heme oxygenase 1


Summary: A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.

Top Publications

  1. Gueron G, De Siervi A, Ferrando M, Salierno M, De Luca P, Elguero B, et al. Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Mol Cancer Res. 2009;7:1745-55 pubmed publisher
    ..Inflammation has been recognized as a risk factor for this disease. Heme oxygenase 1 (HO-1), the inducible isoform of the rate-limiting enzyme in heme degradation, counteracts oxidative and ..
  2. Bastianetto S, Quirion R. Heme oxygenase 1: another possible target to explain the neuroprotective action of resveratrol, a multifaceted nutrient-based molecule. Exp Neurol. 2010;225:237-9 pubmed publisher
    ..C., Doré, S., 2010. Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1. Exp. Neurol. 224, 325-329...
  3. Bai C, Chen J, Chiu H, Chou C, Chau L, Pan W. Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients. J Biomed Sci. 2010;17:12 pubmed publisher
  4. Schipper H, Gupta A, Szarek W. Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD. Curr Alzheimer Res. 2009;6:424-30 pubmed
  5. Goven D, Boutten A, Lecon Malas V, Boczkowski J, Bonay M. Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. FEBS Lett. 2009;583:3508-18 pubmed publisher
    ..These results suggest that ERK(1/2) and JNK are involved in CS-induced biphasic HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1. ..
  6. Biburger M, Theiner G, Schädle M, Schuler G, Tiegs G. Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. J Leukoc Biol. 2010;87:193-202 pubmed publisher
    ..In summary, these data suggest that HO-1 expression by T(regs) might contribute to their typical reluctance to proliferate but does not account independently for their suppressive functions. ..
  7. Surh Y, Kundu J, Li M, Na H, Cha Y. Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch Pharm Res. 2009;32:1163-76 pubmed publisher
  8. Lehmann E, El Tantawy W, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, et al. The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology. 2010;51:398-404 pubmed publisher
    ..The antioxidant biliverdin reduces HCV replication in vitro by triggering the antiviral interferon response and might improve HCV therapy in the future. ..
  9. Song F, Li X, Zhang M, Yao P, Yang N, Sun X, et al. Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes in a Chinese population. Am J Epidemiol. 2009;170:747-56 pubmed publisher
    ..These results support an association between the HO-1 (GT)(n) microsatellite polymorphism, HO-1 expression levels, and the odds of T2DM. ..

More Information


  1. Sutherland B, Rahman R, Clarkson A, Shaw O, Nair S, Appleton I. Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats. Neurosci Res. 2009;65:326-34 pubmed publisher
    ..This report of HO-2 protein expression upregulation following HI coupled with an increase in HO-1 immunoreactivity suggests that this response may be implicated in reducing cell death or repairing damage induced by cerebral ischemia. ..
  2. Miyazaki T, Kirino Y, Takeno M, Hama M, Ushihama A, Watanabe R, et al. Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. Int J Hematol. 2010;91:229-37 pubmed publisher
    ..These data demonstrate that serum HO-1 can distinguish secondary HPS from other hematological diseases, including those associated with hyperferritinemia. ..
  3. Park S, Lee S, Shin H, Chung W, Lee W, Rhim B, et al. Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction. Arthritis Rheum. 2010;62:732-41 pubmed publisher
    ..The expression of NF-kappaB, IkappaBalpha, Bcl-2, Bax, heme oxygenase 1 (HO-1), and Nrf2 was determined by Western blotting...
  4. Sheu C, Zhai R, Wang Z, Gong M, Tejera P, Chen F, et al. Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Intensive Care Med. 2009;35:1343-51 pubmed publisher
    ..The common haplotype S-TAG is associated with increased ARDS risk. Our results suggest that HMOX1 variation may modulate ARDS risk through the promoter microsatellite polymorphism. ..
  5. Enoki T, Okuda S, Kudo Y, Takashima F, Sagawa H, Kato I. Oligosaccharides from agar inhibit pro-inflammatory mediator release by inducing heme oxygenase 1. Biosci Biotechnol Biochem. 2010;74:766-70 pubmed
    ..It is therefore proposed that agaro-oligosaccharides might be a good candidate for a functional food to prevent inflammatory diseases. ..
