nitroanisole o demethylase


Summary: Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.

Top Publications

  1. Mori T, Kitamura R, Imaoka S, Funae Y, Kitada M, Kamataki T. Examination for lipid peroxidation in liver microsomes of guinea pigs as a causal factor in the decrease in the content of cytochrome P-450 due to ascorbic acid deficiency. Res Commun Chem Pathol Pharmacol. 1992;75:209-19 pubmed
  2. Krechniak J, Wrześniowska K. Effects of pyrethroid insecticides on hepatic microsomal enzymes in rats. Environ Res. 1991;55:129-34 pubmed
    ..Only few changes in the investigated parameters were ascertained. These changes have an irregular and transient character. On the whole, the action of pyrethroids on microsomal enzymes results in a slight induction. ..
  3. Bendele A, Hoover D, van Lier R, Foxworthy P, Eacho P. Effects of chronic treatment with the leukotriene D4-antagonist compound LY171883 on B6C3F1 mice. Fundam Appl Toxicol. 1990;15:676-82 pubmed
    ..Hepatocellular adenomas were increased in females in the high dose group but not in males. All groups of treated females had increased nodular hepatocellular hyperplasia.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  4. Qu W, Kauffman F, Thurman R. Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver. Biochem Pharmacol. 1994;48:311-7 pubmed
    ..This, in turn, increases the availability of reducing equivalents in the form of NADPH by a malate-pyruvate exchange system, leading to increased drug metabolism. ..
  5. Pachecka J, Wegiełek J, Kobylińska K, Bicz W. [Structure and effects of benzodiazepines on hepatic microsomal monooxygenases in rats exposed to environmental temperature]. Folia Med Cracov. 1990;31:217-24 pubmed
    ..High environmental temperature modifies the effect of benzodiazepines on tested microsomal enzymes. ..
  6. Coban T, Eke B, Iscan M. The responses of hepatic monooxygenases of guinea pig to cadmium and nickel. Biol Trace Elem Res. 1993;38:129-37 pubmed
    ..In the case of p-NAOD activity, the influence was in favor of Ni, i.e., the inhibition was about 61% by the combined treatment.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  7. Tanaka E, Daling Z, Abe K, Nakamura T, Horie T. Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog. Xenobiotica. 1994;24:293-300 pubmed
    ..However, aniline hydroxylase activity was not significantly changed. 5. Content of P450 2B was significantly increased in E-6123 treated dog, while that of 3A was not.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  8. Putzki H, Reichert B, Leemhuis B, Muckle L. [The behavior of mixed function oxidases in the liver of the rat on the first day after ligation of the ductus choledochus]. Z Exp Chir Transplant Kunstliche Organe. 1990;23:180-2 pubmed
    ..Contradictory results of previous studies seem to be due to different times of measurement. ..
  9. Chengelis C. Age- and sex-related changes in the components of the hepatic microsomal mixed function oxidase system in Sprague-Dawley rats. Xenobiotica. 1988;18:1211-24 pubmed
    ..There are slight but significant differences between sexes only in rats less than 1 year old. There was no significant correlation between rates of p-nitroanisole or aniline metabolism and cytochrome P-450 concentrations. ..

More Information


  1. Daling Z, Tanaka E, Nakamura T, Horie T. Effect of E-5110, a novel non-steroidal anti-inflammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog. Xenobiotica. 1994;24:215-20 pubmed
    ..6. Results of both the in vivo and in vitro studies of the effects of E-5110 treatment in dog on TMO indicate that these effects may be attributed to the induction of CYP2B and 3A. ..