neuronal apoptosis inhibitory protein


Summary: An inhibitor of apoptosis protein that was initially identified during analysis of CHROMOSOME DELETIONS associated with SPINAL MUSCULAR ATROPHY. Naip contains a nucleotide binding oligomerization domain and a carboxy-terminal LEUCINE rich repeat.

Top Publications

  1. Chiu H, Yong T, Wang J, Wang Y, Vessella R, Ueda T, et al. Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer. Cancer Lett. 2010;292:176-85 pubmed publisher
    ..Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation ..
  2. Davoodi J, Ghahremani M, Es Haghi A, Mohammad Gholi A, MacKenzie A. Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9. Int J Biochem Cell Biol. 2010;42:958-64 pubmed publisher
    ..Taken together, these results demonstrate that NAIP is evolved to prevent apoptosis right at the initiation stage of apoptosome formation and this inhibition cannot be antagonized by SMAC-type proteins. ..
  3. Jedrzejowska M, Milewski M, Zimowski J, Borkowska J, Kostera Pruszczyk A, Sielska D, et al. Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease. Acta Biochim Pol. 2009;56:103-8 pubmed
    ..In three patients, we observed genotypes atypical for the chronic forms of SMA: two patients with SMA3a and 3b had a deletion of the NAIP gene, and a third patient with SMA2 had one copy of the SMN2 gene. ..
  4. Akhter A, Gavrilin M, Frantz L, Washington S, Ditty C, Limoli D, et al. Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog. 2009;5:e1000361 pubmed publisher
    ..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium. ..
  5. Romanish M, Nakamura H, Lai C, Wang Y, Mager D. A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. PLoS ONE. 2009;4:e5761 pubmed publisher
    The human neuronal apoptosis inhibitory protein (NAIP) gene is no longer principally considered a member of the Inhibitor of Apoptosis Protein (IAP) family, as its domain structure and functions in innate immunity also warrant inclusion ..
  6. deLuca L, Pikor N, O Leary J, Galicia Rosas G, Ward L, Defreitas D, et al. Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis. J Immunol. 2010;184:3174-85 pubmed publisher
    ..These results demonstrate that substrain differences, perhaps at the level of genomic copy number, can account for variability in the postacute phase of EAE and may drive chronic versus relapsing disease. ..
  7. Buzzo C, Campopiano J, Massis L, Lage S, Cassado A, Leme Souza R, et al. A novel pathway for inducible nitric-oxide synthase activation through inflammasomes. J Biol Chem. 2010;285:32087-95 pubmed publisher
    ..NOD-like receptor family CARD (caspase activation recruitment domain) domain containing 4)/Naip5 (neuronal apoptosis inhibitory protein 5)...
  8. Millino C, Fanin M, Vettori A, Laveder P, Mostacciuolo M, Angelini C, et al. Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy. BMC Med. 2009;7:14 pubmed publisher
    ..This more favorable condition might be due to the over-expression of MTOR that, given its role in the activation of protein synthesis, could lead to compensatory hypertrophy in SMA III muscle fibers. ..
  9. Fortier A, Doiron K, Saleh M, Grinstein S, Gros P. Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun. 2009;77:4794-805 pubmed publisher
    ..They also suggest that flagellin sensing by the NLR proteins Naip5 and Nlrc4 may be coupled to Irf1-Irf8-mediated transcriptional activation of key effector genes essential for macrophage resistance to L. pneumophila infection. ..

More Information


  1. Herman M, Moche M, Flodin S, Welin M, Tr├ęsaugues L, Johansson I, et al. Structures of BIR domains from human NAIP and cIAP2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1091-6 pubmed publisher
    ..In addition to shedding light on the specificity determinants of these two proteins, the structures should now also provide a framework for future structure-based work targeting these proteins. ..
  2. Kang T, Lee G, Kim S, Jin S, Chae G. Comparison of two mice strains, A/J and C57BL/6, in caspase-1 activity and IL-1beta secretion of macrophage to Mycobacterium leprae infection. Mediators Inflamm. 2010;2010:708713 pubmed publisher
    ..However, macrophages from A/J mice exhibited reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages. These results suggest that NLR family proteins may have a role in the innate immune response to M. leprae...
  3. Omrani O, Bonyadi M, Barzgar M. Molecular analysis of the SMN and NAIP genes in Iranian spinal muscular atrophy patients. Pediatr Int. 2009;51:193-6 pubmed publisher
    ..The purpose of the present study was to determine the frequency of SMN and neuronal apoptosis inhibitory protein (NAIP) gene deletions in Iranian SMA patients...
  4. Rudinskiy N, Kaneko Y, Beesen A, Gokce O, Regulier E, D├ęglon N, et al. Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. J Neurochem. 2009;111:460-72 pubmed publisher
    ..Likewise, expression of hippocalcin together with interactor proteins including the neuronal apoptosis inhibitory protein did not increase the survival of striatal cells in cellular models of HD...
  5. Archer K, Ader F, Kobayashi K, Flavell R, Roy C. Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infect Immun. 2010;78:2477-87 pubmed publisher
    ..pneumophila and by recruiting to the site of infection additional phagocytes that eliminate extracellular bacteria. ..