guanylate kinases


Summary: Catalyzes the ATP-dependent PHOSPHORYLATION of GMP to generate GDP and ADP.

Top Publications

  1. Craven S, Bredt D. PDZ proteins organize synaptic signaling pathways. Cell. 1998;93:495-8 pubmed
  2. Tomita S, Nicoll R, Bredt D. PDZ protein interactions regulating glutamate receptor function and plasticity. J Cell Biol. 2001;153:F19-24 pubmed
  3. Kurkewich J, Hansen J, Klopfenstein N, Zhang H, Wood C, Boucher A, et al. The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. PLoS Genet. 2017;13:e1006887 pubmed publisher
    ..In summary, our data demonstrates that mirn23a regulates a complex array of transcription and signaling pathways to modulate adult hematopoiesis. ..
  4. Shirata N, Ihara K, Yamamoto Nonaka K, Seki T, Makino S, Oliva Trejo J, et al. Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes. J Am Soc Nephrol. 2017;28:2654-2669 pubmed publisher
    ..In summary, MAGI-2 and Fyn protect dendrin from Nedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS. ..
  5. Liang C, Kerr A, Qiu Y, Cristofoli F, Van Esch H, Fox M, et al. Optic Nerve Hypoplasia Is a Pervasive Subcortical Pathology of Visual System in Neonates. Invest Ophthalmol Vis Sci. 2017;58:5485-5496 pubmed publisher
  6. Hsueh Y. A versatile player. J Mol Biol. 2011;412:1-2 pubmed publisher
  7. Li J, Han Z, Cao B, Cai C, Lin Y, Li F, et al. Disrupting nNOS-PSD-95 coupling in the hippocampal dentate gyrus promotes extinction memory retrieval. Biochem Biophys Res Commun. 2017;493:862-868 pubmed publisher
    ..These findings suggest that the nNOS-PSD-95 complex may serve as a novel target for the treatment of post-traumatic stress disorder (PTSD). ..
  8. Nakamura K, Nishiyama K, Kodera H, Nakashima M, Tsurusaki Y, Miyake N, et al. A de novo CASK mutation in pontocerebellar hypoplasia type 3 with early myoclonic epilepsy and tetralogy of Fallot. Brain Dev. 2014;36:272-3 pubmed publisher
  9. Zhu D, Li C, Swanson A, Villalba R, Guo J, Zhang Z, et al. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015;125:1497-508 pubmed publisher
    ..Moreover, these results suggest that targeting this pathway has therapeutic potential for a variety of neurological disorders. ..

More Information


  1. Stolzer M, Siewert K, Lai H, Xu M, Durand D. Event inference in multidomain families with phylogenetic reconciliation. BMC Bioinformatics. 2015;16 Suppl 14:S8 pubmed publisher
    ..These case studies reveal a more vivid and detailed evolutionary history than previously provided. Our algorithms have been implemented in software, freely available atËœdurand/Notung. ..
  2. Sen T, Gupta R, Kaiser H, Sen N. Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury. J Neurosci. 2017;37:5900-5911 pubmed publisher
    ..Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI. ..
  3. Frank R, Zhu F, Komiyama N, Grant S. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. J Neurochem. 2017;142:504-511 pubmed publisher
    ..Read the Editorial Highlight for this article on page 500. Cover Image for this issue: doi. 10.1111/jnc.13811. ..
  4. Li J, Zhang W, Yang H, Howrigan D, Wilkinson B, Souaiaia T, et al. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017;20:1150-1161 pubmed publisher
    ..These results were integrated into a software platform, Synaptic Protein/Pathways Resource (SyPPRes), enabling the prioritization of disease risk factors and their placement within synaptic protein interaction networks. ..
  5. Das S, Knust E. Stardust, the Janus-faced partner of Crumbs. J Cell Biol. 2017;216:1219-1221 pubmed publisher
    ..2017. J. Cell Biol report that a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical determinant. ..
  6. Perez Mockus G, Roca V, Mazouni K, Schweisguth F. Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms. J Cell Biol. 2017;216:1405-1420 pubmed publisher
    ..Thus, our study uncovers a novel regulatory mechanism for the developmental control of Crb-mediated morphogenesis. ..
  7. Sheng M, Kim E. The postsynaptic organization of synapses. Cold Spring Harb Perspect Biol. 2011;3: pubmed publisher
  8. Tiffany A, Manganas L, Kim E, Hsueh Y, Sheng M, Trimmer J. PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering. J Cell Biol. 2000;148:147-58 pubmed
    Mechanisms of ion channel clustering by cytoplasmic membrane-associated guanylate kinases such as postsynaptic density 95 (PSD-95) and synapse-associated protein 97 (SAP97) are poorly understood...
  9. Duran Fernández Feijoo C, Carrasco Carrasco C, Villalmazo Francisco N, Cebrià Romero J, Fernández Lorenzo J, Jimenez Chillaron J, et al. Influence of catch up growth on spatial learning and memory in a mouse model of intrauterine growth restriction. PLoS ONE. 2017;12:e0177468 pubmed publisher
    ..CUG after a period of prenatal malnutrition seems to improve learning skills. The functional alterations observed might be related to lower PSD95 activity and a possible dysfunction in the hormone regulation of synaptic plasticity. ..
  10. Reggiani C, Coppens S, Sekhara T, DIMOV I, Pichon B, Lufin N, et al. Novel promoters and coding first exons in DLG2 linked to developmental disorders and intellectual disability. Genome Med. 2017;9:67 pubmed publisher
    ..In addition, our work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases. ..
  11. Lozada L, Desai A, Kevala K, Lee J, Kim H. Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice. J Nutr. 2017;147:1624-1630 pubmed publisher
    ..b>Conclusion: Developmental deprivation of brain DHA by dietary ?-3 FA depletion in mice may have a lasting impact on cognitive function if not corrected at an early age. ..
  12. Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher