adenylate kinase

Summary

Summary: An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.

Top Publications

  1. Milara J, Armengot M, Mata M, Morcillo E, Cortijo J. Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia. Am J Rhinol Allergy. 2010;24:181-5 pubmed publisher
    b>Adenylate kinase 7 (AK7) mediates the reaction 2ADP <--> ATP + AMP, providing energy for the beating of cilia. A study recently showed that AK7 expression may be correlated with the primary ciliary dyskinesia (PCD) phenotype in mice...
  2. Li W, Terakawa T, Wang W, Takada S. Energy landscape and multiroute folding of topologically complex proteins adenylate kinase and 2ouf-knot. Proc Natl Acad Sci U S A. 2012;109:17789-94 pubmed publisher
    ..the energy landscapes and folding routes of two proteins with complex topologies: a multidomain protein adenylate kinase (AKE) and a knotted protein 2ouf-knot...
  3. Song H, Zhu F. Conformational dynamics of a ligand-free adenylate kinase. PLoS ONE. 2013;8:e68023 pubmed publisher
    b>Adenylate kinase (AdK) is a phosphoryl-transfer enzyme with important physiological functions...
  4. Lee Y, Park O. Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells. Oncol Rep. 2010;24:1493-7 pubmed
    ..The investigation of mutual suppression between Akt and AMPK by chemo-preventive agents such as quercetin may provide a mechanistic rational for controlling breast tumor cell growth. ..
  5. Valenti D, Tullo A, Caratozzolo M, Merafina R, Scartezzini P, Marra E, et al. Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy. Biochem J. 2010;431:299-310 pubmed publisher
    ..involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT (adenine nucleotide translocator) and AK (adenylate kinase), in DS-HSF (human skin fibroblasts with trisomic karyotype), comparing them with euploid fibroblasts...
  6. Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, et al. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A. 2010;107:21830-5 pubmed publisher
    ..In summary, our data suggest a potential beneficial role of biguanides such as metformin in the prophylaxis and/or therapy of AD. ..
  7. Kim M, Tian R. Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol. 2011;51:548-53 pubmed publisher
    ..This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure." ..
  8. Lea M, Chacko J, Bolikal S, Hong J, Chung R, Ortega A, et al. Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin. Anticancer Res. 2011;31:421-6 pubmed
    ..Combined incubation of 2-deoxyglucose with either of the biguanides prevented the acidification of the medium but enhanced the growth inhibitory effects. ..
  9. Dzeja P, Chung S, Faustino R, Behfar A, Terzic A. Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. PLoS ONE. 2011;6:e19300 pubmed publisher
    Energetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase (AMPK) constitute a major metabolic signaling axis, yet the role of this system ..

More Information

Publications69

  1. Strunk B, Novak M, Young C, Karbstein K. A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell. 2012;150:111-21 pubmed publisher
    ..This cycle thus provides a functional test of 60S subunit binding and the GTPase site before ribosomes enter the translating pool. ..
  2. Ben Ishay E, Rahamim G, Orevi T, Hazan G, Amir D, Haas E. Fast subdomain folding prior to the global refolding transition of E. coli adenylate kinase: a double kinetics study. J Mol Biol. 2012;423:613-23 pubmed publisher
    ..of a 44-chain segment that includes the AMP(bind) domain, by labeling residues 28 and 71, in Escherichia coli adenylate kinase (AK) and the distribution of the distance between residues 18 and 203, which depends on the overall order of ..
  3. Jan Y, Tsai H, Yang C, Huang M, Yang Y, Lai T, et al. Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3. Cancer Res. 2012;72:5119-29 pubmed publisher
    ..In this study, we show that adenylate kinase-4 (AK4) is a progression-associated gene in human lung cancer that promotes metastasis...
  4. Adén J, Weise C, Brannstrom K, Olofsson A, Wolf Watz M. Structural topology and activation of an initial adenylate kinase-substrate complex. Biochemistry. 2013;52:1055-61 pubmed publisher
    ..Such structures are inherently difficult to study with conventional experimental techniques. The enzyme adenylate kinase undergoes major conformational rearrangements in response to binding of its substrates, ATP and AMP...
  5. Potoyan D, Zhuravlev P, Papoian G. Computing free energy of a large-scale allosteric transition in adenylate kinase using all atom explicit solvent simulations. J Phys Chem B. 2012;116:1709-15 pubmed publisher
    ..computational technique, we calculated the free energy difference between the open and closed states of adenylate kinase, an allosteric protein which was extensively studied previously using both experimental and theoretical ..
