vitamin k epoxide reductases


Summary: OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.

Top Publications

  1. Lemmens R, Abboud S, Vanhees L, Goris A, Thijs V. Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease. J Thromb Haemost. 2008;6:2220-3 pubmed publisher
  2. Garbuzova V, Stroy D, Dosenko V, Dubovyk Y, Borodenko A, Shimko K, et al. [Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke]. Fiziol Zh. 2015;61:19-27 pubmed
    ..The coincidence of patients T/C and G/G, C/C and G/A genotypes, and A/A genotype (G(-7)-->A polymorphism) with any genotype T(2255)-->C polymorphism are increases the risk of IATS. ..
  3. Vandell A, Walker J, Brown K, Zhang G, Lin M, Grosso M, et al. Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism. Heart. 2017;103:1800-1805 pubmed publisher
    ..38 [95% CI 1.11 to 1.71], p=0.0035; highly sensitive responders 1.79 [1.09 to 2.99]; p=0.0252). In this study, CYP2C9 and VKORC1 genotypes identified patients with VTE at increased bleeding risk with warfarin. NCT00986154. ..
  4. Chen D, Xiang Q, Nicholas J. Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. J Virol. 2017;91: pubmed publisher
    ..This is the first report of such a function for a cytokine. ..
  5. Desvars Larrive A, Pascal M, Gasqui P, Cosson J, Benoit E, Lattard V, et al. Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population. PLoS ONE. 2017;12:e0184015 pubmed publisher
    ..Our findings should stimulate future discussions about the development of a long-term rat-control management program in Chanteraines urban park. ..
  6. Klein T, Altman R, Eriksson N, Gage B, Kimmel S, Lee M, et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med. 2009;360:753-64 pubmed publisher
    ..The greatest benefits were observed in the 46.2% of the population that required 21 mg or less of warfarin per week or 49 mg or more per week for therapeutic anticoagulation. ..
  7. Peoc h K, Pruvot S, Gourmel C, Dit Sollier C, Drouet L. A new VKORC1 mutation leading to an isolated resistance to fluindione. Br J Haematol. 2009;145:841-3 pubmed publisher
  8. Schmeits P, Hermans M, van Geest Daalderop J, Poodt J, de Sauvage Nolting P, Conemans J. VKORC1 mutations in patients with partial resistance to phenprocoumon. Br J Haematol. 2010;148:955-7 pubmed publisher
    ..Determination of hormones and the patients' genetic constitution makes possible to apply a personified approach for the vitamin K3 application in the ulcerative hemorrhage. ..

More Information


  1. Johnson J, Caudle K, Gong L, Whirl Carrillo M, Stein C, Scott S, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharmacol Ther. 2017;102:397-404 pubmed publisher
    ..In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry. ..
  2. Langaee T, Stauffer L, Galloway C, Solayman M, Cavallari L. Cross-Validation of High-Resolution Melting Analysis-Based Genotyping Platform. Genet Test Mol Biomarkers. 2017;21:259-264 pubmed publisher
  3. Zhang Y, Wang L, Zhang J, Li Y, He Q, Li H, et al. Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr. 2014;53:221-32 pubmed
    ..fragilis enriched vitamin K2-dependent osteocalcin mechanism in which AdipoR2, LXR-? and PPAR-? signaling were involved. ..
  4. Duzhiy I, Romanyuk A, Lyndin M, Bratushka V, Dubnytskiy V, Shevchenko Y, et al. [HORMONAL-GENETIC SCREENING IN PATIENTS, SUFFERING GASTRODUODENAL ULCER HEMORRHAGE]. Klin Khir. 2015;:24-7 pubmed
    ..Diagnosis of polymorphic gene VKORC1 and expression of the estrogen receptors may serve the base for pathogenetic therapy in patients with hemorrhage occurrence. ..
  5. Levi F, Karaboué A, Saffroy R, Desterke C, Boige V, Smith D, et al. Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). Br J Cancer. 2017;117:965-973 pubmed publisher
    ..VKORC1, NAT2 and ABCB1 variants predicted for HAI efficacy. Pharmacogenetics could guide the personalisation of liver-targeted medico-surgical therapies. ..