phosphoglucomutase

Summary

Summary: An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphate. EC 5.4.2.2.

Top Publications

  1. Paterson G, Cone D, Peters S, Maskell D. The enzyme phosphoglucomutase (Pgm) is required by Salmonella enterica serovar Typhimurium for O-antigen production, resistance to antimicrobial peptides and in vivo fitness. Microbiology. 2009;155:3403-10 pubmed publisher
    The enzyme phosphoglucomutase (Pgm) catalyses the interconversion of glucose 1-phosphate and glucose 6-phosphate and contributes to glycolysis and the generation of sugar nucleotides for biosynthesis...
  2. Naught L, Tipton P. Kinetic mechanism and pH dependence of the kinetic parameters of Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase. Arch Biochem Biophys. 2001;396:111-8 pubmed
    The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) is responsible for the formation of mannose 1-phosphate and glucose 1-phosphate in the human pathogenic bacterium Pseudomonas aeruginosa...
  3. DeLoney C, Bartley T, Visick K. Role for phosphoglucomutase in Vibrio fischeri-Euprymna scolopes symbiosis. J Bacteriol. 2002;184:5121-9 pubmed
    ..We determined that the transposon in this mutant disrupted a gene with high sequence identity to the pgm (phosphoglucomutase) gene of Escherichia coli, which encodes an enzyme that functions in both galactose metabolism and the ..
  4. Sassi A, Lazaroski S, Wu G, Haslam S, Fliegauf M, Mellouli F, et al. Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels. J Allergy Clin Immunol. 2014;133:1410-9, 1419.e1-13 pubmed publisher
    ..One crucial enzyme in the glycosylation pathway is phosphoglucomutase 3 (PGM3), which catalyzes a key step in the synthesis of uridine diphosphate N-acetylglucosamine, which is ..
  5. Pirard M, Collet J, Matthijs G, Van Schaftingen E. Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells. FEBS Lett. 1997;411:251-4 pubmed
    ..Phosphomannomutases belong to a novel mutase family in which the active residue is a phosphoaspartyl or a phosphoglutamyl. ..
  6. Howard S, Deminoff S, Herman P. Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae. Curr Genet. 2006;49:1-6 pubmed
    ..This screen identified two genes, PGM1 and PCM1, that encode proteins with phosphoglucomutase activity...
  7. Regni C, Tipton P, Beamer L. Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors. Structure. 2002;10:269-79 pubmed
    The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from P. aeruginosa is required for the biosynthesis of two bacterial exopolysaccharides: alginate and lipopolysaccharide (LPS)...
  8. Periappuram C, Steinhauer L, Barton D, Taylor D, Chatson B, Zou J. The plastidic phosphoglucomutase from Arabidopsis. A reversible enzyme reaction with an important role in metabolic control. Plant Physiol. 2000;122:1193-9 pubmed
    An Arabidopsis cDNA (AtPGMp) encoding the plastidic phosphoglucomutase (PGM) predicted a 623-amino acid protein with an N-terminal sequence typical of a plastid signal peptide...
  9. Putt W, Ives J, Hollyoake M, Hopkinson D, Whitehouse D, Edwards Y. Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon. Biochem J. 1993;296 ( Pt 2):417-22 pubmed
    In view of its central role in glycolysis and gluconeogenesis and its polymorphic genetic variability, the phosphoglucomutase 1 (PGM1) gene in man has been the target of protein structural studies and genetic analysis for more than 25 ..

More Information

Publications86

  1. Schramm A, Mehra Chaudhary R, Furdui C, Beamer L. Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry. 2008;47:9154-62 pubmed publisher
    The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from the bacterium Pseudomonas aeruginosa is involved in the biosynthesis of several complex carbohydrates, including alginate, lipopolysaccharide, and rhamnolipid...
  2. Coyne M, Russell K, Coyle C, Goldberg J. The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J Bacteriol. 1994;176:3500-7 pubmed
    ..mutant strains had no detectable phosphomannomutase activity and that neither algC strain had detectable phosphoglucomutase (PGM) activity...
  3. Regni C, Schramm A, Beamer L. The reaction of phosphohexomutase from Pseudomonas aeruginosa: structural insights into a simple processive enzyme. J Biol Chem. 2006;281:15564-71 pubmed
    The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars...
