methionine adenosyltransferase

Summary

Summary: An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.

Top Publications

  1. Garcia Estrada C, Pérez Pertejo Y, Ordóñez D, Balaña Fouce R, Reguera R. Analysis of genetic elements regulating the methionine adenosyltransferase gene in Leishmania infantum. Gene. 2007;389:163-73 pubmed
    b>Methionine adenosyltransferase (MAT) is an important enzyme for metabolic processes, inasmuch as its product, S-adenosylmethionine (AdoMet), plays a key role in trans-methylation, trans-sulphuration and polyamine synthesis...
  2. Stabler S, Steegborn C, Wahl M, Oliveriusova J, Kraus J, Allen R, et al. Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism. 2002;51:981-8 pubmed
    ..abnormalities, including deficiency of cystathionine beta-synthase (CBS) or of the isoenzymes of methionine adenosyltransferase (MAT) I and III expressed solely in nonfetal liver (MAT I/III deficiency)...
  3. Takusagawa F, Kamitori S, Misaki S, Markham G. Crystal structure of S-adenosylmethionine synthetase. J Biol Chem. 1996;271:136-47 pubmed
    ..The essential divalent (Mg2+/Co2+) and monovalent (K+) metal ions and one of the product, Pi ions, were found in the active site from three separate structures. ..
  4. Pérez Pertejo Y, Alvarez Velilla R, Estrada C, Balaña Fouce R, Reguera R. Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase. Parasitology. 2011;138:1082-92 pubmed publisher
    b>Methionine adenosyltransferase (MAT) is an important enzyme for metabolic processes, to the extent that its product, S-adenosylmethionine (AdoMet), plays a key role in trans-methylation, trans-sulphuration and polyamine synthesis...
  5. Mato J, Alvarez L, Ortiz P, Pajares M. S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Ther. 1997;73:265-80 pubmed
    b>Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP...
  6. Delgado M, Pérez Miguelsanz J, Garrido F, Rodriguez Tarduchy G, Perez Sala D, Pajares M. Early effects of copper accumulation on methionine metabolism. Cell Mol Life Sci. 2008;65:2080-90 pubmed publisher
    ..Notably, the main change was a redox-mediated 80% decrease in the mRNA levels of the methionine adenosyltransferase regulatory subunit as compared to the control group...
  7. Luo Y, Yuan Z, Luo G, Zhao F. Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization. Biotechnol Prog. 2008;24:214-20 pubmed
    ..The immobilized synthetase was found to be 40.4% of the free enzyme activity in catalyzing the synthesis of SAM from dl-Met and ATP. ..
  8. Chamberlin M, Ubagai T, Mudd S, Wilson W, Leonard J, Chou J. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J Clin Invest. 1996;98:1021-7 pubmed
    Individuals deficient in hepatic methionine adenosyltransferase (MAT) activity (MAT I/III deficiency) have been demonstrated to contain mutations in the gene (MATA1) that encodes the major hepatic forms, MAT I and III...
  9. Drummelsmith J, Girard I, Trudel N, Ouellette M. Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance. J Biol Chem. 2004;279:33273-80 pubmed
    ..The role of one of these, methionine adenosyltransferase, was confirmed by gene transfection and metabolite analysis...

More Information

Publications62

  1. Corrales F, Pérez Mato I, Sánchez Del Pino M, Ruiz F, Castro C, García Trevijano E, et al. Regulation of mammalian liver methionine adenosyltransferase. J Nutr. 2002;132:2377S-2381S pubmed publisher
    ..b>Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP...
  2. Garrido F, Alfonso C, Taylor J, Markham G, Pajares M. Subunit association as the stabilizing determinant for archaeal methionine adenosyltransferases. Biochim Biophys Acta. 2009;1794:1082-90 pubmed publisher
  3. Szabová J, Ruzicka P, Verner Z, Hampl V, Lukes J. Experimental examination of EFL and MATX eukaryotic horizontal gene transfers: coexistence of mutually exclusive transcripts predates functional rescue. Mol Biol Evol. 2011;28:2371-8 pubmed publisher
    ..The capability of EFL to spread by HGT is lower and so the patchy distribution of EF-1?/EFL paralogs was probably shaped mainly by deep paralogy followed by long-term coexistence and differential losses. ..
