coproporphyrinogen oxidase


Summary: An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.

Top Publications

  1. Kruse E, Mock H, Grimm B. Reduction of coproporphyrinogen oxidase level by antisense RNA synthesis leads to deregulated gene expression of plastid proteins and affects the oxidative defense system. EMBO J. 1995;14:3712-20 pubmed
    A full-length cDNA sequence encoding coproporphyrinogen oxidase was inserted in inverse orientation behind a CaMV promoter and transferred to tobacco (Nicotiana tabacum) by standard transformation techniques...
  2. Woods J, Heyer N, Echeverria D, Russo J, Martin M, Bernardo M, et al. Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children. Neurotoxicol Teratol. 2012;34:513-21 pubmed publisher
    ..We examined the hypothesis that CPOX4, a genetic variant of the heme pathway enzyme coproporphyrinogen oxidase (CPOX) that affects susceptibility to mercury toxicity in adults, also modifies the neurotoxic effects ..
  3. Taketani S, Yoshinaga T, Furukawa T, Kohno H, Tokunaga R, Nishimura K, et al. Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells. Eur J Biochem. 1995;230:760-5 pubmed
    ..mRNAs for coproporphyrinogen oxidase (CPO) and ferrochelatase (FEC) were induced within 12 h, and continued to increase with time up to 48 h...
  4. Li T, Woods J. Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans. Toxicol Sci. 2009;109:228-36 pubmed publisher
    b>Coproporphyrinogen oxidase (CPOX) catalyzes the two-step decarboxylation of coproporphyrinogen-III to protoporphyrinogen-IX in the heme biosynthetic pathway...
  5. Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S. Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. J Biol Chem. 1993;268:21359-63 pubmed
    b>Coproporphyrinogen oxidase (EC, the enzyme involved in the sixth step of heme biosynthesis, was purified to apparent homogeneity from bovine liver; it has a molecular mass of 37,000 daltons...
  6. Rosipal R, Lamoril J, Puy H, Da Silva V, Gouya L, de Rooij F, et al. Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update. Hum Mutat. 1999;13:44-53 pubmed
    ..Five intragenic dimorphisms are now well characterized and the high degree of allelic heterogeneity in HC is demonstrated with seven new different mutations making a total of nineteen CPO gene defects reported so far. ..
  7. Echeverria D, Woods J, Heyer N, Rohlman D, Farin F, Li T, et al. The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. Neurotoxicol Teratol. 2006;28:39-48 pubmed
    ..previously described a polymorphism in exon 4 of the gene encoding the heme biosynthetic pathway enzyme, coproporphyrinogen oxidase (CPOX4), which significantly modifies the effect of mercury exposure on urinary porphyrin excretion in ..
  8. Phillips J, Whitby F, Warby C, Labbe P, Yang C, Pflugrath J, et al. Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae. J Biol Chem. 2004;279:38960-8 pubmed
    b>Coproporphyrinogen oxidase (CPO) is an essential enzyme that catalyzes the sixth step of the heme biosynthetic pathway...
  9. Taketani S, Furukawa T, Furuyama K. Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells. Eur J Biochem. 2001;268:1705-11 pubmed
    b>Coproporphyrinogen oxidase (CPOX), the sixth enzyme in the heme-biosynthetic pathway, catalyzes oxidative decarboxylation of coproporphyrinogen to protoporphyrinogen and is located in the intermembrane space of mitochondria...

More Information


  1. Narita S, Taketani S, Inokuchi H. Oxidation of protoporphyrinogen IX in Escherichia coli is mediated by the aerobic coproporphyrinogen oxidase. Mol Gen Genet. 1999;261:1012-20 pubmed detail and had a mutation in the promoter region of the hemF gene, which encodes aerobic coproporphyrinogen oxidase, the enzyme involved in the step immediately before protoporphyrinogen oxidase...