  4. Belkin A, Klimanskaya I, Lukashev M, Lilley K, Critchley D, Koteliansky V. A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells. J Cell Sci. 1994;107 ( Pt 1):159-73 pubmed
    ..protease or cyanogen bromide cleavage showed that the proteins are closely related to the glycolytic enzyme phosphoglucomutase type 1...
  5. Kourtoglou E, Anasontzis G, Mamma D, Topakas E, Hatzinikolaou D, Christakopoulos P. Constitutive expression, purification and characterization of a phosphoglucomutase from Fusarium oxysporum. Enzyme Microb Technol. 2011;48:217-24 pubmed publisher
    The phosphoglucomutase gene from a wild type Fusarium oxysporum strain (F3), was homologously expressed, under the control of the constitutive promoter of gpdA of Aspergillus nidulans...
  6. Qian N, Stanley G, Bunte A, Radstrom P. Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene. Microbiology. 1997;143 ( Pt 3):855-65 pubmed
    ..6-phosphate, a reaction which is reversibly catalysed by a maltose-inducible and glucose-repressible beta-phosphoglucomutase (beta-PGM). The gene encoding beta-PGM (pgmB) was cloned from a genomic library of L...
  7. Johnston M. A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol Rev. 1987;51:458-76 pubmed
  8. Zhou D, Stephens D, Gibson B, Engstrom J, McAllister C, Lee F, et al. Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the phosphoglucomutase gene. J Biol Chem. 1994;269:11162-9 pubmed
    ..analysis showed that the transposon is inserted into the 3' end of a gene that has homology to the human phosphoglucomutase (PGM) gene. Sequence comparison indicated that the putative PGM gene in N. gonorrhoeae 1291 and N...
  9. Ugalde J, Comerci D, Leguizamon M, Ugalde R. Evaluation of Brucella abortus phosphoglucomutase (pgm) mutant as a new live rough-phenotype vaccine. Infect Immun. 2003;71:6264-9 pubmed
    ..A previous study characterized the phenotype associated with the phosphoglucomutase (pgm) gene disruption in Brucella abortus S2308, as well as the possible role for the smooth ..
  10. Lepek V, D Antuono A, Tomatis P, Ugalde J, Giambiagi S, Ugalde R. Analysis of Mesorhizobium loti glycogen operon: effect of phosphoglucomutase (pgm) and glycogen synthase (g/gA) null mutants on nodulation of Lotus tenuis. Mol Plant Microbe Interact. 2002;15:368-75 pubmed
    The phosphoglucomutase (pgm) gene codes for a key enzyme required for the formation of UDP-glucose and ADP-glucose, the sugar donors for the biosynthesis of glucose containing polysaccharides...
  11. Sanfélix Haywood N, Coll Marqués J, Yebra M. Role of ?-phosphoglucomutase and phosphoglucose isomerase activities at the branching point between sugar catabolism and anabolism in Lactobacillus casei. J Appl Microbiol. 2011;111:433-42 pubmed publisher
    To evaluate the role of ?-phosphoglucomutase (?-Pgm) and phosphoglucose isomerase (Pgi) activities in growth rate, sugar-phosphates, UDP-sugars and lactate biosynthesis in Lactobacillus casei...
  12. Hofmann M, Boles E, Zimmermann F. Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase. Eur J Biochem. 1994;221:741-7 pubmed
    A previously cloned gene of Saccharomyces cerevisiae, which complements the growth defect of a phosphoglucomutase (pgm1 delta/pgm2 delta) double deletion mutant on a pure galactose medium [Boles, E., Liebetrau, W., Hofmann, M...
  13. Azmi K, Schonian G, Schnur L, Nasereddin A, Ereqat S, Abdeen Z. Development of assays using hexokinase and phosphoglucomutase gene sequences that distinguish strains of Leishmania tropica from different zymodemes and microsatellite clusters and their application to Palestinian foci of cutaneous leishmaniasis. PLoS Negl Trop Dis. 2013;7:e2464 pubmed publisher
    ..were applied to sequences found in the Hexokinase (HK) gene, an enzyme that is not used in MLEE, and the Phosphoglucomutase (PGM) gene, an enzyme that is used for MLEE, to see if they would facilitate consigning local strains of L...
