chorismate mutase

Summary

Summary: An isomerase that catalyzes the conversion of chorismic acid to prephenic acid. EC 5.4.99.5.

Top Publications

  1. Lassila J, Keeffe J, Oelschlaeger P, Mayo S. Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity. Protein Eng Des Sel. 2005;18:161-3 pubmed
    Computational protein design methods were used to predict five variants of monofunctional Escherichia coli chorismate mutase expected to maintain catalytic activity...
  2. Eberhard J, Ehrler T, Epple P, Felix G, Raesecke H, Amrhein N, et al. Cytosolic and plastidic chorismate mutase isozymes from Arabidopsis thaliana: molecular characterization and enzymatic properties. Plant J. 1996;10:815-21 pubmed
    ..e. chorismate mutase (CM)...
  3. Crehuet R, Field M. A transition path sampling study of the reaction catalyzed by the enzyme chorismate mutase. J Phys Chem B. 2007;111:5708-18 pubmed
    ..We have also devised an approximate technique for locating transition state structures along the paths. ..
  4. Okvist M, Dey R, Sasso S, Grahn E, Kast P, Krengel U. 1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed. J Mol Biol. 2006;357:1483-99 pubmed
    ..Here, we report the high-resolution crystal structure of the secreted dimeric chorismate mutase from M...
  5. Claeyssens F, Ranaghan K, Lawan N, Macrae S, Manby F, Harvey J, et al. Analysis of chorismate mutase catalysis by QM/MM modelling of enzyme-catalysed and uncatalysed reactions. Org Biomol Chem. 2011;9:1578-90 pubmed publisher
    b>Chorismate mutase is at the centre of current controversy about fundamental features of biological catalysts...
  6. Szefczyk B, Mulholland A, Ranaghan K, Sokalski W. Differential transition-state stabilization in enzyme catalysis: quantum chemical analysis of interactions in the chorismate mutase reaction and prediction of the optimal catalytic field. J Am Chem Soc. 2004;126:16148-59 pubmed
    b>Chorismate mutase is a key model system in the development of theories of enzyme catalysis...
  7. Lütke Eversloh T, Stephanopoulos G. Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants. Appl Environ Microbiol. 2005;71:7224-8 pubmed
    In order to get insights into the feedback regulation by tyrosine of the Escherichia coli chorismate mutase/prephenate dehydrogenase (CM/PDH), which is encoded by the tyrA gene, feedback-inhibition-resistant (fbr) mutants were generated ..
  8. Crespo A, Marti M, Estrin D, Roitberg A. Multiple-steering QM-MM calculation of the free energy profile in chorismate mutase. J Am Chem Soc. 2005;127:6940-1 pubmed
    ..The conversion reaction of chorismate to prephenate catalyzed by the Bacillus subtilis enzyme chorismate mutase has been chosen as an illustrative example.
  9. Guimarães C, Repasky M, Chandrasekhar J, Tirado Rives J, Jorgensen W. Contributions of conformational compression and preferential transition state stabilization to the rate enhancement by chorismate mutase. J Am Chem Soc. 2003;125:6892-9 pubmed
    The rate enhancement provided by the chorismate mutase (CM) enzyme for the Claisen rearrangement of chorismate to prephenate has been investigated by application of the concept of near attack conformations (NACs)...

More Information

Publications73

  1. Sasso S, Ramakrishnan C, Gamper M, Hilvert D, Kast P. Characterization of the secreted chorismate mutase from the pathogen Mycobacterium tuberculosis. FEBS J. 2005;272:375-89 pubmed
  2. Lambert K, Allen K, Sussex I. Cloning and characterization of an esophageal-gland-specific chorismate mutase from the phytoparasitic nematode Meloidogyne javanica. Mol Plant Microbe Interact. 1999;12:328-36 pubmed
    ..One clone, shown to be expressed in the nematode's esophageal gland, codes for a potentially secreted chorismate mutase (CM)...
  3. Colquhoun T, Schimmel B, Kim J, Reinhardt D, Cline K, Clark D. A petunia chorismate mutase specialized for the production of floral volatiles. Plant J. 2010;61:145-55 pubmed publisher
    ..understand the regulation of 'upstream' components in the FVBP system, we have cloned and characterized two CHORISMATE MUTASE (PhCM1 and PhCM2) cDNAs from petunia...
