cyclophilin a

Summary

Summary: A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.

Top Publications

  1. Calhoun C, Lu Y, Song J, Chiu R. Knockdown endogenous CypA with siRNA in U2OS cells results in disruption of F-actin structure and alters tumor phenotype. Mol Cell Biochem. 2009;320:35-43 pubmed publisher
    b>Cyclophilin A (CypA) was originally identified as a cytosolic protein possessing peptidyl-prolyl isomerase activity...
  2. Kim J, Kim H, Suk K, Lee W. Activation of CD147 with cyclophilin a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells. Mediators Inflamm. 2010;2010:821940 pubmed publisher
    ..In order to identify genes that are induced by activation of CD147, THP-1 cells were stimulated with Cyclophilin A and differentially expressed genes were detected using PCR-based analysis...
  3. Berthoux L, Sebastian S, Sayah D, Luban J. Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues. J Virol. 2005;79:7883-8 pubmed
    ..is blocked by the alpha isoform of macaque TRIM5 (TRIM5alpha(rh)) or by the product of the owl monkey TRIM5-cyclophilin A gene fusion (TRIMCyp)...
  4. Price A, Marzetta F, Lammers M, Ylinen L, Schaller T, Wilson S, et al. Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nat Struct Mol Biol. 2009;16:1036-42 pubmed publisher
    ..We show that the ancestral cyclophilin A (CypA) domain of RhTC targets HIV-2 capsid with weak affinity, which is strongly increased in RhTC by two ..
  5. Seizer P, Schonberger T, Schött M, Lang M, Langer H, Bigalke B, et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis. 2010;209:51-7 pubmed publisher
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/macrophages and CD34(+) progenitor cells...
  6. Agarwal P, Geist A, Gorin A. Protein dynamics and enzymatic catalysis: investigating the peptidyl-prolyl cis-trans isomerization activity of cyclophilin A. Biochemistry. 2004;43:10605-18 pubmed
    ..of protein dynamics in the detailed mechanism of peptidyl-prolyl cis-trans isomerization catalyzed by human cyclophilin A. The results identify a network of protein vibrations, extending from surface regions of the enzyme to the ..
  7. Berube J, Bouchard A, Berthoux L. Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells. Retrovirology. 2007;4:68 pubmed
    ..We speculate that an unknown factor required for TRIM5alpha and TRIMCyp activity is missing or inadequately expressed in D17 cells. ..
  8. Ciesek S, Steinmann E, Wedemeyer H, Manns M, Neyts J, Tautz N, et al. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A. Hepatology. 2009;50:1638-45 pubmed publisher
    ..This effect is dependent on the presence of NS2 in the viral polyprotein and mediated through cellular cyclophilin A. NS2 is either an additional target for CsA-dependent inhibition or modulates the antiviral activity against ..
  9. Fernandes F, Ansari I, Striker R. Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A. PLoS ONE. 2010;5:e9815 pubmed publisher
    ..Additionally, we demonstrated a novel CsA-sensitive interaction between NS5A and both cyclophilin A and B. Both the mutant NS5A and wild type NS5A bind cyclophilin in vitro...