  2. Quinn J, Nakamoto S, Merchant S. Induction of coproporphyrinogen oxidase in Chlamydomonas chloroplasts occurs via transcriptional regulation of Cpx1 mediated by copper response elements and increased translation from a copper deficiency-specific form of the transcript. J Biol Chem. 1999;274:14444-54 pubmed
    ..The enzyme remains localized to a soluble compartment in the chloroplast even in induced cells, and its abundance is not affected when the tetrapyrrole pathway is manipulated either genetically or by gabaculine treatment. ..
  3. Takahashi S, Taketani S, Akasaka J, Kobayashi A, Hayashi N, Yamamoto M, et al. Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells. Blood. 1998;92:3436-44 pubmed
    b>Coproporphyrinogen oxidase (CPO) catalyzes the sixth step of the heme biosynthetic pathway. To assess the tissue-specific regulation of the CPO gene promoter, mouse genomic DNA clones for CPO were isolated...
  4. Martasek P, Camadro J, Delfau Larue M, Dumas J, Montagne J, De Verneuil H, et al. Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase. Proc Natl Acad Sci U S A. 1994;91:3024-8 pubmed
    b>Coproporphyrinogen oxidase (EC catalyzes the sixth step in the heme biosynthetic pathway, the oxidation of coproporphyrinogen III to protoporphyrinogen IX...
  5. Zagorec M, Buhler J, Treich I, Keng T, Guarente L, Labbe Bois R. Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J Biol Chem. 1988;263:9718-24 pubmed
    The HEM13 gene of Saccharomyces cerevisiae codes for coproporphyrinogen oxidase (EC catalyzing the sixth enzymic step in the heme biosynthetic pathway...
  6. van Tuyll van Serooskerken A, de Rooij F, Edixhoven A, Bladergroen R, Baron J, Joussen S, et al. Digenic inheritance of mutations in the coproporphyrinogen oxidase and protoporphyrinogen oxidase genes in a unique type of porphyria. J Invest Dermatol. 2011;131:2249-54 pubmed publisher
    ..HCP and VP result from a partial enzymatic deficiency of coproporphyrinogen oxidase (CPOX) and protoporphyrinogen oxidase (PPOX), respectively...
  7. Lieb C, Siddiqui R, Hippler B, Jahn D, Friedrich B. The Alcaligenes eutrophus hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth. Arch Microbiol. 1998;169:52-60 pubmed
    ..Analysis of a transcriptional lacZ gene fusion showed that expression of hemN in A. eutrophus is nitrate-independent and repressed by oxygen. ..
  8. Woods J, Southern M. Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney. Toxicol Appl Pharmacol. 1989;97:183-90 pubmed
    ..metal-induced porphyria in rats, with particular emphasis on the action of metals on hepatic and renal coproporphyrinogen oxidase. Prolonged exposure of rats to methyl mercury hydroxide or sodium arsenate at subtoxic dose levels in ..
  9. Gross U, Gerlach R, Kühnel A, Seifert V, Doss M. A description of an HPLC assay of coproporphyrinogen III oxidase activity in mononuclear cells. J Inherit Metab Dis. 2003;26:565-70 pubmed
    ..The enzyme activity of a family with hereditary coproporphyria was measured. The gene carriers exhibit a specific coproporphyrinogen III oxidase activity of 61-90 pkat/g total soluble protein. ..
  10. Arai H, Roh J, Eraso J, Kaplan S. Transcriptome response to nitrosative stress in Rhodobacter sphaeroides 2.4.1. Biosci Biotechnol Biochem. 2013;77:111-8 pubmed
    ..Some genes, including hemN for heme biosynthesis, were subject to dual regulation by NnrR and FnrL...
  11. Petersen N, Käehne M, Christiansen L, Brock A, Hother Nielsen O, Rasmussen K. DGGE analysis of the coproporphyrinogen oxidase gene: two new mutations in DNA from Danish patients with hereditary coproporphyria. Scand J Clin Lab Invest. 2000;60:617-25 pubmed
    The knowledge of at least 21 different mutations and several polymorphisms in the coproporphyrinogen oxidase (CPO) gene demonstrates that the molecular basis of hereditary coproporphyria is heterogeneous...