  4. Chook Y, Ke H, Lipscomb W. Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog. Proc Natl Acad Sci U S A. 1993;90:8600-3 pubmed
    We have solved the structure of a chorismate mutase (chorismate pyruvatemutase, EC 5.4.99.5), the 1.9-A crystal structure of the monofunctional enzyme from Bacillus subtilis...
  5. Adepu R, Shiva Kumar K, Sandra S, Rambabu D, Rama Krishna G, Malla Reddy C, et al. C-N bond formation under Cu-catalysis: synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase. Bioorg Med Chem. 2012;20:5127-38 pubmed publisher
    ..substituted thieno[2,3-d]pyrimidin-4(3H)-ones were designed and synthesized as potential inhibitors of chorismate mutase. Synthesis of this class of compounds was carried out by using Cu-mediated C-N bond forming reaction between ..
  6. Eberhard J, Bischoff M, Raesecke H, Amrhein N, Schmid J. Isolation of a cDNA from tomato coding for an unregulated, cytosolic chorismate mutase. Plant Mol Biol. 1996;31:917-22 pubmed
    A cDNA coding for chorismate mutase was isolated from tomato by complementing a chorismate mutase-deficient Escherichia coli strain with a cDNA library...
  7. Lambert K, Bekal S, Domier L, Niblack T, Noel G, Smyth C. Selection of Heterodera glycines chorismate mutase-1 alleles on nematode-resistant soybean. Mol Plant Microbe Interact. 2005;18:593-601 pubmed
    ..H. glycines chorismate mutase-1 (Hg-CM-1) is a nematode enzyme with the potential to suppress host plant defense compounds; therefore, it ..
  8. Hu P, Meng Y, Wise R. Functional contribution of chorismate synthase, anthranilate synthase, and chorismate mutase to penetration resistance in barley-powdery mildew interactions. Mol Plant Microbe Interact. 2009;22:311-20 pubmed publisher
    ..Barley chorismate synthase (HvCS), anthranilate synthase alpha subunit 2 (HvASa2), and chorismate mutase 1 (HvCM1) occupy pivotal branch points downstream of the shikimate pathway leading to the synthesis of ..
  9. Degrassi G, Devescovi G, Bigirimana J, Venturi V. Xanthomonas oryzae pv. oryzae XKK.12 contains an AroQgamma chorismate mutase that is involved in rice virulence. Phytopathology. 2010;100:262-70 pubmed publisher
    b>Chorismate mutase (CM) is a key enzyme in the shikimate pathway which is responsible for the synthesis of aromatic amino acids...
  10. Kong Y, Ma J, Karplus M, Lipscomb W. The allosteric mechanism of yeast chorismate mutase: a dynamic analysis. J Mol Biol. 2006;356:237-47 pubmed
    The effector-regulated allosteric mechanism of yeast chorismate mutase (YCM) was studied by normal mode analysis and targeted molecular dynamics...
  11. Qamra R, Prakash P, Aruna B, Hasnain S, Mande S. The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions. Biochemistry. 2006;45:6997-7005 pubmed
    b>Chorismate mutase catalyzes the first committed step toward the biosynthesis of the aromatic amino acids, phenylalanine and tyrosine...
  12. Prakash P, Aruna B, Sardesai A, Hasnain S. Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity. J Biol Chem. 2005;280:19641-8 pubmed
    Naturally occurring variants of the enzyme chorismate mutase are known to exist that exhibit diversity in enzyme structure, regulatory properties, and association with other proteins...
  13. Lassila J, Keeffe J, Kast P, Mayo S. Exhaustive mutagenesis of six secondary active-site residues in Escherichia coli chorismate mutase shows the importance of hydrophobic side chains and a helix N-capping position for stability and catalysis. Biochemistry. 2007;46:6883-91 pubmed
    ..molecule, all 19 possible amino acid substitutions were investigated in six positions of the engineered chorismate mutase domain of the Escherichia coli chorismate mutase-prephenate dehydratase...
  14. Guo H, Cui Q, Lipscomb W, Karplus M. Substrate conformational transitions in the active site of chorismate mutase: their role in the catalytic mechanism. Proc Natl Acad Sci U S A. 2001;98:9032-7 pubmed
    b>Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate...
  15. Sasso S, Okvist M, Roderer K, Gamper M, Codoni G, Krengel U, et al. Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner. EMBO J. 2009;28:2128-42 pubmed publisher
    b>Chorismate mutase catalyzes a key step in the shikimate biosynthetic pathway towards phenylalanine and tyrosine...
