chitin synthase

Summary

Summary: An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.

Top Publications

  1. Bulawa C. CSD2, CSD3, and CSD4, genes required for chitin synthesis in Saccharomyces cerevisiae: the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis. Mol Cell Biol. 1992;12:1764-76 pubmed
    ..Three chitin synthetic activities have been detected. Two of them, chitin synthase I and chitin synthase II, are not required for synthesis of most of the chitin present in vivo...
  2. Devrekanli A, Foltman M, Roncero C, Sanchez Diaz A, Labib K. Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. J Cell Sci. 2012;125:5453-66 pubmed publisher
    The chitin synthase that makes the primary septum during cell division in budding yeasts is an important therapeutic target with an unknown activation mechanism...
  3. Horiuchi H. Functional diversity of chitin synthases of Aspergillus nidulans in hyphal growth, conidiophore development and septum formation. Med Mycol. 2009;47 Suppl 1:S47-52 pubmed publisher
    ..Recent advances in genome sequence analyses have revealed that there are more than seven chitin synthase-encoding genes in the genome of filamentous ascomycete fungi...
  4. Werner S, Sugui J, Steinberg G, Deising H. A chitin synthase with a myosin-like motor domain is essential for hyphal growth, appressorium differentiation, and pathogenicity of the maize anthracnose fungus Colletotrichum graminicola. Mol Plant Microbe Interact. 2007;20:1555-67 pubmed
    ..Consequently, DeltaCgChsV mutants did not develop macroscopically visible anthracnose disease symptoms and, thus, were nonpathogenic...
  5. Ziman M, Chuang J, Tsung M, Hamamoto S, Schekman R. Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae. Mol Biol Cell. 1998;9:1565-76 pubmed
    b>Chitin synthase III (CSIII), an enzyme required to form a chitin ring in the nascent division septum of Saccharomyces cerevisiae, may be transported to the cell surface in a regulated manner...
  6. Lam K, Davey M, Sun B, Roth A, Davis N, Conibear E. Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. J Cell Biol. 2006;174:19-25 pubmed
    The yeast chitin synthase Chs3 provides a well-studied paradigm for polytopic membrane protein trafficking...
  7. Banks I, Specht C, Donlin M, Gerik K, Levitz S, Lodge J. A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell. 2005;4:1902-12 pubmed
    ..C. neoformans has eight putative chitin synthases, and strains with any one chitin synthase deleted are viable at 30 degrees C. In addition, C...
  8. Kozubowski L, Panek H, Rosenthal A, Bloecher A, DeMarini D, Tatchell K. A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Mol Biol Cell. 2003;14:26-39 pubmed
    Bni4 is a scaffold protein in the yeast Saccharomyces cerevisiae that tethers chitin synthase III to the bud neck by interacting with septin neck filaments and with Chs4, a regulatory subunit of chitin synthase III...
  9. Lucero H, Kuranda M, Bulik D. A nonradioactive, high throughput assay for chitin synthase activity. Anal Biochem. 2002;305:97-105 pubmed
    ..for antimicrobial agents, making it suitable as a quantitative enzymatic assay for the activity of individual chitin synthase isozymes in yeast...

More Information

Publications62

  1. Gyore J, Parameswar A, Hebbard C, Oh Y, Bi E, Demchenko A, et al. 2-Acylamido analogues of N-acetylglucosamine prime formation of chitin oligosaccharides by yeast chitin synthase 2. J Biol Chem. 2014;289:12835-41 pubmed publisher
    ..The effect of GlcNAc was probed by using a yeast strain expressing a single chitin synthase, Chs2, by examining formation of chitin oligosaccharides (COs) and insoluble chitin, and by replacing GlcNAc ..
  2. Meitinger F, Petrova B, Lombardi I, Bertazzi D, Hub B, Zentgraf H, et al. Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci. 2010;123:1851-61 pubmed publisher
    ..In addition, we found that the chitin synthase Chs2 did not efficiently localize at the bud neck in the absence of MEN activity...
