atp synthetase complexes


Summary: Multisubunit enzyme complexes that synthesize ADENOSINE TRIPHOSPHATE from energy sources such as ions traveling through channels.

Top Publications

  1. Feniouk B, Kozlova M, Knorre D, Cherepanov D, Mulkidjanian A, Junge W. The proton-driven rotor of ATP synthase: ohmic conductance (10 fS), and absence of voltage gating. Biophys J. 2004;86:4094-109 pubmed
    ..The data fit attributed pK values of approximately 6 and approximately 10 to these relays, and placed them close to the membrane/electrolyte interface...
  2. Carroll J, Fearnley I, Wang Q, Walker J. Measurement of the molecular masses of hydrophilic and hydrophobic subunits of ATP synthase and complex I in a single experiment. Anal Biochem. 2009;395:249-55 pubmed publisher
    ..It could be applied to other respiratory and photosynthetic complexes and, in general, to any protein complex that contains both hydrophilic and hydrophobic subunits. ..
  3. Walker J. The ATP synthase: the understood, the uncertain and the unknown. Biochem Soc Trans. 2013;41:1-16 pubmed publisher
    ..Here the enzymes form supermolecular complexes, possibly with specific lipids, and these complexes probably contribute to, or even determine, the formation of the cristae. ..
  4. José Núñez C, Torres Larios A, Ramirez Silva L, Mendoza G, Salcedo G, Gomez Puyou A, et al. Catalysis by isolated beta-subunits of the ATP Synthase/ATPase from Thermophilic bacillus PS3. Hydrolysis of pyrophosphate. J Bioenerg Biomembr. 2008;40:561-8 pubmed publisher
    ..Thus, isolated beta-subunits are catalytically competent with PP(i) as substrate; apparently, the assembly of beta-subunits into the ATPase complex changes substrate specificity, and leads to an increase in catalytic rates. ..
  5. Del Rizzo P, Bi Y, Dunn S. ATP synthase b subunit dimerization domain: a right-handed coiled coil with offset helices. J Mol Biol. 2006;364:735-46 pubmed
    ..The results indicate a right-handed coiled-coil structure with intrinsic asymmetry, the two helices being offset rather than in register. A function for the right-handed coiled coil in rotational catalysis is proposed. ..
  6. Jankovic A, Korac A, Buzadzic B, Otasevic V, Stancic A, Vucetic M, et al. Endocrine and metabolic signaling in retroperitoneal white adipose tissue remodeling during cold acclimation. J Obes. 2013;2013:937572 pubmed publisher
    ..It seems that AMPK ? mediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation. ..
  7. Mayer F, Muller V. Adaptations of anaerobic archaea to life under extreme energy limitation. FEMS Microbiol Rev. 2014;38:449-72 pubmed publisher
    ..In sum, adaptation of anaerobic archaea to energy-limited substrates involves chemiosmotic energy coupling, often with Na+ as coupling ion and a structurally and functionally highly adapted ATP synthase. ..
  8. Porcel B, Aslund L, Pettersson U, Andersson B. Trypanosoma cruzi: a putative vacuolar ATP synthase subunit and a CAAX prenyl protease-encoding gene, as examples of gene identification in genome projects. Exp Parasitol. 2000;95:176-86 pubmed
    ..Computer analysis revealed the presence of several motifs in both proteins, possibly related to the regulation and localization of these proteins in the parasite. ..
  9. Szentpali K, Paszt A, Lazar G, Szell M, Kemeny L, Dobozy A, et al. Esophageal ATP synthase and keratinocyte growth factor gene expression changes after acid and bile-induced mucosal damage. Inflamm Res. 2005;54:152-7 pubmed

More Information

Publications108 found, 100 shown here

  1. Harasym A, Thrush A, Harper M, Wright D, Chan C. Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase. Mitochondrion. 2013;13:320-9 pubmed publisher
    ..We conclude that chronically low insulin secretion leads to adaption in glucose metabolism primarily in liver to maintain euglycemia. ..
  2. Allchin D. To err and win a nobel prize: Paul Boyer, ATP synthase and the emergence of bioenergetics. J Hist Biol. 2002;35:149-72 pubmed
    ..Boyer's work also parallels and illustrates the emergence of bioenergetics in the second half of the twentieth century, rivaling achievements in evolution and molecular biology. ..
  3. Pfeiffer K, Gohil V, Stuart R, Hunte C, Brandt U, Greenberg M, et al. Cardiolipin stabilizes respiratory chain supercomplexes. J Biol Chem. 2003;278:52873-80 pubmed
    ..We show that a cardiolipin-deficient strain harbored almost inactive resting cytochrome c oxidase in the membrane. Transition to the fully active pulsed state occurred on a minute time scale. ..
  4. Oberfeld B, Brunner J, Dimroth P. Phospholipids occupy the internal lumen of the c ring of the ATP synthase of Escherichia coli. Biochemistry. 2006;45:1841-51 pubmed
    ..We conclude therefore that the inner lumen of the c ring is occupied with phospholipids. No evidence was found for an extension of subunit a into this space. ..
  5. Chen L, Nowak B, Ayres M, Krett N, Rosen S, Zhang S, et al. Inhibition of ATP synthase by chlorinated adenosine analogue. Biochem Pharmacol. 2009;78:583-91 pubmed publisher
    ..Collectively, our current work suggests that 8-Cl-ADP may serve as a substrate and the 8-Cl-ATP may be an inhibitor of ATP synthase. ..
  6. Mayer F, Leone V, Langer J, Faraldo Gómez J, Muller V. A c subunit with four transmembrane helices and one ion (Na+)-binding site in an archaeal ATP synthase: implications for c ring function and structure. J Biol Chem. 2012;287:39327-37 pubmed publisher
    ..These findings are discussed in light of their physiological relevance and with respect to the mode of ion coupling in A(1)A(O) ATP synthases...
  7. Merz T, Pereira A, Schürch R, Schefold J, Jakob S, Takala J, et al. Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. PLoS ONE. 2017;12:e0178946 pubmed publisher
    ..Assessed sub-types of immune cells showed differing patterns of regulation. Total ATP-content of human immune cells did not differ between patients in septic shock and healthy volunteers. ..
  8. Auger D, Newton K, Birchler J. Nuclear gene dosage effects upon the expression of maize mitochondrial genes. Genetics. 2001;157:1711-21 pubmed
    ..These results support the concept that although mitochondrial genes are prokaryotic in origin, their regulation has been extensively integrated into the eukaryotic cell. ..
  9. Banford H, Bermingham E, Collette B. Molecular phylogenetics and biogeography of transisthmian and amphi-Atlantic needlefishes (Belonidae: Strongylura and Tylosurus): perspectives on New World marine speciation. Mol Phylogenet Evol. 2004;31:833-51 pubmed
  10. Runswick M, Walker J. The amino acid sequence of the beta-subunit of ATP synthase from bovine heart mitochondria. J Biol Chem. 1983;258:3081-9 pubmed
    ..Sci. U.S.A. 79, 6260-6264) shows that the protein is highly conserved. 70% of residues are identical in E. coli and beef mitochondria. This contrasts with some of the other subunits in the enzyme complex which are much less conserved. ..
  11. Walker J, Saraste M, Runswick M, Gay N. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1982;1:945-51 pubmed
  12. Rust M, Golden S, O Shea E. Light-driven changes in energy metabolism directly entrain the cyanobacterial circadian oscillator. Science. 2011;331:220-3 pubmed publisher
  13. Karol K, McCourt R, Cimino M, Delwiche C. The closest living relatives of land plants. Science. 2001;294:2351-3 pubmed
    ..These findings provide insight into the nature of the ancestor of plants, and have broad implications for understanding the transition from aquatic green algae to terrestrial plants. ..
  14. Schafer I, Rössle M, Biukovic G, Muller V, Gruber G. Structural and functional analysis of the coupling subunit F in solution and topological arrangement of the stalk domains of the methanogenic A1AO ATP synthase. J Bioenerg Biomembr. 2006;38:83-92 pubmed
    ..Based on these data the surface of contact of B-F could be mapped in the high-resolution structure of subunit B of the A(1)A(O) ATP synthase. ..
  15. Dimroth P. Operation of the F(0) motor of the ATP synthase. Biochim Biophys Acta. 2000;1458:374-86 pubmed
    ..Taken together with biophysical data, the operating principles of the motor have been delineated. ..
  16. Cipriano D, Bi Y, Dunn S. Genetic fusions of globular proteins to the epsilon subunit of the Escherichia coli ATP synthase: Implications for in vivo rotational catalysis and epsilon subunit function. J Biol Chem. 2002;277:16782-90 pubmed
    ..It is proposed that the C-terminal domain of epsilon functions to ensure that rotation occurs only in the direction of ATP synthesis when ADP is bound and only in the direction of hydrolysis when ATP is bound. ..