  16. Strater N, Hakansson K, Schnappauf G, Braus G, Lipscomb W. Crystal structure of the T state of allosteric yeast chorismate mutase and comparison with the R state. Proc Natl Acad Sci U S A. 1996;93:3330-4 pubmed
    The crystal structure of the tyrosine-bound T state of allosteric yeast Saccharomyces cerevisiae chorismate mutase was solved by molecular replacement at a resolution of 2...
  17. Chook Y, Gray J, Ke H, Lipscomb W. The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. J Mol Biol. 1994;240:476-500 pubmed
    Structures have been determined for chorismate mutase from Bacillus subtilis and of complexes of this enzyme with product and an endo-oxabicyclic transition state analog using multiple isomorphous replacement plus partial structure phase ..
  18. Maruya A, O Connor M, Backman K. Genetic separability of the chorismate mutase and prephenate dehydrogenase components of the Escherichia coli tyrA gene product. J Bacteriol. 1987;169:4852-3 pubmed
    Fragments of the tyrA gene of Escherichia coli, when suitably engineered, can express either the chorismate mutase activity or the prephenate dehydrogenase activity without the other.
  19. Ishida T, Fedorov D, Kitaura K. All electron quantum chemical calculation of the entire enzyme system confirms a collective catalytic device in the chorismate mutase reaction. J Phys Chem B. 2006;110:1457-63 pubmed
    ..catalytic power of enzymes, we analyzed the reaction profile of Claisen rearrangement of Bacillus subtilis chorismate mutase (BsCM) by all electron quantum chemical calculations using the fragment molecular orbital (FMO) method...
  20. Doyle E, Lambert K. Meloidogyne javanica chorismate mutase 1 alters plant cell development. Mol Plant Microbe Interact. 2003;16:123-31 pubmed
    ..Meloidogyne javanica chorismate mutase 1 (MjCM-1) is one such esophageal gland protein likely to be secreted from the nematode as giant cells form...
  21. Vanholme B, Kast P, Haegeman A, Jacob J, Grunewald W, Gheysen G. Structural and functional investigation of a secreted chorismate mutase from the plant-parasitic nematode Heterodera schachtii in the context of related enzymes from diverse origins. Mol Plant Pathol. 2009;10:189-200 pubmed publisher
    In this article, we present the cloning of Hscm1, a gene for chorismate mutase (CM) from the beet cyst nematode Heterodera schachtii...
  22. Kast P, Asif Ullah M, Jiang N, Hilvert D. Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis. Proc Natl Acad Sci U S A. 1996;93:5043-8 pubmed
    b>Chorismate mutase (EC 5.4.99.5) catalyzes the intramolecular rearrangement of chorismate to prephenate...
  23. Strajbl M, Shurki A, Kato M, Warshel A. Apparent NAC effect in chorismate mutase reflects electrostatic transition state stabilization. J Am Chem Soc. 2003;125:10228-37 pubmed
    The catalytic reaction of chorismate mutase (CM) has been the subject of major current attention. Nevertheless, the origin of the catalytic power of CM remains an open question...
  24. Martí S, Andres J, Moliner V, Silla E, Tuñón I, Bertran J. A comparative study of claisen and cope rearrangements catalyzed by chorismate mutase. An insight into enzymatic efficiency: transition state stabilization or substrate preorganization?. J Am Chem Soc. 2004;126:311-9 pubmed
    ..Transition state stabilization seems to be the dominant effect in this case. ..
  25. Berry A, Bhatnagar R, Jensen R. Enzymic basis for leakiness of auxotrophs for phenylalanine in Pseudomonas aeruginosa. J Gen Microbiol. 1987;133:3257-63 pubmed
    ..aeruginosa (PAT1051) was found to lack the bifunctional P-protein (chorismate mutase-prephenate dehydratase), but retained the monofunctional isozyme species of chorismate mutase (chorismate ..
  26. Choutko A, van Gunsteren W. Molecular dynamics simulation of the last step of a catalytic cycle: product release from the active site of the enzyme chorismate mutase from Mycobacterium tuberculosis. Protein Sci. 2012;21:1672-81 pubmed publisher
    The protein chorismate mutase MtCM from Mycobacterium tuberculosis catalyzes one of the few pericyclic reactions known in biology: the transformation of chorismate to prephenate...
  27. Munack S, Leroux V, Roderer K, Okvist M, van Eerde A, Gundersen L, et al. When inhibitors do not inhibit: critical evaluation of rational drug design targeting chorismate mutase from Mycobacterium tuberculosis. Chem Biodivers. 2012;9:2507-27 pubmed publisher
    ..the structure-guided discovery of several promising and highly active inhibitors targeting the secreted chorismate mutase (*MtCM) from Mycobacterium tuberculosis...
