lipoxygenase

Summary

Summary: An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.

Top Publications

  1. Padilla M, Hernandez M, Sanz C, Martínez Rivas J. Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. J Agric Food Chem. 2009;57:9097-107 pubmed publisher
    ..Biochemical and gene expression data suggest a major involvement of the Oep2LOX2 gene in the biosynthesis of virgin olive oil aroma compounds...
  2. Andreou A, Feussner I. Lipoxygenases - Structure and reaction mechanism. Phytochemistry. 2009;70:1504-10 pubmed publisher
    ..In plants this reaction is mainly catalyzed by lipoxygenase (LOXs) enzymes and during recent years analysis of different plant LOXs revealed insights into their enzyme ..
  3. Reinhold S, Scherl T, Stölcker B, Bergler T, Hoffmann U, Weingart C, et al. Lipoxygenase products in the urine correlate with renal function and body temperature but not with acute transplant rejection. Lipids. 2013;48:167-75 pubmed publisher
    Acute transplant rejection is the leading cause of graft loss in the first months after kidney transplantation. Lipoxygenase products mediate pro- and anti-inflammatory actions and thus we aimed to correlate the histological reports of ..
  4. Yadav M, Bhatla S. Localization of lipoxygenase activity on the oil bodies and in protoplasts using a novel fluorescence imaging method. Plant Physiol Biochem. 2011;49:230-4 pubmed publisher
    b>Lipoxygenase (linoleate:oxygen oxidoreductase; EC 1.13.11.12; LOX) catalyzes oxygenation of polyenoic fatty acids, which precedes the degradation of storage lipids during seed germination in sunflower...
  5. VanDoorn A, Kallenbach M, Borquez A, Baldwin I, Bonaventure G. Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves. BMC Plant Biol. 2010;10:164 pubmed publisher
    ..The formation of these metabolites occurred on the wounded leaf surface and it was dependent on lipoxygenase (LOX) activity; plants silenced in the expression of NaLOX2 and NaLOX3 genes showed more than 50% reduced rates ..
  6. Rui H, Cao S, Shang H, Jin P, Wang K, Zheng Y. Effects of heat treatment on internal browning and membrane fatty acid in loquat fruit in response to chilling stress. J Sci Food Agric. 2010;90:1557-61 pubmed publisher
    ..levels of electrolyte leakage and malondialdehyde content, and inhibited the increases in phospholipase D and lipoxygenase activities compared with the control fruit...
  7. Verlotta A, De Simone V, Mastrangelo A, Cattivelli L, Papa R, Trono D. Insight into durum wheat Lpx-B1: a small gene family coding for the lipoxygenase responsible for carotenoid bleaching in mature grains. BMC Plant Biol. 2010;10:263 pubmed publisher
    ..During pasta processing, oxidative degradation of carotenoid pigments occurs mainly due to lipoxygenase (LOX). In durum wheat (Triticum durum Desf.), two Lpx-1 genes have been identified on chromosome 4B, Lpx-B1...
  8. Jernerén F, Eng F, Hamberg M, Oliw E. Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. Lipids. 2012;47:65-73 pubmed publisher
    Jasmonic acid (JA) is synthesized from linolenic acid (18:3n-3) by sequential action of 13-lipoxygenase, allene oxide synthase (AOS), and allene oxide cyclase...
  9. Shureiqi I, Chen D, Day R, Zuo X, Hochman F, Ross W, et al. Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis. Cancer Prev Res (Phila). 2010;3:829-38 pubmed publisher
    ..15-LOX-1 inhibited interleukin-1beta expression. This study establishes that reduced 13-HODE levels are a specific alteration in the LOX product profile associated with human colorectal tumorigenesis. ..

More Information

Publications62

  1. O Connor Butler E, Mazerik J, Cruff J, Sherwani S, Weis B, Marsh C, et al. Lipoxygenase-catalyzed phospholipid peroxidation: preparation, purification, and characterization of phosphatidylinositol peroxides. Methods Mol Biol. 2010;610:387-401 pubmed publisher
    ..We successfully generated the PI peroxides with soybean type-I lipoxygenase (LOX) in the presence of deoxycholate, which facilitates the LOX-mediated peroxidation of the polyunsaturated ..