  17. Steiner U, Leibner S, Schardl C, Leuchtmann A, Leistner E. Periglandula, a new fungal genus within the Clavicipitaceae and its association with Convolvulaceae. Mycologia. 2011;103:1133-45 pubmed publisher
    ..Based on these findings we propose a new fungal genus, Periglandula, gen. nov., and describe two new species, Periglandula ipomoeae sp. nov., from host plant I. asarifolia, and Periglandula turbinae sp. nov., from T. corymbosa...
  18. Su Y, Sun H, Fang J, Hu G, Xiao M. Brain mitochondrial dysfunction in ovariectomized mice injected with D-galactose. Neurochem Res. 2010;35:399-404 pubmed publisher
    ..These results demonstrated that brain mitochondrial degeneration caused by oxidative stress participated in the etiology of ovarian hormone deprivation and D-galactose-induced neurodegeneration. ..
  19. Janouskovec J, Sobotka R, Lai D, Flegontov P, Konik P, Komenda J, et al. Split photosystem protein, linear-mapping topology, and growth of structural complexity in the plastid genome of Chromera velia. Mol Biol Evol. 2013;30:2447-62 pubmed publisher
  20. Muller A, Schulze Makuch D. Thermal energy and the origin of life. Orig Life Evol Biosph. 2006;36:177-89 pubmed
    ..Possible suitable examples are subsurface environments on Earth and in the outer Solar System, in particular the subsurface oceans of the icy satellites of Jupiter and Saturn. ..
  21. Surase Y, Samby K, Amale S, Sood R, Purnapatre K, Pareek P, et al. Identification and synthesis of novel inhibitors of mycobacterium ATP synthase. Bioorg Med Chem Lett. 2017;27:3454-3459 pubmed publisher
    ..H37Rv strain) around the identified hit 1. A scaffold hopping approach was used to identify compounds 14a, 14b and 24a with improved activity against MTb.H37Rv. ..
  22. Nakata Y, Taniguchi G, Takazaki S, Oda Ueda N, Miyahara K, Ohshima Y. Comparative analysis of cells and proteins of pumpkin plants for the control of fruit size. J Biosci Bioeng. 2012;114:334-41 pubmed publisher
    ..These results provide a step toward the development of plant biotechnology to control fruit size in the future. ..
  23. Evans G, Furneaux R, Gainsford G, Murphy M. The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B. Bioorg Med Chem. 2000;8:1663-75 pubmed
    ..The gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 microM. ..
  24. Morin D, Zini R, Berdeaux A, Tillement J. Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction. Biochem Pharmacol. 2006;72:911-8 pubmed
    ..These data demonstrate that S-15176 interacts with several targets in mitochondria and these pharmacological properties should be considered in the examination of its health benefits as well as its potential cytotoxicity. ..
  25. Deckers Hebestreit G, Greie J, Stalz W, Altendorf K. The ATP synthase of Escherichia coli: structure and function of F(0) subunits. Biochim Biophys Acta. 2000;1458:364-73 pubmed
    ..Consequences on the coupling mechanism between ATP synthesis/hydrolysis and proton translocation are discussed. ..
  26. Muller D, Dencher N, Meier T, Dimroth P, Suda K, Stahlberg H, et al. ATP synthase: constrained stoichiometry of the transmembrane rotor. FEBS Lett. 2001;504:219-22 pubmed
    ..These results suggest the rotor diameter and stoichiometry to be determined by the shape of the subunits and their nearest neighbor interactions. ..
  27. Rich P. A perspective on Peter Mitchell and the chemiosmotic theory. J Bioenerg Biomembr. 2008;40:407-10 pubmed publisher
    ..I here review some of his views of that time on structures and mechanisms of several key bioenergetic components in relation to the subsequent advances that have been made. ..
  28. Andrianaivomananjaona T, Moune Dimala M, Herga S, David V, Haraux F. How the N-terminal extremity of Saccharomyces cerevisiae IF1 interacts with ATP synthase: a kinetic approach. Biochim Biophys Acta. 2011;1807:197-204 pubmed publisher
    ..Moreover, the data obtained using chimeric PsaE-IF1 suggest that before binding IF1 presents to the enzyme with its middle part facing a catalytic interface and its Nter extremity folded in the opposite direction. ..
