diacylglycerol kinase

Summary

Summary: An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol to a phosphatidate. EC 2.7.1.107.

Top Publications

  1. De La Roche M, Smith J, Rico M, Carrasco S, Merida I, Licate L, et al. Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms. Biochem J. 2002;368:809-15 pubmed
    ..Earlier studies indicating that disruption of this locus alters myosin II assembly levels in Dictyostelium raise the intriguing possibility that DG and/or PA metabolism may play a role in controlling myosin II assembly in this system. ..
  2. Gharbi S, Rincón E, Avila Flores A, Torres Ayuso P, Almena M, Cobos M, et al. Diacylglycerol kinase ? controls diacylglycerol metabolism at the immunological synapse. Mol Biol Cell. 2011;22:4406-14 pubmed publisher
    ..This study highlights a DGK?-specific function for local DAG metabolism at the IS and offers new clues to its mode of regulation. ..
  3. Ullrich S, Hellmich U, Ullrich S, Glaubitz C. Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR. Nat Chem Biol. 2011;7:263-70 pubmed publisher
    ..One such enzyme, the Escherichia coli integral membrane protein diacylglycerol kinase (DGK), is a key player in lipid regulation...
  4. Chouquet B, Bozzolan F, Solvar M, Duportets L, Jacquin Joly E, Lucas P, et al. Molecular cloning and expression patterns of a putative olfactory diacylglycerol kinase from the noctuid moth Spodoptera littoralis. Insect Mol Biol. 2008;17:485-93 pubmed
    ..actors of insect olfactory transduction, we have cloned the full cDNA encoding a Spodoptera littoralis diacylglycerol kinase (DGK) named SlDGK...
  5. Chibalin A, Leng Y, Vieira E, Krook A, Björnholm M, Long Y, et al. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008;132:375-86 pubmed publisher
    ..We identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients...
  6. Rincón E, Santos T, Avila Flores A, Albar J, Lalioti V, Lei C, et al. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. Mol Cell Proteomics. 2007;6:1073-87 pubmed
    b>Diacylglycerol kinase zeta is a member of the diacylglycerol kinase family of enzymes, which generate phosphatidic acid through diacylglycerol phosphorylation...
  7. Olenchock B, Guo R, Silverman M, Wu J, Carpenter J, Koretzky G, et al. Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med. 2006;203:1471-80 pubmed
    ..b>Diacylglycerol kinase (DGK)zeta is a negative regulator of diacylglycerol-dependent signaling that acts by converting ..
  8. Li D, Lyons J, Pye V, Vogeley L, Aragao D, Kenyon C, et al. Crystal structure of the integral membrane diacylglycerol kinase. Nature. 2013;497:521-4 pubmed publisher
    b>Diacylglycerol kinase catalyses the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid for use in shuttling water-soluble components to membrane-derived oligosaccharide and lipopolysaccharide in the cell envelope of ..
  9. Li D, Caffrey M. Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes. Proc Natl Acad Sci U S A. 2011;108:8639-44 pubmed publisher
    ..Here, we describe a procedure for characterizing the catalytic properties of the integral membrane enzyme, diacylglycerol kinase, reconstituted into the bilayer of the lipidic cubic phase...

More Information

Publications62

  1. Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato P, et al. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci U S A. 2010;107:4182-7 pubmed publisher
  2. Van Horn W, Kim H, Ellis C, Hadziselimovic A, Sulistijo E, Karra M, et al. Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Science. 2009;324:1726-9 pubmed publisher
    Escherichia coli diacylglycerol kinase (DAGK) represents a family of integral membrane enzymes that is unrelated to all other phosphotransferases...
  3. Arisz S, Testerink C, Munnik T. Plant PA signaling via diacylglycerol kinase. Biochim Biophys Acta. 2009;1791:869-75 pubmed publisher
    ..Besides phospholipase D (PLD) activity, PA can also be generated by diacylglycerol kinase (DGK)...