  28. Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D. A simple selection strategy for evolving highly efficient enzymes. Nat Biotechnol. 2007;25:1145-7 pubmed
    ..This facilitates identification of mutants with wild-type activity, as shown here for an engineered chorismate mutase. Numerous selection formats and cell-based screening methodologies may benefit from the large dynamic range ..
  29. Walter K, Vamvaca K, Hilvert D. An active enzyme constructed from a 9-amino acid alphabet. J Biol Chem. 2005;280:37742-6 pubmed
    ..an enzyme composed entirely from a set of only 9 amino acids that can rescue auxotrophic cells lacking chorismate mutase. The simplified protein captures key structural features of its natural counterpart but appears to be ..
  30. Ranaghan K, Ridder L, Szefczyk B, Sokalski W, Hermann J, Mulholland A. Transition state stabilization and substrate strain in enzyme catalysis: ab initio QM/MM modelling of the chorismate mutase reaction. Org Biomol Chem. 2004;2:968-80 pubmed
    ..have modelled an important model enzyme reaction, the Claisen rearrangement of chorismate to prephenate in chorismate mutase, by combined ab initio quantum mechanics/molecular mechanics (QM/MM) methods...
  31. Ahmad S, Weisburg W, Jensen R. Evolution of aromatic amino acid biosynthesis and application to the fine-tuned phylogenetic positioning of enteric bacteria. J Bacteriol. 1990;172:1051-61 pubmed
    ..This hierarchical framework is proposed as a general working basis for continued refinement of the phylogenetic relationships of enteric bacteria. ..
  32. Bekal S, Niblack T, Lambert K. A chorismate mutase from the soybean cyst nematode Heterodera glycines shows polymorphisms that correlate with virulence. Mol Plant Microbe Interact. 2003;16:439-46 pubmed
    ..One gene that may play several roles in nematode parasitism is chorismate mutase (CM)...
  33. Hur S, Bruice T. Enzymes do what is expected (chalcone isomerase versus chorismate mutase). J Am Chem Soc. 2003;125:1472-3 pubmed
    Madicago sativa chalcone isomerase (CI) catalyzes the isomerization of chalcone to flavanone, whereas E. coli chorismate mutase (CM) catalyzes the pericyclic rearrangement of chorismate to prephenate...
  34. Helmstaedt K, Krappmann S, Braus G. Allosteric regulation of catalytic activity: Escherichia coli aspartate transcarbamoylase versus yeast chorismate mutase. Microbiol Mol Biol Rev. 2001;65:404-21, table of contents pubmed
    ..transcarbamoylase (ATCase) from Escherichia coli, consisting of 12 polypeptides, and the less complicated chorismate mutase derived from baker's yeast, which functions as a homodimer...
  35. Mobley E, Kunkel B, Keith B. Identification, characterization and comparative analysis of a novel chorismate mutase gene in Arabidopsis thaliana. Gene. 1999;240:115-23 pubmed
    ..We have isolated, characterized and determined the expression of Arabidopsis thaliana genes encoding chorismate mutase, the enzyme catalyzing the first committed step in phenylalanine and tyrosine synthesis...
  36. Ball S, Wickner R, Cottarel G, Schaus M, Tirtiaux C. Molecular cloning and characterization of ARO7-OSM2, a single yeast gene necessary for chorismate mutase activity and growth in hypertonic medium. Mol Gen Genet. 1986;205:326-30 pubmed
    The chorismate mutase structural gene, ARO7, which is necessary for both phenylalanine and tyrosine biosynthesis was cloned by complementation in yeast...
  37. Müller M, Kries H, Csuhai E, Kast P, Hilvert D. Design, selection, and characterization of a split chorismate mutase. Protein Sci. 2010;19:1000-10 pubmed publisher
    ..Here, we report a new, particularly small split enzyme, engineered from a thermostable chorismate mutase (CM)...
  38. Gu W, Williams D, Aldrich H, Xie G, Gabriel D, Jensen R. The aroQ and pheA domains of the bifunctional P-protein from Xanthomonas campestris in a context of genomic comparison. Microb Comp Genomics. 1997;2:141-58 pubmed
    The gene (denoted aroQp.pheA) encoding the bifunctional P-protein (chorismate mutase-P/prephenate dehydratase) from Xanthomonas campestris was cloned. aroQp.pheA is essential for L-phenylalanine biosynthesis...