  29. Alger J, Shulman R. NMR studies of enzymatic rates in vitro and in vivo by magnetization transfer. Q Rev Biophys. 1984;17:83-124 pubmed
  30. Cingolani G, Duncan T. Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an autoinhibited conformation. Nat Struct Mol Biol. 2011;18:701-7 pubmed publisher
    ..As a result, the three catalytic subunits are stabilized in a set of conformations and rotational positions distinct from previous F(1) structures. ..
  31. Rimbault B, Esposito D, Drapier D, Choquet Y, Stern D, Wollman F. Identification of the initiation codon for the atpB gene in Chlamydomonas chloroplasts excludes translation of a precursor form of the beta subunit of the ATP synthase. Mol Gen Genet. 2000;264:486-91 pubmed
    ..We provide evidence that translation of atpB is initiated exclusively at the second ATG codon. We conclude that the beta subunit is not synthesized with an N-terminal leader before its assembly into a functional ATP synthase complex. ..
  32. Rodriguez Pena A, Escriva H, Handler A, Vallejo C. Thyroid hormone increases transcription of GA-binding protein/nuclear respiratory factor-2 alpha-subunit in rat liver. FEBS Lett. 2002;514:309-14 pubmed
    ..The results also support the notion that ATP synthase beta-subunit is regulated by TH through the indirect activation of GABP/NRF-2. ..
  33. Walker J. A conversation with John E. Walker interviewed by K. Noelle Gracy. Biochem Biophys Res Commun. 2002;298:1-4 pubmed
  34. Sheng J, Marquis R. Enhanced acid resistance of oral streptococci at lethal pH values associated with acid-tolerant catabolism and with ATP synthase activity. FEMS Microbiol Lett. 2006;262:93-8 pubmed
    ..Protection against acid killing involving catabolism and synthase activity is likely to be important for plaque cariogenicity. ..
  35. Boyer P. A research journey with ATP synthase. J Biol Chem. 2002;277:39045-61 pubmed
  36. Hong Y, Piao F, Zhao Y, Li S, Wang Y, Liu P. Subchronic exposure to arsenic decreased Sdha expression in the brain of mice. Neurotoxicology. 2009;30:538-43 pubmed publisher
    ..It implies that the increased level of ROS by As may also be a factor in the disrupting Sdha expression in brain tissue of mice exposed to As. ..
  37. Manimekalai M, Kumar A, Jeyakanthan J, Gruber G. The transition-like state and Pi entrance into the catalytic a subunit of the biological engine A-ATP synthase. J Mol Biol. 2011;408:736-54 pubmed publisher
    ..The structures presented shed light on the diversity of catalytic mechanisms used by the biological motors A- and F-ATP synthases and eukaryotic V-ATPases. ..
  38. Segala E, Sougakoff W, Nevejans Chauffour A, Jarlier V, Petrella S. New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure. Antimicrob Agents Chemother. 2012;56:2326-34 pubmed publisher
    ..These data shed light on the molecular interactions allowing TMC207 to bind specifically and efficiently at the level of the proton-binding site of the mycobacterial C ring. ..
  39. Balemans W, Vranckx L, Lounis N, Pop O, Guillemont J, Vergauwen K, et al. Novel antibiotics targeting respiratory ATP synthesis in Gram-positive pathogenic bacteria. Antimicrob Agents Chemother. 2012;56:4131-9 pubmed publisher
    ..Development of the diarylquinolines class may represent a promising strategy for combating Gram-positive pathogens. ..
  40. Schuck P, Busanello E, Tonin A, Viegas C, Ferreira G. Neurotoxic effects of trans-glutaconic acid in rats. Oxid Med Cell Longev. 2013;2013:607610 pubmed publisher
    ..tGA also significantly decreased nonenzymatic antioxidant defenses (TRAP and reduced glutathione levels). Our data suggest that tGA may be neurotoxic in rat brain. ..
  41. Palmer D, Jolly R, van Mil H, Tyynela J, Westlake V. Different patterns of hydrophobic protein storage in different forms of neuronal ceroid lipofuscinosis (NCL, Batten disease). Neuropediatrics. 1997;28:45-8 pubmed
    ..These results suggest two classes of NCL, the subunit c-storing diseases, related by a series of lesions in a subunit c-turnover pathway, and the SAP-storing diseases. ..
