histone deacetylase 1


Summary: A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.

Top Publications

  1. Schneider G, Kramer O, Saur D. A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer. Gut. 2012;61:329-30 pubmed publisher
  2. Ye J. Improving insulin sensitivity with HDAC inhibitor. Diabetes. 2013;62:685-7 pubmed publisher
  3. Shao M, He L, Zheng L, Huang L, Zhou Y, Wang T, et al. Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors. Bioorg Med Chem Lett. 2017;27:4051-4055 pubmed publisher
    ..Those results indicated that 16ae is a potent dual BRD4/HDAC inhibitor and deserves further investigation. ..
  4. He Q, Li G, Wang X, Wang S, Hu J, Yang L, et al. A Decrease of Histone Deacetylase 6 Expression Caused by Helicobacter Pylori Infection is Associated with Oncogenic Transformation in Gastric Cancer. Cell Physiol Biochem. 2017;42:1326-1335 pubmed publisher
    ..HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. HDAC6 is a promising biomarker for early diagnosis and prognosis during the oncogenic transformation of gastric cancer. ..
  5. Tikhanovich I, Zhao J, Bridges B, Kumer S, Roberts B, Weinman S. Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300. J Biol Chem. 2017;292:13333-13344 pubmed publisher
    ..PRMT1 inhibition decreased p300 recruitment to c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decreasing transcription at these sites...
  6. Kumar P, Gogulamudi V, Periasamy R, Raghavaraju G, Subramanian U, Pandey K. Inhibition of HDAC enhances STAT acetylation, blocks NF-?B, and suppresses the renal inflammation and fibrosis in Npr1 haplotype male mice. Am J Physiol Renal Physiol. 2017;313:F781-F795 pubmed publisher
    ..The current findings will help in developing the molecular therapeutic targets and new treatment strategies for hypertension and renal dysfunction in humans. ..
  7. Zhang X, Yang L, Liu X, Nie Z, Wang X, Pan Y, et al. Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia. Br J Haematol. 2017;178:728-738 pubmed publisher
    ..PTPN6 is associated with progression of CML. Low expression level of PTPN6 was associated with DNA methylation and regulated by histone acetylation. HDAC1 participates in the regulation of PTPN6. ..
  8. Jian W, Yan B, Huang S, Qiu Y. Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly. FASEB J. 2017;31:4104-4116 pubmed publisher
    ..Jian, W., Yan, B., Huang, S., Qiu, Y. Histone deacetylase 1 activates PU...
  9. Wakahara M, Sakabe T, Kubouchi Y, Hosoya K, Hirooka Y, Yurugi Y, et al. Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer. Anticancer Res. 2017;37:5071-5077 pubmed
    Maspin is known to be a tumor suppressor protein. Its nuclear localization and endogenous inhibition of histone deacetylase 1 (HDAC1) are considered crucial for its tumor suppressor activity...