  2. Bhardwaj P, Kaur J, Sobti R, Ahuja P, Kumar S. Lipoxygenase in Caragana jubata responds to low temperature, abscisic acid, methyl jasmonate and salicylic acid. Gene. 2011;483:49-53 pubmed publisher
    b>Lipoxygenase (LOX) catalyses oxygenation of free polyunsaturated fatty acids into oxylipins, and is a critical enzyme of the jasmonate signaling pathway...
  3. Vicente J, Cascón T, Vicedo B, García Agustín P, Hamberg M, Castresana C. Role of 9-lipoxygenase and ?-dioxygenase oxylipin pathways as modulators of local and systemic defense. Mol Plant. 2012;5:914-28 pubmed publisher
  4. Andreou A, Gobel C, Hamberg M, Feussner I. A bisallylic mini-lipoxygenase from cyanobacterium Cyanothece sp. that has an iron as cofactor. J Biol Chem. 2010;285:14178-86 pubmed publisher
    ..This product had previously only been described for the manganese lipoxygenase from the take all fungus, Gaeumannomyces graminis. By contrast, CspLOX2 was shown to be an iron lipoxygenase...
  5. Buchhaupt M, Guder J, Etschmann M, Schrader J. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. Appl Microbiol Biotechnol. 2012;93:159-68 pubmed publisher
    ..In plants, they are synthesized by conversion of linolenic or linoleic acid via the enzymes lipoxygenase (LOX) and hydroperoxide lyase (HPL) to short-chained aldehydes...
  6. Hansen J, Garreta A, Benincasa M, Fusté M, Busquets M, Manresa A. Bacterial lipoxygenases, a new subfamily of enzymes? A phylogenetic approach. Appl Microbiol Biotechnol. 2013;97:4737-47 pubmed publisher
    ..a eukaryotic feature, present in mammals, plants, small marine invertebrates, and fungi, but now, some lipoxygenase sequences have been detected on prokaryotic organisms, changing the idea that lipoxygenases are exclusively a ..
  7. Rakkestad K, Holme J, Paulsen R, Schwarze P, Becher R. Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha. Inhal Toxicol. 2010;22:140-50 pubmed publisher
    ..Next, we elucidated possible effects of MEHP on the 5-lipoxygenase (5-LO) pathway and found that MEHP caused increased leukotriene (LTB(4)) release...
  8. Wejksza K, Lee Chang C, Bodogai M, Bonzo J, Gonzalez F, Lehrmann E, et al. Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α. J Immunol. 2013;190:2575-84 pubmed publisher
    ..We report in this study that, to do this, breast cancer cells produce metabolites of the 5-lipoxygenase pathway such as leukotriene B4 to activate the peroxisome proliferator-activated receptor α (PPARα) in B ..
  9. Choi Y, Jeong Y, Ok S, Shin I, Lee S, Park J, et al. The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release. Anesth Analg. 2010;110:341-9 pubmed publisher
    ..nonspecific phospholipase A(2) inhibitor: 2 x 10(-5), 4 x 10(-5) M), nordihydroguaiaretic acid (NDGA) (lipoxygenase inhibitor: 10(-5), 3 x 10(-5) M), indomethacin (nonspecific cyclooxygenase inhibitor: 10(-5) M), AA-861 (5-..
  10. Liu S, Han B. Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. BMC Plant Biol. 2010;10:228 pubmed publisher
    b>Lipoxygenase (LOXs) is a large family of plant enzymes that catalyse the hydroperoxidation of free polyunsaturated fatty acids into diverse biologically active compounds, collectively named phyto-oxylipins...
  11. Bruinsma M, van Broekhoven S, Poelman E, Posthumus M, Muller M, van Loon J, et al. Inhibition of lipoxygenase affects induction of both direct and indirect plant defences against herbivorous insects. Oecologia. 2010;162:393-404 pubmed publisher
    ..hypothesis in our plant-herbivore-parasitoid tritrophic system, we used phenidone, an inhibitor of the enzyme lipoxygenase (LOX), that catalyses the initial step in the octadecanoid pathway...
  12. Christensen S, Nemchenko A, Borrego E, Murray I, Sobhy I, Bosak L, et al. The maize lipoxygenase, ZmLOX10, mediates green leaf volatile, jasmonate and herbivore-induced plant volatile production for defense against insect attack. Plant J. 2013;74:59-73 pubmed publisher
    ..Here we show that products and signals derived from a single Zea mays (maize) lipoxygenase (LOX), ZmLOX10, are critical for both direct and indirect defenses to herbivory...
  13. Hallenborg P, Jørgensen C, Petersen R, Feddersen S, Araujo P, Markt P, et al. Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity. Mol Cell Biol. 2010;30:4077-91 pubmed publisher
    ..Previously, we showed that lipoxygenase (LOX) activity is involved in activation of PPAR gamma during the early stages of adipocyte differentiation...
  14. Hersberger M. Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins. Clin Chem Lab Med. 2010;48:1063-73 pubmed publisher
    Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the ..
  15. Jin J, Boeglin W, Cha J, Brash A. 8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-?-linolenic acid: a distinctive transformation compared with S-lipoxygenases. J Lipid Res. 2012;53:292-9 pubmed publisher
    ..Here we report on R-specific lipoxygenase synthesis of a cis-epoxyalcohol...
  16. Chaitidis P, Adel S, Anton M, Heydeck D, Kuhn H, Horn T. Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms. J Lipid Res. 2013;54:1397-409 pubmed publisher
    ..mulatta) and other mammals (mice, rats), this ancient hominid expressed a 15-lipoxygenating ALOX15. Expression of ALOXE3 and ALOX12 was compromised, which might have caused problems in epidermal differentiation. ..
  17. Zheng Y, Brash A. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. J Biol Chem. 2010;285:39866-75 pubmed publisher
    Epidermal lipoxygenase-3 (eLOX3) exhibits hydroperoxide isomerase activity implicated in epidermal barrier formation, but its potential dioxygenase activity has remained elusive...
  18. Lamari N, Ruggiero M, d Ippolito G, Kooistra W, Fontana A, Montresor M. Specificity of lipoxygenase pathways supports species delineation in the marine diatom genus Pseudo-nitzschia. PLoS ONE. 2013;8:e73281 pubmed publisher
    ..b>Lipoxygenase compounds were mapped on phylogenies of the genus Pseudo-nitzschia inferred from the nuclear encoded hyper-..
  19. Padilla M, Hernandez M, Sanz C, Martínez Rivas J. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. Phytochemistry. 2012;74:58-68 pubmed publisher
    A lipoxygenase (LOX) cDNA clone (Oep2LOX1) has been isolated from olive fruit (Olea europaea cv. Picual). The deduced amino acid sequence displayed significant similarity to known plant LOX1 sequences...
  20. Gaffney B, Bradshaw M, Frausto S, Wu F, Freed J, Borbat P. Locating a lipid at the portal to the lipoxygenase active site. Biophys J. 2012;103:2134-44 pubmed publisher
    b>Lipoxygenase enzymes initiate diverse signaling pathways by specifically directing oxygen to different carbons of arachidonate and other polyunsaturated acyl chains, but structural origins of this specificity have remained unclear...
  21. Forsell P, Brunnström A, Johannesson M, Claesson H. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. Lipids. 2012;47:781-91 pubmed publisher
    Human 15-lipoxygenase-1 (15-LO-1) can metabolize arachidonic acid (ARA) into pro-inflammatory mediators such as the eoxins, 15-hydroperoxyeicosatetraenoic acid (HPETE), and 15-hydroxyeicosatetraenoyl-phosphatidylethanolamine...
  22. Wennman A, Jernerén F, Hamberg M, Oliw E. Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid. J Biol Chem. 2012;287:31757-65 pubmed publisher
    ..Our goal was to study the importance of this region (Gly(332), Leu(336), and Phe(337)) of a lipoxygenase with catalytic manganese (13R-MnLOX)...
  23. Carr C, Klinman J. Hydrogen tunneling in a prokaryotic lipoxygenase. Biochemistry. 2014;53:2212-4 pubmed publisher
    A bacterial lipoxygenase (LOX) shows a deuterium kinetic isotope effect (KIE) that is similar in magnitude and temperature dependence to the very large KIE of eukaryotic LOXs...
  24. Martín Venegas R, Casillas R, Jauregui O, Moreno J. Rapid simultaneous analysis of cyclooxygenase, lipoxygenase and cytochrome P-450 metabolites of arachidonic and linoleic acids using high performance liquid chromatography/mass spectrometry in tandem mode. J Pharm Biomed Anal. 2011;56:976-82 pubmed publisher
    Eicosanoids are oxidized arachidonate-derived lipid products generated by cyclooxygenase, lipoxygenase and cytochrome P-450 pathways. They are involved in diverse processes in health and disease and they are highly bioactive...
  25. Wennman A, Oliw E. Secretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii. J Lipid Res. 2013;54:762-75 pubmed publisher
    The mycelium of the rice stem pathogen, Magnaporthe salvinii, secreted linoleate 9S-lipoxygenase (9S-LOX) and epoxy alcohol synthase (EAS)...
  26. Zeng H, Liu X, Dou S, Xu W, Li N, Liu X, et al. Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway. J Pharm Pharmacol. 2009;61:1699-707 pubmed publisher
    ..Also, HLJDT may exert its anti-inflammatory effects by its suppression on eicosanoid generation, NO production and gene transcription of chemotactic factors, which supports its effectiveness in the treatment of inflammatory diseases. ..
  27. Zheng Y, Brash A. On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. J Biol Chem. 2010;285:39876-87 pubmed publisher
    ..Epidermal lipoxygenase-3 (eLOX3) is atypical in displaying hydroperoxide isomerase activity with fatty acid hydroperoxides through ..
  28. Rudolph M, Schlereth A, Körner M, Feussner K, Berndt E, Melzer M, et al. The lipoxygenase-dependent oxygenation of lipid body membranes is promoted by a patatin-type phospholipase in cucumber cotyledons. J Exp Bot. 2011;62:749-60 pubmed publisher
    ..on the storage lipids, a second degradation pathway that is dependent on a specific lipid body trilinoleate 13-lipoxygenase (13-LOX) has been proposed in several plant species...
  29. Jansen C, Hofheinz K, Vogel R, Roffeis J, Anton M, Reddanna P, et al. Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept. J Biol Chem. 2011;286:37804-12 pubmed publisher
    ..Taken together these data indicate that the Ala-versus-Gly concept may not always predict the reaction specificity of vertebrate LOX isoforms. ..
  30. Weinberger F, Lion U, Delage L, Kloareg B, Potin P, Beltrán J, et al. Up-regulation of lipoxygenase, phospholipase, and oxylipin-production in the induced chemical defense of the red alga Gracilaria chilensis against epiphytes. J Chem Ecol. 2011;37:677-86 pubmed publisher
    ..RT-PCR and enzyme assays demonstrated that this metabolic response occurs after an increase in lipoxygenase and phospholipase A2 activity...
  31. Shin J, Van K, Kim K, Lee Y, Jun T, Lee S. Molecular sequence variations of the lipoxygenase-2 gene in soybean. Theor Appl Genet. 2012;124:613-22 pubmed publisher
    Soybean lipoxygenase genes comprise a multi-gene family, with the seed lipoxygenase isozymes LOX1, LOX2, and LOX3 present in soybean seeds...
  32. Yu S, Kuhn H, Daniliuc C, Ivanov I, Jones P, du Mont W. 5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors. Org Biomol Chem. 2010;8:828-34 pubmed publisher
    ..Several products were identified as selective inhibitors of the pro-inflammatory 5-lipoxygenase (LOX) but had little effect on the catalytic activity of 12/15-LOX, which has been implicated in the synthesis ..
  33. Lu X, Liu S, Zhang D, Zhou X, Wang M, Liu Y, et al. Enhanced thermal stability and specific activity of Pseudomonas aeruginosa lipoxygenase by fusing with self-assembling amphipathic peptides. Appl Microbiol Biotechnol. 2013;97:9419-27 pubmed publisher
    ..In this study, we investigated the potential of fusion technique with SAPs to improve the thermal stability of lipoxygenase (LOX) from Pseudomonas aeruginosa...
  34. Choudhary A, Kumar A, Juyal V. Quantitative structure activity relationship (QSAR) analysis of substituted 4-oxothiazolidines and 5-arylidines as lipoxygenase inhibitors. Mini Rev Med Chem. 2010;10:705-14 pubmed
    ..derivatives using linear free energy related (LFER) model of Hansch to explain the structural requirements for lipoxygenase inhibition...
  35. Hwang I, Hwang B. The pepper 9-lipoxygenase gene CaLOX1 functions in defense and cell death responses to microbial pathogens. Plant Physiol. 2010;152:948-67 pubmed publisher
    ..A pepper (Capsicum annuum) 9-LOX gene, CaLOX1, which encodes a 9-specific lipoxygenase, was isolated from pepper leaves...
  36. Detsi A, Majdalani M, Kontogiorgis C, Hadjipavlou Litina D, Kefalas P. Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. Bioorg Med Chem. 2009;17:8073-85 pubmed publisher
    ..and their oxidative cyclization products, aurones, have been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The natural product aureusidin (31) was synthesized in high yield by a new approach...
  37. Mariutto M, Duby F, Adam A, Bureau C, Fauconnier M, Ongena M, et al. The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. BMC Plant Biol. 2011;11:29 pubmed publisher
    ..We analyzed the activities of phenylalanine ammonia-lyase (PAL) and lipoxygenase (LOX), key enzymes of the phenylpropanoid and oxylipin pathways respectively, in tomato treated or not with P...
  38. Liu S, Liu X, Jiang L. Genome-wide identification, phylogeny and expression analysis of the lipoxygenase gene family in cucumber. Genet Mol Res. 2011;10:2613-36 pubmed publisher
    Plant lipoxygenase (LOX) is involved in growth and developmental control processes, through the biosynthesis of regulatory molecules and defense responses to pathogens, wounding and stress...
  39. Allmann S, Halitschke R, Schuurink R, Baldwin I. Oxylipin channelling in Nicotiana attenuata: lipoxygenase 2 supplies substrates for green leaf volatile production. Plant Cell Environ. 2010;33:2028-40 pubmed publisher
    ..These results demonstrate that N. attenuata channels the flux of HPs through the activities of different LOXs, leading to different direct and indirect defence responses mediating the plant's herbivore resistance. ..
  40. Jansen R, Miebach M, Kleist E, van Henten E, Wildt J. Release of lipoxygenase products and monoterpenes by tomato plants as an indicator of Botrytis cinerea-induced stress. Plant Biol (Stuttg). 2009;11:859-68 pubmed publisher
    ..The predominant VOCs emitted after inoculation were volatile products from the lipoxygenase pathway (LOX products)...
  41. Ivanov I, Heydeck D, Hofheinz K, Roffeis J, O Donnell V, Kuhn H, et al. Molecular enzymology of lipoxygenases. Arch Biochem Biophys. 2010;503:161-74 pubmed publisher
    ..Although the biological role of LOXs in lower organisms is far from clear, sequence data suggests that this enzyme family might have evolved shortly after the appearance of atmospheric oxygen on earth. ..
  42. Brodhun F, Cristobal Sarramian A, Zabel S, Newie J, Hamberg M, Feussner I. An iron 13S-lipoxygenase with an ?-linolenic acid specific hydroperoxidase activity from Fusarium oxysporum. PLoS ONE. 2013;8:e64919 pubmed publisher
    ..The biosynthetic pathway leading to plant jasmonates is initiated by 13-lipoxygenase-catalyzed oxygenation of ?-linolenic acid into its 13-hydroperoxide derivative...
  43. Dolegowska B, Blogowski W, Safranow K, Domanski L, Jakubowska K, Olszewska M. Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function?. Nephrol Dial Transplant. 2010;25:4061-7 pubmed publisher
    ..The aims of this study were to measure perioperative variations in lipoxygenase (LOX)-derived 5-, 12- and 15-hydroxyeicosatetraenoic (HETE) acids levels, and to examine whether (i) dynamics ..
  44. Vellosillo T, Aguilera V, Marcos R, Bartsch M, Vicente J, Cascón T, et al. Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins. Plant Physiol. 2013;161:617-27 pubmed publisher
    ..The results suggest that the defensive responses and cell wall modifications caused by 9-HOT are under mitochondrial retrograde control and that mitochondria play a fundamental role in innate immunity signaling. ..
  45. Chauvin A, Caldelari D, Wolfender J, Farmer E. Four 13-lipoxygenases contribute to rapid jasmonate synthesis in wounded Arabidopsis thaliana leaves: a role for lipoxygenase 6 in responses to long-distance wound signals. New Phytol. 2013;197:566-75 pubmed publisher
    ..Consistent with this, we found that LOX6 promoter activity was strong in the apical region of rosettes. The LOX6 promoter was active in and near developing xylem cells and in expression domains we term subtrichomal mounds. ..
  46. Park Y, Kunze S, Ni X, Feussner I, Kolomiets M. Comparative molecular and biochemical characterization of segmentally duplicated 9-lipoxygenase genes ZmLOX4 and ZmLOX5 of maize. Planta. 2010;231:1425-37 pubmed publisher
    ..Herein we report on molecular and biochemical characterization of two closely related maize 9-lipoxygenase paralogs, ZmLOX4 and ZmLOX5...
  47. Stavniichuk R, Drel V, Shevalye H, Vareniuk I, Stevens M, Nadler J, et al. Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies. Free Radic Biol Med. 2010;49:1036-45 pubmed publisher
    This study evaluated the role of 12/15-lipoxygenase, which converts arachidonic acid to 12(S)- and 15(S)-hydroxyeicosatetraenoic acids, in nitrosative stress in the peripheral nervous system and peripheral prediabetic and diabetic ..
  48. Bui P, Imaizumi S, Beedanagari S, Reddy S, Hankinson O. Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. Drug Metab Dispos. 2011;39:180-90 pubmed publisher
    ..In this article, we investigated whether human CYP2S1 can metabolize cyclooxygenase- and lipoxygenase-derived lipid peroxides in a NADPH-independent fashion...
  49. Eder A, Koegl E, von Duvillard S, Sinzinger H, Berent R. Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis. Arch Oral Biol. 2012;57:1133-40 pubmed publisher
    ..The size of granuloma did not influence the amount of synthesized eicosanoids, IPs or LOX-metabolites out of (14)C-AA whereas cigarette smoking was a significantly influencing and modifiable risk factor. ..
  50. Chen C, Chan H, Chu Y, Ho H, Chen P, Lee T, et al. Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase. Molecules. 2009;14:2947-58 pubmed publisher
    ..This was performed by assessing the activities of lipoxygenase, xanthine oxidase and tyrosinase following incubation with extracts from these plants...
  51. Garreta A, Val Moraes S, García Fernández Q, Busquets M, Juan C, Oliver A, et al. Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. FASEB J. 2013;27:4811-21 pubmed publisher
    ..The findings in these studies suggest that Pa_LOX has the capacity to extract and modify unsaturated phospholipids from eukaryotic membranes, allowing this LOX to play a role in the interaction of P. aeruginosa with host cells. ..
  52. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, et al. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010;30:1157-67 pubmed publisher
    12/15-lipoxygenase (12/15-LOX) contributes to acute neuronal injury and edema formation in mouse models of middle cerebral artery occlusion (MCAO)...
  53. Dainese E, Angelucci C, Sabatucci A, De Filippis V, Mei G, Maccarrone M. A novel role for iron in modulating the activity and membrane-binding ability of a trimmed soybean lipoxygenase-1. FASEB J. 2010;24:1725-36 pubmed publisher
    ..Furthermore, miniLOX reconstituted with Fe(II) or Fe(III) partially recovered its membrane-binding ability (K(d)=21.4+/-2.4 and 18.9+/-5.5 microM, respectively), overall supporting a novel noncatalytic role for iron in the LOX family. ..