arginine kinase

Summary

Summary: An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.

Top Publications

  1. Holt S, Kinsey S. Osmotic effects on arginine kinase function in living muscle of the blue crab Callinectes sapidus. J Exp Biol. 2002;205:1775-85 pubmed
    Flux was examined through the reaction catalyzed by arginine kinase in intact blue crab (Callinectes sapidus) muscle during simulated changes in salinity...
  2. Kotlyar S, Weihrauch D, Paulsen R, Towle D. Expression of arginine kinase enzymatic activity and mRNA in gills of the euryhaline crabs Carcinus maenas and Callinectes sapidus. J Exp Biol. 2000;203:2395-404 pubmed
    ..The major invertebrate phosphagen kinase, arginine kinase, is expressed in the gills of two species of euryhaline crabs, the blue crab Callinectes sapidus and the ..
  3. Zuniga F, Ochoa G, Kelly S, Robles L. S-crystallin and arginine kinase bind F-actin in light- and dark-adapted octopus retinas. Curr Eye Res. 2004;28:343-50 pubmed
    ..These proteins and the 26 kD protein were sequenced and identified as hemocynanin, transitional ER ATPase, arginine kinase and S-crystallin, respectively...
  4. Ma F, Liu Q, Guan G, Li C, Huang J. Arginine kinase of Litopenaeus vannamei involved in white spot syndrome virus infection. Gene. 2014;539:99-106 pubmed publisher
    ..In this study, we explored the interaction of VP14 with host cell. A new shrimp protein (arginine kinase of Litopenaeus vannamei, LvAK) is selected and its localization in shrimp cells is also confirmed...
  5. Shi X, Wang L, Zhou Z, Yang C, Gao Y, Wang L, et al. The arginine kinase in Zhikong scallop Chlamys farreri is involved in immunomodulation. Dev Comp Immunol. 2012;37:270-8 pubmed publisher
    b>Arginine kinase (AK) catalyzes the reversible phosphorylation of l-arginine to form phosphoarginine, and plays a critical role in energy metabolism in invertebrates...
  6. Yousef M, Fabiola F, Gattis J, Somasundaram T, Chapman M. Refinement of the arginine kinase transition-state analogue complex at 1.2 A resolution: mechanistic insights. Acta Crystallogr D Biol Crystallogr. 2002;58:2009-17 pubmed
    The three-dimensional crystal structure of an arginine kinase transition-state analogue complex has been refined at 1.2 A resolution, with an overall R factor of 12.3%...
  7. Yousef M, Clark S, Pruett P, Somasundaram T, Ellington W, Chapman M. Induced fit in guanidino kinases--comparison of substrate-free and transition state analog structures of arginine kinase. Protein Sci. 2003;12:103-11 pubmed
    b>Arginine kinase (AK) is a member of the guanidino kinase family that plays an important role in buffering ATP concentration in cells with high and fluctuating energy demands...
  8. Garcia Orozco K, Aispuro Hernandez E, Yepiz Plascencia G, Calderón de la Barca A, Sotelo Mundo R. Molecular characterization of arginine kinase, an allergen from the shrimp Litopenaeus vannamei. Int Arch Allergy Immunol. 2007;144:23-8 pubmed
    ..vannamei muscle cDNA library. A 40-kDa protein was purified and identified as arginine kinase and its cDNA of 1.4 kb encoded a 356 amino acid protein...
  9. Wickramasinghe S, Uda K, Nagataki M, Yatawara L, Rajapakse R, Watanabe Y, et al. Toxocara canis: molecular cloning, characterization, expression and comparison of the kinetics of cDNA-derived arginine kinase. Exp Parasitol. 2007;117:124-32 pubmed
    b>Arginine kinase (AK) is a member of a highly conserved family of phosphagen kinases...