  39. Lu S, Tian D, Borchardt Wier H, Wang X. Alternative splicing: a novel mechanism of regulation identified in the chorismate mutase gene of the potato cyst nematode Globodera rostochiensis. Mol Biochem Parasitol. 2008;162:1-15 pubmed publisher
    b>Chorismate mutase (CM) secreted from the stylet of plant-parasitic nematodes plays an important role in plant parasitism...
  40. Taylor S, Walter K, Kast P, Hilvert D. Searching sequence space for protein catalysts. Proc Natl Acad Sci U S A. 2001;98:10596-601 pubmed
    ..degenerate libraries were prepared by replacing all secondary structure units in a dimeric, helical bundle chorismate mutase with simple binary-patterned modules based on a limited set of four polar and four nonpolar residues...
  41. Chen S, Vincent S, Wilson D, Ganem B. Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein. Eur J Biochem. 2003;270:757-63 pubmed
    ..The 373 amino acid T-protein is a homodimer that exhibits chorismate mutase (CM) and prephenate dehydrogenase (PDH) activities, both of which are feedback-inhibited by tyrosine...
  42. Jordan P, Bohle D, Ramilo C, Evans J. New insights into the metal center of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Biochemistry. 2001;40:8387-96 pubmed
  43. Husain A, Chen S, Wilson D, Ganem B. A selective inhibitor of Escherichia coli prephenate dehydratase. Bioorg Med Chem Lett. 2001;11:2485-8 pubmed
    ..To identify selective prephenate dehydratase (PDT) inhibitors, a series of substituted biphenic acid derivatives was synthesized using the Ullmann reaction. Screening experiments identified 18 as a promising new PDT inhibitor. ..
  44. Woodcock H, Hodoscek M, Brooks B. Exploring SCC-DFTB paths for mapping QM/MM reaction mechanisms. J Phys Chem A. 2007;111:5720-8 pubmed
    ..This newly added functionality has been applied to the chorismate mutase-catalyzed interconversion of chorismate to prephenate, which is a key step in the shikimate pathway of ..
  45. Qi Y, Grishin N. Structural classification of thioredoxin-like fold proteins. Proteins. 2005;58:376-88 pubmed
    ..Considering these structurally similar domains together sheds new light on the relationships between sequence, structure, function and evolution of thioredoxins. ..
  46. Drew K, Winters P, Butterfoss G, Berstis V, Uplinger K, Armstrong J, et al. The Proteome Folding Project: proteome-scale prediction of structure and function. Genome Res. 2011;21:1981-94 pubmed publisher
    ..We demonstrate that predicted structures can be combined with annotations from the Gene Ontology database to predict new and more specific molecular functions. ..
  47. Lee A, Stewart J, Clardy J, Ganem B. New insight into the catalytic mechanism of chorismate mutases from structural studies. Chem Biol. 1995;2:195-203 pubmed
    b>Chorismate mutase catalyzes the rearrangement of chorismic acid to prephenic acid, which is the first committed step in the biosynthesis of aromatic amino acids. Its catalytic mechanism has been much studied, but is poorly understood...
  48. Xia T, Zhao G, Jensen R. Loss of allosteric control but retention of the bifunctional catalytic competence of a fusion protein formed by excision of 260 base pairs from the 3' terminus of pheA from Erwinia herbicola. Appl Environ Microbiol. 1992;58:2792-8 pubmed
    ..This P protein carries catalytic domains that specify chorismate mutase (CM-P) and prephenate dehydratase...
  49. White P, Millar G, Coggins J. The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa. Biochem J. 1988;251:313-22 pubmed
    ..crassa enzyme show that it is also tetrameric with a subunit Mr of 50,000. It is proposed that the subunits of the N. crassa enzyme are larger because they contain a diaphorase domain that is absent from the E. coli enzyme...
  50. Djamei A, Schipper K, Rabe F, Ghosh A, Vincon V, Kahnt J, et al. Metabolic priming by a secreted fungal effector. Nature. 2011;478:395-8 pubmed publisher
    ..modification and host penetration as well as proteins unlikely to act in the fungal-host interface like a chorismate mutase. Chorismate mutases are key enzymes of the shikimate pathway and catalyse the conversion of chorismate to ..
  51. Ishida T. Probing protein environment in an enzymatic process: All-electron quantum chemical analysis combined with ab initio quantum mechanical/molecular mechanical modeling of chorismate mutase. J Chem Phys. 2008;129:125105 pubmed publisher
    ..For a practical application, we selected the chorismate mutase catalyzed reaction as an example...