  12. Hippler B, Homuth G, Hoffmann T, Hungerer C, Schumann W, Jahn D. Characterization of Bacillus subtilis hemN. J Bacteriol. 1997;179:7181-5 pubmed
    ..subtilis was obtained. Moreover, B. subtilis hemY did not substitute for hemF hemN deficiency in S. typhimurium. These results indicate the absence of hemF and suggest the presence of a second hemN-like gene in B. subtilis. ..
  13. Sinha A, Anand S, Ortel B, Chang Y, Mai Z, Hasan T, et al. Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. Br J Cancer. 2006;95:485-95 pubmed
    ..Searching for an effect among porphyrin synthetic enzymes, we found that coproporphyrinogen oxidase (CPO) was increased three-fold by MTX at the mRNA and protein levels...
  14. Martasek P, Nordmann Y, Grandchamp B. Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms. Hum Mol Genet. 1994;3:477-80 pubmed
    b>Coproporphyrinogen oxidase is a mitochondrial heme-biosynthetic enzyme that converts coproporphyrinogen to protoporphyrinogen. Inherited deficiency of this enzyme causes the human genetic disease hereditary coproporphyria...
  15. Fischer H, Velasco L, Delgado M, Bedmar E, Schären S, Zingg D, et al. One of two hemN genes in Bradyrhizobium japonicum is functional during anaerobic growth and in symbiosis. J Bacteriol. 2001;183:1300-11 pubmed
  16. Nagaraj V, Prasad D, Arumugam R, Rangarajan P, Padmanaban G. Characterization of coproporphyrinogen III oxidase in Plasmodium falciparum cytosol. Parasitol Int. 2010;59:121-7 pubmed publisher
    ..The cytosolic presence of PfCPO provides evidence for a hybrid heme-biosynthetic pathway in the malarial parasite...
  17. Gross U, Puy H, Kühnel A, Meissauer U, Deybach J, Jacob K, et al. Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria. Cell Mol Biol (Noisy-le-grand). 2002;48:49-55 pubmed
    ..b>Coproporphyrinogen oxidase activity was decreased to 35% in the patient (normal=138+/-21 pkat/g protein; x+/-s), whereas the ..
  18. Lalitha P, Siti Suraiya M, Lim K, Lee S, Nur Haslindawaty A, Chan Y, et al. Analysis of lolB gene sequence and its use in the development of a PCR assay for the detection of Vibrio cholerae. J Microbiol Methods. 2008;75:142-4 pubmed publisher
    ..The analytical specificity of this assay was 100% while the analytical sensitivity was 10 pg/microL and 10(3) CFU/mL at DNA and bacterial level respectively. The diagnostic sensitivity and specificity was 98.5% and 100% respectively. ..
  19. Dailey H. Terminal steps of haem biosynthesis. Biochem Soc Trans. 2002;30:590-5 pubmed
    ..Interestingly, Nature has evolved distinct enzymic machinery to deal with the antepenultimate (coproporphyrinogen oxidase) and penultimate (protoporphyrinogen oxidase) steps for aerobic compared with anaerobic organisms...
  20. Cleary S, Tan F, Nakrieko K, Thompson S, Mullineaux P, Creissen G, et al. Isolated plant mitochondria import chloroplast precursor proteins in vitro with the same efficiency as chloroplasts. J Biol Chem. 2002;277:5562-9 pubmed
    ..Finally, we show that disruption of potential amphipathic helices in one presequence does not block import into pea mitochondria, indicating that other features are recognized. ..
  21. Wang Y, Gatti P, Sadilek M, Scott C, Turecek F, Gelb M. Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. Anal Chem. 2008;80:2599-605 pubmed publisher
    ..066 +/- 0.009 microM). The assays show good reproducibility, use simple workup by liquid-liquid extraction of enzymatic products, and employ commercially available substrates and internal standards. ..
  22. Schreiber W, Zhang X, Senz J, Jamani A. Hereditary coproporphyria: exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene. Hum Mutat. 1997;10:196-200 pubmed a dominantly inherited disorder of porphyrin metabolism caused by a partial deficiency of coproporphyrinogen oxidase, the sixth enzyme in the heme synthetic pathway...