More Information

Publications108 found, 100 shown here

  1. He H, Zhou D, Fan W, Fu X, Zhang J, Shen Z, et al. Cyclophilin A inhibits rotavirus replication by facilitating host IFN-I production. Biochem Biophys Res Commun. 2012;422:664-9 pubmed publisher
    ..Our previous study revealed that cyclophilin A (CYPA), a peptidyl-prolyl cis-trans isomerase (PPIase), could be temporarily upregulated in RV-infected MA104 ..
  2. Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schumperli D. Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A. Nucleic Acids Res. 2004;32:3752-9 pubmed
    Human immunodeficiency virus 1 (HIV-1) multiplication depends on a cellular protein, cyclophilin A (CyPA), that gets integrated into viral particles...
  3. Wissing S, Ludovico P, Herker E, Buttner S, Engelhardt S, Decker T, et al. An AIF orthologue regulates apoptosis in yeast. J Cell Biol. 2004;166:969-74 pubmed
    ..stimulates apoptotic cell death induced by hydrogen peroxide and this effect is attenuated by disruption of cyclophilin A or the yeast caspase YCA1...
  4. Javanbakht H, Diaz Griffero F, Yuan W, Yeung D, Li X, Song B, et al. The ability of multimerized cyclophilin A to restrict retrovirus infection. Virology. 2007;367:19-29 pubmed
    ..of the TRIM5 RING, B-box 2 and coiled-coil domains, as well as the intervening linker regions, fused with cyclophilin A. TRIMCyp restricts infection of retroviruses, such as human immunodeficiency virus (HIV-1) and feline ..
  5. Dietrich I, MacIntyre A, McMonagle E, Price A, James L, McEwan W, et al. Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion. J Virol. 2010;84:8980-5 pubmed publisher
    A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells...
  6. Li Y, Kar A, Sodroski J. Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A. J Virol. 2009;83:10951-62 pubmed publisher
    The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells...
  7. Yang F, Robotham J, Grise H, Frausto S, Madan V, Zayas M, et al. A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PLoS Pathog. 2010;6:e1001118 pubmed publisher
    ..One such cofactor is cyclophilin A (CyPA), upon which hepatitis C virus (HCV) replication critically depends...
  8. Nigro P, Satoh K, O Dell M, Soe N, Cui Z, Mohan A, et al. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2011;208:53-66 pubmed publisher
    b>Cyclophilin A (CyPA; encoded by Ppia) is a ubiquitously expressed protein secreted in response to inflammatory stimuli...
  9. Rosnoblet C, Fritzinger B, Legrand D, Launay H, Wieruszeski J, Lippens G, et al. Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A. J Biol Chem. 2012;287:44249-60 pubmed publisher
    ..HCV replication occurs in a membrane-associated multiprotein complex in which HCV NS5A and host cyclophilin A (CypA) have been shown to be present together with the viral polymerase...
  10. Damsker J, Bukrinsky M, Constant S. Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A. J Leukoc Biol. 2007;82:613-8 pubmed
    ..CD147 has been identified as the main signaling receptor for cyclophilin A (CypA) on human leukocytes...
  11. Bosco D, Eisenmesser E, Clarkson M, Wolf Watz M, Labeikovsky W, Millet O, et al. Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR. J Mol Biol. 2010;403:723-38 pubmed publisher
    ..Employing the cyclophilin A PPIase together with its biologically relevant and natively folded substrate, the N-terminal domain of the ..
  12. Seizer P, Klingel K, Sauter M, Westermann D, Ochmann C, Schonberger T, et al. Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. J Mol Cell Cardiol. 2012;53:6-14 pubmed publisher
    Extracellular cyclophilin A (CyPA) and its receptor Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) modulate inflammatory processes beyond metalloproteinase (MMP) activity...
  13. Solbak S, Reksten T, Wray V, Bruns K, Horvli O, Raae A, et al. The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. BMC Struct Biol. 2010;10:31 pubmed publisher
    b>Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication, although the mechanism through which CypA modulates HIV-1 ..
  14. Kovalev N, Nagy P. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. J Virol. 2013;87:13330-42 pubmed publisher
    ..In this report, we further characterize single-domain cyclophilins, including the mammalian cyclophilin A and plant Roc1 and Roc2, which are orthologs of the yeast Cpr1p cyclophilin, a known inhibitor of TBSV ..
  15. Keckesova Z, Ylinen L, Towers G. Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J Virol. 2006;80:4683-90 pubmed
    ..Here we investigate the role of the peptidyl prolyl isomerase enzyme cyclophilin A in TRIM5alpha antiviral activity...
  16. Lin T, Emerman M. Cyclophilin A interacts with diverse lentiviral capsids. Retrovirology. 2006;3:70 pubmed
    The capsid (CA) protein of HIV-1 binds with high affinity to the host protein cyclophilin A (CypA)...
  17. Lou J, Fatima N, Xiao Z, Stauffer S, Smythers G, Greenwald P, et al. Proteomic profiling identifies cyclooxygenase-2-independent global proteomic changes by celecoxib in colorectal cancer cells. Cancer Epidemiol Biomarkers Prev. 2006;15:1598-606 pubmed
