transaldolase

Summary

Summary: An enzyme of the transferase class that catalyzes the reaction sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to yield D-erythrose 4-phosphate and D-fructose phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.2.

Top Publications

  1. Sugiyama M, Suzuki S, Tonouchi N, Yokozeki K. Transaldolase/glucose-6-phosphate isomerase bifunctional enzyme and ribulokinase as factors to increase xylitol production from D-arabitol in Gluconobacter oxydans. Biosci Biotechnol Biochem. 2003;67:2524-32 pubmed
    ..cloned genes in Escherichia coli showed that one of the xylitol-increasing factors is the bifunctional enzyme transaldolase/glucose-6-phosphate isomerase, and the other is ribulokinase. Using membrane and soluble fractions of G...
  2. Perl A, Colombo E, Samoilova E, Butler M, Banki K. Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. J Biol Chem. 2000;275:7261-72 pubmed
    Repetitive elements flanked by exons 2 and 3 of the human transaldolase gene, thus termed transaldolase-associated repetitive elements, TARE, were identified in human DNA...
  3. Thorell S, Gergely P, Banki K, Perl A, Schneider G. The three-dimensional structure of human transaldolase. FEBS Lett. 2000;475:205-8 pubmed
    The crystal structure of human transaldolase has been determined to 2.45 A resolution. The enzyme folds into an alpha/beta barrel structure and is thus similar in structure to other class I aldolases...
  4. Verhoeven N, Huck J, Roos B, Struys E, Salomons G, Douwes A, et al. Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. Am J Hum Genet. 2001;68:1086-92 pubmed
    This article describes the first patient with a deficiency of transaldolase (TALDO1 [E.C.2.2.1.2]). Clinically, the patient presented with liver cirrhosis and hepatosplenomegaly during early infancy...
  5. Huang S, Zhang Y, Zhong J. A thermostable recombinant transaldolase with high activity over a broad pH range. Appl Microbiol Biotechnol. 2012;93:2403-10 pubmed publisher
    ..In this work, an open reading frame TM0295, which encodes a putative transaldolase (TAL) from a hyper-thermophilic microorganism, Thermotoga maritima, was cloned and expressed in Escherichia ..
  6. Perl A. The pathogenesis of transaldolase deficiency. IUBMB Life. 2007;59:365-73 pubmed
    ..Balancing of NADPH and ROI levels by the PPP enzyme transaldolase (TAL) regulates the mitochondrial trans-membrane potential (Deltapsi(m)), a critical checkpoint of ATP ..
  7. Wamelink M, Struys E, Salomons G, Fowler D, Jakobs C, Clayton P. Transaldolase deficiency in a two-year-old boy with cirrhosis. Mol Genet Metab. 2008;94:255-8 pubmed publisher
    b>Transaldolase (TALDO) deficiency is a rare inborn error of the pentose phosphate pathway. We report the clinical presentation and laboratory findings of a new patient with TALDO deficiency...
  8. Verhoeven N, Wallot M, Huck J, Dirsch O, Ballauf A, Neudorf U, et al. A newborn with severe liver failure, cardiomyopathy and transaldolase deficiency. J Inherit Metab Dis. 2005;28:169-79 pubmed
    This paper describes the second patient found to be affected with a deficiency of transaldolase (TALDO1; EC 2.2.1.2)...
  9. Perl A, Hanczko R, Telarico T, Oaks Z, Landas S. Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase. Trends Mol Med. 2011;17:395-403 pubmed publisher
    ..Recently, inactivation of another PPP enzyme, transaldolase (TAL), has been implicated in male infertility and fatty liver progressing to steatohepatitis and cancer...

More Information

Publications62

  1. Fan J, Yang X, Song J, Huang X, Cheng Z, Yao L, et al. Heterologous expression of transaldolase gene Tal from Saccharomyces cerevisiae in Fusarium oxysporum for enhanced bioethanol production. Appl Biochem Biotechnol. 2011;164:1023-36 pubmed publisher
    ..However, efficiency of xylose utilization and ethanol yield was low. In this study, the transaldolase gene from Saccharomyces cerevisiae has been successfully expressed in F...
  2. Wamelink M, Smith D, Jansen E, Verhoeven N, Struys E, Jakobs C. Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine. J Inherit Metab Dis. 2007;30:735-42 pubmed
    b>Transaldolase deficiency, a recently discovered disorder of carbohydrate metabolism with multisystem involvement, has been diagnosed in 6 patients...