  14. Verrelli B, Eanes W. Extensive amino acid polymorphism at the pgm locus is consistent with adaptive protein evolution in Drosophila melanogaster. Genetics. 2000;156:1737-52 pubmed
    ..Like G6pd, Pgm shows strong evidence for a branch point enzyme that exhibits adaptive protein evolution...
  15. Kato N, Mueller C, Wessely V, Lan Q, Christensen B. Aedes aegypti phosphohexomutases and uridine diphosphate-hexose pyrophosphorylases: comparison of primary sequences, substrate specificities and temporal transcription. Insect Mol Biol. 2005;14:615-24 pubmed
    ..Herein we describe Ae. aegypti phosphoglucomutase 1, phosphoglucomutase 2, phosphoacetylglucosamine mutase, UDP-glucose pyrophosphorylase, and UDP-N-..
  16. Gao H, Leary J. Kinetic measurements of phosphoglucomutase by direct analysis of glucose-1-phosphate and glucose-6-phosphate using ion/molecule reactions and Fourier transform ion cyclotron resonance mass spectrometry. Anal Biochem. 2004;329:269-75 pubmed
    A method for the direct determination of kinetic constants for phosphoglucomutase and its phosphorylated products is described...
  17. Schramm A, Karr D, Mehra Chaudhary R, Van Doren S, Furdui C, Beamer L. Breaking the covalent connection: Chain connectivity and the catalytic reaction of PMM/PGM. Protein Sci. 2010;19:1235-42 pubmed publisher
    ..has been used to investigate the role of chain connectivity in the catalytic reaction of phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa, a human pathogen...
  18. Egli B, Kölling K, Kohler C, Zeeman S, Streb S. Loss of cytosolic phosphoglucomutase compromises gametophyte development in Arabidopsis. Plant Physiol. 2010;154:1659-71 pubmed publisher
    Cytosolic phosphoglucomutase (cPGM) interconverts glucose-6-phosphate and glucose-1-phosphate and is a key enzyme of central metabolism...
  19. Davies E, Tetlow I, Bowsher C, Emes M. Molecular and biochemical characterization of cytosolic phosphoglucomutase in wheat endosperm (Triticum aestivum L. cv. Axona). J Exp Bot. 2003;54:1351-60 pubmed
    Evidence from a number of plant tissues suggests that phosphoglucomutase (PGM) is present in both the cytosol and the plastid...
  20. Ehrmann M, Vogel R. Maltose metabolism of Lactobacillus sanfranciscensis: cloning and heterologous expression of the key enzymes, maltose phosphorylase and phosphoglucomutase. FEMS Microbiol Lett. 1998;169:81-6 pubmed
    The maltose degradation operon containing genes encoding maltose phosphorylase mapA and phosphoglucomutase pgmA from Lactobacillus sanfranciscensis DSM20451T were cloned and expressed in Escherichia coli...
  21. Bakke I, Berg L, Aune T, Brautaset T, Sletta H, Tøndervik A, et al. Random mutagenesis of the PM promoter as a powerful strategy for improvement of recombinant-gene expression. Appl Environ Microbiol. 2009;75:2002-11 pubmed publisher
    ..stimulated the expression of two other reporter genes, luc (encoding firefly luciferase) and celB (encoding phosphoglucomutase), and were found to significantly improve (twofold) a previously optimized process for high-level ..
  22. Liaw S, Lee Y, Hsueh P. Multidrug resistance in clinical isolates of Stenotrophomonas maltophilia: roles of integrons, efflux pumps, phosphoglucomutase (SpgM), and melanin and biofilm formation. Int J Antimicrob Agents. 2010;35:126-30 pubmed publisher
    Integrons, efflux pumps, phosphoglucomutase (SpgM), and melanin and biofilm formation were investigated in 40 multidrug-resistant (MDR) and 30 non-MDR Stenotrophomonas maltophilia isolates recovered from patients treated at National ..
  23. Regni C, Naught L, Tipton P, Beamer L. Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa. Structure. 2004;12:55-63 pubmed
    Enzyme-substrate complexes of phosphomannomutase/phosphoglucomutase (PMM/PGM) reveal the structural basis of the enzyme's ability to use four different substrates in catalysis...