    ..Our study presents a comprehensive analysis of large-scale celecoxib-modulated proteomic alterations, at least some of which may be mechanistically related to the COX-2-independent chemopreventive effect of celecoxib. ..
  18. Howard B, Furumai R, Campa M, Rabbani Z, Vujaskovic Z, Wang X, et al. Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. Cancer Res. 2005;65:8853-60 pubmed
    b>Cyclophilin A (CypA) was recently reported to be overexpressed in non-small-cell lung cancer, and represents a potentially novel therapeutic target...
  19. Leone V, Lattanzi G, Molteni C, Carloni P. Mechanism of action of cyclophilin a explored by metadynamics simulations. PLoS Comput Biol. 2009;5:e1000309 pubmed publisher
    ..protein (CA), such a process takes place in the uncoating and recruitment of the virion and is catalyzed by cyclophilin A (CypA)...
  20. Stremlau M, Song B, Javanbakht H, Perron M, Sodroski J. Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. Virology. 2006;351:112-20 pubmed
    b>Cyclophilin A (Cyp A) binds the human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein and contributes to the early events in virus replication in some cells...
  21. Spisni E, Valerii M, Manerba M, Strillacci A, Polazzi E, Mattia T, et al. Effect of copper on extracellular levels of key pro-inflammatory molecules in hypothalamic GN11 and primary neurons. Neurotoxicology. 2009;30:605-12 pubmed publisher
    ..affects the secretion of molecules involved in the protection of neurons against oxidative stress, such as cyclophilin A (CypA), or of molecules capable of shifting neuronal cells towards a pro-inflammatory state, such as IL-1alpha,..
  22. Kuglstatter A, Mueller F, Kusznir E, Gsell B, Stihle M, Thoma R, et al. Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin). Acta Crystallogr D Biol Crystallogr. 2011;67:119-23 pubmed publisher
    ..The X-ray crystal structures of E-ISA247 and its stereoisomer Z-ISA247 bound to cyclophilin A have been determined and their binding affinities were measured to be 15 and 61?nM, respectively, by ..
  23. Elvers M, Herrmann A, Seizer P, Münzer P, Beck S, Schonberger T, et al. Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation. Blood. 2012;120:1317-26 pubmed publisher
    ..In the present study, we show for the first time that the chaperone protein cyclophilin A (CyPA) acts as a Ca(2+) modulator in platelets...
  24. Ylinen L, Price A, Rasaiyaah J, Hue S, Rose N, Marzetta F, et al. Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity. PLoS Pathog. 2010;6:e1001062 pubmed publisher
    ..Our results suggest that lentiviruses may have been important pathogens in Asian macaques despite the fact that there are no reported lentiviral infections in current macaque populations. ..
  25. Schaller T, Ocwieja K, Rasaiyaah J, Price A, Brady T, Roth S, et al. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 2011;7:e1002439 pubmed publisher
    ..Our findings link HIV-1 engagement of cyclophilins with both integration targeting and replication efficiency and provide insight into the conservation of viral cyclophilin recruitment. ..
  26. Yang Y, Moir E, Kontopidis G, Taylor P, Wear M, Malone K, et al. Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans. Biochem Biophys Res Commun. 2007;363:1013-9 pubmed
    ..a conserved 'ball and socket' binding mode with a dimethyl group in the hydrophobic binding pocket of human cyclophilin A (CypA) mimicking a key interaction of the natural inhibitor cyclosporin A (CsA)...
  27. Lo W, Tsai F, Liu C, Tang N, Su S, Lin S, et al. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Am J Chin Med. 2010;38:745-59 pubmed
    ..The results indicated that macrophage migration inhibitory factor (MIF) and cyclophilin A were under expressed in frontal cortex by an average of 0.19- and 0.23-fold, respectively...
  28. Huang C, Sun Z, Zhao Y, Chen X, Jia J, Zhang W. Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue. Oral Dis. 2011;17:328-34 pubmed publisher
    The aim of this study was to assess the expression levels of two proteins, such as PRDX6 and cyclophilin A (CypA), and to evaluate their relationship with clinicopathologic features and survival in tongue squamous cell carcinomas (TSCCs).
  29. Pacheco B, Finzi A, Stremlau M, Sodroski J. Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5?. Virology. 2010;408:204-12 pubmed publisher
    ..The capsid of the escape virus exhibited a reduced affinity for TRIM5?(rh), but retained the ability to bind cyclophilin A efficiently...
  30. Lee M, Kim D, Sohn E, Jeong H, Shin M, Kang H, et al. Anti-inflammatory effect of transduced PEP-1-cyclophilin A in Raw264.7 cells and 12-O-tetradecanoylphorbol-13-acetate-induced mice. Life Sci. 2011;89:896-904 pubmed publisher
    b>Cyclophilin A (CypA) is an immunophilin that acts as a receptor for the immunosuppressant drug cyclosporine A (CsA)...
  31. Wang M, Shetty J, Howard B, Campa M, Patz E, Fitzgerald M. Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate. Anal Chem. 2004;76:4343-8 pubmed