  4. Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato P, Traini S, et al. Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. Mol Biol Cell. 2007;18:4859-71 pubmed
  5. Liu C, Machado F, Guo R, Nichols K, Burks A, Aliberti J, et al. Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. J Exp Med. 2007;204:781-92 pubmed
  6. Martin J, Yan A, Bailey Kellogg C, Zhou P, Donald B. A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. Protein Sci. 2011;20:970-85 pubmed publisher
    ..We demonstrate our method for the trimeric E. coli diacylglycerol kinase, addressing the challenges in obtaining subunit assignments for distance restraints...
  7. Owens R, Hsu F, VanderVen B, Purdy G, Hesteande E, Giannakas P, et al. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Mol Microbiol. 2006;60:1152-63 pubmed
    ..tuberculosis derived diacylglycerol. Targeted deletion of the rv2252 gene resulted in disruption of the production of certain higher order PIM species, suggesting a role for Rv2252 in the biosynthetic pathway of PI, a PIM precursor. ..
  8. Han G, O Hara L, Siniossoglou S, Carman G. Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase. J Biol Chem. 2008;283:20443-53 pubmed publisher
    The Saccharomyces cerevisiae DGK1 gene encodes a diacylglycerol kinase enzyme that catalyzes the formation of phosphatidate from diacylglycerol...
  9. Tsushima S, Kai M, Yamada K, Imai S, Houkin K, Kanoh H, et al. Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. J Biol Chem. 2004;279:28603-13 pubmed
    Nine diacylglycerol kinase (DGK) isozymes have been identified. However, our knowledge of their individual functions is still limited. Here, we demonstrate the role of DGKgamma in regulating Rac1-governed cell morphology...
  10. Takeishi Y, Goto K, Kubota I. Role of diacylglycerol kinase in cellular regulatory processes: a new regulator for cardiomyocyte hypertrophy. Pharmacol Ther. 2007;115:352-9 pubmed
    ..These data provide a novel insight for subcellular mechanisms of cardiac hypertrophy and heart failure, and DGKzeta may be a new therapeutic target to prevent cardiac hypertrophy and progression to heart failure. ..
  11. Kobayashi N, Hozumi Y, Ito T, Hosoya T, Kondo H, Goto K. Differential subcellular targeting and activity-dependent subcellular localization of diacylglycerol kinase isozymes in transfected cells. Eur J Cell Biol. 2007;86:433-44 pubmed
    b>Diacylglycerol kinase (DGK) plays a pivotal role in cellular signal transduction through regulating levels of the second messenger diacylglycerol (DG)...
  12. Temes E, Martin Puig S, Acosta Iborra B, Castellanos M, Feijóo Cuaresma M, Olmos G, et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J Biol Chem. 2005;280:24238-44 pubmed
    ..shown that the hypoxia-induced accumulation of HIF-alpha protein is strongly impaired by the inhibitor of diacylglycerol kinase, R59949. Here, we have investigated the mechanisms through which this inhibitor exerts its effect...
  13. Dickson E, Falkenburger B, Hille B. Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling. J Gen Physiol. 2013;141:521-35 pubmed publisher
    ..Hence, weak PLC activation can elicit robust calcium signals without net PIP2 depletion or KCNQ2/3 channel inhibition. ..
  14. Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, et al. SAP-mediated inhibition of diacylglycerol kinase ? regulates TCR-induced diacylglycerol signaling. J Immunol. 2011;187:5941-51 pubmed publisher
    ..Thus SAP-mediated inhibition of DGK? sustains diacylglycerol signaling, thereby regulating T cell activation, and it may represent a novel pharmacological strategy for X-linked lymphoproliferative disease treatment. ..
  15. Zhong X, Shin J, Gorentla B, O Brien T, Srivatsan S, Xu L, et al. Receptor signaling in immune cell development and function. Immunol Res. 2011;49:109-23 pubmed publisher
    ..Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages. ..