  3. Schneider S, Gutierrez M, Sandalova T, Schneider G, Clapés P, Sprenger G, et al. Redesigning the active site of transaldolase TalB from Escherichia coli: new variants with improved affinity towards nonphosphorylated substrates. Chembiochem. 2010;11:681-90 pubmed publisher
    Recently, we reported on a transaldolase B variant (TalB F178Y) that is able to use dihydroxyacetone (DHA) as donor in aldol reactions...
  4. Grossman C, Qian Y, Banki K, Perl A. ZNF143 mediates basal and tissue-specific expression of human transaldolase. J Biol Chem. 2004;279:12190-205 pubmed
    b>Transaldolase regulates redox-dependent apoptosis through controlling NADPH and ribose 5-phosphate production via the pentose phosphate pathway...
  5. Schneider G, Sprenger G. Transaldolase B: trapping of Schiff base intermediate between dihydroxyacetone and epsilon-amino group of active-site lysine residue by borohydride reduction. Methods Enzymol. 2002;354:197-201 pubmed
  6. Requena T, Burton J, Matsuki T, Munro K, Simon M, Tanaka R, et al. Identification, detection, and enumeration of human bifidobacterium species by PCR targeting the transaldolase gene. Appl Environ Microbiol. 2002;68:2420-7 pubmed
    ..that enabled the identification, detection, and enumeration of Bifidobacterium species by PCR targeting the transaldolase gene were tested...
  7. Banki K, Colombo E, Sia F, Halladay D, Mattson D, Tatum A, et al. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J Exp Med. 1994;180:1649-63 pubmed
    ..human retrotransposon was cloned and found to constitute an integral part of the coding sequence of the human transaldolase gene (TAL-H)...
  8. Loeffen Y, Biebuyck N, Wamelink M, Jakobs C, Mulder M, Tylki Szymanska A, et al. Nephrological abnormalities in patients with transaldolase deficiency. Nephrol Dial Transplant. 2012;27:3224-7 pubmed publisher
    b>Transaldolase deficiency (OMIM 606003) is a multisystem disorder first described in 2001. Transaldolase is an enzyme of the reversible part of the pentose phosphate pathway...
  9. Lachaise F, Martin G, Drougard C, Perl A, Vuillaume M, Wegnez M, et al. Relationship between posttranslational modification of transaldolase and catalase deficiency in UV-sensitive repair-deficient xeroderma pigmentosum fibroblasts and SV40-transformed human cells. Free Radic Biol Med. 2001;30:1365-73 pubmed
    ..Here we have analyzed transaldolase, which regulates NADPH levels produced by the pentose phosphate pathway in order to examine how it influences ..
  10. Schörken U, Thorell S, Schurmann M, Jia J, Sprenger G, Schneider G. Identification of catalytically important residues in the active site of Escherichia coli transaldolase. Eur J Biochem. 2001;268:2408-15 pubmed
    The roles of invariant residues at the active site of transaldolase B from Escherichia coli have been probed by site-directed mutagenesis...
  11. Fan J, Yang Q, Liu Z, Huang X, Song J, Chen Z, et al. The characterization of transaldolase gene tal from Pichia stipitis and its heterologous expression in Fusarium oxysporum. Mol Biol Rep. 2011;38:1831-40 pubmed publisher
    The 972 bp length of transaldolase gene tal was cloned from Pichia stipitis CICC1960, encoding a 323 amino acid protein with a calculated molecular mass of 35.36 kDa and isoelectric point of 5.20...
  12. Chen S, Hwang D, Chen G, Hsu N, Wu Y, Li T, et al. Engineering transaldolase in Pichia stipitis to improve bioethanol production. ACS Chem Biol. 2012;7:481-6 pubmed publisher
    In our effort to improve the efficiency and yield of xylose-to-ethanol bioconversion in Pichia stipitis, the transaldolase (TAL) in the pentose phosphate pathway was identified as a rate-limiting enzyme for improvement...
  13. Engelke U, Zijlstra F, Mochel F, Valayannopoulos V, Rabier D, Kluijtmans L, et al. Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency. Biochim Biophys Acta. 2010;1802:1028-35 pubmed publisher
    ..Sedoheptulose, arabitol, ribitol, and erythritol have been identified as key diagnostic metabolites in TALDO deficiency...
  14. Niland B, Banki K, Biddison W, Perl A. CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J Immunol. 2005;175:8365-78 pubmed
    b>Transaldolase (TAL) is expressed at selectively high levels in oligodendrocytes and targeted by autoreactive T cells of patients with multiple sclerosis (MS)...
  15. Nakahigashi K, Toya Y, Ishii N, Soga T, Hasegawa M, Watanabe H, et al. Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism. Mol Syst Biol. 2009;5:306 pubmed publisher
    ..of sedoheptulose-7-phosphate to erythrose-4-phosphate and dihydroxyacetone phosphate were observed in transaldolase-deficient mutants, without any noticeable changes in gene expression...