More Information

Publications67

  1. Brown A, Grossman S. The mechanism and modes of inhibition of arginine kinase from the cockroach (Periplaneta americana). Arch Insect Biochem Physiol. 2004;57:166-77 pubmed
    The kinetic mechanism and evaluation of several potential inhibitors of purified arginine kinase from the cockroach (Periplanta americana) were investigated...
  2. Perovic Ottstadt S, Wiens M, Schröder H, Batel R, Giovine M, Krasko A, et al. Arginine kinase in the demosponge Suberites domuncula: regulation of its expression and catalytic activity by silicic acid. J Exp Biol. 2005;208:637-46 pubmed
    ..The present study demonstrates that primmorphs from the demosponge Suberites domuncula express the gene for arginine kinase after exposure to exogenous silicic acid...
  3. Fujimoto N, Tanaka K, Suzuki T. Amino acid residues 62 and 193 play the key role in regulating the synergism of substrate binding in oyster arginine kinase. FEBS Lett. 2005;579:1688-92 pubmed
    ..of this study is to clarify the amino acid residues responsible for the synergism in substrate binding of arginine kinase (AK), a key enzyme in invertebrate energy metabolism...
  4. Wright Weber B, Held B, Brown A, Grossman S. Immunological and physical comparison of monomeric and dimeric phosphagen kinases: Some evolutionary implications. Biochim Biophys Acta. 2006;1760:364-71 pubmed
    ..Antibodies against dimeric arginine kinase from the sea cucumber cross-reacted with dimeric arginine kinase purified from sea urchin eggs, but failed to ..
  5. Sookrung N, Chaicumpa W, Tungtrongchitr A, Vichyanond P, Bunnag C, Ramasoota P, et al. Periplaneta americana arginine kinase as a major cockroach allergen among Thai patients with major cockroach allergies. Environ Health Perspect. 2006;114:875-80 pubmed
    ..americana is a pan-insect protein. The MAb-bound protein of P. americana was shown to be arginine kinase that reacted to IgE in the sera of all of the CR-allergic Thai patients by immunoblotting, implying its high ..
  6. Xia Y, Park Y, Mu H, Zhou H, Wang X, Meng F. The protective effects of osmolytes on arginine kinase unfolding and aggregation. Int J Biol Macromol. 2007;40:437-43 pubmed
    ..e., proline, sucrose, DMSO and glycerol, were studied during arginine kinase (EC 2.7.3.3) unfolding and aggregation...
  7. Pruett P, Azzi A, Clark S, Yousef M, Gattis J, Somasundaram T, et al. The putative catalytic bases have, at most, an accessory role in the mechanism of arginine kinase. J Biol Chem. 2003;278:26952-7 pubmed
    b>Arginine kinase is a member of the phosphagen kinase family that includes creatine kinase and likely shares a common reaction mechanism in catalyzing the buffering of cellular ATP energy levels...
  8. Compaan D, Ellington W. Functional consequences of a gene duplication and fusion event in an arginine kinase. J Exp Biol. 2003;206:1545-56 pubmed
    b>Arginine kinase (AK) from the foot of the razor clam Ensis directus consists of two full-length AK domains, denoted D1 and D2, fused in a single polypeptide chain...
  9. Pereira C, Alonso G, Ivaldi S, Silber A, Alves M, Bouvier L, et al. Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication. FEBS Lett. 2002;526:111-4 pubmed
    ..In this work we propose a relationship between L-arginine uptake, arginine kinase activity and the parasite replication ability...
  10. Pereira C, Alonso G, Torres H, Flawia M. Arginine kinase: a common feature for management of energy reserves in African and American flagellated trypanosomatids. J Eukaryot Microbiol. 2002;49:82-5 pubmed
    This work reports the characterization of an arginine kinase in the unicellular parasitic flagellate Trypanosoma brucei, the etiological agent of human sleeping sickness and Nagana in livestock...