  3. Fukuda K, Yamada K, Deoka K, Yamashita S, Ohta A, Horiuchi H. Class III chitin synthase ChsB of Aspergillus nidulans localizes at the sites of polarized cell wall synthesis and is required for conidial development. Eukaryot Cell. 2009;8:945-56 pubmed publisher
    ..To address these issues, we characterized the deletion mutant of a class III chitin synthase-encoding gene of Aspergillus nidulans, chsB, and investigated ChsB localization in the hyphae and ..
  4. Sanchatjate S, Schekman R. Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface. Mol Biol Cell. 2006;17:4157-66 pubmed
    ..cerevisiae, the polysaccharide chitin is deposited at the mother bud junction by an integral membrane enzyme, chitin synthase 3 (Chs3p)...
  5. Moussian B, Schwarz H, Bartoszewski S, NUSSLEIN VOLHARD C. Involvement of chitin in exoskeleton morphogenesis in Drosophila melanogaster. J Morphol. 2005;264:117-30 pubmed
    ..the consequences of chitin absence in the embryo of Drosophila melanogaster caused by mutations in the Chitin Synthase-1 (CS-1) gene, called krotzkopf verkehrt (kkv)...
  6. Ichinomiya M, Horiuchi H, Ohta A. Different functions of the class I and class II chitin synthase genes, chsC and chsA, are revealed by repression of chsB expression in Aspergillus nidulans. Curr Genet. 2002;42:51-8 pubmed
    The filamentous fungus, Aspergillus nidulans, genome contains at least five chitin synthase-encoding genes. chsB is essential for normal hyphal growth. chsA and chsC are likely to be cooperatively required for hyphal wall integrity...
  7. Munro C, Winter K, Buchan A, Henry K, Becker J, Brown A, et al. Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol Microbiol. 2001;39:1414-26 pubmed
    CaCHS1 of the fungal pathogen Candida albicans encodes an essential chitin synthase that is required for septum formation, viability, cell shape and integrity...
  8. Takeshita N, Ohta A, Horiuchi H. csmA, a gene encoding a class V chitin synthase with a myosin motor-like domain of Aspergillus nidulans, is translated as a single polypeptide and regulated in response to osmotic conditions. Biochem Biophys Res Commun. 2002;298:103-9 pubmed
    ..nidulans encodes a polypeptide that consists of an N-terminal myosin motor-like domain and a C-terminal chitin synthase domain...
  9. Mio T, Yabe T, Sudoh M, Satoh Y, Nakajima T, Arisawa M, et al. Role of three chitin synthase genes in the growth of Candida albicans. J Bacteriol. 1996;178:2416-9 pubmed
    ..There were only small differences in virulence to immunocompromised mice of homozygous chs2 delta amd chs3 delta null mutants. ..
  10. Ziman M, Chuang J, Schekman R. Chs1p and Chs3p, two proteins involved in chitin synthesis, populate a compartment of the Saccharomyces cerevisiae endocytic pathway. Mol Biol Cell. 1996;7:1909-19 pubmed
    ..Using immunological reagents, we found that steady-state levels of Chs1p and Chs3p, two chitin synthase enzymes, did not fluctuate during the cell cycle, indicating that they are not simply regulated by synthesis ..
  11. Yamada E, Ichinomiya M, Ohta A, Horiuchi H. The class V chitin synthase gene csmA is crucial for the growth of the chsA chsC double mutant in Aspergillus nidulans. Biosci Biotechnol Biochem. 2005;69:87-97 pubmed
    ..These and other results suggest that the function of csmA is important for the maintenance of cell wall integrity and the polarized growth of the chsA chsC double mutant. ..
  12. Zimoch L, Hogenkamp D, Kramer K, Muthukrishnan S, Merzendorfer H. Regulation of chitin synthesis in the larval midgut of Manduca sexta. Insect Biochem Mol Biol. 2005;35:515-27 pubmed
    ..Using anti-chitin synthase (CHS) antibodies, we previously demonstrated that in the midgut of Manduca sexta, CHS is expressed by two ..