  24. Staykova T. Genetically-determined polymorphism of nonspecific esterases and phosphoglucomutase in eight introduced breeds of the silkworm, Bombyx mori, raised in Bulgaria. J Insect Sci. 2008;8:18 pubmed publisher
    ..Polymorphism of nonspecific esterases from pupal haemolymph was analyzed, as well as of phosphoglucomutase from different organs of larvae, pupae and imago, from eight introduced breeds...
  25. Shimazu K, Takahashi Y, Uchikawa Y, Shimazu Y, Yajima A, Takashima E, et al. Identification of the Streptococcus gordonii glmM gene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibiotics. FEMS Immunol Med Microbiol. 2008;53:166-77 pubmed publisher
    ..These results suggest that, in S. gordonii, mutations in glmM appear to influence bacterial cell growth and morphology, biofilm formation, and sensitivity to penicillins. ..
  26. Rashid N, Kanai T, Atomi H, Imanaka T. Among multiple phosphomannomutase gene orthologues, only one gene encodes a protein with phosphoglucomutase and phosphomannomutase activities in Thermococcus kodakaraensis. J Bacteriol. 2004;186:6070-6 pubmed publisher
    ..In order to determine which of the remaining three orthologues encodes a phosphoglucomutase (PGM), we examined the PGM activity in T...
  27. Levander F, Andersson U, Radstrom P. Physiological role of beta-phosphoglucomutase in Lactococcus lactis. Appl Environ Microbiol. 2001;67:4546-53 pubmed
    A beta-phosphoglucomutase (beta-PGM) mutant of Lactococcus lactis subsp. lactis ATCC 19435 was constructed using a minimal integration vector and double-crossover recombination...
  28. Andersson U, Levander F, R dstr m P. Trehalose-6-phosphate phosphorylase is part of a novel metabolic pathway for trehalose utilization in Lactococcus lactis. J Biol Chem. 2001;276:42707-13 pubmed publisher
    ..lactis. This operon includes the gene encoding beta-phosphoglucomutase in addition to three open reading frames believed to encode a transcriptional regulator and two trehalose-..
  29. De Reuse H, Labigne A, Mengin Lecreulx D. The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase. J Bacteriol. 1997;179:3488-93 pubmed
    ..We propose renaming the H. pylori ureC gene the glmM gene...
  30. Ning T, Kin W, Noordin R, Cun S, Chong F, Mohamed Z, et al. Evaluation of Entamoeba histolytica recombinant phosphoglucomutase protein for serodiagnosis of amoebic liver abscess. BMC Infect Dis. 2013;13:144 pubmed publisher
    ..Analysis of crude antigen showed that phosphoglucomutase (PGM) has the diagnostic potential. Recombinant PGM (rPGM) showed 79.17% (19/24) sensitivity and 86...
  31. Mehra Chaudhary R, Mick J, Tanner J, Henzl M, Beamer L. Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens. Proteins. 2011;79:1215-29 pubmed publisher
    The crystal structure of the enzyme phosphoglucomutase from Salmonella typhimurium (StPGM) is reported at 1.7 A resolution...
  32. West N, Jungnitz H, Fitter J, McArthur J, Guzm n C, Walker M. Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infect Immun. 2000;68:4673-80 pubmed
    The phosphoglucomutase (PGM)-encoding gene of Bordetella bronchiseptica is required for lipopolysaccharide (LPS) biosynthesis. An insertion mutant of the wild-type B...
  33. Lytovchenko A, Hajirezaei M, Eickmeier I, Mittendorf V, Sonnewald U, Willmitzer L, et al. Expression of an Escherichia coli phosphoglucomutase in potato (Solanum tuberosum L.) results in minor changes in tuber metabolism and a considerable delay in tuber sprouting. Planta. 2005;221:915-27 pubmed
    The aim of this work was to evaluate the influence of elevating the cytosolic activity of phosphoglucomutase (PGM; EC 5.4.2.2) on photosynthesis, growth and heterotrophic metabolism...
  34. Zhang Y, Yu X, Ichikawa M, Lyons J, Datta S, Lamborn I, et al. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. J Allergy Clin Immunol. 2014;133:1400-9, 1409.e1-5 pubmed publisher
    ..Disease segregated with novel autosomal recessive mutations in a single gene, phosphoglucomutase 3 (PGM3)...