  11. Miranda M, Bouvier L, Canepa G, Pereira C. Subcellular localization of Trypanosoma cruzi arginine kinase. Parasitology. 2009;136:1201-7 pubmed publisher
    Phosphoarginine is a cell energy buffer molecule synthesized by the enzyme arginine kinase. In Trypanosoma cruzi, the aetiological agent of Chagas' disease, 2 different isoforms were identified by data mining, but only 1 was expressed ..
  12. Alonso G, Pereira C, Remedi M, Paveto M, Cochella L, Ivaldi M, et al. Arginine kinase of the flagellate protozoa Trypanosoma cruzi. Regulation of its expression and catalytic activity. FEBS Lett. 2001;498:22-5 pubmed
    In epimastigotes of Trypanosoma cruzi, the etiological agent of Chagas' disease, arginine kinase activity increased continuously during the exponential phase of growth...
  13. Suzuki T, Kamidochi M, Inoue N, Kawamichi H, Yazawa Y, Furukohri T, et al. Arginine kinase evolved twice: evidence that echinoderm arginine kinase originated from creatine kinase. Biochem J. 1999;340 ( Pt 3):671-5 pubmed
    b>Arginine kinase (AK) was isolated from the longitudinal muscle of the sea cucumber Stichopus japonicus...
  14. Tanaka K, Ichinari S, Iwanami K, Yoshimatsu S, Suzuki T. Arginine kinase from the beetle Cissites cephalotes (Olivier). Molecular cloning, phylogenetic analysis and enzymatic properties. Insect Biochem Mol Biol. 2007;37:338-45 pubmed
    Here, we report the PCR amplification and cloning of a cDNA for arginine kinase (AK) from the beetle Cissites cephalotes (Olivier)...
  15. Mahon B, Neigel J. Utility of arginine kinase for resolution of phylogenetic relationships among Brachyuran genera and families. Mol Phylogenet Evol. 2008;48:718-27 pubmed publisher
    ..Here we examine the utility of the nuclear gene that encodes arginine kinase for phylogenetic reconstruction at intermediate levels (relationships among genera and families) within the ..
  16. Canepa G, Carrillo C, Miranda M, Sayé M, Pereira C. Arginine kinase in Phytomonas, a trypanosomatid parasite of plants. Comp Biochem Physiol B Biochem Mol Biol. 2011;160:40-3 pubmed publisher
    ..Little is known about the biology of these organisms including aspects of their metabolism. Arginine kinase (E.C. 2.7.3...
  17. Kucharski R, Maleszka R. Arginine kinase is highly expressed in the compound eye of the honey bee, Apis mellifera. Gene. 1998;211:343-9 pubmed
    We have cloned and sequenced a 1.68-kb cDNA encoding arginine kinase in the honey bee, Apis mellifera...
  18. Hoffman G, Ellington W. Arginine kinase isoforms in the closest protozoan relative of metazoans. Comp Biochem Physiol Part D Genomics Proteomics. 2011;6:171-7 pubmed publisher
    ..the choanoflagellate Monosiga brevicollis contains at least three genes for the phosphoryl transfer enzyme, arginine kinase (AK; EC 2.7.3.3)...
  19. Kemppainen P, Lindskog T, Butlin R, Johannesson K. Intron sequences of arginine kinase in an intertidal snail suggest an ecotype-specific selective sweep and a gene duplication. Heredity (Edinb). 2011;106:808-16 pubmed publisher
    ..Here we sequenced an intron in the arginine kinase gene (Ark), which shows strong clinal variation between two locally adapted ecotypes of the flat periwinkle, ..
  20. Niu X, Bruschweiler Li L, Davulcu O, Skalicky J, Bruschweiler R, Chapman M. Arginine kinase: joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility. J Mol Biol. 2011;405:479-96 pubmed publisher
    ..Thus, "substrate-induced" motions are along modes that are intrinsically flexible in the substrate-free enzyme and likely involve some degree of conformational selection. ..