  6. Sakata Y, Zhuang H, Kwansa H, Koehler R, DORE S. Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1. Exp Neurol. 2010;224:325-9 pubmed publisher
    ..This study revealed that resveratrol, an enriched bioactive polyphenol in red wine, selectively induces heme oxygenase 1 (HO1) in a dose- and time-dependent manner in cultured mouse cortical neuronal cells and provides ..
  7. Lüblinghoff N, Winkler K, Winkelmann B, Seelhorst U, Wellnitz B, Boehm B, et al. Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (the Ludwigshafen Risk and Cardiovascular Health study). BMC Med Genet. 2009;10:36 pubmed publisher
  8. Cheng C, Noorderloos M, van Deel E, Tempel D, den Dekker W, Wagtmans K, et al. Dendritic cell function in transplantation arteriosclerosis is regulated by heme oxygenase 1. Circ Res. 2010;106:1656-66 pubmed publisher
    ..These findings demonstrate that HO1 plays an important role in the genetic regulation of the vascular alloimmune response elicited by DCs. ..
  9. Baruscotti I, Barchiesi F, Jackson E, Imthurn B, Stiller R, Kim J, et al. Estradiol stimulates capillary formation by human endothelial progenitor cells: role of estrogen receptor-{alpha}/{beta}, heme oxygenase 1, and tyrosine kinase. Hypertension. 2010;56:397-404 pubmed publisher
    ..damaged endothelium and promote capillary formation, processes involving receptor tyrosine kinases (RTKs) and heme oxygenase 1 (HO-1)...
  10. Bharucha A, Kulkarni A, Choi K, Camilleri M, Lempke M, Brunn G, et al. First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans. Clin Pharmacol Ther. 2010;87:187-90 pubmed publisher
    ..70 +/- 9.20 (baseline), 1,126.20 +/- 293.30 (24 h), 1,192.20 +/- 333.30 (48 h)) in four of five subjects as compared with albumin alone (P </= 0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans. ..
  11. Fer N, Shoemaker R, Monks A. Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1. J Exp Clin Cancer Res. 2010;29:91 pubmed publisher
    ..This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant role in modulation of drug-induced toxicity in the non-small cell lung ..
  12. Barker E, Gatbonton Schwager T, Han Y, Clay J, Letterio J, Tochtrop G. Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages. J Nat Prod. 2010;73:1064-8 pubmed publisher
    ..products led us to discover that BA induces a marked increase in the expression of a phase 2 response enzyme, heme oxygenase 1 (HO-1), in a dose-dependent manner...
  13. Mateo I, Infante J, Sanchez Juan P, Garcia Gorostiaga I, Rodriguez Rodriguez E, Vázquez Higuera J, et al. Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease. Acta Neurol Scand. 2010;121:136-8 pubmed publisher
    ..The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain. ..
  14. Liu P, Tsai J, Charles A, Hwang J, Chou S, Ping Y, et al. Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases. Mol Nutr Food Res. 2010;54 Suppl 2:S196-204 pubmed publisher
    ..The inhibitory effects of resveratrol on MMP expression and invasion of lung cancer cells are, in part, associated with the HO-1-mediated NF-kappaB pathway. ..
  15. Schipper H, Song W, Zukor H, Hascalovici J, Zeligman D. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem. 2009;110:469-85 pubmed publisher
    ..Glial HO-1 expression may also impact cell survival and neuroplasticity in these conditions by modulating brain sterol metabolism and proteosomal degradation of neurotoxic protein aggregates. ..
  16. Zeynalov E, Shah Z, Li R, DORE S. Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia. Neurobiol Dis. 2009;35:264-9 pubmed publisher
    ..Our goal was to determine if the inducible heme oxygenase 1 (HO1) is required for such protection...
  17. Cheng C, Noordeloos A, Jeney V, Soares M, Moll F, Pasterkamp G, et al. Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. Circulation. 2009;119:3017-27 pubmed publisher
    The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in ..
  18. Vallabhaneni R, Kaczorowski D, Yaakovian M, Rao J, Zuckerbraun B. Heme oxygenase 1 protects against hepatic hypoxia and injury from hemorrhage via regulation of cellular respiration. Shock. 2010;33:274-81 pubmed publisher
    b>Heme oxygenase 1 (HO-1) is an important regulator of the cellular response to stress and inflammation...