  42. Hernandez Castro R, Verdugo Rodríguez A, Gutierrez Pabello J, Adams L, Suárez Güemes F, Sahagun Ruiz A. Identification of four genes of the Brucella melitensis ATP synthase operon F0 sector: relationship with the Rhodospirillaceae family. Microb Comp Genomics. 2000;5:163-71 pubmed
    ..This feature has been found only in photosynthetic bacteria and chloroplasts. In addition, the gene cluster was separated from the F1 sector, a characteristic described only for the Rhodospirillaceae family...
  43. Noji H. [Molecular mechanism of torque generation in F1-motor]. Tanpakushitsu Kakusan Koso. 2002;47:1174-81 pubmed
  44. Jugdutt B, Sawicki G. AT1 receptor blockade alters metabolic, functional and structural proteins after reperfused myocardial infarction: detection using proteomics. Mol Cell Biochem. 2004;263:179-88 pubmed
    ..Thus, proteomics can detect regional changes in metabolic, contractile, and structural proteins after RMI and several of these proteins are favorably modified by ARBs, suggesting that they may be novel therapeutic targets. ..
  45. Mourier A, Devin A, Rigoulet M. Active proton leak in mitochondria: a new way to regulate substrate oxidation. Biochim Biophys Acta. 2010;1797:255-61 pubmed publisher
    ..We propose to name this new mechanism "active proton leak." Such a mechanism could allow a wide modulation of substrate oxidation in response to cellular redox constraints. ..
  46. Novelli E, Souza G, Ebaid G, Rocha K, Seiva F, Mani F, et al. Energy expenditure and oxygen consumption as novel biomarkers of obesity-induced cardiac disease in rats. Obesity (Silver Spring). 2010;18:1754-61 pubmed publisher
    ..The results serve to highlight the role of calorimetric changes as novel biomarkers of risk to obesity-induced cardiac effects. ..
  47. Symersky J, Osowski D, Walters D, Mueller D. Oligomycin frames a common drug-binding site in the ATP synthase. Proc Natl Acad Sci U S A. 2012;109:13961-5 pubmed publisher
    ..quot; We anticipate that this drug-binding site will serve as an effective target for new antibiotics developed by rational design. ..
  48. Dunn S, McLachlin D, Revington M. The second stalk of Escherichia coli ATP synthase. Biochim Biophys Acta. 2000;1458:356-63 pubmed
    ..However, the weak interactions between the polypeptides in b(2)delta pose a challenge for the proposed stator function. ..
  49. Hunziker R, Escher B, Schwarzenbach R. Acute toxicity of triorganotin compounds: different specific effects on the energy metabolism and role of pH. Environ Toxicol Chem. 2002;21:1191-7 pubmed
    ..It was concluded that chromatophores of R. sphaeroides are a useful system to discriminate various effects of toxicants on the energy metabolism of a cell. ..
  50. Pavlova P, Shimabukuro K, Hisabori T, Groth G, Lill H, Bald D. Complete inhibition and partial Re-activation of single F1-ATPase molecules by tentoxin: new properties of the re-activated enzyme. J Biol Chem. 2004;279:9685-8 pubmed
  51. Jarmuszkiewicz W, Czarna M, Sluse Goffart C, Sluse F. The contribution of uncoupling protein and ATP synthase to state 3 respiration in Acanthamoeba castellanii mitochondria. Acta Biochim Pol. 2004;51:533-8 pubmed
    ..castellanii mitochondria fully depleted of free fatty acid-activated and describes how the two contributions vary when the rate of succinate dehydrogenase is decreased by succinate uptake limitation. ..
  52. Rapenne G. Synthesis of technomimetic molecules: towards rotation control in single-molecular machines and motors. Org Biomol Chem. 2005;3:1165-9 pubmed
    ..These molecules are designed to operate as single molecules on surfaces under the control of the tip of a scanning tunneling microscope or atomic force microscope. ..
  53. Selivanov V, Votyakova T, Pivtoraiko V, Zeak J, Sukhomlin T, Trucco M, et al. Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol. 2011;7:e1001115 pubmed publisher
    ..These findings provide a new insight into the mechanisms of ROS production in RC. ..
