phosphoglycerate mutase

Summary

Summary: An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate.

Top Publications

  1. Stein M, Gabdoulline R, Wade R. Cross-species analysis of the glycolytic pathway by comparison of molecular interaction fields. Mol Biosyst. 2010;6:152-64 pubmed publisher
    ..Along the core glycolytic pathway, phosphoglycerate mutase displays the most conserved electrostatic potential...
  2. Papini M, Nookaew I, Scalcinati G, Siewers V, Nielsen J. Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis. Biotechnol J. 2010;5:1016-27 pubmed publisher
    ..Here, we studied the response to the deletion of the glycolytic and gluconeogenic gene GPM1, encoding for phosphoglycerate mutase. It was previously shown that a S...
  3. Heinisch J, Muller S, Schlüter E, Jacoby J, Rodicio R. Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase. Yeast. 1998;14:203-13 pubmed
    Our previous data indicated that GPM1 encodes the only functional phosphoglycerate mutase in yeast. However, in the course of the yeast genome sequencing project, two homologous sequences, designated GPM2 and GPM3, were detected...
  4. Graham D, Xu H, White R. A divergent archaeal member of the alkaline phosphatase binuclear metalloenzyme superfamily has phosphoglycerate mutase activity. FEBS Lett. 2002;517:190-4 pubmed
    ..A highly diverged gene from that organism has been proposed to function as a phosphoglycerate mutase. Like the canonical cofactor-independent phosphoglycerate mutase and other members of the binuclear ..
  5. Hazlett K, Rusnak F, Kehres D, Bearden S, La Vake C, La Vake M, et al. The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase. J Biol Chem. 2003;278:20687-94 pubmed
    ..an ABC transporter (TroABCD), a transcriptional repressor (TroR), and the essential glycolytic enzyme phosphoglycerate mutase (Gpm)...
  6. Vander Heiden M, Locasale J, Swanson K, Sharfi H, Heffron G, Amador Noguez D, et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010;329:1492-9 pubmed publisher
    ..donor in mammalian cells because PEP participates in the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells...
  7. Bourgis F, Botha F, Mani S, Hiten F, Rigden D, Verbruggen N. Characterization and functional investigation of an Arabidopsis cDNA encoding a homologue to the d-PGMase superfamily. J Exp Bot. 2005;56:1129-42 pubmed
    ..Two overexpressing At-74 lines showed a clear increase in glucose uptake. This paper introduces the At-74 homologue of the d-PGMase superfamily members and supports a possible role of At-74 in carbohydrate metabolism. ..
  8. Foster J, Raverdy S, Ganatra M, Colussi P, Taron C, Carlow C. The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapies. Parasitol Res. 2009;104:1047-52 pubmed publisher
    ..A putative cofactor-independent phosphoglycerate mutase gene (iPGM) was identified in the genome sequence of the Wolbachia endosymbiont from the filarial ..
  9. Johnsen U, Sch nheit P. Characterization of cofactor-dependent and cofactor-independent phosphoglycerate mutases from Archaea. Extremophiles. 2007;11:647-57 pubmed publisher
    ..A comprehensive phylogenetic analysis of both types of archaeal phosphoglycerate mutases is also presented...

More Information

Publications75

  1. Rigden D, Bagyan I, Lamani E, Setlow P, Jedrzejas M. A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase. Protein Sci. 2001;10:1835-46 pubmed
    The distribution of phosphoglycerate mutase (PGM) activity in bacteria is complex, with some organisms possessing both a cofactor-dependent and a cofactor-independent PGM and others having only one of these enzymes...
  2. Zhao Z, Assmann S. The glycolytic enzyme, phosphoglycerate mutase, has critical roles in stomatal movement, vegetative growth, and pollen production in Arabidopsis thaliana. J Exp Bot. 2011;62:5179-89 pubmed publisher
    ..2,3-biphosphoglycerate-independent phosphoglycerate mutase (iPGAM) is a key enzymatic activity in glycolysis and catalyses the reversible interconversion of 3-..
  3. Nairn J, Price N, Fothergill Gilmore L, Walker G, Fothergill J, Dunbar B. The amino acid sequence of the small monomeric phosphoglycerate mutase from the fission yeast Schizosaccharomyces pombe. Biochem J. 1994;297 ( Pt 3):603-8 pubmed
    The amino acid sequence of the monomeric 2,3-bisphosphoglycerate (BPG)-dependent phosphoglycerate mutase (PGAM) from the fission yeast Schizosaccharomyces pombe has been determined...