  16. Cai J, Abramovici H, Gee S, Topham M. Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta. 2009;1791:942-8 pubmed publisher
    ..In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns). ..
  17. Song J, Li J, Mourot J, Evers B, Chung D. Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury. Biochem Biophys Res Commun. 2008;375:200-4 pubmed publisher
    ..PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells. ..
  18. Imai S, Kai M, Yamada K, Kanoh H, Sakane F. The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. Biochem J. 2004;382:957-66 pubmed
    DGK (diacylglycerol kinase) regulates the concentration of two bioactive lipids, diacylglycerol and phosphatidic acid...
  19. Nakano T, Hozumi Y, Ali H, Saino Saito S, Kamii H, Sato S, et al. Diacylglycerol kinase zeta is involved in the process of cerebral infarction. Eur J Neurosci. 2006;23:1427-35 pubmed
    b>Diacylglycerol kinase (DGK) is an enzyme that phosphorylates a second messenger diacylglycerol (DG) and is involved in a variety of pathophysiological cellular responses...
  20. Cipres A, Carrasco S, Merino E, Díaz E, Krishna U, Falck J, et al. Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products. J Biol Chem. 2003;278:35629-35 pubmed
    b>Diacylglycerol kinase alpha (DAGK alpha), like all type I DAGKs, has calcium regulatory motifs that act as negative regulators of enzyme activity and localization...
  21. Sakane F, Imai S, Kai M, Yasuda S, Kanoh H. Diacylglycerol kinases: why so many of them?. Biochim Biophys Acta. 2007;1771:793-806 pubmed
  22. Zheng Y, Zha Y, Driessens G, Locke F, Gajewski T. Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med. 2012;209:2157-63 pubmed publisher
    ..Using the key anergy target gene diacylglycerol kinase (DGK) ? as a focal point, we identified early growth response gene 2 (Egr2) as a central transcription ..
  23. Alonso R, Rodríguez M, Pindado J, Merino E, Merida I, Izquierdo M. Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. J Biol Chem. 2005;280:28439-50 pubmed
    ..b>Diacylglycerol kinase alpha (DGKalpha), a diacylglycerol (DAG)-consuming enzyme, is involved in the attenuation of DAG-derived ..
  24. Nelson C, Perry S, Regier D, Prescott S, Topham M, Lefkowitz R. Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science. 2007;315:663-6 pubmed
    ..Thus, beta-arrestins can serve similar regulatory functions for disparate classes of 7TMRs through structurally dissimilar enzymes that degrade chemically distinct second messengers. ..
  25. Luo B, Regier D, Prescott S, Topham M. Diacylglycerol kinases. Cell Signal. 2004;16:983-9 pubmed
    ..By modulating the activity of these proteins, DGKs potentially affect a number of biological events including-but likely not limited to-cell growth, neuronal transmission, and cytoskeleton remodeling. ..
  26. Nakano T, Iseki K, Hozumi Y, Kawamae K, Wakabayashi I, Goto K. Brain trauma induces expression of diacylglycerol kinase zeta in microglia. Neurosci Lett. 2009;461:110-5 pubmed publisher
    b>Diacylglycerol kinase (DGK) is an enzyme which phosphorylates a second messenger diacylglycerol and consists of a family of isozymes that differ in terms of structural motifs, enzymological property, and cell and tissue distribution...
  27. Merino E, Sanjuan M, Moraga I, Cipres A, Merida I. Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells. J Biol Chem. 2007;282:35396-404 pubmed
    b>Diacylglycerol kinase (DGK) phosphorylates diacylglycerol to phosphatidic acid, modifying the cellular levels of these two lipid mediators. Ten DGK isoforms, grouped into five subtypes, are found in higher organisms...
  28. Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, et al. Diacylglycerol kinase ? knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE. 2010;5:e13447 pubmed publisher
    b>Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA)...
  29. Lukiw W, Cui J, Musto A, Musto B, Bazan N. Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun. 2005;338:77-81 pubmed
    b>Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to yield phosphatidic acid, two neural signaling elements that function to modulate synaptic activity...