  23. Vizoso Vázquez A, Blanco M, Zaborowska J, Soengas P, González Siso M, Becerra M, et al. Two proteins with different functions are derived from the KlHEM13 gene. Eukaryot Cell. 2011;10:1331-9 pubmed publisher
    ..A hypothetical model of the evolutionary origins and coexistence of these two proteins in K. lactis is discussed. ..
  24. Takahashi S, Furuyama K, Kobayashi A, Taketani S, Harigae H, Yamamoto M, et al. Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. Biochem Biophys Res Commun. 2000;273:596-602 pubmed
    b>Coproporphyrinogen oxidase [CPO] gene promoter regulatory element (CPRE) plays an important role in CPO gene regulation...
  25. Lash T, Kaprak T, Shen L, Jones M. Metabolism of analogues of coproporphyrinogen-III with modified side chains: implications for binding at the active site of coproporphyrinogen oxidase. Bioorg Med Chem Lett. 2002;12:451-6 pubmed
    ..with modified propionate side chains bearing methyl substituents were found to be modest substrates for coproporphyrinogen oxidase; the results indicate that alteration of the substituents involved in secondary binding interactions has ..
  26. Kusaba A, Ansai T, Akifusa S, Nakahigashi K, Taketani S, Inokuchi H, et al. Cloning and expression of a Porphyromonas gingivalis gene for protoporphyrinogen oxidase by complementation of a hemG mutant of Escherichia coli. Oral Microbiol Immunol. 2002;17:290-5 pubmed
    ..We postulated that a porphyrin biosynthetic pathway to heme from preuroporphyrin may be conserved in P. gingivalis. ..
  27. Jones M, Taneja M, Xu Y, Chung W, Stob C, Lash T. An effective chromatographic separation of chicken red blood cell coproporphyrinogen oxidase and uroporphyrinogen decarboxylase, two enzymes in heme biosynthesis. Bioorg Med Chem Lett. 2004;14:5559-64 pubmed
    Of the heme biosynthetic pathway enzymes, coproporphyrinogen oxidase is one of the least understood. Substrate recognition studies [Prepr. Biochem. Biotech.1997, 27, 47, J. Org. Chem...
  28. De Matteis F, Harvey C. Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents. Arch Toxicol. 2005;79:381-9 pubmed
    ..the coproporphyrinogen III metabolism was blocked, even though no inhibition of the relevant enzyme, coproporphyrinogen oxidase, could be demonstrated...
  29. Gibson L, McGlynn P, Chaudhri M, Hunter C. A putative anaerobic coproporphyrinogen III oxidase in Rhodobacter sphaeroides. II. Analysis of a region of the genome encoding hemF and the puc operon. Mol Microbiol. 1992;6:3171-86 pubmed
    ..Ultrastructural studies indicated that the morphology of the intracytoplasmic membrane may depend upon expression of pucC as well as pucBA. ..
  30. Madsen O, Sandal L, Sandal N, Marcker K. A soybean coproporphyrinogen oxidase gene is highly expressed in root nodules. Plant Mol Biol. 1993;23:35-43 pubmed
    In plants the enzyme coproporphyrinogen oxidase catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX in the heme and chlorophyll biosynthesis pathway(s)...
  31. Stephenson J, Stacey J, Morgenthaler J, Friesen J, Lash T, Jones M. Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase. Protein Sci. 2007;16:401-10 pubmed
    b>Coproporphyrinogen oxidase (CPO) is the sixth enzyme in the heme biosynthetic pathway, catalyzing two sequential oxidative decarboxylations of propionate moieties on coproporphyrinogen-III forming protoporphyrinogen-IX through a monovinyl ..
  32. Moseley J, Quinn J, Eriksson M, Merchant S. The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii. EMBO J. 2000;19:2139-51 pubmed
    ..copper deficiency by degrading apoplastocyanin and inducing Cyc6 and Cpx1 encoding cytochrome c(6) and coproporphyrinogen oxidase, respectively...