  4. Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart M, Tsusaka T, et al. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol. 2014;204:729-45 pubmed publisher
    ..Here, we report that, during oncogene- or DNA damage-induced senescence, Pak1-mediated phosphorylation of phosphoglycerate mutase (PGAM) predisposes the glycolytic enzyme to ubiquitin-mediated degradation...
  5. Kimura A, Sakurai T, Koumura A, Yamada M, Hayashi Y, Tanaka Y, et al. High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. J Neuroimmunol. 2010;219:105-8 pubmed publisher
    We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis...
  6. Oh S, Park K, Ryan H, Danon M, Lu J, Naini A, et al. Exercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. Muscle Nerve. 2006;34:572-6 pubmed
    We report two patients in whom phosphoglycerate mutase (PGAM) deficiency was associated with the triad of exercise-induced cramps, recurrent myoglobinuria, and tubular aggregates in the muscle biopsy...
  7. Qiu H, Zhao S, Xu X, Yerle M, Liu B. Assignment and expression patterns of porcine muscle-specific isoform of phosphoglycerate mutase gene. J Genet Genomics. 2008;35:257-60 pubmed publisher
    It has been reported that the muscle-specific isoform (type M, PGAM2) of phosphoglycerate mutase (PGAM) is a housekeeping enzyme; it catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate in the glycolysis process to ..
  8. Usuba T, Ishibashi Y, Okawa Y, Hirakawa T, Takada K, Ohkawa K. Purification and identification of monoubiquitin-phosphoglycerate mutase B complex from human colorectal cancer tissues. Int J Cancer. 2001;94:662-8 pubmed
    ..sequences of these peptides showed complete sequence identity to those derived from either ubiquitin or phosphoglycerate mutase-B, suggesting that the 38-kDa protein is monoubiquitinated phosphoglycerate mutase-B, whose calculated ..
  9. Jiao Y, Jin X, Yan J, Jiao F, Li X, Roe B, et al. An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant mice. Genes Genet Syst. 2009;84:327-34 pubmed
  10. Liu L, Wang S, Zhang Q, Ding Y. Identification of potential genes/proteins regulated by Tiam1 in colorectal cancer by microarray analysis and proteome analysis. Cell Biol Int. 2008;32:1215-22 pubmed publisher
    ..Our analysis identified three genes, high-mobility group box1 (HMGB1), annexin IV (ANXA4) and phosphoglycerate mutase 1 (PGAM1) that were associated with Tiam1...
  11. van der Oost J, Huynen M, Verhees C. Molecular characterization of phosphoglycerate mutase in archaea. FEMS Microbiol Lett. 2002;212:111-20 pubmed
    ..of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis and gluconeogenesis is catalyzed by phosphoglycerate mutase (PGM)...
  12. Bond C, White M, Hunter W. Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex. J Mol Biol. 2002;316:1071-81 pubmed publisher
    The structure of Escherichia coli cofactor-dependent phosphoglycerate mutase (dPGM), complexed with the potent inhibitor vanadate, has been determined to a resolution of 1.30 A (R-factor 0.159; R-free 0.213)...
  13. Engel M, Mazurek S, Eigenbrodt E, Welter C. Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines. J Biol Chem. 2004;279:35803-12 pubmed
    ..In this study we show that the glycolytic enzyme phosphoglycerate mutase B (PGM) becomes phosphorylated in the presence of the Nm23-H1.GAPDH complex in vitro...
  14. Dierick H, Mercer J, Glover T. A phosphoglycerate mutase brain isoform (PGAM 1) pseudogene is localized within the human Menkes disease gene (ATP7 A). Gene. 1997;198:37-41 pubmed
    We have identified a phosphoglycerate mutase brain isoform (PGAM 1, PGAM B) cDNA that is localized between exons 1 and 2 of the Menkes disease gene (ATP7 A, MNK) at Xq13.3...
  15. Narayanan N, Narayanan B, Nixon D. Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evalua. Cancer Detect Prev. 2004;28:443-52 pubmed
    ..analysis of human prostate cells that have been treated with resveratrol clearly identifies the role of phosphoglycerate mutase B...
  16. Andriotis V, Kruger N, Pike M, Smith A. Plastidial glycolysis in developing Arabidopsis embryos. New Phytol. 2010;185:649-62 pubmed publisher
    ..The results highlight the importance for oil production of translocators that facilitate interchange of glycolytic intermediates between the cytosol and the plastid stroma. ..