  4. Lu S, Huang Z, Yang H, Mato J, Avila M, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G178-85 pubmed
    Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM)...
  5. Cano A, Buqué X, Martínez Uña M, Aurrekoetxea I, Menor A, García Rodriguez J, et al. Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. Hepatology. 2011;54:1975-86 pubmed publisher
    ..In nonalcoholic fatty liver disease (NAFLD), VLDL secretion disturbances are unclear. Methionine adenosyltransferase (MAT) is responsible for S-adenosylmethionine (SAMe) synthesis and MAT I and III are the products of ..
  6. Newman E, Budman L, Chan E, Greene R, Lin R, Woldringh C, et al. Lack of S-adenosylmethionine results in a cell division defect in Escherichia coli. J Bacteriol. 1998;180:3614-9 pubmed
    ..Expression of a plasmid-carried metK gene prevents filamentation and restores normal growth to the metK mutant. This indicates that lack of SAM results in a division defect. ..
  7. Yocum R, Perkins J, Howitt C, Pero J. Cloning and characterization of the metE gene encoding S-adenosylmethionine synthetase from Bacillus subtilis. J Bacteriol. 1996;178:4604-10 pubmed
    ..subtilis, suggesting that S-adenosylmethionine is a corepressor of methionine biosynthesis in B. subtilis, as others have already shown for Escherichia coli. ..
  8. Horikawa S, Tsukada K. Molecular cloning and developmental expression of a human kidney S-adenosylmethionine synthetase. FEBS Lett. 1992;312:37-41 pubmed
    ..In addition, the developmental expression of these two isozyme mRNAs has been studied in the human liver using the reverse transcription-polymerase chain reaction (RT-PCR). ..
  9. Merali S, Clarkson A. S-adenosylmethionine and Pneumocystis. FEMS Microbiol Lett. 2004;237:179-86 pubmed
    ..Preliminary data indicate that deliberate reduction of host lung AdoMet by nicotine treatment is therapeutic in the rat model of Pneumocystis pneumonia. ..
  10. Chamberlin M, Ubagai T, Mudd S, Thomas J, Pao V, Nguyen T, et al. Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. Am J Hum Genet. 2000;66:347-55 pubmed
    b>Methionine adenosyltransferase (MAT) I/III deficiency, caused by mutations in the MAT1A gene, is characterized by persistent hypermethioninemia without elevated homocysteine or tyrosine...
  11. Yang H, Ara A, Magilnick N, Xia M, Ramani K, Chen H, et al. Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. Gastroenterology. 2008;134:281-91 pubmed
    b>Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis...
  12. Zhang T, Zheng Z, Liu Y, Zhang J, Zhao Y, Liu Y, et al. Overexpression of methionine adenosyltransferase II alpha (MAT2A) in gastric cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene. Acta Histochem. 2013;115:48-55 pubmed publisher
    The aim of this study was to clarify the methionine adenosyltransferase II alpha (MAT2A) expression pattern and to explore its potential role in gastric cancer...
  13. Komoto J, Yamada T, Takata Y, Markham G, Takusagawa F. Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met. Biochemistry. 2004;43:1821-31 pubmed
    ..Pajares, M. A., Hermoso, J. A., Guillerm, D., Guillerm, G., and Sanz-Aparicio. J. (2003) J. Mol. Biol. 331, 407] is substantially different from our mechanism. ..
  14. Slapeta J, Stejskal F, Keithly J. Characterization of S-adenosylmethionine synthetase in Cryptosporidium parvum (Apicomplexa). FEMS Microbiol Lett. 2003;225:271-7 pubmed
    ..parvum, HCT-8 cells were infected with C. parvum and assayed over 72 h. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) confirmed the differential expression of CpSAMS. ..
  15. Huang T, Wahlqvist M, Li D. Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism. Nutrition. 2010;26:112-9 pubmed publisher
    ..TO rich in 22:6omega-3 decreases the concentration of Hcy despite increasing MAT activity and upregulating MAT mRNA expression through compensatory cystathionine-gamma-lyase mRNA expression, both of which are involved in Hcy metabolism. ..