  6. Nagarajan S, Amir D, Grupi A, Goldenberg D, Minton A, Haas E. Modulation of functionally significant conformational equilibria in adenylate kinase by high concentrations of trimethylamine oxide attributed to volume exclusion. Biophys J. 2011;100:2991-9 pubmed publisher
    ..molecule osmolyte, trimethyl amine N-oxide (TMAO), upon the conformational equilibria of Escherichia coli adenylate kinase was studied using time-resolved FRET...
  7. Peng X, Wang L, Chen G, Wang X. Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats. J Mol Neurosci. 2012;47:150-7 pubmed publisher
    Studies have shown that adenylate kinase 2 (AK2) is released from the mitochondrial inner membrane space during neuronal apoptosis, which plays an important role in temporal lobe epilepsy (TLE)...
  8. Armenta Medina D, Perez Rueda E, Segovia L. Identification of functional motions in the adenylate kinase (ADK) protein family by computational hybrid approaches. Proteins. 2011;79:1662-71 pubmed publisher
    ..normal mode analysis (NMA), evolutionarily coupled residues involved in functionally relevant motion in the adenylate kinase protein family were identified...
  9. Aksentijevic D, Lygate C, Makinen K, Zervou S, Sebag Montefiore L, Medway D, et al. High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes. Eur J Heart Fail. 2010;12:1282-9 pubmed publisher
    To measure the activity of the key phosphotransfer enzymes creatine kinase (CK), adenylate kinase (AK), and glycolytic enzymes in two common mouse models of chronic heart failure...
  10. Jana B, Adkar B, Biswas R, Bagchi B. Dynamic coupling between the LID and NMP domain motions in the catalytic conversion of ATP and AMP to ADP by adenylate kinase. J Chem Phys. 2011;134:035101 pubmed publisher
    ..of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP ..
  11. Burkart A, Shi X, Chouinard M, Corvera S. Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem. 2011;286:4081-9 pubmed publisher
    ..Here we find that adenylate kinase 2 (AK2), a mitochondrial enzyme that regulates adenine nucleotide interconversion within the intermembrane ..
  12. Segall Shapiro T, Nguyen P, Dos Santos E, Subedi S, Judd J, Suh J, et al. Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation. J Mol Biol. 2011;406:135-48 pubmed publisher
    ..approach to create libraries of vectors that express structurally-related fragments of Bacillus subtilis adenylate kinase (BsAK) and Thermotoga neapolitana adenylate kinase (TnAK) with identical modifications at their termini, and ..
  13. Panayiotou C, Solaroli N, Xu Y, Johansson M, Karlsson A. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. Biochem J. 2011;433:527-34 pubmed publisher
    ..expression profiles, substrate specificities, kinetic properties and subcellular localization among the AK (adenylate kinase) isoenzymes have been shown to be important for maintaining a proper adenine nucleotide composition for many ..
  14. Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, et al. Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. Biochem Biophys Res Commun. 2013;433:586-90 pubmed publisher
    ..AMPK stimulation with an AMPK activator, AICAR, enhanced BBB functions. These findings indicate that metformin induces up-regulation of BBB functions via AMPK activation. ..
  15. Gur M, Madura J, Bahar I. Global transitions of proteins explored by a multiscale hybrid methodology: application to adenylate kinase. Biophys J. 2013;105:1643-52 pubmed publisher
    ..Application to adenylate kinase, an allosteric enzyme composed of three domains, CORE, LID, and NMP, shows that both open-to-closed and ..
  16. Ouyang J, Parakhia R, Ochs R. Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem. 2011;286:1-11 pubmed publisher
    ..Knockdown of adenylate kinase also failed to affect metformin stimulation of glucose transport...
  17. Fu D, Wakabayashi Y, Lippincott Schwartz J, Arias I. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc Natl Acad Sci U S A. 2011;108:1403-8 pubmed publisher
    ..Linkage between bile acid synthesis, hepatocyte polarization, and regulation of energy metabolism is likely important in normal hepatocyte development and disease. ..
  18. Birnbaum M, Shaw R. Genomics: Drugs, diabetes and cancer. Nature. 2011;470:338-9 pubmed publisher
  19. Wang Z, Pini M, Yao T, Zhou Z, Sun C, Fantuzzi G, et al. Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway. Am J Physiol Endocrinol Metab. 2011;301:E703-12 pubmed publisher
    ..Moreover, Hcy supplementation was associated with elevated leptin levels and reduced adiponectin levels in plasma. These results show that Hcy inhibits lipolysis through a pathway that involves AMPK activation. ..