  35. March R, Putt W, Hollyoake M, Ives J, Lovegrove J, Hopkinson D, et al. The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination. Proc Natl Acad Sci U S A. 1993;90:10730-3 pubmed
    The molecular basis of the classical human phosphoglucomutase 1 (PGM1) isozyme polymorphism has been established...
  36. Buchanan J, Stannard J, Lauth X, Ostland V, Powell H, Westerman M, et al. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development. Infect Immun. 2005;73:6935-44 pubmed
    ..iniae mutants. The Tn917 insertion in one mutant disrupted an S. iniae homologue of a phosphoglucomutase (pgm) gene...
  37. Naught L, Tipton P. Formation and reorientation of glucose 1,6-bisphosphate in the PMM/PGM reaction: transient-state kinetic studies. Biochemistry. 2005;44:6831-6 pubmed
    ..of glucose 1-phosphate and glucose 6-phosphate, catalyzed by Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase, has been studied by transient-state kinetic techniques...
  38. Pang H, Koda Y, Soejima M, Kimura H. Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1). Ann Hum Genet. 2002;66:139-44 pubmed
    We performed phenotyping of human phosphoglucomutase 3 (PGM(3)) and screening for mutations in the human N-acetylglucosamine-phosphate mutase gene (AGM(1)) to identify PGM(3) as AGM(1)...
  39. Levander F, R dstr m P. Requirement for phosphoglucomutase in exopolysaccharide biosynthesis in glucose- and lactose-utilizing Streptococcus thermophilus. Appl Environ Microbiol. 2001;67:2734-8 pubmed publisher
    To study the influence of phosphoglucomutase (PGM) activity on exopolysaccharide (EPS) synthesis in glucose- and lactose-growing Streptococcus thermophilus, a knockout PGM mutant and a strain with elevated PGM activity were constructed...
  40. Uttaro A, Ugalde R. A chromosomal cluster of genes encoding ADP-glucose synthetase, glycogen synthase and phosphoglucomutase in Agrobacterium tumefaciens. Gene. 1994;150:117-22 pubmed
    ..4.1.21). Based on Tn5 mutagenesis and protein homology, ORF3 was identified as the structural gene encoding phosphoglucomutase (Pgm, EC 2.7.5.1). ORF3 encodes a 542-aa protein with 52.6% homology to rabbit Pgm...
  41. Dai J, Liu Y, Ray W, Konno M. The crystal structure of muscle phosphoglucomutase refined at 2.7-angstrom resolution. J Biol Chem. 1992;267:6322-37 pubmed
    A model of rabbit muscle phosphoglucomutase was refined at 2...
  42. Liu H, Wang Z, Regni C, Zou X, Tipton P. Detailed kinetic studies of an aggregating inhibitor; inhibition of phosphomannomutase/phosphoglucomutase by disperse blue 56. Biochemistry. 2004;43:8662-9 pubmed
    Phosphomannomutase/phosphoglucomutase occupies a central position in the pathways by which several virulence factors are synthesized in Pseudomonas aeruginosa...
  43. Sergeeva L, Vonk J, Keurentjes J, van der Plas L, Koornneef M, Vreugdenhil D. Histochemical analysis reveals organ-specific quantitative trait loci for enzyme activities in Arabidopsis. Plant Physiol. 2004;134:237-45 pubmed
    ..Using phosphoglucomutase (PGM) as an example, it is shown that enzyme activity can specifically, and with high resolution, be ..
  44. Masuda C, Xavier M, Mattos K, Galina A, Montero Lomeli M. Phosphoglucomutase is an in vivo lithium target in yeast. J Biol Chem. 2001;276:37794-801 pubmed
    ..2 mm) and human (IC50 approximately 1.5 mm) phosphoglucomutase, the enzyme that catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate...
  45. Jolly L, Wu S, van Heijenoort J, de Lencastre H, Mengin Lecreulx D, Tomasz A. The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase. J Bacteriol. 1997;179:5321-5 pubmed
    ..On the basis of these findings, we propose to change the names femR315 and femD to the functionally more appropriate name glmM. ..
  46. Lazarevic V, Soldo B, Médico N, Pooley H, Bron S, Karamata D. Bacillus subtilis alpha-phosphoglucomutase is required for normal cell morphology and biofilm formation. Appl Environ Microbiol. 2005;71:39-45 pubmed
    Mutations designated gtaC and gtaE that affect alpha-phosphoglucomutase activity required for interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate were mapped to the Bacillus subtilis pgcA (yhxB) gene...