  16. Pérez Pertejo Y, Reguera R, Ordóñez D, Balaña Fouce R. Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani. Biochim Biophys Acta. 2006;1760:10-9 pubmed
    b>Methionine adenosyltransferase (MAT: EC 2.5.1.6) catalyzes the synthesis of S-adenosylmethionine (AdoMet) in two sequential steps, AdoMet formation and subsequent tripolyphosphate (PPPi) cleavage, induced by AdoMet...
  17. Okamoto S, Lezhava A, Hosaka T, Okamoto Hosoya Y, Ochi K. Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J Bacteriol. 2003;185:601-9 pubmed
    ..The addition of SAM also caused hyperproduction of streptomycin in Streptomyces griseus. These findings implicate the significant involvement of intracellular SAM in initiating the onset of secondary metabolism in STREPTOMYCES: ..
  18. Mato J, Lu S. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007;45:1306-12 pubmed
    ..occurs in all mammalian cells as the first step in methionine catabolism in a reaction catalyzed by methionine adenosyltransferase (MAT). Decreased hepatic SAMe biosynthesis is a consequence of all forms of chronic liver injury...
  19. Liu Q, Chen J, Liu L, Zhang J, Wang D, Ma L, et al. The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production. J Biol Chem. 2011;286:17168-80 pubmed publisher
    ..HBx) of hepatitis B virus (HBV) is involved in the development of hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) promotes the growth of liver cancer cells through altering S-adenosylmethionine homeostasis...
  20. Sanchez Perez G, Gasset M, Calvete J, Pajares M. Role of an intrasubunit disulfide in the association state of the cytosolic homo-oligomer methionine adenosyltransferase. J Biol Chem. 2003;278:7285-93 pubmed
    Recombinant rat liver methionine adenosyltransferase has been refolded into fully active tetramers (MAT I) and dimers (MAT III), using as a source chaotrope-solubilized aggregates resulting from specific washes of inclusion bodies...
  21. Wang Q, Liu Q, Liu Z, Qian Q, Sun Q, Pan D. Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma. World J Gastroenterol. 2008;14:4633-42 pubmed
    To investigate the effects of lentivirus vector mediated short hairpin RNA interference targeting methionine adenosyltransferase 2beta gene (LV-shMAT2B) on hepatocelluar carcinoma (HCC) cells...
  22. Graham D, Bock C, Schalk Hihi C, Lu Z, Markham G. Identification of a highly diverged class of S-adenosylmethionine synthetases in the archaea. J Biol Chem. 2000;275:4055-9 pubmed
    ..This identification of a second major class of MAT emphasizes the long evolutionary history of the archaeal lineage and the structural diversity found even in crucial metabolic enzymes...
  23. Chamberlin M, Ubagai T, Mudd S, Levy H, Chou J. Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. Am J Hum Genet. 1997;60:540-6 pubmed
    b>Methionine adenosyltransferase (MAT) I/III deficiency, characterized by isolated persistent hypermethioninemia, is caused by mutations in the MAT1A gene encoding MAT(alpha)1, the subunit of major hepatic enzymes MAT I ([alpha1]4) and III([..
  24. Reczkowski R, Markham G. Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase. J Biol Chem. 1995;270:18484-90 pubmed
    ..Remarkably all of the mutants are much more thermally stable than the wild type enzyme. ..
  25. Horikawa S, Sasuga J, Shimizu K, Ozasa H, Tsukada K. Molecular cloning and nucleotide sequence of cDNA encoding the rat kidney S-adenosylmethionine synthetase. J Biol Chem. 1990;265:13683-6 pubmed
    ..Thus, kidney- and liver-type S-adenosylmethionine synthetase isozyme mRNAs were expressed in various tissues with different tissue specificities. ..
  26. Garrido F, Taylor J, Alfonso C, Markham G, Pajares M. Structural basis for the stability of a thermophilic methionine adenosyltransferase against guanidinium chloride. Amino Acids. 2012;42:361-73 pubmed publisher
    The methionine adenosyltransferase from the thermophile Methanococcus jannaschii is fully and irreversibly unfolded in the presence of guanidinium chloride...