  13. Merzendorfer H. Insect chitin synthases: a review. J Comp Physiol B. 2006;176:1-15 pubmed
    ..composed of N-acetylglucosamines that are joined in a reaction catalyzed by the membrane-integral enzyme chitin synthase, a member of the family 2 of glycosyltransferases...
  14. Zhang J, Zhu K. Characterization of a chitin synthase cDNA and its increased mRNA level associated with decreased chitin synthesis in Anopheles quadrimaculatus exposed to diflubenzuron. Insect Biochem Mol Biol. 2006;36:712-25 pubmed
    b>Chitin synthase (EC 2.4.1.16) is a crucial enzyme responsible for chitin biosynthesis in all chitin-containing organisms...
  15. Pammer M, Briza P, Ellinger A, Schuster T, Stucka R, Feldmann H, et al. DIT101 (CSD2, CAL1), a cell cycle-regulated yeast gene required for synthesis of chitin in cell walls and chitosan in spore walls. Yeast. 1992;8:1089-99 pubmed
    ..cells and the absence of chitosan in spores suggested that the mutant dit101 could be defective in a chitin synthase. Indeed, a genomic yeast clone harboring the gene, CSD2, sharing significant sequence similarity with yeast ..
  16. Bulawa C, Miller D, Henry L, Becker J. Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc Natl Acad Sci U S A. 1995;92:10570-4 pubmed
    ..Chitin-deficient strains can colonize the organs of infected mice, suggesting that the reduced virulence of the mutants is not due to accelerated clearing. ..
  17. Odenbach D, Thines E, Anke H, Foster A. The Magnaporthe grisea class VII chitin synthase is required for normal appressorial development and function. Mol Plant Pathol. 2009;10:81-94 pubmed publisher
    ..Previously, we have described how the transcription of a class VII chitin synthase-encoding gene CHS7 is completely dependent on the putative transcription factor Con7p during the germination ..
  18. Abramczyk D, Park C, Szaniszlo P. Cytolocalization of the class V chitin synthase in the yeast, hyphal and sclerotic morphotypes of Wangiella (Exophiala) dermatitidis. Fungal Genet Biol. 2009;46:28-41 pubmed publisher
    ..Our prior studies have demonstrated the existence of seven chitin synthase structural genes in W. dermatitidis, each of which encodes an isoenzyme of a different class...
  19. Reyes A, Sanz M, Duran A, Roncero C. Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane. J Cell Sci. 2007;120:1998-2009 pubmed
    In Saccharomyces cerevisiae, Chs4p is required for chitin synthase III (CSIII) activity and hence for chitin synthesis. This protein is transported in vesicles in a polarized fashion independently of the other Chs proteins...
  20. Lenardon M, Whitton R, Munro C, Marshall D, Gow N. Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall. Mol Microbiol. 2007;66:1164-73 pubmed
    ..The human pathogenic fungus Candida albicans has four genes, CHS1, CHS2, CHS3 and CHS8, which encode chitin synthase isoenzymes with different biochemical properties and physiological functions...
  21. Soulié M, Piffeteau A, Choquer M, Boccara M, Vidal Cros A. Disruption of Botrytis cinerea class I chitin synthase gene Bcchs1 results in cell wall weakening and reduced virulence. Fungal Genet Biol. 2003;40:38-46 pubmed
    ..between cell wall integrity and pathogenicity of the fungus Botrytis cinerea, we have constructed chitin synthase mutants...
  22. Meissner D, Odman Naresh J, Vogelpohl I, Merzendorfer H. A novel role of the yeast CaaX protease Ste24 in chitin synthesis. Mol Biol Cell. 2010;21:2425-33 pubmed publisher
  23. Tsuizaki M, Ohta A, Horiuchi H. Myosin motor-like domain of class VI chitin synthase CsmB of Aspergillus nidulans is not functionally equivalent to that of class V chitin synthase CsmA. Biosci Biotechnol Biochem. 2013;77:369-74 pubmed
    Chitin is a major cell wall component of many filamentous fungi. Among the eight chitin synthase genes of Aspergillus nidulans, csmA and csmB encode a myosin motor-like domain (MMD) and a chitin synthase domain (CSD) at their N- and C-..
