one carbon group transferases


Summary: A subclass of transferases that transfer chemical groups containing a single carbon. These include the METHYLTRANSFERASES, the HYDROXYMETHYL AND FORMYL TRANSFERASES, the CARBOXYL AND CARBAMOYL TRANSFERASES, and the AMIDINOTRANSFERASES. EC 2.1.

Top Publications

  1. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging. 2002;6:39-42 pubmed
    ..We need more studies to confirm that these vitamins have important functions in the etiology of these diseases. We also need to establish if these diseases can be prevented or diminished by proper nutrition starting at a younger age. ..
  2. Weinstein S, Stolzenberg Solomon R, Pietinen P, Taylor P, Virtamo J, Albanes D. Dietary factors of one-carbon metabolism and prostate cancer risk. Am J Clin Nutr. 2006;84:929-35 pubmed
    ..The possible modest protective association with vitamin B-6 and the significantly elevated risk with vitamin B-12 intake warrant further investigation. ..
  3. Stevens V, McCullough M, Pavluck A, Talbot J, Feigelson H, Thun M, et al. Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2007;16:1140-7 pubmed
    ..However, larger studies are needed to further examine gene/gene and gene/diet interactions in this pathway. ..
  4. Frankenburg F. The role of one-carbon metabolism in schizophrenia and depression. Harv Rev Psychiatry. 2007;15:146-60 pubmed
    ..Folate supplementation is indicated in pregnancy but may exacerbate the effects of cobalamin deficiency. SAMe may prove to be a useful antidepressant. In the future, screening for MTHFR polymorphisms might be useful. ..
  5. Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, et al. Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population. Lung Cancer. 2008;61:21-9 pubmed publisher
    ..08%, p<0.001). These findings suggest that genetic variants in one-carbon metabolizing genes might modulate the risk of lung cancer. Validation of these findings in larger studies is needed. ..
  6. Johansson M, Van Guelpen B, Vollset S, Hultdin J, Bergh A, Key T, et al. One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites. Cancer Epidemiol Biomarkers Prev. 2009;18:1538-43 pubmed publisher
    ..These novel findings support a role of one-carbon metabolism in prostate cancer etiology and warrant further investigation. ..
  7. Surtees R. Demyelination and inborn errors of the single carbon transfer pathway. Eur J Pediatr. 1998;157 Suppl 2:S118-21 pubmed
    ..Some treatments can only have an indirect effect on the brain and this is discussed with other evidence that the liver may produce factors that are necessary for the maintenance of central myelin. ..
  8. Fox J, Stover P. Folate-mediated one-carbon metabolism. Vitam Horm. 2008;79:1-44 pubmed publisher
    ..This chapter focuses on our current understanding of mammalian folate-mediated one-carbon metabolism, its cellular compartmentation, and knowledge gaps that limit our understanding of one-carbon metabolism and its regulation. ..
  9. Stevens V, Rodriguez C, Sun J, Talbot J, Thun M, Calle E. No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:3612-4 pubmed publisher
    ..Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk. ..

More Information


  1. Eussen S, Vollset S, Hustad S, Midttun Ø, Meyer K, Fredriksen A, et al. Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2010;19:28-38 pubmed publisher
    ..In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk. ..
  2. Tibbetts A, Appling D. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr. 2010;30:57-81 pubmed publisher
    ..Identifying the mitochondrial transporters for the one-carbon donors and elucidating how flux through these pathways is controlled are two areas ripe for exploration. ..
  3. Xu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, et al. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis. 2007;28:1504-9 pubmed
    ..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk. ..
  4. Hazra A, Wu K, Kraft P, Fuchs C, Giovannucci E, Hunter D. Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study. Carcinogenesis. 2007;28:1510-9 pubmed
    ..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma. ..
  5. Nijhout H, Reed M, Ulrich C. Mathematical models of folate-mediated one-carbon metabolism. Vitam Horm. 2008;79:45-82 pubmed publisher
  6. Lee Y, Xu X, Wallenstein S, Chen J. Gene expression profiles of the one-carbon metabolism pathway. J Genet Genomics. 2009;36:277-82 pubmed publisher
    ..The components identified by the program agreed with existing knowledge about one-carbon metabolism. This study helps us better understand the biological functions of one-carbon metabolism. ..