  16. Perl A, Qian Y, Chohan K, Shirley C, Amidon W, Banerjee S, et al. Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa. Proc Natl Acad Sci U S A. 2006;103:14813-8 pubmed
    ..Here, we report that male mice lacking transaldolase (TAL)(-/-) are sterile because of defective forward motility...
  17. Qian Y, Banerjee S, Grossman C, Amidon W, Nagy G, Barcza M, et al. Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing. Biochem J. 2008;415:123-34 pubmed publisher
    TAL (transaldolase) was originally described in the yeast as an enzyme of the PPP (pentose phosphate pathway). However, certain organisms and mammalian tissues lack TAL, and the overall reason for its existence is unclear...
  18. Schaaff Gerstenschläger I, Zimmermann F. Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase. Curr Genet. 1993;24:373-6 pubmed
    ..We also isolated double and triple mutants for transketolase (tkl1), transaldolase (tal1), and glucose 6-phosphate dehydrogenase (zwf1) by crossing the different mutants...
  19. Gonzalez Rodriguez I, Sanchez B, Ruiz L, Turroni F, Ventura M, Ruas Madiedo P, et al. Role of extracellular transaldolase from Bifidobacterium bifidum in mucin adhesion and aggregation. Appl Environ Microbiol. 2012;78:3992-8 pubmed publisher
    ..bifidum A8 surface proteins showed a high adhesive capability for its transaldolase (Tal). The localization of this enzyme on the surface of B...
  20. Pueyo J, Couso J. The 11-aminoacid long Tarsal-less peptides trigger a cell signal in Drosophila leg development. Dev Biol. 2008;324:192-201 pubmed publisher
    ..These regulatory effects complement the known genetic scenario required for distal leg development and explain the requirements for tarsal-less in this process. ..
  21. Jones J, Garcia P, Barosa C, Delgado T, Caldeira M, Diogo L. Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans. Magn Reson Med. 2008;59:423-9 pubmed publisher
    Exchange of hepatic glucose-6-phosphate (G6P) and glyceraldehyde-3-phosphate via transaldolase modifies hepatic G6P enrichment from glucose or gluconeogenic tracers...
  22. Sprenger G, Schörken U, Sprenger G, Sahm H. Transaldolase B of Escherichia coli K-12: cloning of its gene, talB, and characterization of the enzyme from recombinant strains. J Bacteriol. 1995;177:5930-6 pubmed
    ..20:3305-3308) from the 0.2-min region of the Escherichia coli K-12 chromosome is shown to encode a functional transaldolase activity...
  23. Samland A, Rale M, Sprenger G, Fessner W. The transaldolase family: new synthetic opportunities from an ancient enzyme scaffold. Chembiochem. 2011;12:1454-74 pubmed publisher
    ..New aldolases derived from the transaldolase scaffold (based on transaldolase B and fructose-6-phosphate aldolase from Escherichia coli) have been shown to ..
  24. Galindo M, Pueyo J, Fouix S, Bishop S, Couso J. Peptides encoded by short ORFs control development and define a new eukaryotic gene family. PLoS Biol. 2007;5:e106 pubmed publisher
    ..Our results open a new avenue for the annotation and functional analysis of genes and sequenced genomes, in which thousands of short ORFs are still uncharacterised...
  25. Valayannopoulos V, Verhoeven N, Mention K, Salomons G, Sommelet D, Gonzales M, et al. Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease. J Pediatr. 2006;149:713-7 pubmed
    b>Transaldolase (TALDO) deficiency is a newly recognized metabolic disease, which has been reported so far in 2 patients presenting with liver failure and cirrhosis...
  26. Walfridsson M, Hallborn J, Penttila M, Keranen S, Hahn Hagerdal B. Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol. 1995;61:4184-90 pubmed
    ..cerevisiae TKL1 and TAL1 genes encoding transketolase and transaldolase were overexpressed. A XYL1- and XYL2-containing S...
  27. Wang C, Guo K, Gao D, Kang X, Jiang K, Li Y, et al. Identification of transaldolase as a novel serum biomarker for hepatocellular carcinoma metastasis using xenografted mouse model and clinic samples. Cancer Lett. 2011;313:154-66 pubmed publisher
    ..Among them, expression level of transaldolase (TALDO) was validated in mouse and human serum...
  28. Schneider S, Sandalova T, Schneider G, Sprenger G, Samland A. Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin. J Biol Chem. 2008;283:30064-72 pubmed publisher
    ..on a structure-assisted sequence alignment we designed 11 focused libraries at residues in the active site of transaldolase B from Escherichia coli and screened them for their ability to synthesize fructose 6-phosphate from ..