  47. Penha L, Sant Anna C, Mendonça Previato L, Cunha e Silva N, Previato J, Lima A. Sorting of phosphoglucomutase to glycosomes in Trypanosoma cruzi is mediated by an internal domain. Glycobiology. 2009;19:1462-72 pubmed publisher
    ..The synthesis of UDP-galactose in T. cruzi requires the activity of phosphoglucomutase (PGM), the enzyme that catalyzes the interconversion of glucose-6-phosphate and glucose-1-phosphate...
  48. Mitra S, Cui J, Robbins P, Samuelson J. A deeply divergent phosphoglucomutase (PGM) of Giardia lamblia has both PGM and phosphomannomutase activities. Glycobiology. 2010;20:1233-40 pubmed publisher
    ..A necessary step for glucose activation is isomerization of glucose-6-phosphate to glucose-1-phosphate by a phosphoglucomutase (PGM). Similarly, a phosphomannomutase (PMM) converts mannose-6-phosphate to mannose-1-phosphate...
  49. Verrelli B, Eanes W. The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster. Genetics. 2001;159:201-10 pubmed
    ..This suggests that amino acid polymorphism is under selection at this branch point and may be favored for increased metabolic storage associated with stress resistance and adaptation to temperate regions. ..
  50. Fernie A, Roessner U, Trethewey R, Willmitzer L. The contribution of plastidial phosphoglucomutase to the control of starch synthesis within the potato tuber. Planta. 2001;213:418-26 pubmed
    The aim of this work was to evaluate the extent to which plastidial phosphoglucomutase (PGM) activity controls starch synthesis within potato (Solanum tuberosum L. cv. Desirée) tubers...
  51. Landar A, Caddell G, Chessher J, Zimmer D. Identification of an S100A1/S100B target protein: phosphoglucomutase. Cell Calcium. 1996;20:279-85 pubmed
    b>Phosphoglucomutase was identified as a potential intracellular S100 target protein because it interacted with two members of the S100 family of calcium-modulated proteins, S100A1 and S100B, in gel overlay experiments...
  52. Bandini G, Mariño K, Güther M, Wernimont A, Kuettel S, Qiu W, et al. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase. Mol Microbiol. 2012;85:513-34 pubmed publisher
    The enzymes phosphomannomutase (PMM), phospho-N-acetylglucosamine mutase (PAGM) and phosphoglucomutase (PGM) reversibly catalyse the transfer of phosphate between the C6 and C1 hydroxyl groups of mannose, N-acetylglucosamine and glucose ..
  53. Liu X, Duan J, Guo L. Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans. Oral Microbiol Immunol. 2009;24:272-7 pubmed publisher
    ..These results proved that peptidoglycan biosynthesis plays an important part in a series of bacterial morphologies. The glmM gene may have a constructive role in the virulence properties of S. mutans...
  54. Oh D, Hopper J. Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. Mol Cell Biol. 1990;10:1415-22 pubmed
    The Saccharomyces cerevisiae GAL5 (PGM2) gene was isolated and shown to encode the major isozyme of phosphoglucomutase. Northern (RNA) blot hybridization revealed that the GAL5 transcript level increased three- to fourfold in response to ..
  55. Kofler H, Häusler R, Schulz B, Groner F, Flügge U, Weber A. Molecular characterisation of a new mutant allele of the plastid phosphoglucomutase in Arabidopsis, and complementation of the mutant with the wild-type cDNA. Mol Gen Genet. 2000;263:978-86 pubmed
    ..with known mutants showed that stf1 represents a new mutant allele of the plastid isoform of the enzyme phosphoglucomutase (PGMp). The mutation was mapped to chromosome 5...
  56. Verrelli B, Eanes W. Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster. Genetics. 2001;157:1649-63 pubmed
    ..Although the enzyme phosphoglucomutase (PGM) possesses several allozyme polymorphisms, it is unique in that it had been reported to show no clinal ..
  57. Lytovchenko A, Sweetlove L, Pauly M, Fernie A. The influence of cytosolic phosphoglucomutase on photosynthetic carbohydrate metabolism. Planta. 2002;215:1013-21 pubmed
    The aim of this work was to examine the role of cytosolic phosphoglucomutase (cPGM; EC 5.4.2.2) in photosynthetic carbon partitioning...