  24. Xu Y, Li H, Zhang J, Song B, Chen F, Duan X, et al. Disruption of the chitin synthase gene CHS1 from Fusarium asiaticum results in an altered structure of cell walls and reduced virulence. Fungal Genet Biol. 2010;47:205-15 pubmed publisher
    ..In this study, a class I chitin synthase gene (CHS1) from Fusarium asiaticum, the predominant species of FHB pathogens on wheat in China, was ..
  25. Devine W, Lubarsky B, Shaw K, Luschnig S, Messina L, Krasnow M. Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc Natl Acad Sci U S A. 2005;102:17014-9 pubmed
    ..These findings show that chitin regulates epithelial tube morphogenesis, in addition to its classical role protecting mature epithelia. ..
  26. Xie J, Thellend A, Becker H, Vidal Cros A. Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase. Carbohydr Res. 2001;334:177-82 pubmed
    ..The synthetic strategy relies on the consecutive coupling of nucleoside and amino C-glycosyl moieties with L-tartaric acid. However, this compound inhibited only weakly chitin synthase I, with an IC(50) value of 20 mM.
  27. Chen L, Yang W, Cong L, Xu K, Wang J. Molecular cloning, characterization and mRNA expression of a chitin synthase 2 gene from the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae). Int J Mol Sci. 2013;14:17055-72 pubmed publisher
    b>Chitin synthase (CHS), a potential target for eco-friendly insecticides, plays an essential role in chitin formation in insects...
  28. Bolognesi R, Arakane Y, Muthukrishnan S, Kramer K, Terra W, Ferreira C. Sequences of cDNAs and expression of genes encoding chitin synthase and chitinase in the midgut of Spodoptera frugiperda. Insect Biochem Mol Biol. 2005;35:1249-59 pubmed
    ..and expression of genes encoding enzymes responsible for the synthesis and degradation of chitin, chitin synthase (SfCHSB) and chitinase (SfCHI), respectively, in the midgut of the fall armyworm, Spodoptera frugiperda...
  29. Borgia P, Iartchouk N, Riggle P, Winter K, Koltin Y, Bulawa C. The chsB gene of Aspergillus nidulans is necessary for normal hyphal growth and development. Fungal Genet Biol. 1996;20:193-203 pubmed
    The chsB gene from Aspergillus nidulans encodes a class III chitin synthase, an enzyme class found in filamentous fungi but not in yeast-like organisms...
  30. Cabib E, Schmidt M. Chitin synthase III activity, but not the chitin ring, is required for remedial septa formation in budding yeast. FEMS Microbiol Lett. 2003;224:299-305 pubmed
    Chitin is a minor but essential component of the Saccharomyces cerevisiae cell wall. In wild-type, chitin synthase II is required for the formation of primary septa and chitin synthase III (CSIII) is not essential...
  31. Qu M, Yang Q. A novel alternative splicing site of class A chitin synthase from the insect Ostrinia furnacalis - gene organization, expression pattern and physiological significance. Insect Biochem Mol Biol. 2011;41:923-31 pubmed publisher
    Insect chitin synthase A (CHSA) catalyzes chitin biosynthesis in tissues that develop from ectoderm...
  32. Sánchez León E, Verdin J, Freitag M, Roberson R, Bartnicki Garcia S, Riquelme M. Traffic of chitin synthase 1 (CHS-1) to the Spitzenkörper and developing septa in hyphae of Neurospora crassa: actin dependence and evidence of distinct microvesicle populations. Eukaryot Cell. 2011;10:683-95 pubmed publisher
    We describe the subcellular location of chitin synthase 1 (CHS-1), one of seven chitin synthases in Neurospora crassa...