  27. Huang Y, Gou X, Hu H, Xu Q, Lu Y, Cheng J. Enhanced S-adenosyl-l-methionine production in Saccharomyces cerevisiae by spaceflight culture, overexpressing methionine adenosyltransferase and optimizing cultivation. J Appl Microbiol. 2012;112:683-94 pubmed publisher
    ..Through recombinant DNA technology, the heterologous gene encoding methionine adenosyltransferase was integrated into the genome of strain H5M147...
  28. Alvarez L, Corrales F, Martin Duce A, Mato J. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem J. 1993;293 ( Pt 2):481-6 pubmed
    ..Based on these results, a possible mechanism of regulation of human liver S-adenosylmethionine synthetase is discussed. ..
  29. Thomas D, Surdin Kerjan Y. SAM1, the structural gene for one of the S-adenosylmethionine synthetases in Saccharomyces cerevisiae. Sequence and expression. J Biol Chem. 1987;262:16704-9 pubmed
    ..The DNA sequence of SAM1 is reported. The translation product shows a high homology with the one deduced from the sequence of the MetK gene encoding the SAM synthetase of Escherichia coli. ..
  30. Rountree C, Senadheera S, Mato J, Crooks G, Lu S. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008;47:1288-97 pubmed publisher
    b>Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S-adenosylmethionine...
  31. Zano S, Bhansali P, Luniwal A, Viola R. Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria. Arch Biochem Biophys. 2013;536:64-71 pubmed publisher
  32. Chiang P, Chamberlin M, Nicholson D, Soubes S, Su X, Subramanian G, et al. Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetase. Biochem J. 1999;344 Pt 2:571-6 pubmed
    ..Based on phylogenetic analysis using protein parsimony and neighbour-joining algorithms, the malarial PfSAMS is closely related to SAMS of other protozoans and plants. ..
  33. LeGros H, Halim A, Geller A, Kotb M. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). J Biol Chem. 2000;275:2359-66 pubmed
    MAT II, the extrahepatic form of methionine adenosyltransferase (MAT), consists of catalytic alpha(2)/alpha(2') subunits and a noncatalytic beta subunit, believed to have a regulatory function...
  34. Yang H, Huang Z, Wang J, Lu S. The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. FASEB J. 2001;15:1507-16 pubmed
    Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine...
  35. Ramani K, Yang H, Xia M, Ara A, Mato J, Lu S. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. Hepatology. 2008;47:521-31 pubmed
    ..Whether leptin can act as a mitogen in normal hepatocytes is unclear. Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAMe), the ..
  36. De la Rosa J, Ostrowski J, Hryniewicz M, Kredich N, Kotb M, LeGros H, et al. Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem. 1995;270:21860-8 pubmed
    Human lymphocyte methionine adenosyltransferase (HuLy MAT) consists of heterologous subunits alpha and beta...
  37. Kotb M, Mudd S, Mato J, Geller A, Kredich N, Chou J, et al. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet. 1997;13:51-2 pubmed
  38. García Trevijano E, Latasa M, Carretero M, Berasain C, Mato J, Avila M. S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. FASEB J. 2000;14:2511-8 pubmed
    ..This reaction is catalyzed by methionine adenosyltransferase (MAT)...
  39. Halim A, Legros L, Chamberlin M, Geller A, Kotb M. Regulation of the human MAT2A gene encoding the catalytic alpha 2 subunit of methionine adenosyltransferase, MAT II: gene organization, promoter characterization, and identification of a site in the proximal promoter that is essential for its activit. J Biol Chem. 2001;276:9784-91 pubmed
    Mammalian methionine adenosyltransferase II (MAT II) consists of a catalytic alpha2/alpha2' and a regulatory beta subunit...
  40. Reguera R, Balaña Fouce R, Pérez Pertejo Y, Fernandez F, Garcia Estrada C, Cubría J, et al. Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes. J Biol Chem. 2002;277:3158-67 pubmed
    b>Methionine adenosyltransferase (MAT) catalyzes the synthesis of s-adenosylmethionine (AdoMet), a metabolite that plays an important role in a variety of cellular functions, such as methylation, sulfuration, and polyamine synthesis...