More Information


  1. Cao L, Song X, Pei L, Liu L, Wang H, Jia M. Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis. Medicine (Baltimore). 2017;96:e7663 pubmed publisher
    b>Histone deacetylase 1 (HDAC1) is an important epigenetic factor, and is thought to be associated with the progression and prognosis of some types of cancer...
  2. Song K, Choi C, Lee H, Oh S, Woo S, Hong S, et al. HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells. Cancer Res. 2017;77:5039-5053 pubmed publisher
    ..i>Cancer Res; 77(18); 5039-53. ©2017 AACR. ..
  3. Shi L, Zhang G, Zheng Z, Lu B, Ji L. Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1?: The involvement of JNK and MTA1/HDCA. Chem Biol Interact. 2017;273:228-236 pubmed publisher
    ..Andro reduced the expression of metastasis-associated protein 1 (MTA1) and histone deacetylase 1 (HDAC1) in hepatoma cancer cells...
  4. Wang J, Zhao H, Fan Z, Li G, Ma Q, Tao Z, et al. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization. Stroke. 2017;48:2211-2221 pubmed publisher
    ..H19 siRNA and histone deacetylase 1 (HDAC1) plasmid were used to knock down H19 and overexpress HDAC1, respectively...
  5. Wang Y, Liu M, Jin Y, Jiang S, Pan J. In vitro and in vivo anti-uveal melanoma activity of JSL-1, a novel HDAC inhibitor. Cancer Lett. 2017;400:47-60 pubmed publisher
    ..Importantly, JSL-1 potently inhibited the growth of uveal melanoma xenograft in NOD-SCID mice. These results suggested that JSL-1 may be a promising therapeutic agent for UM. ..
  6. Li X, Zhang Y, Jiang Y, Wu J, Inks E, Chou C, et al. Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. Eur J Med Chem. 2017;134:185-206 pubmed publisher
  7. Moruno Manchon J, Uzor N, Blasco Conesa M, Mannuru S, Putluri N, Furr Stimming E, et al. Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. Hum Mol Genet. 2017;26:1305-1317 pubmed publisher
    ..Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing therapies for HD. ..
  8. Woods D, Woan K, Cheng F, Sodre A, Wang D, Wu Y, et al. T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood. 2017;130:146-155 pubmed publisher
    ..Taken together, these data demonstrate a previously unknown role of HDAC11 as a negative epigenetic regulator of T-cell effector phenotype and function. ..
  9. Liu H, Chen S, Yao X, Li Y, Chen C, Liu J, et al. Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development. 2018;145: pubmed publisher
    ..We conclude that the epigenetic regulators HDAC1 and HDAC2 control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles. ..
  10. Sharma D, Liu Y, Uht R. Estradiol (E2)- and tamoxifen (Tmx)-bound ER-alpha (ER?) interact differentially with histone deacetylases 1 and 3 (HDACs 1 and 3). J Steroid Biochem Mol Biol. 2017;174:128-132 pubmed publisher
    ..In distinction, only HDAC3 knock-down led to increased activity in the presence of Tmx. In summary, ER? differentially interacts with HDACs 1 and 3 to regulate transcriptional activity. ..
  11. Hou M, Luo C, Chang T, Hung W, Chen T, Tsai Y, et al. The NuRD complex-mediated p21 suppression facilitates chemoresistance in BRCA-proficient breast cancer. Exp Cell Res. 2017;359:458-465 pubmed publisher
  12. Bohnsack J, Patel V, Morrow A. Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. J Pharmacol Exp Ther. 2017;363:1-11 pubmed publisher
  13. Tang Z, Ding S, Huang H, Luo P, Qing B, Zhang S, et al. HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8. Biol Chem. 2017;398:1347-1356 pubmed publisher
    ..Collectively, our data showed that HDAC1 can trigger the proliferation and migration of breast cancer cells via activation of Snail/IL-8 signals. ..
  14. Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed publisher
    Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to precede axonal damage in culture, but the in vivo relevance of these findings and the potential posttranslational modifications of HDAC1 ..
  15. Wang H, Kohashi K, Yoshizumi T, Okumura Y, Tanaka Y, Shimokawa M, et al. Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. Hum Pathol. 2017;64:69-75 pubmed publisher
    ..has demonstrated that SALL4 interacts with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2)...
  16. Zhang Z, Lei A, Xu L, Chen L, Chen Y, Zhang X, et al. Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells. J Biol Chem. 2017;292:12842-12859 pubmed publisher
    ..This observed similarity in regulatory mechanisms suggests that cancer cells might share characteristics of embryonic neural cells. ..
  17. Kim B, Ratnayake R, Lee H, Shi G, Zeller S, Li C, et al. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorg Med Chem. 2017;25:3077-3086 pubmed publisher
  18. Mehndiratta S, Wang R, Huang H, Su C, Hsu C, Wu Y, et al. 4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo. Eur J Med Chem. 2017;134:13-23 pubmed publisher
    ..Therefore, compound 13 could be a suitable lead for further investigation and the development of selective HDAC 2 inhibitors as potent anti-cancer compounds. ..
  19. Mishra V, Wegwitz F, Kosinsky R, Sen M, Baumgartner R, Wulff T, et al. Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner. Nucleic Acids Res. 2017;45:6334-6349 pubmed publisher
    ..Taken together, our study uncovers a previously unknown role of BRD4 and MYC in eliciting the HDACi-mediated induction of a subset of genes and provides molecular insight into the mechanisms of HDACi action in PDAC. ..
  20. Bosio M, Fermi B, Spagnoli G, Levati E, Rubbi L, Ferrari R, et al. Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast. Nucleic Acids Res. 2017;45:4493-4506 pubmed publisher
    ..Our observations point to GRFs as new multifaceted players in Ribi gene regulation both during exponential growth and under repressive conditions. ..
  21. Durham B, Grigg R, Wood I. Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism. J Neurochem. 2017;143:214-224 pubmed publisher
    ..Taken together, this study supports the idea that inhibitors selective towards HDAC1 or HDAC2, may be therapeutically useful for targeting neuroinflammation in brain injuries and neurodegenerative disease. ..
  22. Li H, Richardson W. Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration. Nat Neurosci. 2009;12:815-7 pubmed publisher
  23. Streubel G, Fitzpatrick D, Oliviero G, Scelfo A, Moran B, Das S, et al. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017;36:2216-2232 pubmed publisher
    ..Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation. ..
  24. Sancho Pelluz J, Paquet Durand F. HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. Adv Exp Med Biol. 2012;723:107-13 pubmed publisher
  25. Gao S, Zang J, Gao Q, Liang X, Ding Q, Li X, et al. Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups. Bioorg Med Chem. 2017;25:2981-2994 pubmed publisher
    ..163, 0.396 and 0.605µM, respectively), compound 9n with IC50 values of 0.032, 0.256 and 0.311µM for HDAC1, 2 and 3 respectively, showed a moderate HDAC1 selectivity. ..