  19. Minelli A, Conte C, Grottelli S, Bellezza I, Emiliani C, Bolanos J. Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. J Neurochem. 2009;111:956-66 pubmed publisher
    ..These results suggest that cyclo(His-Pro), acting as a selective activator of the brain modulable Nrf2 pathway, may be a promising candidate as neuroprotective agent that act through induction of phase II genes. ..
  20. Zhong J, Edwards G, Raval C, Li H, Tyrrell R. The role of Nrf2 in ultraviolet A mediated heme oxygenase 1 induction in human skin fibroblasts. Photochem Photobiol Sci. 2010;9:18-24 pubmed publisher
    Ultraviolet-A (UVA, 320-380 nm) radiation is an oxidative stress that strongly induces heme oxygenase 1 (HO-1) expression in cultured human primary skin fibroblasts (FEK4)...
  21. Sambuceti G, Morbelli S, Vanella L, Kusmic C, Marini C, Massollo M, et al. Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin. Stem Cells. 2009;27:399-407 pubmed publisher
    ..Type II DM and its related oxidant damage hamper the interaction between the vascular wall and normal EPCs by mechanisms that are, at least partially, reversed by the induction of HO-1 gene expression, adiponectin, and pAMPK levels. ..
  22. Chang A, Chan J, Cheng H, Tsai C, Chan S. Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death. Shock. 2009;32:651-8 pubmed publisher
    ..significant hypoxia in RVLM, this study evaluated the hypothesis that the hypoxia-inducible factor 1 (HIF-1)/heme oxygenase 1 (HO-1) cascade acts as upstream signals in the prolife role of HSP70 at RVLM during experimental brain stem ..
  23. Abraham N, Kushida T, McClung J, Weiss M, Quan S, Lafaro R, et al. Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res. 2003;93:507-14 pubmed
    ..These findings identify a novel effect of HO-1 on endothelial cell growth and indicate that heme metabolism and HO-1 expression regulate signaling systems in cells exposed to high glucose, which controls cell-cycle progression. ..
  24. Zaki M, Fujii S, Okamoto T, Islam S, Khan S, Ahmed K, et al. Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol. 2009;182:3746-56 pubmed publisher
    ..In this study, we report a unique signal pathway for cytoprotection during Salmonella infection that involves heme oxygenase 1 (HO-1) induced by a nitrated cyclic nucleotide, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)...
  25. Kuwano Y, Rabinovic A, Srikantan S, Gorospe M, Demple B. Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation. Mol Cell Biol. 2009;29:2622-35 pubmed publisher
    We previously observed that nitric oxide (NO) exposure increases the stability of mRNAs encoding heme oxygenase 1 (HO-1) and TIEG-1 in human and mouse fibroblasts...
  26. Manzo N, Slade R, Richards J, McGee J, Martin L, Dye J. Susceptibility of inflamed alveolar and airway epithelial cells to injury induced by diesel exhaust particles of varying organic carbon content. J Toxicol Environ Health A. 2010;73:565-80 pubmed publisher
    ..Adverse health outcomes associated with exposure to traffic-related air pollutants, like DEP, in patients with preexisting inflammatory respiratory diseases may be due, in part, to similar mechanisms. ..
  27. Park E, Lim J, Nam S, Park J, Kwon T. Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. Biochimie. 2010;92:110-5 pubmed publisher
    ..Taken together, the present study identified rottlerin as a novel inducer of HO-1 expression and identified the mechanisms involved in this process. ..
  28. Liu S, Yang C, Pan H, Sung Y, Liao K, Chen W, et al. IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cell Mol Life Sci. 2010;67:1465-76 pubmed publisher
    ..These results indicate that an ER stress-related calpain-down-regulated PPAR-gamma/HO-1 pathway is involved in the IL-13-enhanced activated death of microglia. ..
  29. Li N, Wang Y, Wang C, He X, Dai Y. [Effects of transfection of rat heme oxygenase-1 on cardiomyocyte apoptosis induced by myocardial ischemia/ reperfusion injury in rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009;21:325-8 pubmed
    ..There was no significant difference between group II and group III. rAAV-mediated rHO-1 gene transfection may attenuate myocardium I/R injury by inhibiting apoptosis of cardiomyocyte in rats. ..