  41. Hu H, Qian J, Chu J, Wang Y, Zhuang Y, Zhang S. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J Biotechnol. 2009;141:97-103 pubmed publisher
    ..S-Adenosyl-L-methionine (SAM) is an important molecule for normal cell function and survival. To enhance methionine adenosyltransferase (MAT, EC2.5.1...
  42. Reytor E, Pérez Miguelsanz J, Alvarez L, Perez Sala D, Pajares M. Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution. FASEB J. 2009;23:3347-60 pubmed publisher
    The methyl donor S-adenosylmethionine is synthesized in mammalian cytosol by three isoenzymes. Methionine adenosyltransferase II is ubiquitously expressed, whereas isoenzymes I (homotetramer) and III (homodimer) are considered the hepatic ..
  43. Lu Z, Markham G. Enzymatic properties of S-adenosylmethionine synthetase from the archaeon Methanococcus jannaschii. J Biol Chem. 2002;277:16624-31 pubmed
    ..The broad substrate tolerance of this enzyme proffers routes to preparation of novel AdoMet analogs. ..
  44. Legros L, Halim A, Chamberlin M, Geller A, Kotb M. Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II. J Biol Chem. 2001;276:24918-24 pubmed
    b>Methionine adenosyltransferase (MAT) catalyzes the biosynthesis of S-adenosylmethionine (AdoMet), a key molecule in transmethylation reactions and polyamine biosynthesis...
  45. Martinez Chantar M, Corrales F, Martínez Cruz L, García Trevijano E, Huang Z, Chen L, et al. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002;16:1292-4 pubmed
    In mammals, methionine metabolism occurs mainly in the liver via methionine adenosyltransferase-catalyzed conversion to S-adenosylmethionine...
  46. Katoh Y, Ikura T, Hoshikawa Y, Tashiro S, Ito T, Ohta M, et al. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein. Mol Cell. 2011;41:554-66 pubmed publisher
    Protein methylation pathways comprise methionine adenosyltransferase (MAT), which produces S-adenosylmethionine (SAM) and SAM-dependent substrate-specific methyltransferases. However, the function of MAT in the nucleus is largely unknown...
  47. Sanchez Perez G, Bautista J, Pajares M. Methionine adenosyltransferase as a useful molecular systematics tool revealed by phylogenetic and structural analyses. J Mol Biol. 2004;335:693-706 pubmed
    Structural and phylogenetic relationships among Bacteria and Eukaryota were analyzed by examining 292 methionine adenosyltransferase (MAT) amino acid sequences with respect to the crystal structure of this enzyme established for ..
  48. Chen L, Zeng Y, Yang H, Lee T, French S, Corrales F, et al. Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J. 2004;18:914-6 pubmed
    b>Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S-adenosylmethionine (SAMe), the principal biological methyl donor...
  49. Lu S, Mato J. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol. 2005;35:227-34 pubmed
    Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and, in the liver, a precursor of glutathione...
  50. Yang H, Magilnick N, Noureddin M, Mato J, Lu S. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007;210:766-73 pubmed
    ..b>Methionine adenosyltransferase (MAT) is an essential enzyme encoded by two genes (MAT1A and MAT2A), while a third gene (MAT2beta) ..
  51. Shafqat N, Muniz J, Pilka E, Papagrigoriou E, von Delft F, Oppermann U, et al. Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits. Biochem J. 2013;452:27-36 pubmed publisher
    MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation...
  52. Markham G, Satishchandran C. Identification of the reactive sulfhydryl groups of S-adenosylmethionine synthetase. J Biol Chem. 1988;263:8666-70 pubmed
    ..Upon modification the strength of dimer-dimer interactions is diminished by at least 9 kcal/mol. ..
  53. Ikeda R, Nishida T, Watanabe F, Shimizu Saito K, Asahina K, Horikawa S, et al. Involvement of CCAAT/enhancer binding protein-beta (C/EBPbeta) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression. Int J Biochem Cell Biol. 2008;40:1956-69 pubmed publisher
    b>Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the main methyl donor in cellular transmethylation reactions and the aminopropyl moiety in polyamine biosynthesis...