fatty acid synthases


Summary: Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.

Top Publications

  1. Klain G, Meikle A. Mannoheptulose and fatty acid synthesis in the rat. J Nutr. 1974;104:473-7 pubmed
  2. Menendez J, Lupu R. Fatty acid synthase (FASN) as a therapeutic target in breast cancer. Expert Opin Ther Targets. 2017;21:1001-1016 pubmed publisher
  3. Wang F, Liu J, Zhou R, Zhao X, Liu M, Ye H, et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPAR?-mediated lipogenic gene expression. Chem Biol Interact. 2017;275:171-177 pubmed publisher
  4. Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, et al. Engineering fatty acid synthases for directed polyketide production. Nat Chem Biol. 2017;13:363-365 pubmed publisher
    In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach...
  5. Soares G, Cantelli K, Balbo S, Ribeiro R, Alegre Maller A, Barbosa Sampaio H, et al. Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. Life Sci. 2017;188:68-75 pubmed publisher
  6. Guan M, Wu X, Chu P, Chow W. Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas. PLoS ONE. 2017;12:e0179692 pubmed publisher
    ..Our results provide mechanistic insight into the pathobiology of the "lipogenic phenotype of cancer." Here, FASN reprograms the Ut-LMS epigenome through chromatin remodeling to promote the "malignant phenotype." ..
  7. Zhang F, Chen Y, Long J, Dong L, Wang Y, Chen Y. Dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model. Clin Lab. 2015;61:389-95 pubmed
    ..Our study showed that different dietary PUFAs may affect lipid metabolism in breast cancer tissues by altering the expression of FABP5, CD-36, FAS, and ER, which may change treatment response and even prognosis of breast cancer. ..
  8. Zimhony O, Cox J, Welch J, Vilcheze C, Jacobs W. Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000;6:1043-7 pubmed
    ..tuberculosis and may provide more options for treatment against M. bovis, M. avium and drug resistant M. tuberculosis. ..
  9. Alam N, Saggerson E. Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle. Biochem J. 1998;334 ( Pt 1):233-41 pubmed
    ..A cytosolic activity of malonyl-CoA decarboxylase would seem to offer a feasible route for the disposal of malonyl-CoA in skeletal muscle. ..

More Information


  1. Ren B, Thelen A, Peters J, Gonzalez F, Jump D. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem. 1997;272:26827-32 pubmed
    ..One requires PPARalpha and is involved in regulating peroxisomal and microsomal enzymes. The other pathway does not require PPARalpha and is involved in the PUFA-mediated suppression of lipogenic gene expression. ..
  2. Liu D, Mai K, Zhang Y, Xu W, Ai Q. GSK-3b participates in the regulation of hepatic lipid deposition in large yellow croaker (Larmichthys crocea). Fish Physiol Biochem. 2016;42:379-88 pubmed
    ..The results indicate that GSK-3β/β-catenin may participate in regulating LPL and FAS through PPARγ in the liver of large yellow croaker, which will lead to the inhibition of hepatic lipid deposition. ..
  3. Abd Eldaim M, Matsuoka S, Okamatsu Ogura Y, Kamikawa A, Ahmed M, Terao A, et al. Retinoic acid modulates lipid accumulation glucose concentration dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes. Genes Cells. 2017;22:568-582 pubmed publisher
    ..These results suggest that RA suppresses and enhances lipid accumulation through extracellular glucose concentration-dependent modulation of SREBP-1 expression. ..
  4. Abramson H. The lipogenesis pathway as a cancer target. J Med Chem. 2011;54:5615-38 pubmed publisher
  5. Xie C, Li Y, Li J, Zhang L, Zhou G, Gao F. Dietary starch types affect liver nutrient metabolism of finishing pigs. Br J Nutr. 2017;118:353-359 pubmed publisher
  6. Hudlicka O, Brown M, Cotter M, Smith M, Vrbova G. The effect of long-term stimulation of fast muscles on their blood flow, metabolism and ability to withstand fatigue. Pflugers Arch. 1977;369:141-9 pubmed
    ..The latter also enables more efficient delivery of oxygen, and therefore smaller fatiguability, already after 4 days of chronic stimulation. ..
  7. Lu C, Ma J, Cai D. Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis. Tumour Biol. 2017;39:1010428317697574 pubmed publisher
    ..Therefore, targeting HAGLR may be a possible therapeutic strategy for non-small cell lung cancer. ..
  8. Cuthbert C, Foster J, Ramdath D. A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation. Br J Nutr. 2017;118:580-588 pubmed publisher
    ..Maternal HFS diet alters offspring insulin sensitivity and de novo hepatic lipogenesis via altered gene and protein expression, which appears to be potentiated by folate supplementation...