  21. Zhang X, Wang W, Wang J, Pan J. PPIase independent chaperone-like function of recombinant human Cyclophilin A during arginine kinase refolding. FEBS Lett. 2013;587:666-72 pubmed publisher
    ..However, these variants were able to suppress aggregation during arginine kinase (AK) refolding as efficient as wild-type rhCyPA, especially, variant Q63A had even more efficiency to ..
  22. Gattis J, Ruben E, Fenley M, Ellington W, Chapman M. The active site cysteine of arginine kinase: structural and functional analysis of partially active mutants. Biochemistry. 2004;43:8680-9 pubmed
    b>Arginine kinase buffers cellular ATP levels by catalyzing reversible phosphoryl transfer between ATP and arginine. A conserved cysteine has long been thought important in catalysis...
  23. Davulcu O, Skalicky J, Chapman M. Rate-limiting domain and loop motions in arginine kinase. Biochemistry. 2011;50:4011-8 pubmed publisher
    b>Arginine kinase catalyzes the reversible transfer of a phosphoryl group between ATP and arginine. It is the arthropod homologue of creatine kinase, buffering cellular ATP levels...
  24. Binder M, Mahler V, Hayek B, Sperr W, Scholler M, Prozell S, et al. Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen. J Immunol. 2001;167:5470-7 pubmed
    ..interpunctella larvae. cDNAs coding for arginine kinase (EC 2.7.3...
  25. Wang H, Zhang L, Zhang L, Lin Q, Liu N. Arginine kinase: differentiation of gene expression and protein activity in the red imported fire ant, Solenopsis invicta. Gene. 2009;430:38-43 pubmed publisher
    b>Arginine kinase (AK), a primary enzyme in cell metabolism and adenosine 5'-triphosphate (ATP)-consuming processes, plays an important role in cellular energy metabolism and maintaining constant ATP levels in invertebrate cells...
  26. Wickramasinghe S, Yatawara L, Nagataki M, Takamoto M, Watanabe Y, Rajapakse R, et al. Development of a highly sensitive IgG-ELISA based on recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model. Parasitol Res. 2008;103:853-8 pubmed publisher
    ..The present study describes the development of IgG-ELISA based on antiserum prepared against the recombinant arginine kinase of Toxocara canis...
  27. Fernandez P, Haouz A, Pereira C, Aguilar C, Alzari P. The crystal structure of Trypanosoma cruzi arginine kinase. Proteins. 2007;69:209-12 pubmed publisher
  28. Yu C, Lin Y, Chiang B, Chow L. Proteomics and immunological analysis of a novel shrimp allergen, Pen m 2. J Immunol. 2003;170:445-53 pubmed
    ..Comparison of the Pen m 2 sequence with known protein sequences revealed extensive similarity with arginine kinase (EC 2.7.3.3) from crustaceans...
  29. Suzuki T, Tomoyuki T, Uda K. Kinetic properties and structural characteristics of an unusual two-domain arginine kinase of the clam Corbicula japonica. FEBS Lett. 2003;533:95-8 pubmed
    b>Arginine kinase (AK) from the clam Corbicula japonica is a unique enzyme in that it has an unusual two-domain structure with molecular mass of 80 kDa...
  30. Pereira C, Alonso G, Ivaldi S, Bouvier L, Torres H, Flawia M. Screening of substrate analogs as potential enzyme inhibitors for the arginine kinase of Trypanosoma cruzi. J Eukaryot Microbiol. 2003;50:132-4 pubmed
    b>Arginine kinase catalyzes the transphosphorylation between phosphoarginine and ADP. Phosphoarginine is involved in temporal ATP buffering and inorganic phosphate regulation...