  30. Oxenoid K, SONNICHSEN F, Sanders C. Topology and secondary structure of the N-terminal domain of diacylglycerol kinase. Biochemistry. 2002;41:12876-82 pubmed
    Prokaryotic diacylglycerol kinase (DAGK) functions as a homotrimer of 13 kDa subunits, each of which has three transmembrane segments...
  31. Leach N, Sun Y, Michaud S, Zheng Y, Ligon K, Ligon A, et al. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet. 2007;80:792-9 pubmed
    ..2, whereas diacylglycerol kinase delta (DGKD) is disrupted at 2q37...
  32. Williams J, Pettitt T, Powell W, Grove J, Savage C, Wakelam M. Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation. J Am Soc Nephrol. 2007;18:1112-20 pubmed
    ..This study shows that diacylglycerol kinase is selectively activated by ANCA and that the generated phosphatidic acid is responsible for promoting ..
  33. Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble J, et al. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase. Circ Res. 2004;94:1515-22 pubmed
    ..These findings thus demonstrate a novel molecular action of PPARgamma agonists to suppress the DAG-PKC signaling pathway via upregulation of an endogenous attenuator, DGK. ..
  34. Sanjuan M, Pradet Balade B, Jones D, Martinez A C, Stone J, Garcia Sanz J, et al. T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation. J Immunol. 2003;170:2877-83 pubmed
    b>Diacylglycerol kinase (DGK) phosphorylates diacylglycerol to produce phosphatidic acid, leading to decreased and increased levels, respectively, of these two lipid messengers that play a central role in T cell activation...
  35. Fakas S, Konstantinou C, Carman G. DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae. J Biol Chem. 2011;286:1464-74 pubmed publisher
    ..In this work, we provide evidence that DGK1-encoded diacylglycerol kinase activity is required to convert triacylglycerol-derived diacylglycerol to phosphatidate for phospholipid ..
  36. McMullan R, Hiley E, Morrison P, Nurrish S. Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans. Genes Dev. 2006;20:65-76 pubmed
    ..Surprisingly, many commonly available human RhoA constructs contain an uncharacterized mutation that severely reduces binding of RhoA to DAG kinase. Thus, a role for RhoA in controlling DAG levels is likely to have been underestimated. ..
  37. Topham M, Prescott S. Diacylglycerol kinases: regulation and signaling roles. Thromb Haemost. 2002;88:912-8 pubmed
    ..Although little is known of the specific function of DGKs in platelets, they likely influence actin reorganization and other signaling events requiring diacylglycerol. ..
  38. Cai J, Crotty T, Reichert E, Carraway K, Stafforini D, Topham M. Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem. 2010;285:6952-9 pubmed publisher
    ..We found that de-ubiquitination of EGFR was regulated by diacylglycerol kinase delta (DGKdelta), a lipid kinase that terminates diacylglycerol signaling...
  39. Harada M, Takeishi Y, Arimoto T, Niizeki T, Kitahara T, Goto K, et al. Diacylglycerol kinase zeta attenuates pressure overload-induced cardiac hypertrophy. Circ J. 2007;71:276-82 pubmed
    ..These results are the first in vivo evidence that DGKzeta suppresses cardiac hypertrophy and fibrosis and prevents impaired left ventricular systolic function caused by pressure overload. ..
  40. Harada B, Knight M, Imai S, Qiao F, Ramachander R, Sawaya M, et al. Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1. Structure. 2008;16:380-7 pubmed publisher
    The diacylglycerol kinase (DGK) enzymes function as regulators of intracellular signaling by altering the levels of the second messengers, diacylglycerol and phosphatidic acid...