  33. Larson T, Kendra D, Busman M, Brown D. Fusarium verticillioides chitin synthases CHS5 and CHS7 are required for normal growth and pathogenicity. Curr Genet. 2011;57:177-89 pubmed publisher
    ..We identified eight putative chitin synthase (CHS) genes in F...
  34. Wang Y, Fan H, Huang H, Xue J, Wu W, Bao Y, et al. Chitin synthase 1 gene and its two alternative splicing variants from two sap-sucking insects, Nilaparvata lugens and Laodelphax striatellus (Hemiptera: Delphacidae). Insect Biochem Mol Biol. 2012;42:637-46 pubmed publisher
    b>Chitin synthase (CHS) is an enzyme that is required for chitin formation in insect cuticles and other tissues...
  35. Leal Morales C, Bracker C, Bartnicki Garcia S. Subcellular localization, abundance and stability of chitin synthetases 1 and 2 from Saccharomyces cerevisiae. Microbiology. 1994;140 ( Pt 9):2207-16 pubmed
    ..We confirmed that 1,3-beta-glucan synthetase and chitin synthetase exhibit a partially different subcellular distribution-an indication that these two enzymes are mobilized through different secretory pathways. ..
  36. Munro C, Whitton R, Hughes H, Rella M, Selvaggini S, Gow N. CHS8-a fourth chitin synthase gene of Candida albicans contributes to in vitro chitin synthase activity, but is dispensable for growth. Fungal Genet Biol. 2003;40:146-58 pubmed
    ..pathogenic fungus Candida albicans identified an open reading frame encoding a putative fourth member of the chitin synthase gene family...
  37. Larson J, Bharucha J, Ceaser S, Salamon J, Richardson C, Rivera S, et al. Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:3040-51 pubmed publisher
    Yeast chitin synthase III (CSIII) is targeted to the bud neck, where it is thought to be tethered by the septin-associated protein Bni4. Bni4 also associates with the yeast protein phosphatase (PP1) catalytic subunit, Glc7...
  38. Grabińska K, Magnelli P, Robbins P. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Eukaryot Cell. 2007;6:328-36 pubmed
    ..was identified as a protein factor physically interacting with Chs3p, the catalytic subunit of chitin synthase III (CSIII), and is indispensable for its enzymatic activity in vivo...
  39. Santos B, Snyder M. Targeting of chitin synthase 3 to polarized growth sites in yeast requires Chs5p and Myo2p. J Cell Biol. 1997;136:95-110 pubmed
    ..vegetative growth and mating of Saccharomyces cerevisiae by localization of the putative catalytic subunit of chitin synthase III, Chs3p, and its regulator, Chs5p...
  40. Zhang G, Kashimshetty R, Ng K, Tan H, Yeong F. Exit from mitosis triggers Chs2p transport from the endoplasmic reticulum to mother-daughter neck via the secretory pathway in budding yeast. J Cell Biol. 2006;174:207-20 pubmed
    Budding yeast chitin synthase 2 (Chs2p), which lays down the primary septum, localizes to the mother-daughter neck in telophase. However, the mechanism underlying the timely neck localization of Chs2p is not known...
  41. Bansal R, Mian M, Mittapalli O, Michel A. Characterization of a chitin synthase encoding gene and effect of diflubenzuron in soybean aphid, Aphis glycines. Int J Biol Sci. 2012;8:1323-34 pubmed publisher
    ..We identified the cDNA of chitin synthase gene (CHS) in Aphis glycines, the soybean aphid, which is a serious pest of soybean...
  42. Yang W, Xu K, Cong L, Wang J. Identification, mRNA expression, and functional analysis of chitin synthase 1 gene and its two alternative splicing variants in oriental fruit fly, Bactrocera dorsalis. Int J Biol Sci. 2013;9:331-42 pubmed publisher
    Two alternative splicing variants of chitin synthase 1 gene (BdCHS1) were cloned and characterized from the oriental fruit fly, Bactrocera dorsalis (Hendel)...