  31. Kinsey S, Lee B. The effects of rapid salinity change on in vivo arginine kinase flux in the juvenile blue crab, Callinectes sapidus. Comp Biochem Physiol B Biochem Mol Biol. 2003;135:521-31 pubmed
    ..of acclimation salinity and salinity changes on the concentration of high-energy phosphate metabolites and arginine kinase (AK) flux was examined in vivo in juvenile blue crabs using 31P-nuclear magnetic resonance (NMR)...
  32. Miranda M, Canepa G, Bouvier L, Pereira C. Trypanosoma cruzi: Oxidative stress induces arginine kinase expression. Exp Parasitol. 2006;114:341-4 pubmed
    Trypanosoma cruzi arginine kinase is a key enzyme in cell energy management and is also involved in pH and nutritional stress response mechanisms. T...
  33. Yao C, Wu C, Xiang J, Dong B. Molecular cloning and response to laminarin stimulation of arginine kinase in haemolymph in Chinese shrimp, Fenneropenaeus chinensis. Fish Shellfish Immunol. 2005;19:317-29 pubmed
    b>Arginine kinase (AK) was previously reported as a phosphagen-ATP phosphotransferase found in invertebrates. In this study, an 1184 bp cDNA was cloned and sequenced...
  34. Nagataki M, Uda K, Jarilla B, Tokuhiro S, Wickramasinghe S, Suzuki T, et al. Molecular and catalytic properties of an arginine kinase from the nematode Ascaris suum. J Helminthol. 2012;86:276-86 pubmed publisher
    We amplified the cDNA coding for arginine kinase (AK) from the parasitic nematode Ascaris suum, cloned it in pMAL plasmid and expressed the enzyme as a fusion protein with the maltose-binding protein...
  35. Canonaco F, Schlattner U, Wallimann T, Sauer U. Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli. Biotechnol Lett. 2003;25:1013-7 pubmed
    ..By overexpression of arginine kinase from Limulus polyphemus in E. coli, we improved the recovery from a transient pH stress. While wild type E...
  36. Wu Q, Li F, Wang X. Evidence that amino-acid residues are responsible for substrate synergism of locust arginine kinase. Insect Biochem Mol Biol. 2008;38:59-65 pubmed
    ..were constructed to investigate the amino-acid residues responsible for the synergism in substrate binding of arginine kinase (AK). AK contains a pair of highly conserved amino acids (Y75 and P272) that form a hydrogen bond...
  37. Pereira C, Alonso G, Ivaldi S, Silber A, Alves M, Torres H, et al. Arginine kinase overexpression improves Trypanosoma cruzi survival capability. FEBS Lett. 2003;554:201-5 pubmed
    b>Arginine kinase catalyzes the reversible transphosphorylation between adenosine diphosphate (ADP) and phosphoarginine, which is involved in temporal and spatial adenosine triphosphate (ATP) buffering...
  38. Azzi A, Clark S, Ellington W, Chapman M. The role of phosphagen specificity loops in arginine kinase. Protein Sci. 2004;13:575-85 pubmed
    ..In the present work, chimeric mutants were constructed with creatine kinase loop elements inserted into arginine kinase. Contrary to the prior rationalizations of specificity, most had measurable arginine kinase activity but no ..
  39. Uda K, Suzuki T. Role of amino acid residues on the GS region of Stichopus arginine kinase and Danio creatine kinase. Protein J. 2004;23:53-64 pubmed
    Stichopus arginine kinase (AK) is a unique enzyme in that it evolved not from the AK gene but from the creatine kinase (CK) gene: the entire amino acid sequence is homologous with other CKs apart from the guanidine specificity region (GS ..
  40. Liu Z, Xia L, Wu Y, Xia Q, Chen J, Roux K. Identification and characterization of an arginine kinase as a major allergen from silkworm (Bombyx mori) larvae. Int Arch Allergy Immunol. 2009;150:8-14 pubmed publisher
    ..The cDNA of arginine kinase from the B. mori silkworm was also cloned and expressed in high yield in Escherichia coli...