  17. Evans M, Saghatelian A, Sorensen E, Cravatt B. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 2005;23:1303-7 pubmed
    ..profiling revealed that MJE3, but not other library members, covalently labeled the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), resulting in enzyme inhibition...
  18. Nukui M, Mello L, Littlejohn J, Setlow B, Setlow P, Kim K, et al. Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species. Biophys J. 2007;92:977-88 pubmed publisher
  19. Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, et al. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 2010;9:81 pubmed publisher
    ..01). Phosphoglycerate mutase 1 (PGAM1) was found markedly upregulated...
  20. Wang Y, Wei Z, Liu L, Cheng Z, Lin Y, Ji F, et al. Crystal structure of human B-type phosphoglycerate mutase bound with citrate. Biochem Biophys Res Commun. 2005;331:1207-15 pubmed
    The B-type cofactor-dependent phosphoglycerate mutase (dPGM-B) catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways using 2,3-bisphosphoglycerate as the cofactor...
  21. Vissing J, Quistorff B, Haller R. Effect of fuels on exercise capacity in muscle phosphoglycerate mutase deficiency. Arch Neurol. 2005;62:1440-3 pubmed
    Muscle phosphoglycerate mutase deficiency (PGAMD) is a rare, recessively inherited metabolic myopathy that affects one of the last steps of glycolysis...
  22. Nowicki M, Kuaprasert B, McNae I, Morgan H, Harding M, Michels P, et al. Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass. J Mol Biol. 2009;394:535-43 pubmed publisher
    The structures of Leishmania mexicana cofactor-independent phosphoglycerate mutase (Lm iPGAM) crystallised with the substrate 3-phosphoglycerate at high and low cobalt concentrations have been solved at 2.00- and 1.90-A resolutions...
  23. Rigden D. Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase. FEBS Lett. 2003;536:77-84 pubmed
    The cofactor-dependent phosphoglycerate mutase (dPGM) superfamily contains, besides mutases, a variety of phosphatases, both broadly and narrowly substrate-specific...
  24. Kowalski W, Nocon D, Gamian A, Kołodziej J, Rakus D. Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells. J Cell Physiol. 2012;227:2613-21 pubmed publisher
    ..High concentrations of exogenous lactate reduces association of the C-terminal region phosphoglycerate mutase (PGAM) with the complex which results in its disruption and inhibition of ATP synthesis...
  25. Durany N, Joseph J, Jimenez O, Climent F, Fernandez P, Rivera F, et al. Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma. Br J Cancer. 2000;82:20-7 pubmed
    We have compared the levels of phosphoglycerate mutase (EC 5.4.2.1), 2,3-bisphosphoglycerate phosphatase (EC 3.1.3.13), creatine kinase (EC 2.7.3.2) and enolase (EC 4.2.1...
  26. Bond C, White M, Hunter W. High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase. J Biol Chem. 2001;276:3247-53 pubmed
    The active conformation of the dimeric cofactor-dependent phosphoglycerate mutase (dPGM) from Escherichia coli has been elucidated by crystallographic methods to a resolution of 1.25 A (R-factor 0.121; R-free 0.168)...
  27. Corcoran C, Huang Y, Sheikh M. The regulation of energy generating metabolic pathways by p53. Cancer Biol Ther. 2006;5:1610-3 pubmed
    ..now demonstrate the ability of p53 to regulate the expression of several novel genes including PGM (phosphoglycerate mutase), TIGAR (TP53-induced glycolysis and apoptosis regulator) and, SCO2 (synthesis of cytochrome c oxidase 2),..
  28. Durany N, Joseph J, Campo E, Molina R, Carreras J. Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. Br J Cancer. 1997;75:969-77 pubmed
    We have compared the levels of phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activities and the distribution of their isoenzymes in normal colon, liver and lung tissues, and in colon, liver and lung ..
  29. Sharma O, Vadlamudi Y, Liao Q, Strodel B, Suresh Kumar M. Molecular modeling, dynamics, and an insight into the structural inhibition of cofactor independent phosphoglycerate mutase isoform 1 from Wuchereria bancrofti using cheminformatics and mutational studies. J Biomol Struct Dyn. 2013;31:765-78 pubmed publisher
    b>Phosphoglycerate mutase catalyzes the interconversion between 2-phosphoglycerate and 3-phosphoglycerate in the glycolytic and gluconeogenic pathways...
