peroxisomal bifunctional enzyme

Summary

Summary: A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.

Top Publications

  1. Carney E. Tubular disease: mistargeted protein disrupts mitochondrial metabolism in inherited Fanconi syndrome. Nat Rev Nephrol. 2014;10:125 pubmed publisher
  2. Jun G, Chung J, Mez J, Barber R, Beecham G, Bennett D, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017;13:727-738 pubmed publisher
    ..7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6). Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. ..