  33. Gorman C, Gill D, Darby C, Crowley V, Mahony M. Hereditary coproporphyria: report of an Irish kindred and identification of a novel gene mutation. Ir Med J. 2008;101:125 pubmed
  34. Sato D, Shimokawa O, Harada N, Olsen O, Hou J, Muhlbauer W, et al. Congenital arhinia: molecular-genetic analysis of five patients. Am J Med Genet A. 2007;143A:546-52 pubmed
    ..Although our study failed to identify the putative arhinia gene, the data may become a clue to unravel the underlying mechanism of arhinia. ..
  35. Elder G, Lee G, Tovey J. Decreased activity of hepatic uroporphyrinogen decarboxylase in sporadic porphyria cutanea tarda. N Engl J Med. 1978;299:274-8 pubmed
    ..tarda, we measured this enzyme in liver, erythrocytes and cultured skin fibroblasts, and also measured coproporphyrinogen oxidase and the total iron concentration in liver...
  36. Xu K, Elliott T. Cloning, DNA sequence, and complementation analysis of the Salmonella typhimurium hemN gene encoding a putative oxygen-independent coproporphyrinogen III oxidase. J Bacteriol. 1994;176:3196-203 pubmed
    ..Anaerobic heme synthesis requires an oxygen-independent coproporphyrinogen oxidase, which is probably encoded by the hemN gene in S. typhimurium...
  37. Layer G, Kervio E, Morlock G, Heinz D, Jahn D, Retey J, et al. Structural and functional comparison of HemN to other radical SAM enzymes. Biol Chem. 2005;386:971-80 pubmed
    ..The enzymes are compared to other radical SAM enzymes and in particular the three reported crystal structures from this family, HemN, biotin synthase and MoaA, are discussed...
  38. Daimon M, Gojyou E, Sugawara M, Yamatani K, Tominaga M, Sasaki H. A novel missense mutation in exon 4 of the human coproporphyrinogen oxidase gene in two patients with hereditary coproporphyria. Hum Genet. 1997;99:199-201 pubmed
    Hereditary coproporphyria (HCP) is an autosomal dominant disease characterized by a deficiency of coproporphyrinogen oxidase. To date, four mutations of the gene have been reported...
  39. Castro Prego R, Lamas Maceiras M, Soengas P, Fernández Leiro R, Carneiro I, Becerra M, et al. Ixr1p regulates oxygen-dependent HEM13 transcription. FEMS Yeast Res. 2010;10:309-21 pubmed publisher
    ..Their interactions with the HEM13 promoter might change in the transition from aerobiosis to hypoxia. ..
  40. Ogihara K, Isomoto H, Kurumi H, Kanda T, Hashisako M, Tabata K, et al. Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis. Photodiagnosis Photodyn Ther. 2017;19:15-21 pubmed publisher
    ..for the expression of ATP-binding cassette sub-family G member 2, oligopeptide transporter-1, and coproporphyrinogen oxidase. Photodynamic diagnosis was negative in four cases (17.4%)...
  41. Amillet J, Buisson N, Labbe Bois R. Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae. Curr Genet. 1995;28:503-11 pubmed
    The Saccharomyces cerevisiae HEM13 gene codes for coproporphyrinogen oxidase (CPO), an oxygen-requiring enzyme catalysing the sixth step of heme biosynthesis...
  42. Troup B, Hungerer C, Jahn D. Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase. J Bacteriol. 1995;177:3326-31 pubmed
    ..Removal of iron from the growth medium resulted in an approximately fourfold decrease of aerobic hemN expression. Subsequent addition of iron restored normal expression. ..
  43. Morgenthaler J, Barto R, Lash T, Jones M. Use of di- and tripropionate substrate analogs to probe the active site of human recombinant coproporphyrinogen oxidase. Med Sci Monit. 2008;14:BR1-7 pubmed
    Defects in the enzyme coproporphyrinogen oxidase result in accumulation of porphyrins which may affect the severity of a subset of porphyrias. Thus evaluation of this enzyme for substrate selectivity is of value...