  30. Broceño C, Ruiz P, Reina M, Vilaro S, Pons G. The muscle-specific phosphoglycerate mutase gene is specifically expressed in testis during spermatogenesis. Eur J Biochem. 1995;227:629-35 pubmed
    ..into this process, we have investigated the expression during spermatogenesis of the genes that encode phosphoglycerate mutase, an essential glycolytic enzyme for the spermatozoa energy supply...
  31. Jedrzejas M, Chander M, Setlow P, Krishnasamy G. Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilus. EMBO J. 2000;19:1419-31 pubmed
    Bacillus stearothermophilus phosphoglycerate mutase (PGM), which interconverts 2- and 3-phosphoglyceric acid (PGA), does not require 2,3-diphosphoglyceric acid for activity...
  32. Naini A, Toscano A, Musumeci O, Vissing J, Akman H, DiMauro S. Muscle phosphoglycerate mutase deficiency revisited. Arch Neurol. 2009;66:394-8 pubmed publisher
    b>Phosphoglycerate mutase (PGAM) deficiency (glycogen storage disease type X) has been reported in 12 patients of whom 9 were African American...
  33. Fuad F, Fothergill Gilmore L, Nowicki M, Eades L, Morgan H, McNae I, et al. Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics. 2011;3:1310-7 pubmed publisher
    ..Cofactor-independent phosphoglycerate mutase (iPGAM) is particularly attractive as a drug target because it shows no similarity to the corresponding ..
  34. Collet J, Stroobant V, Van Schaftingen E. The 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from Trypanosoma brucei: metal-ion dependency and phosphoenzyme formation. FEMS Microbiol Lett. 2001;204:39-44 pubmed
    Recombinant cofactor-independent phosphoglycerate mutase from Trypanosoma brucei was inactivated by EDTA, and reactivated by Co(2+) much more than by Mn(2+) or Fe(2+)...
  35. Rigden D, Mello L, Setlow P, Jedrzejas M. Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity. J Mol Biol. 2002;315:1129-43 pubmed
    ..PhoE, already identified as a homolog of a cofactor-dependent phosphoglycerate mutase, shares with the latter an alpha/beta/alpha sandwich structure spanning, as a structural excursion, a ..
  36. Motshwene P, Brandt W, Lindsey G. Significant quantities of the glycolytic enzyme phosphoglycerate mutase are present in the cell wall of yeast Saccharomyces cerevisiae. Biochem J. 2003;369:357-62 pubmed
    ..found to be the late-embryogenic-abundant-like protein heat-shock protein 12 and the glycolytic enzyme phosphoglycerate mutase. The presence of phosphoglycerate mutase in the cell wall was confirmed by immunocytochemical analysis...
  37. DiMauro S, Miranda A, Khan S, Gitlin K, Friedman R. Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy. Science. 1981;212:1277-9 pubmed
    Muscle phosphoglycerate mutase activity was decreased (5.7 percent of the lowest control value) in a 52-year-old man with intolerance for strenuous exercise and recurrent pigmenturia since adolescence...
  38. Leyva Vazquez M, Setlow P. Cloning and nucleotide sequences of the genes encoding triose phosphate isomerase, phosphoglycerate mutase, and enolase from Bacillus subtilis. J Bacteriol. 1994;176:3903-10 pubmed
    The Bacillus subtilis genes tpi, pgm, and eno, encoding triose phosphate isomerase, phosphoglycerate mutase (PGM), and enolase, respectively, have been cloned and sequenced...
  39. Nairn J, Price N, Kelly S, Rigden D, Fothergill Gilmore L, Krell T. Phosphoglycerate mutase from Schizosaccharomyces pombe: development of an expression system and characterisation of three histidine mutants of the enzyme. Biochim Biophys Acta. 1996;1296:69-75 pubmed
    The small, monomeric, phosphoglycerate mutase (PGAM) from Schizosaccharomyces pombe has been overexpressed in a strain of Saccharomyces cerevisiae in which the gene encoding PGAM has been deleted, with a yield of purified enzyme of 10-15 ..
  40. Rigden D, Littlejohn J, Henderson K, Jedrzejas M. Structures of phosphate and trivanadate complexes of Bacillus stearothermophilus phosphatase PhoE: structural and functional analysis in the cofactor-dependent phosphoglycerate mutase superfamily. J Mol Biol. 2003;325:411-20 pubmed
    Bacillus stearothermophilus phosphatase PhoE is a member of the cofactor-dependent phosphoglycerate mutase superfamily possessing broad specificity phosphatase activity...