  30. Yoshikawa Y, Morita M, Hosomi H, Tsuneyama K, Fukami T, Nakajima M, et al. Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat. Toxicology. 2009;264:89-95 pubmed publisher
    ..This is the first report of a SOD2-knockdown rat model that could be useful to evaluate the drug-induced hepatotoxicity with high sensitivity. ..
  31. Zhao H, Wong R, Kalish F, Nayak N, Stevenson D. Effect of heme oxygenase-1 deficiency on placental development. Placenta. 2009;30:861-8 pubmed publisher
    ..We conclude that a partial deficiency in HO-1 is associated with morphological changes in the placenta and elevations in maternal diastolic blood pressure and plasma sFlt-1 levels, despite a compensatory increase in HO-2 expression...
  32. Park H, Kim S, Kwon D, Park J, Kim Y. Protective effect of quercetin against paraquat-induced lung injury in rats. Life Sci. 2010;87:181-6 pubmed publisher
    ..The present results demonstrate that quercetin administration to rats effectively inhibits the development of PQ-induced pulmonary injury most probably via its antioxidant activity. ..
  33. Zhao H, Zhang F, Shen G, Li Y, Li Y, Jing H, et al. Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway. World J Gastroenterol. 2010;16:3002-10 pubmed
    ..05), which was in parallel with the increased level of liver Nrf2 and HO-1 expression. SFN pretreatment attenuates liver injury induced by intestinal I/R in rats, attributable to the antioxidant effect through Nrf2-ARE pathway. ..
  34. Eom H, Choi J. Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicol Lett. 2009;187:77-83 pubmed publisher
  35. Lee Y, Jeong G, Lim H, An R, Kim Y, Kim E. Isoliquiritigenin 2'-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1. Toxicol In Vitro. 2010;24:776-82 pubmed publisher
    ..Thus, ILME could be considered to be a potential chemotherapeutic target for anti-oral cancer treatment strategies. ..
  36. Tinahones F, Salas J, Mayas M, Ruiz Villalba A, Macias Gonzalez M, Garrido Sanchez L, et al. VEGF gene expression in adult human thymus fat: a correlative study with hypoxic induced factor and cyclooxygenase-2. PLoS ONE. 2009;4:e8213 pubmed publisher
    ..The expression of VEGF seems to be associated with COX-2, HO-1 and adipogenesis related genes, suggesting the importance that this new fat has acquired in research in relation to adipogenesis and angiogenesis. ..
  37. Bains S, Foresti R, Howard J, Atwal S, Green C, Motterlini R. Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity. Arterioscler Thromb Vasc Biol. 2010;30:305-12 pubmed publisher
    ..Our results highlight important associations between SCD and HO byproducts, which may counteract vascular complications of SCD. ..
  38. Barbagallo I, Vanella A, Peterson S, Kim D, Tibullo D, Giallongo C, et al. Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation. J Bone Miner Metab. 2010;28:276-88 pubmed publisher
    ..Thus, the targeting of HO-1 gene expression presents a portal to increase osteoblast function and differentiation and attenuate osteoporosis by promoting bone formation. ..
  39. Vanella L, Kim D, Asprinio D, Peterson S, Barbagallo I, Vanella A, et al. HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage. Bone. 2010;46:236-43 pubmed publisher
    ..Thus, targeting HO-1 expression is a portal to increased osteoblast stem cell differentiation and to the attenuation of osteoporosis by the promotion of bone formation. ..
  40. Ohnishi M, Katsuki H, Unemura K, Izumi Y, Kume T, Takada Takatori Y, et al. Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture. Brain Res. 2010;1347:170-8 pubmed publisher
    ..Thrombin-induced cortical injury may be also regulated by the expression of HO-1 and the resultant production of heme degradation products such as carbon monoxide. ..
  41. Shih R, Cheng S, Tung W, Yang C. Up-regulation of heme oxygenase-1 protects against cold injury-induced brain damage: a laboratory-based study. J Neurotrauma. 2010;27:1477-87 pubmed publisher
    ..3 cells. In summary, HO-1 overexpression appears to offer an effective neuroprotection against cold-induced secondary brain injury...