  20. Wolsk E, Mygind H, Grøndahl T, Pedersen B, van Hall G. IL-6 selectively stimulates fat metabolism in human skeletal muscle. Am J Physiol Endocrinol Metab. 2010;299:E832-40 pubmed publisher
    ..Our findings suggest that an acute increase in IL-6 at a normophysiological level selectively stimulates lipolysis in skeletal muscle, whereas adipose tissue is unaffected...
  21. Miller C, Davlieva M, Wilson C, White K, Couñago R, Wu G, et al. Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability. Biophys J. 2010;99:887-96 pubmed publisher
    ..In an earlier study, we used a weak-link method to favor changes to an essential but maladapted protein, adenylate kinase (AK), within a microbial population...
  22. Ford R, Rush J. Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent. Am J Physiol Heart Circ Physiol. 2011;300:H64-75 pubmed publisher
  23. Chang X, Ravi R, Pham V, Bedi A, Chatterjee A, Sidransky D. Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance. PLoS ONE. 2011;6:e20806 pubmed publisher
    ..In addition, we found that the expression of mitochondrial-resident protein adenylate kinase-3 (AK3) is decreased by CSC vapor...
  24. Feng X, Yang R, Zheng X, Zhang F. Identification of a novel nuclear-localized adenylate kinase 6 from Arabidopsis thaliana as an essential stem growth factor. Plant Physiol Biochem. 2012;61:180-6 pubmed publisher
    b>Adenylate kinase (AK; EC 2.7.4.3) is highly conserved across a wide range of organisms, including Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana, and Homo sapiens...
  25. Malekkou A, Lederer C, Lamond A, Santama N. The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition. FEBS Lett. 2010;584:4559-64 pubmed publisher
    ..In DNCs, hCINAP co-localizes with Paraspeckle Protein (PSP1) and also co-segregates with PSP1, and not coilin, in nuclear and nucleolar foci upon UV irradiation. ..
  26. Peng C, Zhang L, Head Gordon T. Instantaneous normal modes as an unforced reaction coordinate for protein conformational transitions. Biophys J. 2010;98:2356-64 pubmed publisher
    ..We use adenylate kinase as a test system to show that instantaneous normal modes can be used to identify substates that drive the ..
  27. Wilson G, Layman D, Moulton C, Norton L, Anthony T, Proud C, et al. Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. Am J Physiol Endocrinol Metab. 2011;301:E1236-42 pubmed publisher
    ..Administering Leu or CHO supplements ?2 h after a meal maintains cellular energy status and extends the postprandial duration of MPS. ..
  28. Buchko G, Robinson H, Abendroth J, Staker B, Myler P. Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. Biochem Biophys Res Commun. 2010;394:1012-7 pubmed publisher
    ..46 A. These two BpAdk conformations may represent 'open' Adk sub-states along the preferential pathway to the 'closed' substrate-bound state...
  29. Mata M, Lluch Estellés J, Armengot M, Sarrión I, Carda C, Cortijo J. New adenylate kinase 7 (AK7) mutation in primary ciliary dyskinesia. Am J Rhinol Allergy. 2012;26:260-4 pubmed publisher
    ..1214insT) that, to the best of our knowledge, has not been described previously. Family and functional studies indicated that c.1214insT could be related to PCD. Our results indicate that AK7 may be involved in the development of PCD. ..
  30. Daily M, Phillips G, Cui Q. Many local motions cooperate to produce the adenylate kinase conformational transition. J Mol Biol. 2010;400:618-31 pubmed publisher
    Conformational transitions are functionally important in many proteins. In the enzyme adenylate kinase (AK), two small domains (LID and NMP) close over the larger CORE domain; the reverse (opening) motion limits the rate of catalytic ..
  31. Lammens A, Hopfner K. Structural basis for adenylate kinase activity in ABC ATPases. J Mol Biol. 2010;401:265-73 pubmed publisher
    ..cystic fibrosis transmembrane conductance regulator and the DNA repair protein Rad50 can also catalyze the adenylate kinase reaction (ATP+AMP<-->2ADP)...
  32. Cabreiro F, Au C, Leung K, Vergara Irigaray N, Cocheme H, Noori T, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell. 2013;153:228-39 pubmed publisher
    ..Thus, metformin-induced alteration of microbial metabolism could contribute to therapeutic efficacy-and also to its side effects, which include folate deficiency and gastrointestinal upset...