  54. Merino F, Rivas Pardo J, Caniuguir A, García I, Guixé V. Catalytic and regulatory roles of divalent metal cations on the phosphoryl-transfer mechanism of ADP-dependent sugar kinases from hyperthermophilic archaea. Biochimie. 2012;94:516-24 pubmed publisher
  55. Castro Fernández V, Herrera Morande A, Zamora R, Merino F, Gonzalez Ordenes F, Padilla Salinas F, et al. Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases. J Biol Chem. 2017;292:15598-15610 pubmed publisher
  56. Fusani L, Metzdorf R, Hutchison J, Gahr M. Aromatase inhibition affects testosterone-induced masculinization of song and the neural song system in female canaries. J Neurobiol. 2003;54:370-9 pubmed
    ..Our results provide the first example of estrogen-sensitive mechanisms controlling the structural features of adult birdsong...
  57. Berry R. ATP synthesis: the world's smallest wind-up toy. Curr Biol. 2005;15:R385-7 pubmed
    ..Half of this process has now been reproduced in vitro, using tiny magnets instead of F0 to drive the reverse rotation of a single F1 molecule. ..
  58. Kinbara K, Aida T. Chemistry. From electron pump to proton channel. Science. 2006;313:51-2 pubmed
  59. Astolfi S, Zuchi S, Hubberten H, Pinton R, Hoefgen R. Supply of sulphur to S-deficient young barley seedlings restores their capability to cope with iron shortage. J Exp Bot. 2010;61:799-806 pubmed publisher
    ..In particular, our results are indicative that barley plants fully recover their capability to cope with Fe shortage after the supply of S is restored to S-deficient plants. ..
  60. Balakrishna A, Hunke C, Gruber G. Purification and crystallization of the entire recombinant subunit E of the energy producer A(1)A(o) ATP synthase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:324-6 pubmed publisher
    ..3 A resolution with 99.4% completeness using a synchrotron-radiation source. The crystals belonged to space group I4, with unit-cell parameters a = 112.51, b = 112.51, c = 96.25 A, and contained three molecules in the asymmetric unit. ..
  61. Ramalingam S, Periandy S, Sugunakala S, Prabhu T, Bououdina M. Insilico molecular modeling, docking and spectroscopic [FT-IR/FT-Raman/UV/NMR] analysis of Chlorfenson using computational calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2013;115:118-35 pubmed publisher
    ..By using these properties, the mechanism of action of this compound on ATP Synthase of Tetranychus urticae is found and it is very much useful to develop efficient pesticides having less toxic to the environment. ..
  62. Malik Ghulam M, Ghulam M, Courtois F, Lerbs Mache S, Merendino L. Complex processing patterns of mRNAs of the large ATP synthase operon in Arabidopsis chloroplasts. PLoS ONE. 2013;8:e78265 pubmed publisher
    ..Our findings suggest that during evolution of different plant species as maize and Arabidopsis, chloroplasts have evolved multiple strategies to produce mature transcripts suitable for translation. ..
  63. Tifrea D, Barta M, Pal S, Hefty P, de la Maza L. Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen. Microbes Infect. 2016;18:245-53 pubmed publisher
    ..These protection levels support that, these highly conserved Chlamydia proteins, in combination with other antigens, may serve as potential vaccine candidates. ..
  64. Li C, Gao X, Huang J, Liang Y. Studies of the viral binding proteins of shrimp BP53, a receptor of white spot syndrome virus. J Invertebr Pathol. 2016;134:48-53 pubmed publisher
    ..The identification of the viral binding proteins of shrimp BP53 is helpful for better understanding the pathogenic mechanisms of WSSV to infect shrimp at the cellular level. ..
  65. Medd S, Walker J, Jolly R. Characterization of the expressed genes for subunit c of mitochondrial ATP synthase in sheep with ceroid lipofuscinosis. Biochem J. 1993;293 ( Pt 1):65-73 pubmed
    ..However, restriction fragment analysis of genomic DNA from a further 12 sheep established that the sequence differences were not linked to ceroid lipofuscinosis. ..
  66. Chamala S, Beckstead W, Rowe M, McClellan D. Evolutionary selective pressure on three mitochondrial SNPs is consistent with their influence on metabolic efficiency in Pima Indians. Int J Bioinform Res Appl. 2007;3:504-22 pubmed
    ..Our results suggest that two SNPs were affected by selection during mammalian evolution in a manner consistent with their effects on metabolic efficiency in Pima Indians. ..
  67. Målen H, Berven F, Søfteland T, Arntzen M, D Santos C, de Souza G, et al. Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies. Proteomics. 2008;8:1859-70 pubmed publisher
    ..ATP synthase, NAD(P) transhydrogenase, ubiquinone oxidoreductase and ubiquinol-cytochrome C reductase appear to represent major enzyme complexes in the membrane of Mycobacterium tuberculosis complex organisms. ..