  52. Guo H, Cui Q, Lipscomb W, Karplus M. Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations. Angew Chem Int Ed Engl. 2003;42:1508-11 pubmed
  53. Zhang S, Pohnert G, Kongsaeree P, Wilson D, Clardy J, Ganem B. Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins. J Biol Chem. 1998;273:6248-53 pubmed
    ..which plays a central role in Escherichia coli phenylalanine biosynthesis, contains two catalytic domains (chorismate mutase and prephenate dehydratase activities) as well as one R-domain (for feedback inhibition by phenylalanine)...
  54. Regan L. Protein redesign. Curr Opin Struct Biol. 1999;9:494-9 pubmed
  55. Bolotin A, Khazak V, Stoynova N, Ratmanova K, Yomantas Y, Kozlov Y. Identical amino acid sequence of the aroA(G) gene products of Bacillus subtilis 168 and B. subtilis Marburg strain. Microbiology. 1995;141 ( Pt 9):2219-22 pubmed
    ..aroA(G) gene of Bacillus subtilis 168, encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase-chorismate mutase, was cloned and sequenced...
  56. Marti S, Andres J, Moliner V, Silla E, Tuñón I, Bertran J. Theoretical QM/MM studies of enzymatic pericyclic reactions. Interdiscip Sci. 2010;2:115-31 pubmed publisher
    ..that other protein scaffolds such as catalytic antibodies or some promiscuous enzymes present certain chorismate mutase activity...
  57. Helmstaedt K, Heinrich G, Lipscomb W, Braus G. Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase. Proc Natl Acad Sci U S A. 2002;99:6631-6 pubmed
    The yeast chorismate mutase is regulated by tyrosine as feedback inhibitor and tryptophan as crosspathway activator...
  58. Wortmann A, Pimenova T, Alves S, Zenobi R. Investigation of the first shot phenomenon in MALDI mass spectrometry of protein complexes. Analyst. 2007;132:199-207 pubmed
    ..Segregation of the large protein complexes to the exterior and dissociation of the complexes in the crystal interior during sample crystallization can rationalize this observation. ..
  59. Ogawa D, Nakajima N, Sano T, Tamaoki M, Aono M, Kubo A, et al. Salicylic acid accumulation under O3 exposure is regulated by ethylene in tobacco plants. Plant Cell Physiol. 2005;46:1062-72 pubmed publisher
    ..O3 increased the activity of phenylalanine ammonia-lyase (PAL) and the transcript levels of the chorismate mutase (CM) and PAL genes in wild-type tobacco, but their induction was suppressed in the transgenic plants...
  60. Prasad B, Adepu R, Sandra S, Rambabu D, Krishna G, Reddy C, et al. AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest. Chem Commun (Camb). 2012;48:10434-6 pubmed
    ..an indole ring has been achieved via AlCl(3) mediated unexpected regioselective sulfonyl group migration for N-alkyl/aryl/heteroarylsulfonyl indoles affording potential inhibitors of Mycobacterium tuberculosis H37Rv chorismate mutase.
  61. Zhang X, Zhang X, Bruice T. A definitive mechanism for chorismate mutase. Biochemistry. 2005;44:10443-8 pubmed
    ..These findings compare most favorably with those previous observations of this laboratory employing molecular dynamics and thermodynamic integrations. A definitive mechanism for the chorismate mutase enzymes is provided.
  62. Bakolitsa C, Kumar A, Jin K, McMullan D, Krishna S, Miller M, et al. Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:1182-9 pubmed publisher
    ..Structural analysis revealed that both structures adopt a variant of the Bacillus chorismate mutase fold (BCM)...
  63. Kloosterman H, Hessels G, Vrijbloed J, Euverink G, Dijkhuizen L. (De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica. Microbiology. 2003;149:3321-30 pubmed
    Prephenate dehydratase (PDT), chorismate mutase (CM) and 3-deoxy-D-arabino-7-heptulosonate 7-phosphate (DAHP) synthase are key regulatory enzymes in aromatic amino acid biosynthesis in the actinomycete Amycolatopsis methanolica...
  64. Zhang X, Bruice T. Temperature dependence of the structure of the substrate and active site of the Thermus thermophilus chorismate mutase E x S complex. Biochemistry. 2006;45:8562-7 pubmed
    Molecular dynamics (MD) simulations of Thermus thermophilus chorismate mutase substrate complex (TtCM x S) have been carried out at 298 K, 333 K, and the temperature of optimum activity: 343 K...