronal cell proliferation, differentiation, and neurite outgrowth...
  52. Willems R, Slegers H, Rodrigus I, Moulijn A, Lenjou M, Nijs G, et al. Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation. Exp Hematol. 2002;30:640-8 pubmed
    We previously demonstrated the presence of nucleoside diphosphate kinase NDPK/NM23 in normal human plasma. It also was reported that extracellular NM23 could inhibit differentiation of certain hematopoietic cell lines...
  53. Rumjahn S, Javed M, Wong N, Law W, Buxton I. Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase. Br J Cancer. 2007;97:1372-80 pubmed
    MDA-MB-435S human breast cancer cells (435S) secrete nucleoside diphosphate kinase (NDPK) that supports metastases and is inhibited by epigallocatechin gallate (EGCG) and ellagic acid (EA)...
  54. Gallois Montbrun S, Veron M, Deville Bonne D. Antiviral nucleoside analogs phosphorylation by nucleoside diphosphate kinase. Mini Rev Med Chem. 2004;4:361-9 pubmed
    ..The catalytic efficiency, also related to the affinity of the analog, is mainly dependent on the presence of a 3'-OH group on the ribose moiety. ..
  55. Chen C, Liu M, Chang T, Chang W, Wang B, Le Gall J. Crystal structure of a nucleoside diphosphate kinase from Bacillus halodenitrificans: coexpression of its activity with a Mn-superoxide dismutase. J Struct Biol. 2003;142:247-55 pubmed
    ..and reassociates into two active components, a Mn-containing superoxide dismutase (SOD) and a nucleoside diphosphate kinase (BhNDK). The crystal structure of this latter enzyme has been determined at 2...
  56. Misra G, Aggarwal A, Dube D, Zaman M, Singh Y, Ramachandran R. Crystal structure of the Bacillus anthracis nucleoside diphosphate kinase and its characterization reveals an enzyme adapted to perform under stress conditions. Proteins. 2009;76:496-506 pubmed publisher
    ..We report the characterization and crystal structure of the enzyme from B. anthracis nucleoside diphosphate kinase (BaNdk), the first from sporulating bacteria...
  57. Shi X, Zhao X, Wang J. Molecular cloning and analysis of function of nucleoside diphosphate kinase (NDPK) from the scallop Chlamys farreri. Biochemistry (Mosc). 2008;73:686-92 pubmed
    b>Nucleoside diphosphate kinase (NDPK) is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate (NTP) by transferring the terminal phosphate between nucleoside diphosphate (NDP) and NTP...
  58. Tokunaga H, Ishibashi M, Arisaka F, Arai S, Kuroki R, Arakawa T, et al. Residue 134 determines the dimer-tetramer assembly of nucleoside diphosphate kinase from moderately halophilic bacteria. FEBS Lett. 2008;582:1049-54 pubmed publisher
    Halomonas nucleoside diphosphate kinase (HaNDK) forms a dimeric assembly and Pseudomonas NDK (PaNDK) forms a tetrameric assembly...
  59. Yoshida Y, Hasunuma K. Light-dependent subcellular localization of nucleoside diphosphate kinase-1 in Neurospora crassa. FEMS Microbiol Lett. 2006;261:64-8 pubmed publisher
    b>Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme localized in cellular organelles and distributed in various organs in prokaryotes and eukaryotes...
  60. Kumar M, Jayaram H, Vasquez Del Carpio R, Jiang X, Taraporewala Z, Jacobson R, et al. Crystallographic and biochemical analysis of rotavirus NSP2 with nucleotides reveals a nucleoside diphosphate kinase-like activity. J Virol. 2007;81:12272-84 pubmed
    ..The newly observed phosphoryl-transfer activity of NSP2 may be utilized for homeostasis of nucleotide pools in viroplasms during genome replication. ..
  61. Fan Z, Beresford P, Oh D, Zhang D, Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 2003;112:659-72 pubmed
    ..We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET...
  62. Tang L, Kim M, Yang K, Kwon S, Kim S, Kim J, et al. Enhanced tolerance of transgenic potato plants overexpressing nucleoside diphosphate kinase 2 against multiple environmental stresses. Transgenic Res. 2008;17:705-15 pubmed
    In plants, nucleoside diphosphate kinase 2 (NDPK2) is known to regulate the expression of antioxidant genes. In this study, we developed transgenic potato plants (Solanum tuberosum L. cv...
  63. Tiwari S, Kishan K, Chakrabarti T, Chakraborti P. Amino acid residues involved in autophosphorylation and phosphotransfer activities are distinct in nucleoside diphosphate kinase from Mycobacterium tuberculosis. J Biol Chem. 2004;279:43595-603 pubmed
    b>Nucleoside diphosphate kinase (NdK) is a ubiquitous enzyme in both prokaryotes and eukaryotes and is primarily involved in the maintenance of cellular nucleotide pools...
  64. Moynié L, Giraud M, Georgescauld F, Lascu I, Dautant A. The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family. Proteins. 2007;67:755-65 pubmed
    b>Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates...
  65. Veluthakal R, Suresh M, Kowluru A. Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity. Mol Cell Biochem. 2009;329:121-9 pubmed publisher
    Previously, we reported a significant reduction in expression and the activity of nucleoside diphosphate kinase (NDP kinase) in islets derived from the Goto-Kakizaki rat (GK rat), an animal model for type 2 diabetes...
  66. Narayanan R, Ramaswami M. Regulation of dynamin by nucleoside diphosphate kinase. J Bioenerg Biomembr. 2003;35:49-55 pubmed
    ..In this context, we discuss the possible relevance of NDP kinase and dynamin interaction for tumor suppression. ..
  67. Srivastava S, Li Z, Ko K, Choudhury P, Albaqumi M, Johnson A, et al. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Mol Cell. 2006;24:665-675 pubmed publisher
    ..We show that nucleoside diphosphate kinase B (NDPK-B), a mammalian histidine kinase, functions downstream of PI(3)P to activate KCa3.1...
  68. Yoon J, Singh P, Lee D, Qiu J, Cai S, O Connor T, et al. Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues. Biochemistry. 2005;44:15774-86 pubmed
    ..These results suggest that, in addition to maintenance of nucleotide pool balance, the human NDK-like proteins may have previously unrecognized roles in DNA nucleolytic processing. ..
  69. Okabe Kado J, Kasukabe T. Physiological and pathological relevance of extracellular NM23/NDP kinases. J Bioenerg Biomembr. 2003;35:89-93 pubmed
    ..These results suggest that the effect of NM23-H1 protein on normal PBMNC may be associated with a poor prognosis in hematological malignancies. ..
  70. Miranda M, Canepa G, Bouvier L, Pereira C. Trypanosoma cruzi: multiple nucleoside diphosphate kinase isoforms in a single cell. Exp Parasitol. 2008;120:103-7 pubmed publisher
    ..cruzi genome database. The large number and diversity of NDPK isoforms are in agreement with those previously observed for other T. cruzi phosphotransferases, such as adenylate kinases. ..
  71. Treharne K, Best O, Mehta A. The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP. Mol Cell Biochem. 2009;329:107-14 pubmed publisher
    b>Nucleoside diphosphate kinase (NDPK) has many roles and is present in different locations in the cell. Membrane-bound NDPK is present in epithelial fractions enriched for the apical membrane...