  29. Huck J, Struys E, Verhoeven N, Jakobs C, van der Knaap M. Profiling of pentose phosphate pathway intermediates in blood spots by tandem mass spectrometry: application to transaldolase deficiency. Clin Chem. 2003;49:1375-80 pubmed
    ..The method was used to study sugar phosphates abnormalities in a patient affected with a deficiency of transaldolase (TALDO1; EC 2.2.1.2)...
  30. Huang H, Rong H, Li X, Tong S, Zhu Z, Niu L, et al. The crystal structure and identification of NQM1/YGR043C, a transaldolase from Saccharomyces cerevisiae. Proteins. 2008;73:1076-81 pubmed publisher
  31. Tylki Szymanska A, Stradomska T, Wamelink M, Salomons G, Taybert J, Pawłowska J, et al. Transaldolase deficiency in two new patients with a relative mild phenotype. Mol Genet Metab. 2009;97:15-7 pubmed publisher
    b>Transaldolase (TALDO) deficiency is a recently described inborn error of metabolism of the pentose phosphate pathway that so far has been diagnosed in only eight patients...
  32. Basu R, Chandramouli V, Schumann W, Basu A, Landau B, Rizza R. Additional evidence that transaldolase exchange, isotope discrimination during the triose-isomerase reaction, or both occur in humans: effects of type 2 diabetes. Diabetes. 2009;58:1539-43 pubmed publisher
    ..81 +/- 0.01 vs. 0.79 +/- 0.01, respectively). That the C5-to-C3 glucose ratio is <1 indicates that transaldolase exchange, selective retention of deuterium at the level of the triose-isomerase reaction, or both occur in ..
  33. Matsushika A, Goshima T, Fujii T, Inoue H, Sawayama S, Yano S. Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae. Enzyme Microb Technol. 2012;51:16-25 pubmed publisher
    The activity of transaldolase and transketolase, key enzymes in the non-oxidative pentose phosphate pathway, is rate-limiting for xylose utilization in recombinant Saccharomyces cerevisiae...
  34. Caillau M, Paul Quick W. New insights into plant transaldolase. Plant J. 2005;43:1-16 pubmed
    ..TA genes appear to be differentially regulated at the level of gene expression in plant tissues and in response to environmental factors which suggests that TA isoforms have a non-overlapping role for plant metabolism. ..
  35. Samland A, Sprenger G. Transaldolase: from biochemistry to human disease. Int J Biochem Cell Biol. 2009;41:1482-94 pubmed publisher
    The role of the enzyme transaldolase (TAL) in central metabolism, its biochemical properties, structure, and role in human disease is reviewed...
  36. Choi K, Shi J, Hopkins C, Tolan D, Allen K. Snapshots of catalysis: the structure of fructose-1,6-(bis)phosphate aldolase covalently bound to the substrate dihydroxyacetone phosphate. Biochemistry. 2001;40:13868-75 pubmed
    ..structure with that of the covalent enzyme-dihydroxyacetone structure of the mechanistically similar transaldolase and KDPG aldolase allows the identification of a conserved Lys-Glu dyad involved in Schiff-base formation and ..
  37. Wamelink M, Struys E, Huck J, Roos B, van der Knaap M, Jakobs C, et al. Quantification of sugar phosphate intermediates of the pentose phosphate pathway by LC-MS/MS: application to two new inherited defects of metabolism. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;823:18-25 pubmed
    ..The method was applied to cells from patients affected with a deficiency of transaldolase. The transaldolase-deficient cells showed an increased concentration of sedoheptulose-7-phosphate...
  38. Missall T, Pusateri M, Donlin M, Chambers K, Corbett J, Lodge J. Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot Cell. 2006;5:518-29 pubmed
    ..Posttranslational modifications of transaldolase (Tal1), aconitase (Aco1), and the thiol peroxidase, Tsa1, are regulated during nitrosative stress...
  39. Gu Y, Li J, Zhang L, Chen J, Niu L, Yang Y, et al. Improvement of xylose utilization in Clostridium acetobutylicum via expression of the talA gene encoding transaldolase from Escherichia coli. J Biotechnol. 2009;143:284-7 pubmed publisher
    ..The gene talA, which encodes transaldolase from Escherichia coli K-12, was cloned and overexpressed in C. acetobutylicum ATCC 824. Compared with C...