  41. Pan J, Yu Z, Hui E, Zhou H. Conformational change and inactivation of arginine kinase from shrimp Feneropenaeus chinensis in oxidized dithiothreitol solutions. Biochem Cell Biol. 2004;82:361-7 pubmed
    The effect of oxidized dithiothreitol (DTT) on the conformation and function of arginine kinase from shrimp Feneropenaeus chinensis was investigated with the methods of intrinsic fluorescence, ANS fluorescence, size exclusion ..
  42. Voncken F, Gao F, Wadforth C, Harley M, Colasante C. The phosphoarginine energy-buffering system of trypanosoma brucei involves multiple arginine kinase isoforms with different subcellular locations. PLoS ONE. 2013;8:e65908 pubmed publisher
    ..Here we describe the phosphoarginine/arginine kinase system of the kinetoplastid parasite Trypanosoma brucei, consisting of three highly similar arginine kinase ..
  43. Uda K, Ellington W, Suzuki T. A diverse array of creatine kinase and arginine kinase isoform genes is present in the starlet sea anemone Nematostella vectensis, a cnidarian model system for studying developmental evolution. Gene. 2012;497:214-27 pubmed publisher
    ..Prior work has shown that PKs can be phylogenetically separated into two distinct groups- an arginine kinase (AK) subfamily and a creatine kinase (CK) subfamily...
  44. Noguchi M, Sawada T, Akazawa T. ATP-regenerating system in the cilia of Paramecium caudatum. J Exp Biol. 2001;204:1063-71 pubmed
    ..is thought to be maintained by ATP-regenerating enzymes such as adenylate kinase, creatine kinase and arginine kinase. In this study, the energy-supplying system for the ciliary movement of Paramecium caudatum was examined...
  45. Kang L, Shi H, Liu X, Zhang C, Yao Q, Wang Y, et al. Arginine kinase is highly expressed in a resistant strain of silkworm (Bombyx mori, Lepidoptera): Implication of its role in resistance to Bombyx mori nucleopolyhedrovirus. Comp Biochem Physiol B Biochem Mol Biol. 2011;158:230-4 pubmed publisher
    A gene encoding Bombyx mori arginine kinase (BmAK) has been indentified differentially expressed in the midguts of Bombyx mori strain NB which is resistant to nucleopolyhedrovirus (BmNPV), strain 306 which is susceptible to NPV and a ..
  46. Tang H, Yu H. Intermediate studies on refolding of arginine kinase denatured by guanidine hydrochloride. Biochem Cell Biol. 2005;83:109-14 pubmed
    The refolding course and intermediate of guanidine hydrochloride (GuHCl)-denatured arginine kinase (AK) were studied in terms of enzymatic activity, intrinsic fluorescence, 1-anilino-8-naphthalenesulfonte (ANS) fluorescence, and far-UV ..
  47. Wu X, Zhu W, Lu Z, Xia Y, Yang J, Zou F, et al. The effect of rutin on arginine kinase: inhibition kinetics and thermodynamics merging with docking simulation. Int J Biol Macromol. 2009;44:149-55 pubmed publisher
    b>Arginine kinase (AK; EC 2.7.3.3) is a key enzyme in the cellular energy metabolism of insects. Screening on potential effective inhibitors of AK may provide a pathway for novel, environmentally friendly insecticides...
  48. Canonaco F, Schlattner U, Pruett P, Wallimann T, Sauer U. Functional expression of phosphagen kinase systems confers resistance to transient stresses in Saccharomyces cerevisiae by buffering the ATP pool. J Biol Chem. 2002;277:31303-9 pubmed
    ..Second, using arginine kinase, we successfully installed an intracellular phosphagen pool of about 5 mM phosphoarginine...