    ..e., K(d) value) were determined for the binding of cyclosporin A (CsA) to a cyclophilin A (CypA) sample in which the protein was a component of a tissue lysate derived from fresh frozen lung tumor...
  32. Saini M, Potash M. Novel activities of cyclophilin A and cyclosporin A during HIV-1 infection of primary lymphocytes and macrophages. J Immunol. 2006;177:443-9 pubmed
    Studies conducted in cell lines indicate that cyclophilin A (CypA) is a component of HIV type 1 (HIV-1) virions, and that when CypA incorporation into virions is inhibited by treatment of infected cells with the immunosuppressive agent ..
  33. Song F, Zhang X, Ren X, Zhu P, Xu J, Wang L, et al. Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147. J Biol Chem. 2011;286:8197-203 pubmed publisher
    b>Cyclophilin A (CyPA) is a ubiquitously distributed peptidylprolyl cis-trans isomerase (PPIase) that possesses diverse biological functions...
  34. Li J, Zhuang W, Cong L, Shi W, Cai X, Huang F, et al. Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice. Parasit Vectors. 2013;6:330 pubmed publisher
    ..A cyclophilin A homologue of Schistosoma japonicum was reported to be an egg-stage specific antigen, but its immunogenicity ..
  35. Noser J, Towers G, Sakuma R, Dumont J, Collins M, Ikeda Y. Cyclosporine increases human immunodeficiency virus type 1 vector transduction of primary mouse cells. J Virol. 2006;80:7769-74 pubmed
    ..Sensitivity to TRIM5alpha is altered by interactions between cyclophilin A and the HIV-1 capsid...
  36. Li J, Xie H, Yi M, Peng L, Lei D, Chen X, et al. Expression of cyclophilin A and CD147 during skin aging. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:203-11 pubmed publisher
    To investigate the role of cyclophilin A (CypA) and CD147 in the process of skin aging...
  37. Seizer P, Ochmann C, Schonberger T, Zach S, Rose M, Borst O, et al. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler Thromb Vasc Biol. 2011;31:1377-86 pubmed publisher
    ..The extracellular matrix metalloproteinase inducer EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) may be involved in both processes...
  38. Berthoux L, Sebastian S, Sokolskaja E, Luban J. Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA. J Virol. 2004;78:11739-50 pubmed
    ..to restriction by Lv1 maps to a region of the HIV-1 CA required for interaction with the cellular protein cyclophilin A. A similar antiviral activity in mammalian cells, Ref1, inhibits reverse transcription of murine leukemia ..
  39. Yang H, Li M, Chai H, Yan S, Lin P, Lumsden A, et al. Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. J Surg Res. 2005;123:312-9 pubmed
    b>Cyclophilin A (CypA) is a cytosolic protein which involves many biological functions including immune modulation, cell growth, tumorigenesis, and vascular disease...
  40. Colgan J, Asmal M, Yu B, Luban J. Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol. 2005;174:6030-8 pubmed
    ..of cyclosporine on immune cells and mice lacking Ppia, the gene encoding the prototypical cyclophilin protein cyclophilin A. TCR-induced proliferation and signal transduction by Ppia(-/-) CD4(+) T cells were resistant to cyclosporine, ..
  41. Rits M, van Dort K, Kootstra N. Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection. PLoS ONE. 2008;3:e3975 pubmed publisher
    Previous studies have demonstrated an association between polymorphisms in the regulatory regions of Cyclophilin A (CypA) and susceptibility to both HIV-1 infection and disease progression...
  42. Lammers M, Neumann H, Chin J, James L. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010;6:331-7 pubmed publisher
    b>Cyclophilin A (CypA) is a ubiquitous cis-trans prolyl isomerase with key roles in immunity and viral infection...
  43. Fischer G, Gallay P, Hopkins S. Cyclophilin inhibitors for the treatment of HCV infection. Curr Opin Investig Drugs. 2010;11:911-8 pubmed
  44. Mittal N, Voldman J. Nonmitogenic survival-enhancing autocrine factors including cyclophilin A contribute to density-dependent mouse embryonic stem cell growth. Stem Cell Res. 2011;6:168-76 pubmed publisher
    ..Proteomic analysis of proteins secreted by mouse ESCs demonstrates significant levels of cyclophilin A which increases the growth rate of mouse ESCs in a dose-dependent manner...
  45. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, et al. Plasma cyclophilin A is a novel biomarker for coronary artery disease. Circ J. 2013;77:447-55 pubmed
    Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice...
  46. Gatanaga H, Das D, Suzuki Y, Yeh D, Hussain K, Ghosh A, et al. Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop. J Biol Chem. 2006;281:1241-50 pubmed
    HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness. Among the amino acid substitutions identified in Gag noncleavage sites in HIV-1 variants resistant to protease inhibitors, H219Q (Gatanaga, H...
  47. Sokolskaja E, Berthoux L, Luban J. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol. 2006;80:2855-62 pubmed
    b>Cyclophilin A (CypA), a cytoplasmic, human immunodeficiency virus type 1 (HIV-1) CA-binding protein, acts after virion membrane fusion with human cells to increase HIV-1 infectivity...
  48. