Summary: Dioxygenases that catalyze the peroxidation of methylene-interrupted UNSATURATED FATTY ACIDS.

Top Publications

  1. Haeggstrom J, Funk C. Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease. Chem Rev. 2011;111:5866-98 pubmed publisher
  2. Wang W, Ma X, Huang S, Ren L, Liu Y. A comparative study of effect of autograft compared with allograft anterior cruciate ligament reconstruction on expressions of LOXs and MMPs. Biosci Rep. 2017;37: pubmed publisher
    ..the effect of autograft or allograft anterior cruciate ligament (ACL) reconstruction on the expressions of lipoxygenases (LOXs) and matrix metalloproteinases (MMPs) in a New Zealand white rabbit model...
  3. Krutetskaya Z, Melnitskaya A, Antonov V, Nozdrachev A. Lipoxygenases modulate the effect of glutoxim on Na+ transport in the frog skin epithelium. Dokl Biochem Biophys. 2017;474:193-195 pubmed publisher
    Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na+ transport in frog skin was investigated...
  4. Gong Y, Fu Z, Liegl R, Chen J, Hellstrom A, Smith L. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017;106:16-26 pubmed publisher
    ..The ?-3 LC-PUFA metabolites from 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the ?-6 (n-6) LC-PUFA metabolites promote] inflammation and angiogenesis...