  49. Zhu J, Fang Q, Wang L, Hu C, Ye G. Proteomic analysis of the venom from the endoparasitoid wasp Pteromalus puparum (Hymenoptera: Pteromalidae). Arch Insect Biochem Physiol. 2010;75:28-44 pubmed publisher
    ..Several venom proteins such as calreticulin, venom acid phosphatase, serine protease, arginine kinase, serine protease homolog, aminotransferase-like venom protein, and heat shock protein 70, were identified in ..
  50. Kaltenpoth M, Showers Corneli P, Dunn D, Weiss R, Strohm E, Seger J. Accelerated evolution of mitochondrial but not nuclear genomes of Hymenoptera: new evidence from crabronid wasps. PLoS ONE. 2012;7:e32826 pubmed publisher
    ..reconstructed with whole mitochondrial genomes as well as four single-copy nuclear genes (18S rRNA, arginine kinase, wingless, phosphoenolpyruvate carboxykinase). The mt-genome of P...
  51. Hornáková D, Matousková P, Kindl J, Valterova I, Pichova I. Selection of reference genes for real-time polymerase chain reaction analysis in tissues from Bombus terrestris and Bombus lucorum of different ages. Anal Biochem. 2010;397:118-20 pubmed publisher
    ..To date, no reference genes have been identified for these species. Our data show that arginine kinase (AK) and phospholipase A2 (PLA2) are the most stable genes in both tissues of B. terrestris...
  52. Ercan A, Grossman S. Proteolytic susceptibility of creatine kinase isozymes and arginine kinase. Biochem Biophys Res Commun. 2003;306:1014-8 pubmed
    ..isozymes of creatine kinase, CK-MM (muscle), CK-BB (brain), and CK-MB (heart) and the homologous monomer, arginine kinase were compared...
  53. Jiang S, Jia Z, Chen H, Wang L, Song L. The modulation of haemolymph arginine kinase on the extracellular ATP induced bactericidal immune responses in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2016;54:282-93 pubmed publisher
    b>Arginine kinase is an important phosphagen kinase (PK) which plays an essential role in ATP buffering systems in invertebrates...
  54. Tang H, Yang Y, Zhang S. Effects of aspartic acid and potassium chloride on arginine kinase from shrimp. Int J Biol Macromol. 2006;40:15-21 pubmed
    The aspartic acid (Asp)-induced unfolding and the salt-induced folding of arginine kinase (AK) were studied in terms of enzyme activity, intrinsic fluorescence emission spectra, 1-anilino-8-naphthalenesulfonate (ANS) fluorescence spectra ..
  55. Johnson L, Dillaman R, Gay D, Blum J, Kinsey S. Metabolic influences of fiber size in aerobic and anaerobic locomotor muscles of the blue crab, Callinectes sapidus. J Exp Biol. 2004;207:4045-56 pubmed
  56. Suzuki T, Yamamoto Y. Gene structure of two-domain arginine kinases from Anthopleura japonicus and Pseudocardium sachalinensis. Comp Biochem Physiol B Biochem Mol Biol. 2000;127:513-8 pubmed
    ..elegans AK genes indicates that there is no intron conserved through the three AK lineages, in sharp contrast to relatively conservative intron positions in creatine kinase (CK) gene family. ..
  57. Ge L, Huang L, Yang G, Song Q, Stanley D, Gurr G, et al. Molecular basis for insecticide-enhanced thermotolerance in the brown planthopper Nilaparvata lugens Stål (Hemiptera:Delphacidae). Mol Ecol. 2013;22:5624-34 pubmed publisher
    ..To investigate the underlying molecular mechanism of this tzp-enhanced thermotolerance, we selected Hsp70 and Arginine kinase (Argk) for detailed study...
  58. Walter G, Barton E, Sweeney H. Noninvasive measurement of gene expression in skeletal muscle. Proc Natl Acad Sci U S A. 2000;97:5151-5 pubmed
    ..A recombinant adenovirus was constructed by using the gene for arginine kinase (AK), which is the invertebrate correlate to the vertebrate ATP-buffering enzyme, creatine kinase...