  41. Tonin P, Bruno C, Cassandrini D, Savio C, Tavazzi E, Tomelleri G, et al. Unusual presentation of phosphoglycerate mutase deficiency due to two different mutations in PGAM-M gene. Neuromuscul Disord. 2009;19:776-8 pubmed publisher
    b>Phosphoglycerate mutase (PGAM) deficiency causes a rare metabolic myopathy characterized by exercise-related myalgia and myoglobinuria...
  42. Chiba Y, Oshima K, Arai H, Ishii M, Igarashi Y. Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus. J Biol Chem. 2012;287:11934-41 pubmed publisher
    ..proteins belonged to the histidine phosphatase superfamily and had been annotated as cofactor-dependent phosphoglycerate mutase (dPGM)...
  43. Jedrzejas M, Chander M, Setlow P, Krishnasamy G. Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate. J Biol Chem. 2000;275:23146-53 pubmed
    The structure of the complex between the 2, 3-diphosphoglycerate-independent phosphoglycerate mutase (iPGM) from Bacillus stearothermophilus and its 3-phosphoglycerate substrate has recently been solved, and analysis of this structure ..
  44. Uhrinova S, Uhrin D, Nairn J, Price N, Fothergill Gilmore L, Barlow P. Solution structure and dynamics of an open beta-sheet, glycolytic enzyme, monomeric 23.7 kDa phosphoglycerate mutase from Schizosaccharomyces pombe. J Mol Biol. 2001;306:275-90 pubmed
    The structure and backbone dynamics of a double labelled (15N,13C) monomeric, 23.7 kD phosphoglycerate mutase (PGAM) from Schizosaccharomyces pombe have been investigated in solution using NMR spectroscopy...
  45. Hitosugi T, Zhou L, Elf S, Fan J, Kang H, Seo J, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012;22:585-600 pubmed publisher
    ..We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis ..
  46. Dierick H, Ambrosini L, Spencer J, Glover T, Mercer J. Molecular structure of the Menkes disease gene (ATP7A). Genomics. 1995;28:462-9 pubmed
    ..The striking similarity of the MNK and WND genes at the genomic level is consistent with their relatively recent divergence from a common ancestral gene. ..
  47. Rigden D, Alexeev D, Phillips S, Fothergill Gilmore L. The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase. J Mol Biol. 1998;276:449-59 pubmed
    The high resolution crystal structure of Saccharomyces cerevisiae phosphoglycerate mutase has been determined. This structure shows important differences from the lower resolution structure deposited in 1982...
  48. Muller P, Sawaya M, Pashkov I, Chan S, Nguyen C, Wu Y, et al. The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. Acta Crystallogr D Biol Crystallogr. 2005;61:309-15 pubmed
    The single-crystal X-ray structure of phosphoglycerate mutase from Mycobacterium tuberculosis has been determined at a resolution of 1.70 angstroms...
  49. Zhang Y, Foster J, Kumar S, Fougere M, Carlow C. Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes. J Biol Chem. 2004;279:37185-90 pubmed
    ..Caenorhabditis elegans has been predicted to have only independent phosphoglycerate mutase. In this study, we have cloned and produced recombinant, independent phosphoglycerate mutases from C...
  50. Guerra D, Vertommen D, Fothergill Gilmore L, Opperdoes F, Michels P. Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification. Eur J Biochem. 2004;271:1798-810 pubmed
    b>Phosphoglycerate mutase (PGAM) activity in promastigotes of the protozoan parasite Leishmania mexicana is found only in the cytosol...
  51. Rigden D, Lamani E, Mello L, Littlejohn J, Jedrzejas M. Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling. J Mol Biol. 2003;328:909-20 pubmed
    ..Here, we further characterize the 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGM) from Bacillus stearothermophilus by determination of a high-resolution (1...
  52. Kondoh H, Lleonart M, Gil J, Wang J, Degan P, Peters G, et al. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005;65:177-85 pubmed
    ..screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM)...
  53. Chander M, Setlow P, Lamani E, Jedrzejas M. Structural studies on a 2,3-diphosphoglycerate independent phosphoglycerate mutase from Bacillus stearothermophilus. J Struct Biol. 1999;126:156-65 pubmed
    b>Phosphoglycerate mutase (PGM), an important enzyme in the glycolytic pathway, catalyzes the transfer of a phosphate group between the 2 and the 3 positions of glyceric acid...