  43. Zhang X, Zhang J, Park Y, Zhu K. Identification and characterization of two chitin synthase genes in African malaria mosquito, Anopheles gambiae. Insect Biochem Mol Biol. 2012;42:674-82 pubmed publisher
    b>Chitin synthase (CHS) represents an attractive target site for combating insect pests as insect growth and development are strictly dependent on precisely tuned chitin biosynthesis and this pathway is absent in humans and other ..
  44. Munro C, Gow N. Chitin synthesis in human pathogenic fungi. Med Mycol. 2001;39 Suppl 1:41-53 pubmed
    ..that the structural polysaccharide chitin is synthesized from a family of enzymes encoded by multiple CHS chitin synthase genes, and regulated by an array of ancillary gene products that influence CHS activation and localization...
  45. Maue L, Meissner D, Merzendorfer H. Purification of an active, oligomeric chitin synthase complex from the midgut of the tobacco hornworm. Insect Biochem Mol Biol. 2009;39:654-9 pubmed publisher
    Chitin formation depends on the activity of a family II glycosyltransferase known as chitin synthase, whose biochemical and structural properties are largely unknown...
  46. Gunasekera A, Alvarez F, Douglas L, Wang H, Rosebrock A, Konopka J. Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z. Eukaryot Cell. 2010;9:1476-83 pubmed publisher
    ..Significantly, a gig1? mutant displayed increased resistance to nikkomycin Z, which inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin...
  47. Zhang X, Zhang J, Zhu K. Chitosan/double-stranded RNA nanoparticle-mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae). Insect Mol Biol. 2010;19:683-93 pubmed publisher
    The purpose of this study was to examine whether the expression of two chitin synthase genes, AgCHS1 and AgCHS2, can be repressed by chitosan/AgCHS dsRNA-based nanoparticles through larval feeding in Anopheles gambiae...
  48. Rezende G, Martins A, Gentile C, Farnesi L, Pelajo Machado M, Peixoto A, et al. Embryonic desiccation resistance in Aedes aegypti: presumptive role of the chitinized serosal cuticle. BMC Dev Biol. 2008;8:82 pubmed publisher
    ..The Ae. aegypti Chitin Synthase A gene (AaCHS1) possesses two alternatively spliced variants, AaCHS1a and AaCHS1b, differentially expressed ..
  49. Suzuki M, Sakuda S, Nagasawa H. Identification of chitin in the prismatic layer of the shell and a chitin synthase gene from the Japanese pearl oyster, Pinctada fucata. Biosci Biotechnol Biochem. 2007;71:1735-44 pubmed
    ..Furthermore, we cloned a cDNA encoding chitin synthase (PfCHS1) that produces chitin, contributing to the formation of the framework for calcification in the shell.
  50. Stevens D. Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens. Antimicrob Agents Chemother. 2000;44:2547-8 pubmed
    ..With Aspergillus fumigatus synergy was noted for inhibition and killing, and synergistic activity was also noted for some isolates of other species presently regarded as difficult to treat. ..
  51. Weiss I, Schönitzer V, Eichner N, Sumper M. The chitin synthase involved in marine bivalve mollusk shell formation contains a myosin domain. FEBS Lett. 2006;580:1846-52 pubmed
    ..We cloned and characterized the chitin synthase of the marine bivalve mollusk Atrina rigida...
  52. Dobbelaere J, Barral Y. Spatial coordination of cytokinetic events by compartmentalization of the cell cortex. Science. 2004;305:393-6 pubmed
    ..In turn, such factors were required for actomyosin ring function and membrane abscission. Thus, a specialized cortical compartment ensures the spatial coordination of cytokinetic events. ..
  53. Cos T, Ford R, Trilla J, Duran A, Cabib E, Roncero C. Molecular analysis of Chs3p participation in chitin synthase III activity. Eur J Biochem. 1998;256:419-26 pubmed
    ..Of the three chitin synthases present in yeast, chitin synthase III (CSIII) is responsible for the synthesis of most of the chitin found in the cell, including a chitin ring ..