  68. Pipinos I, Swanson S, Zhu Z, Nella A, Weiss D, Gutti T, et al. Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage. Am J Physiol Regul Integr Comp Physiol. 2008;295:R290-6 pubmed publisher
    ..e., in the absence of other comorbid conditions, causes myopathy with mitochondrial dysfunction and increased oxidative stress, recapitulating the muscle pathology of PAD patients. ..
  69. Price C, Driessen A. Biogenesis of membrane bound respiratory complexes in Escherichia coli. Biochim Biophys Acta. 2010;1803:748-66 pubmed publisher
    ..Lastly, we address the supramolecular organization of respiratory enzymes into supercomplexes and their localization to specialized domains in the membrane. ..
  70. Seelert H, Dencher N. ATP synthase superassemblies in animals and plants: two or more are better. Biochim Biophys Acta. 2011;1807:1185-97 pubmed publisher
    ..Therefore, this review focusses on the interplay between metabolism and supramolecular organisation of ATP synthase in different organisms. ..
  71. Wojewoda M, Zabłocki K, Szczepanowska J. [Diseases caused by mutations in mitochondrial DNA]. Postepy Biochem. 2011;57:222-9 pubmed
    ..It is worth to note that mitochondrial dysfunction can also be caused by mutations within nuclear genes coding for mitochondrial proteins. ..
  72. Rouan M, Lounis N, Gevers T, Dillen L, Gilissen R, Raoof A, et al. Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis. Antimicrob Agents Chemother. 2012;56:1444-51 pubmed publisher
    ..The PK-PD profile supports intermittent administration of TMC207, in agreement with its slow release from tissues. ..
  73. Kim N, Ripple M, Springett R. Measurement of the mitochondrial membrane potential and pH gradient from the redox poise of the hemes of the bc1 complex. Biophys J. 2012;102:1194-203 pubmed publisher
    ..The technique allows absolute quantification of the membrane potential, pH gradient, and proton-motive force without the need for genetic manipulation or exogenous compounds. ..
  74. Dyer M, Gay N, Walker J. DNA sequences of a bovine gene and of two related pseudogenes for the proteolipid subunit of mitochondrial ATP synthase. Biochem J. 1989;260:249-58 pubmed
    ..An alternative, but less likely, explanation is that rather than being a retroposon, this sequence arose by duplication of an expressed gene at a time when it had only one intron. ..
  75. Walker J, Saraste M, Gay N. The unc operon. Nucleotide sequence, regulation and structure of ATP-synthase. Biochim Biophys Acta. 1984;768:164-200 pubmed
  76. Bianchet M, Hullihen J, Pedersen P, Amzel L. The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis. Proc Natl Acad Sci U S A. 1998;95:11065-70 pubmed
    ..Incorporation of this structure suggests a mechanism of ATP synthesis/hydrolysis in which configurations of the enzyme with three bound nucleotides play an essential role. ..
  77. Junaid M, Pullarkat R. Biochemistry of neuronal ceroid lipofuscinoses. Adv Genet. 2001;45:93-106 pubmed
    ..Identification of natural substrates for the various enzymes involved in NCL may help in the characterization of the cytotoxic factor(s) and also in designing rationale therapeutic interventions for these group of devastating diseases. ..
  78. Koul A, Dendouga N, Vergauwen K, Molenberghs B, Vranckx L, Willebrords R, et al. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat Chem Biol. 2007;3:323-4 pubmed
    ..Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery. ..
  79. Li W, Brudecki L, Senior A, Ahmad Z. Role of {alpha}-subunit VISIT-DG sequence residues Ser-347 and Gly-351 in the catalytic sites of Escherichia coli ATP synthase. J Biol Chem. 2009;284:10747-54 pubmed publisher
    ..In contrast, alphaGly-351, although strongly conserved and clearly important for function, appears not to play a direct role. ..
  80. Upadhayaya R, Kulkarni G, Vasireddy N, Vandavasi J, Dixit S, Sharma V, et al. Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis. Bioorg Med Chem. 2009;17:4681-92 pubmed publisher
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    ..9 ± 0.2 for the mitochondrial enzyme and 3.9 ± 0.3 for the chloroplast enzyme. The data show that the thermodynamic H(+)/ATP ratio depends on the stoichiometry of the c-subunit, although it is not identical to the c/? ratio. ..