  40. Wamelink M, Struys E, Valayannopoulos V, Gonzales M, Saudubray J, Jakobs C. Retrospective detection of transaldolase deficiency in amniotic fluid: implications for prenatal diagnosis. Prenat Diagn. 2008;28:460-2 pubmed publisher
  41. Alberio T, Pippione A, Zibetti M, Olgiati S, Cecconi D, Comi C, et al. Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease. Sci Rep. 2012;2:953 pubmed publisher
    ..We chose to verify by Western blotting the identity of spots corresponding to ?-fibrinogen and transaldolase, two recurrent proteins in six out of 20 spots...
  42. Jia J, Huang W, Schörken U, Sahm H, Sprenger G, Lindqvist Y, et al. Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family. Structure. 1996;4:715-24 pubmed
    b>Transaldolase is one of the enzymes in the non-oxidative branch of the pentose phosphate pathway. It transfers a C3 ketol fragment from a ketose donor to an aldose acceptor...
  43. Gao J, Simon M. A comparative study of human GS2, its paralogues, and its rat orthologue. Biochem Biophys Res Commun. 2007;360:501-6 pubmed
    ..Since retinoid and triglyceride metabolites are transcription factor ligands, we expect that these enzymes will coordinately regulate epidermal homeostasis. ..
  44. Kusuda J, Hirai M, Toyoda A, Hashimoto K. Localization of the human transaldolase gene (TALDO) to chromosome 1p33-p34.1 by fluorescence in situ hybridization and PCR analysis of somatic cell hybirds. Genomics. 1997;40:378-81 pubmed
  45. Jin E, Sherry A, Malloy C. Evidence for transaldolase activity in the isolated heart supplied with [U-13C3]glycerol. J Biol Chem. 2013;288:2914-22 pubmed publisher
    ..3-phosphate followed by rearrangements in the nonoxidative branch of the pentose phosphate pathway involving transaldolase that places this (13)C-enriched 3-carbon unit only in the bottom half of hexose phosphate molecules ..
  46. Zhang Q, Lee H, Han J, Kang S, Lee N, Baik M, et al. Differentially expressed proteins associated with myogenesis and adipogenesis in skeletal muscle and adipose tissue between bulls and steers. Mol Biol Rep. 2012;39:953-60 pubmed publisher
    ..cofilin 2 (CFL2) that was down-regulated, and also identified two down-regulated proteins in adipose tissue, transaldolase 1 (TALDO1) and L: -lactate dehydrogenase B chain (LDHB)...
  47. Puskas F, Gergely P, Niland B, Banki K, Perl A. Differential regulation of hydrogen peroxide and Fas-dependent apoptosis pathways by dehydroascorbate, the oxidized form of vitamin C. Antioxid Redox Signal. 2002;4:357-69 pubmed
    ..of pentose phosphate pathway enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase, elevated intracellular glutathione levels, and inhibited H(2)O(2)-induced changes in mitochondrial ..
  48. Pácal L, Tomandl J, Svojanovsky J, Krusová D, Stepankova S, Rehorová J, et al. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. Nephrol Dial Transplant. 2011;26:1229-36 pubmed publisher
    ..levels of thiamine and its esters) together with genetic variability in key PPP enzymes-transketolase (TKT), transaldolase and TKT-like-might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics...
  49. Hsieh B, Huang L, Su S, Cheng H, Hu Y, Hung T, et al. Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species. J Nutr Biochem. 2011;22:234-41 pubmed publisher
    ..also reduced the activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and transaldolase in the pentose phosphate pathway, a major mechanism for producing NADPH, resulting in a marked decrease in ..
  50. Cha M, Rhim T, Kim K, Jang A, Paik Y, Park C. Proteomic identification of macrophage migration-inhibitory factor upon exposure to TiO2 particles. Mol Cell Proteomics. 2007;6:56-63 pubmed
    ..Carbon black and diesel exhaust particles also induced expression of MIF protein in the epithelial cells. ..
  51. Pueyo J, Couso J. Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. Dev Biol. 2011;355:183-93 pubmed publisher
  52. Rale M, Schneider S, Sprenger G, Samland A, Fessner W. Broadening deoxysugar glycodiversity: natural and engineered transaldolases unlock a complementary substrate space. Chemistry. 2011;17:2623-32 pubmed publisher
    ..by the choice of enzyme and aldol components, we have investigated the substrate scope of the F178Y mutant of transaldolase B, TalB(F178Y), and fructose 6-phosphate aldolase, FSA, from E...
  53. Niland B, Perl A. Evaluation of autoimmunity to transaldolase in multiple sclerosis. Methods Mol Med. 2004;102:155-71 pubmed
    b>Transaldolase is a target of autoimmunity mediated by T cells and antibody (Ab) in patients with multiple sclerosis...