  44. Layer G, Pierik A, Trost M, Rigby S, Leech H, Grage K, et al. The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. J Biol Chem. 2006;281:15727-34 pubmed
    ..The observed hyperfine constants and g values show that this coproporphyrinogenyl radical is allylic and encompasses carbon atoms 3', 3, and 4. ..
  45. Colloc h N, Mornon J, Camadro J. Towards a new T-fold protein?: the coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase. FEBS Lett. 2002;526:5-10 pubmed
    ..This overall model is supported by mutation data and is coherent with the chemical events expected for substrate processing by CPO. ..
  46. Lash T, Hall T, Mani U, Jones M. Normal and abnormal heme biosynthesis. 3.(1)Synthesis and metabolism of tripropionate analogues of coproporphyrinogen-III: novel probes for the active site of coproporphyrinogen oxidase. J Org Chem. 2001;66:3753-9 pubmed
    b>Coproporphyrinogen oxidase (copro'gen oxidase) catalyses the oxidative decarboxylation of two propionate side chains on coproporphyrinogen-III to produce protoporphyrinogen-IX...
  47. Susa S, Daimon M, Kondo H, Kondo M, Yamatani K, Sasaki H. Identification of a novel mutation of the CPO gene in a Japanese hereditary coproporphyria family. Am J Med Genet. 1998;80:204-6 pubmed
    Hereditary coproporphyria (HCP) is an autosomal dominant disease characterized by a deficiency of coproporphyrinogen oxidase (CPO) caused by a mutation in the CPO gene. Only 11 mutations of the gene have been reported in HCP patients...
  48. Woods J, Fowler B. Metal alteration of uroporphyrinogen decarboxylase and coproporphyrinogen oxidase. Ann N Y Acad Sci. 1987;514:55-64 pubmed
    ..Advantage might be taken of such chemical- and organ-specific changes in porphyrin metabolism and porphyrin excretion patterns in monitoring prolonged, subclinical exposure to such chemicals in human populations. ..
  49. Mock H, Heller W, Molina A, Neubohn B, Sandermann H, Grimm B. Expression of uroporphyrinogen decarboxylase or coproporphyrinogen oxidase antisense RNA in tobacco induces pathogen defense responses conferring increased resistance to tobacco mosaic virus. J Biol Chem. 1999;274:4231-8 pubmed
    Transgenic tobacco plants with reduced activity of either uroporphyrinogen decarboxylase or coproporphyrinogen oxidase, two enzymes of the tetrapyrrole biosynthetic pathway, are characterized by the accumulation of photosensitizing ..
  50. Sun C, Liu L, Tang J, Lin A, Zhang F, Fang J, et al. RLIN1, encoding a putative coproporphyrinogen III oxidase, is involved in lesion initiation in rice. J Genet Genomics. 2011;38:29-37 pubmed publisher
    ..Histochemical analysis demonstrated that lesion formation in rlin1 was light-dependent accompanied by reactive oxygen species accumulated. These results suggest that tetrapyrrole participates in lesion formation in rice. ..
  51. Azzouzi A, Steunou A, Durand A, Khalfaoui Hassani B, Bourbon M, Astier C, et al. Coproporphyrin III excretion identifies the anaerobic coproporphyrinogen III oxidase HemN as a copper target in the Cu?-ATPase mutant copA? of Rubrivivax gelatinosus. Mol Microbiol. 2013;88:339-51 pubmed publisher
    ..In light of these results and similar findings in Escherichia coli, the potential role of copper ions in the evolution of [4Fe-4S] enzymes and the Cu(+) -ATPases is discussed. ..
  52. Troup B, Jahn M, Hungerer C, Jahn D. Isolation of the hemF operon containing the gene for the Escherichia coli aerobic coproporphyrinogen III oxidase by in vivo complementation of a yeast HEM13 mutant. J Bacteriol. 1994;176:673-80 pubmed
    ..It encodes a protein of 40.2 kDa that showed significant homology to proteins of the XylS/AraC family of transcriptional regulators. ..