  33. Matsunaga Y, Fujisaki H, Terada T, Furuta T, Moritsugu K, Kidera A. Minimum free energy path of ligand-induced transition in adenylate kinase. PLoS Comput Biol. 2012;8:e1002555 pubmed publisher
    ..ratio (MBAR) method, the free energy profile of a conformational transition pathway in Escherichia coli adenylate kinase can be characterized in a high-dimensional space...
  34. Yegutkin G, Wieringa B, Robson S, Jalkanen S. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012;26:3875-83 pubmed publisher
    ..of [?-(32)P]ATP and AMP by human and murine sera, which was progressively inhibited by specific adenylate kinase (AK) inhibitor Ap(5)A...
  35. Milagros Camara M, Bouvier L, Miranda M, Pereira C. Identification and validation of Trypanosoma cruzi's glycosomal adenylate kinase containing a peroxisomal targeting signal. Exp Parasitol. 2012;130:408-11 pubmed publisher
    ..In this work we study an adenylate kinase, TcADK3, the only Trypanosoma cruzi protein harboring the putative peroxisomal (glycosomal) targeting signal, ..
  36. Pyra K, Saha D, Reimer R. Prebiotic fiber increases hepatic acetyl CoA carboxylase phosphorylation and suppresses glucose-dependent insulinotropic polypeptide secretion more effectively when used with metformin in obese rats. J Nutr. 2012;142:213-20 pubmed publisher
    ..In conclusion, the combined actions of OFS and MET were associated with important interaction effects that have the potential to improve metabolic outcomes associated with obesity. ..
  37. Drakou C, Malekkou A, Hayes J, Lederer C, Leonidas D, Oikonomakos N, et al. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Proteins. 2012;80:206-20 pubmed publisher
    ..hCINAP has previously been designated as an adenylate kinase (AK6), but is very atypical as it exhibits unusually broad substrate specificity, structural features ..
  38. Grochowski L, Censky K, Xu H, White R. A new class of adenylate kinase in methanogens is related to uridylate kinase. Arch Microbiol. 2012;194:141-5 pubmed publisher
    ..predicted protein sequence indicated that it is a unique kinase with few similarities to either uridylate or adenylate kinase. Here, we report that the MJ0458 gene product is a second type of archaeal adenylate kinase, AdkB...
  39. Ben Sahra I, Le Marchand Brustel Y, Tanti J, Bost F. Metformin in cancer therapy: a new perspective for an old antidiabetic drug?. Mol Cancer Ther. 2010;9:1092-9 pubmed publisher
    ..Finally, metformin activates the AMP activated protein kinase (AMPK) pathway, a major sensor of the energetic status of the cell, which has been proposed as a promising therapeutic target in cancer. ..
  40. Li W, Wolynes P, Takada S. Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins. Proc Natl Acad Sci U S A. 2011;108:3504-9 pubmed publisher
    ..Third, using the new model for adenylate kinase, we show that intrinsic fluctuations in one state contain rare and large-amplitude motions nearly reaching ..
  41. Song C, Lee H, Dings R, Williams B, Powers J, Santos T, et al. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci Rep. 2012;2:362 pubmed publisher
    ..Metformin kills and radiosensitizes cancer cells and eradicates radioresistant cancer stem cells by activating AMPK and suppressing mTOR. ..
  42. Brokaw J, Chu J. On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase. Biophys J. 2010;99:3420-9 pubmed publisher
    We characterized the conformational change of adenylate kinase (AK) between open and closed forms by conducting five all-atom molecular-dynamics simulations, each of 100 ns duration...
  43. Rafalski V, Brunet A. Energy metabolism in adult neural stem cell fate. Prog Neurobiol. 2011;93:182-203 pubmed publisher
    ..A better understanding of how neural stem cells are influenced by changes in energy availability will help unravel the complex nature of neural stem cell biology in both the normal and diseased state. ..
  44. Lin J, Wu S, Huang S, Lu B, Lin S, Tsai S. Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction. Chin J Physiol. 2011;54:406-12 pubmed publisher
    ..In proteomic analysis, the MI group showed decreased expression of adenylate kinase 1 (AK1) and mitochondrial NADP?-dependent isocitrate dehydrogenase (IDPm) after MI compared with the sham ..
  45. Potestio R, Pontiggia F, Micheletti C. Coarse-grained description of protein internal dynamics: an optimal strategy for decomposing proteins in rigid subunits. Biophys J. 2009;96:4993-5002 pubmed publisher
    ..To illustrate this point, we first discuss the decomposition of adenylate kinase and HIV-1 protease and then extend the investigation to several representatives of the hydrolase enzymatic ..