  54. Mazarei M, Lennon K, Puthoff D, Rodermel S, Baum T. Expression of an Arabidopsis phosphoglycerate mutase homologue is localized to apical meristems, regulated by hormones, and induced by sedentary plant-parasitic nematodes. Plant Mol Biol. 2003;53:513-30 pubmed publisher
    ..cDNA and determined that the predicted gene product was similar to the group of cofactor-dependent phosphoglycerate mutase/bisphosphoglycerate mutase enzymes (PGM/bPGM; EC 5.4.2.1/5.4.2.4)...
  55. Kowalski W, Gizak A, Rakus D. Phosphoglycerate mutase in mammalian striated muscles: subcellular localization and binding partners. FEBS Lett. 2009;583:1841-5 pubmed publisher
    Contrary to previously published data, we have found that in mammalian skeletal muscles, phosphoglycerate mutase (PGM) is organized in a regular, striated fashion within the sarcomere...
  56. Hallows W, Yu W, Denu J. Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. J Biol Chem. 2012;287:3850-8 pubmed publisher
    ..Here, we reveal that the glycolytic enzyme phosphoglycerate mutase-1 (PGAM1) is negatively regulated by Sirt1, a member of the NAD(+)-dependent protein deacetylases...
  57. BETRAN E, Wang W, Jin L, Long M. Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene. Mol Biol Evol. 2002;19:654-63 pubmed
    ..We have studied the evolution of a Phosphoglycerate mutase processed gene (PGAM3) described in humans and believed to be a pseudogene...
  58. Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, et al. Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice. PLoS ONE. 2013;8:e72173 pubmed publisher
    ..We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on cardiac energy metabolism and function...
  59. Mercaldi G, Pereira H, Cordeiro A, Michels P, Thiemann O. Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase. FEBS J. 2012;279:2012-21 pubmed publisher
    ..Database Structural data for the Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM) has been deposited with the Research Collaboratory for Structural Bioinformatics (RCSB) Protein ..
  60. Fraser H, Kvaratskhelia M, White M. The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett. 1999;455:344-8 pubmed
    The glycolytic enzyme phosphoglycerate mutase exists in two evolutionarily unrelated forms. Vertebrates have only the 2,3-bisphosphoglycerate-dependent enzyme (dPGM), whilst higher plants have only the cofactor-independent enzyme (iPGM)...
  61. Chevalier N, Rigden D, Van Roy J, Opperdoes F, Michels P. Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase. Eur J Biochem. 2000;267:1464-72 pubmed
    Assays of phosphoglycerate mutase (PGAM) activity in lysates of bloodstream form Trypanosoma brucei appeared not to require exogenous 2,3-bisphosphoglycerate, thus suggesting that this protist contains an enzyme belonging to the class of ..
  62. Zhang J, Yu L, Fu Q, Gao J, Xie Y, Chen J, et al. Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping. Gene. 2001;264:273-9 pubmed
    ..non-muscle-specific or brain isoform (type B, Pgam1) and the muscle-specific isoform (type M, Pgam2) of phosphoglycerate mutase (PGAM) were isolated and characterized...
  63. Gonzalez Cinca N, Perez de la Ossa P, Carreras J, Climent F. Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivo. Horm Res. 2004;62:191-6 pubmed
    ..We also present the changes produced by T(3) and hypoxia on phosphoglycerate mutase (PGAM), which requires 2,3-BPG as a cofactor, and 2,3-BPG synthase (BPGS), the enzyme responsible for 2,3-..
  64. Solem C, Petranovic D, Koebmann B, Mijakovic I, Jensen P. Phosphoglycerate mutase is a highly efficient enzyme without flux control in Lactococcus lactis. J Mol Microbiol Biotechnol. 2010;18:174-80 pubmed publisher
    The glycolytic enzyme phosphoglycerate mutase (PGM), which catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate, was examined in Lactococcus lactis with respect to its function, kinetics and glycolytic flux control...
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    Sequence analysis of the probable archaeal phosphoglycerate mutase resulted in the identification of a superfamily of metalloenzymes with similar metal-binding sites and predicted conserved structural fold...
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    ..with clinical diagnosis of Hereditary Spherocytosis and partial deficiency (50%) of red blood cell phosphoglycerate mutase (PGAM) activity, we have recently reported [A. Repiso, P. Pérez de la Ossa, X. Avilés, B. Oliva, J...