  58. Marchase R, Bounelis P, Brumley L, Dey N, Browne B, Auger D, et al. Phosphoglucomutase in Saccharomyces cerevisiae is a cytoplasmic glycoprotein and the acceptor for a Glc-phosphotransferase. J Biol Chem. 1993;268:8341-9 pubmed
    ..acceptor was purified, and partial amino acid sequences showed a high level of identity with rabbit muscle phosphoglucomutase. Subsequently, both yeast and rabbit muscle phosphoglucomutase were found to be acceptors in the Glc-..
  59. Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, et al. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 2009;83:80-8 pubmed publisher
    ..Localization of the ZASP/Cypher-binding protein was examined at the cellular level in rat cardiomyocytes. Phosphoglucomutase 1 (PGM1), a metabolic enzyme involved in glycolysis and gluconeogenesis, was identified as a protein ..
  60. Hardy G, Caimano M, Yother J. Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase. J Bacteriol. 2000;182:1854-63 pubmed
    ..The generation of UDP-Glc proceeds by conversion of Glc-6-P to Glc-1-P to UDP-Glc and is mediated by a phosphoglucomutase (PGM) and a Glc-1-P uridylyltransferase, respectively...
  61. Hardy G, Magee A, Ventura C, Caimano M, Yother J. Essential role for cellular phosphoglucomutase in virulence of type 3 Streptococcus pneumoniae. Infect Immun. 2001;69:2309-17 pubmed
    ..The phosphoglucomutase (PGM) and Glc-1-P uridylyltransferase activities necessary for the first two steps are derived largely ..
  62. McKay G, Woods D, MacDonald K, Poole K. Role of phosphoglucomutase of Stenotrophomonas maltophilia in lipopolysaccharide biosynthesis, virulence, and antibiotic resistance. Infect Immun. 2003;71:3068-75 pubmed
    A homologue of the algC gene, responsible for the production of a phosphoglucomutase (PGM) associated with LPS and alginate biosynthesis in Pseudomonas aeruginosa, spgM, was cloned from Stenotrophomonas maltophilia...
  63. Lu M, Kleckner N. Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli. J Bacteriol. 1994;176:5847-51 pubmed
    ..here the identification and characterization of pgm, a gene in Escherichia coli that encodes the enzyme phosphoglucomutase, specifically required for the catalysis of the interconversion of glucose 1-phosphate and glucose 6-..
  64. Hong J, Wang Y, Ye X, Zhang Y. Simple protein purification through affinity adsorption on regenerated amorphous cellulose followed by intein self-cleavage. J Chromatogr A. 2008;1194:150-4 pubmed publisher
    ..0 to 6.5. Four recombinant proteins (green fluorescence protein, phosphoglucomutase, cellobiose phosphorylase, and glucan phosphorylase) have been purified successfully.
  65. Lahiri S, Zhang G, Dunaway Mariano D, Allen K. Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis. Biochemistry. 2002;41:8351-9 pubmed
    ..The crystal structure of the Mg(II) complex of phosphorylated beta-phosphoglucomutase (beta-PGM) from Lactococcus lactis has been determined to 2...
  66. Monteiro M, Fortuna Nevin M, Farley J, Pavliak V. Phase-variation of the truncated lipo-oligosaccharide of Neisseria meningitidis NMB phosphoglucomutase isogenic mutant NMB-R6. Carbohydr Res. 2003;338:2905-12 pubmed
    ..meningitidis NMB isogenic phosphoglucomutase (Pgm) mutant (NMB-R6)...
  67. Bizzini A, Majcherczyk P, Beggah Möller S, Soldo B, Entenza J, Gaillard M, et al. Effects of alpha-phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii. Microbiology. 2007;153:490-8 pubmed
    Streptococcus gordonii alpha-phosphoglucomutase, which converts glucose 6-phosphate to glucose 1-phosphate, is encoded by pgm. The pgm transcript is monocistronic and is initiated from a sigma(A)-like promoter...