  82. Tyynela J, Suopanki J, Baumann M, Haltia M. Sphingolipid activator proteins (SAPs) in neuronal ceroid lipofuscinoses (NCL). Neuropediatrics. 1997;28:49-52 pubmed
    ..The SAPs, their functions and occurrence in different forms of NCL, as well as the relationship between SAPs and palmitoyl protein thioesterase, an enzyme implicated in INCL, are discussed. ..
  83. Rigoulet M, Leverve X, Fontaine E, Ouhabi R, Guerin B. Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: dependence upon both fluxes and forces. Mol Cell Biochem. 1998;184:35-52 pubmed
    ..e. redox loop or proton pump) and their kinetic control versus regulation of mitochondrial oxidative phosphorylation. ..
  84. Huitric E, Verhasselt P, Andries K, Hoffner S. In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor. Antimicrob Agents Chemother. 2007;51:4202-4 pubmed
    ..032 microg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes. ..
  85. Wood K, Dunn S. Role of the asymmetry of the homodimeric b2 stator stalk in the interaction with the F1 sector of Escherichia coli ATP synthase. J Biol Chem. 2007;282:31920-7 pubmed
    ..These results imply that the polypeptide in the bN position is more important for F1 binding than the one in the bC position and illustrate the significance of the asymmetry of the b dimer in the enzyme. ..
  86. Zaida T, Hornung T, Volkov O, Hoffman A, Pandey S, Wise J, et al. Conformational changes in the Escherichia coli ATP synthase b-dimer upon binding to F(1)-ATPase. J Bioenerg Biomembr. 2008;40:551-9 pubmed publisher
    ..Mechanistic implications of this "bubble" formation in the tether domain of ATP synthase b ( 2 ) are discussed. ..
  87. Belogrudov G. Recent advances in structure-functional studies of mitochondrial factor B. J Bioenerg Biomembr. 2009;41:137-43 pubmed publisher
    ..We propose that the binding of the ATP synthase dimers with factor B tetramers could be a means to enhance the efficiency of the terminal step of oxidative phosphorylation in animal mitochondria. ..
  88. Novakova Z, Bobalova J, Vidová M, Hapala I, Smigán P. Tributyltin-resistant Methanothermobacter thermautotrophicus mutant with mutational substitutions in the A1A0-ATP synthase operon. FEMS Microbiol Lett. 2009;298:255-9 pubmed publisher
    ..The results imply that change of TBT sensitivities of TBT-resistant mutant is due to mutational substitutions in the A(1)A(0)-ATP synthase operon. ..
  89. Chaikeeratisak V, Somboonwiwat K, Wang H, Lo C, Tassanakajon A. Proteomic analysis of differentially expressed proteins in the lymphoid organ of Vibrio harveyi-infected Penaeus monodon. Mol Biol Rep. 2012;39:6367-77 pubmed publisher
    ..3%) and a dramatic reduction of the total hemocyte numbers in the survival shrimps. These altered proteins are likely to play essential roles in shrimp defense against the pathogenic bacterium V. harveyi...
  90. Jovic M, Stancic A, Nenadic D, Cekic O, Nezic D, Milojevic P, et al. Mitochondrial molecular basis of sevoflurane and propofol cardioprotection in patients undergoing aortic valve replacement with cardiopulmonary bypass. Cell Physiol Biochem. 2012;29:131-42 pubmed publisher
    ..It appears that sevoflurane acts regulating cytochrome c oxidase and ATP synthase, while the effects of propofol occur through regulation of cytochrome c, Cx43, mtDNA transcription and UCP2. ..
  91. Andersson B, Aslund L, Tammi M, Tran A, Hoheisel J, Pettersson U. Complete sequence of a 93.4-kb contig from chromosome 3 of Trypanosoma cruzi containing a strand-switch region. Genome Res. 1998;8:809-16 pubmed
    ..cruzi and shows the potential of this approach for rapid identification of novel genes. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF052831-AF052833.] ..
  92. He Z, Hu Y, Zhong H, Hu W, Xu J. Preliminary proteomic analysis of Thiobacillus ferrooxidans growing on elemental sulphur and Fe2+ separately. J Biochem Mol Biol. 2005;38:307-13 pubmed
    ..ATP synthase Beta chain is the catalytic subunit, and ATP synthase alpha chain is a regulatory subunit. The function of ATPase produces ATP from ADP in the presence of a proton gradient across the membrane. ..