  41. Nishimaru K, Arimoto T, Takeishi Y, Kubota I, Ishii K, Endoh M. Overexpression of diacylglycerol kinase zeta inhibits endothelin-1-induced decreases in Ca2+ transients and cell shortening in mouse ventricular myocytes. J Mol Cell Cardiol. 2008;44:520-6 pubmed publisher
  42. Gómez Merino F, Brearley C, Ornatowska M, Abdel Haliem M, Zanor M, Mueller Roeber B. AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression. J Biol Chem. 2004;279:8230-41 pubmed
    b>Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Both DAG and PA are implicated in signal transduction pathways...
  43. Li D, Urs A, Allegood J, Leon A, Merrill A, Sewer M. Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol. 2007;27:6669-85 pubmed
    ..Activation of the ACTH/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase (DGK) activity and PA production...
  44. Murakami T, Sakane F, Imai S, Houkin K, Kanoh H. Identification and characterization of two splice variants of human diacylglycerol kinase eta. J Biol Chem. 2003;278:34364-72 pubmed
    b>Diacylglycerol kinase (DGK) participates in regulating the intracellular concentrations of two bioactive lipids, diacylglycerol and phosphatidic acid...
  45. Imai S, Yasuda S, Kai M, Kanoh H, Sakane F. Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1. Biochim Biophys Acta. 2009;1791:246-53 pubmed publisher
    The delta-isozyme (type II) of diacylglycerol kinase (DGK) is known to positively regulate growth factor receptor signaling...
  46. Abramovici H, Hogan A, Obagi C, Topham M, Gee S. Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins. Mol Biol Cell. 2003;14:4499-511 pubmed
    ..We previously reported that syntrophins interact with diacylglycerol kinase-zeta (DGK-zeta), which phosphorylates diacylglycerol to yield phosphatidic acid...
  47. Hardie R, Martin F, Chyb S, Raghu P. Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. J Biol Chem. 2003;278:18851-8 pubmed
    ..phototransduction, suggest that activation by metabolic inhibition is primarily because of the failure of diacylglycerol kinase, and are consistent with the proposal that polyunsaturated fatty acids, which are potential DAG ..
  48. Nørholm M, Shulga Y, Aoki S, Epand R, von Heijne G. Flanking residues help determine whether a hydrophobic segment adopts a monotopic or bitopic topology in the endoplasmic reticulum membrane. J Biol Chem. 2011;286:25284-90 pubmed publisher
    ..Here, we probe the topology of a membrane-attached enzyme, the ? isoform of human diacylglycerol kinase (DGK?), when inserted into rough microsomes and compare it with the monotopic membrane protein mouse ..
  49. Takeishi K, Taketomi A, Shirabe K, Toshima T, Motomura T, Ikegami T, et al. Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway. J Hepatol. 2012;57:77-83 pubmed publisher
    ..DGK? is involved in HCC progression by activation of the MAPK pathway. DGK? could be a novel target for HCC therapeutics as well as a prognostic marker. ..
  50. Los A, van Baal J, de Widt J, Divecha N, van Blitterswijk W. Structure-activity relationship of diacylglycerol kinase theta. Biochim Biophys Acta. 2004;1636:169-74 pubmed
    b>Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to phosphatidic acid (PA)...
  51. Ozaltin F, Li B, Rauhauser A, An S, Soylemezoglu O, Gonul I, et al. DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol. 2013;24:377-84 pubmed publisher
    ..This gene encodes the diacylglycerol kinase DGK?, which is an intracellular lipid kinase that phosphorylates diacylglycerol to phosphatidic acid...
  52. Baum A, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, et al. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry. 2008;13:197-207 pubmed
    ..genotyping, the strongest association signal was detected at a marker within the first intron of diacylglycerol kinase eta (DGKH; P=1.5 x 10(-8), experiment-wide P<0.01, OR=1.59)...
  53. Zhong X, Hainey E, Olenchock B, Zhao H, Topham M, Koretzky G. Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem. 2002;277:31089-98 pubmed
    ..Collectively these studies demonstrate a potential role of DGKzeta to function as a selective negative regulator of DAG signaling on T cell activation and provide the first structure/function analysis of this enzyme in T cells. ..