  46. Lagresle Peyrou C, Six E, Picard C, Rieux Laucat F, Michel V, Ditadi A, et al. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet. 2009;41:106-11 pubmed publisher
    ..Here we identify biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis...
  47. Vazquez Martin A, Oliveras Ferraros C, del Barco S, Martin Castillo B, Menendez J. The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy. Ann Oncol. 2009;20:592-5 pubmed publisher
  48. Gigliobianco T, Lakaye B, Makarchikov A, Wins P, Bettendorff L. Adenylate kinase-independent thiamine triphosphate accumulation under severe energy stress in Escherichia coli. BMC Microbiol. 2008;8:16 pubmed publisher
    ..However, it is also known that vertebrate adenylate kinase 1 catalyzes ThTP synthesis at a very low rate and it has been postulated that this enzyme is responsible for ..
  49. Feng Y, Yang L, Kloczkowski A, Jernigan R. The energy profiles of atomic conformational transition intermediates of adenylate kinase. Proteins. 2009;77:551-8 pubmed publisher
    ..we use ENI to generate conformational transition intermediates between the open form and the closed form of adenylate kinase (AK)...
  50. Qiu B, Turner N, Li Y, Gu M, Huang M, Wu F, et al. High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes. 2010;59:256-65 pubmed publisher
    ..These findings suggest that compounds regulating mitochondrial function may have therapeutic potential for type 2 diabetes. ..
  51. Thompson A, Zou A, Yan J, Duggal R, Hao W, Molina D, et al. Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity. Biochemistry. 2009;48:906-16 pubmed publisher
    ..In addition to the hydrolysis of NTP and NDP substrates, adenylate kinase activity was detected in purified preparations of NS4B with the reverse reaction 2ADP --> ATP + ADP, ..
  52. Huang X, Wullschleger S, Shpiro N, McGuire V, Sakamoto K, Woods Y, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J. 2008;412:211-21 pubmed publisher
  53. Henzler Wildman K, Lei M, Thai V, Kerns S, Karplus M, Kern D. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature. 2007;450:913-6 pubmed
    ..Here we show that pico- to nano-second timescale atomic fluctuations in hinge regions of adenylate kinase facilitate the large-scale, slower lid motions that produce a catalytically competent state...
  54. Doran P, O CONNELL K, Gannon J, Kavanagh M, Ohlendieck K. Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis. Proteomics. 2008;8:364-77 pubmed
    ..the mitochondrial ATP synthase, succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase and adenylate kinase (AK) were increased in senescent fibres...
  55. Ramjeesingh M, Ugwu F, Stratford F, Huan L, Li C, Bear C. The intact CFTR protein mediates ATPase rather than adenylate kinase activity. Biochem J. 2008;412:315-21 pubmed publisher
    ..Recently, it was shown that the individual NBDs isolated from CFTR primarily mediate adenylate kinase activity, raising the possibility that this activity may also contribute to gating of the CFTR channel...
  56. Stanojevic V, Habener J, Holz G, Leech C. Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun. 2008;368:614-9 pubmed publisher
    The role of adenylate kinase (AK) as a determinant of K-ATP channel activity in human pancreatic beta-cells was investigated. We have identified that two cytosolic isoforms of AK, AK1 and AK5 are expressed in human islets and INS-1 cells...
  57. Papandreou I, Lim A, Laderoute K, Denko N. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ. 2008;15:1572-81 pubmed publisher
  58. Pontiggia F, Zen A, Micheletti C. Small- and large-scale conformational changes of adenylate kinase: a molecular dynamics study of the subdomain motion and mechanics. Biophys J. 2008;95:5901-12 pubmed publisher
    b>Adenylate kinase, an enzyme that catalyzes the phosphoryl transfer between ATP and AMP, can interconvert between the open and catalytically potent (closed) forms even without binding ligands...
  59. Chiarugi P, Fiaschi T. Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration. Expert Opin Ther Targets. 2010;14:193-206 pubmed publisher
    ..Indeed, this adipokine behaves as a stem factor for several tissues, giving a new perspective for its use as a tool for cell-based therapy of diseased/injured tissues. ..
  60. Korkut A, Hendrickson W. Computation of conformational transitions in proteins by virtual atom molecular mechanics as validated in application to adenylate kinase. Proc Natl Acad Sci U S A. 2009;106:15673-8 pubmed publisher
    ..transitions, and we validate this algorithm in application to a transition between open and closed states of adenylate kinase (ADK)...