  42. Diers A, Higdon A, Ricart K, Johnson M, Agarwal A, Kalyanaraman B, et al. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. Biochem J. 2010;426:31-41 pubmed publisher
    ..These results demonstrate the feasibility of modulating the biological effects of electrophiles by targeting the pharmacophore to mitochondria. ..
  43. Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright M, et al. Carbon monoxide rescues heme oxygenase-1-deficient mice from arterial thrombosis in allogeneic aortic transplantation. Am J Pathol. 2009;175:422-9 pubmed publisher
    ..These studies demonstrate an important role for systemic HO-1/CO for protection against vascular arterial thrombosis in murine aortic allotransplantation. ..
  44. Ohnuma T, Komatsu T, Nakayama S, Nishiyama T, Ogura K, Hiratsuka A. Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. Arch Biochem Biophys. 2009;488:34-41 pubmed publisher
    ..We found that falcarindiol was a novel inducer of AOEs and phase 2 DMEs and falcarindiol might exhibit chemopreventive activity. ..
  45. Zhong W, Xia Z, Hinrichs D, Rosenbaum J, Wegmann K, Meyrowitz J, et al. Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis. J Pediatr Gastroenterol Nutr. 2010;50:132-9 pubmed publisher
    ..These results demonstrate that upregulation of HO-1 by hemin ameliorated experimental colitis. Moreover, our study suggests a broader protective mechanism of hemin. ..
  46. Koch N, Jung M, Sabat R, Krätzschmar J, Döcke W, Asadullah K, et al. IL-10 protects monocytes and macrophages from complement-mediated lysis. J Leukoc Biol. 2009;86:155-66 pubmed publisher
    ..Our results suggest that IL-10 generates pathogen-clearing phagocytes, which are resistant to complement lysis and thereby, enabled to survive longer in a hostile inflammatory environment...
  47. Wang C, Chau L. Heme oxygenase-1 in cardiovascular diseases: molecular mechanisms and clinical perspectives. Chang Gung Med J. 2010;33:13-24 pubmed
    ..Specifically, there is a focus on the enzyme's role in various cardiovascular diseases. ..
  48. Meng D, Wang X, Chang Q, Hitron A, Zhang Z, Xu M, et al. Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Toxicol Appl Pharmacol. 2010;244:291-9 pubmed publisher
    ..These findings demonstrate a role for HO-1 in arsenite-mediated angiogenesis in vitro. ..
  49. Yakovlev V, Rabender C, Sankala H, Gauter Fleckenstein B, Fleckenstein K, Batinic Haberle I, et al. Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). Int J Radiat Oncol Biol Phys. 2010;78:547-54 pubmed publisher
    ..Radiation induced a biphasic stress response in the lung, as shown by the induction of heme oxygenase 1 at 1-3 days and at 6-8 weeks after irradiation...
  50. Zhou C, Irani R, Zhang Y, Blackwell S, Mi T, Wen J, et al. Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia. Circulation. 2010;121:436-44 pubmed publisher
    ..Our results provide important new targets for diagnosis and therapeutic intervention in the management of preeclampsia. ..
  51. Valacchi G, Pecorelli A, Mencarelli M, Maioli E, Davis P. Beta-carotene prevents ozone-induced proinflammatory markers in murine skin. Toxicol Ind Health. 2009;25:241-7 pubmed publisher
    ..We conclude that beta-carotene provides protection against O3-induced skin oxidative stress in vivo, which is consistent with a protective role for beta-carotene in the skin. ..
  52. Qi H, Siu S, Chen Y, Han Y, Chu I, Tong Y, et al. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chem Biol Interact. 2010;183:380-9 pubmed publisher
    ..Thus, this study demonstrated that senkyunolide-H and -I attenuated oxidative damage via activation of HO-1 pathway. ..
  53. Zhang J, Hung A, Ng P, Nakayama K, Hu Y, Li B, et al. PKCdelta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis. Biochem Biophys Res Commun. 2009;386:750-6 pubmed publisher
    ..Hence, PKCdelta is an important positive modulator of NO-induced Nrf2/ARE-dependent signaling that counteracts NO-mediated apoptosis in neuronal cells. ..