  68. Gloria Bottini F, Magrini A, Antonacci E, La Torre M, Di Renzo L, De Lorenzo A, et al. Phosphoglucomutase genetic polymorphism and body mass. Am J Med Sci. 2007;334:421-5 pubmed
    We have searched for a possible association of the genetic polymorphism of Phosphoglucomutase locus 1 (PGM1), a key enzyme in carbohydrate metabolism, with body mass...
  69. Felek S, Muszynski A, Carlson R, Tsang T, Hinnebusch B, Krukonis E. Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance. Infect Immun. 2010;78:1163-75 pubmed publisher
    ..pools were identified, each with a transposon insertion at a different position within the gene encoding phosphoglucomutase (pgmA; y1258). Targeted deletion of pgmA in Y. pestis KIM5 also resulted in loss of autoaggregation...
  70. Ward P, Jann P, Blanckenhorn W. Temperature-mediated seasonal variation in phosphoglucomutase allozyme frequency in the yellow dung fly, Scathophaga stercoraria. Mol Ecol. 2004;13:3213-8 pubmed
    ..examined the seasonal (12 days over 1 year) and daily (nine samples over each day) allozyme variation at the phosphoglucomutase (PGM) locus in one population of yellow dung flies (Scathophaga stercoraria; Diptera: Scathophagidae)...
  71. Olvera C, Goldberg J, Sanchez R, Soberón Chávez G. The Pseudomonas aeruginosa algC gene product participates in rhamnolipid biosynthesis. FEMS Microbiol Lett. 1999;179:85-90 pubmed
    ..is involved in alginate production through its phosphomannomutase activity and in LPS synthesis through its phosphoglucomutase activity) participates in rhamnolipid production, presumably catalyzing the first step in the deoxy-..
  72. Manjunath S, Lee C, VanWinkle P, Bailey Serres J. Molecular and biochemical characterization of cytosolic phosphoglucomutase in maize. Expression during development and in response to oxygen deprivation. Plant Physiol. 1998;117:997-1006 pubmed
    b>Phosphoglucomutase (PGM) catalyzes the interconversion of glucose (Glc)-1- and Glc-6-phosphate in the synthesis and consumption of sucrose. We isolated two maize (Zea mays L.) cDNAs that encode PGM with 98...
  73. Moiseeva E, Belkin A, Spurr N, Koteliansky V, Critchley D. A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily. Eur J Biochem. 1996;235:103-13 pubmed
    ..In this study, we report the complete sequence of this protein, and show that it is a novel member of the phosphoglucomutase (PGM) family of proteins. The PGM-related protein (PGM-RP), which contains 506 amino acids (55...
  74. de Jongh W, Bro C, Ostergaard S, Regenberg B, Olsson L, Nielsen J. The roles of galactitol, galactose-1-phosphate, and phosphoglucomutase in galactose-induced toxicity in Saccharomyces cerevisiae. Biotechnol Bioeng. 2008;101:317-26 pubmed publisher
    ..but indications were found that galactose-1-phosphate might cause a negative effect through inhibition of phosphoglucomutase. Furthermore, we show that galactitol is formed in S...
  75. Lale R, Berg L, Stüttgen F, Netzer R, Stafsnes M, Brautaset T, et al. Continuous control of the flow in biochemical pathways through 5' untranslated region sequence modifications in mRNA expressed from the broad-host-range promoter Pm. Appl Environ Microbiol. 2011;77:2648-55 pubmed publisher
    ..reduced uninduced expression of three different reporter genes (encoding ?-lactamase, luciferase, and phosphoglucomutase) in Escherichia coli...
  76. Li S, Kang J, Yu W, Zhou Y, Zhang W, Xin Y, et al. Identification of M. tuberculosis Rv3441c and M. smegmatis MSMEG_1556 and essentiality of M. smegmatis MSMEG_1556. PLoS ONE. 2012;7:e42769 pubmed publisher
    ..These results demonstrated that MSMEG_1556 is essential for growth of M. smegmatis. This study provided evidence that GlmM enzyme could be as a potential target for developing anti-tuberculosis drugs...
  77. Sandlin R, Stein D. Role of phosphoglucomutase in lipooligosaccharide biosynthesis in Neisseria gonorrhoeae. J Bacteriol. 1994;176:2930-7 pubmed
    ..Enzymatic analysis of gonococcal crude protein extracts demonstrated that pSG30 encodes phosphoglucomutase (PGM) and phosphomannomutase activity...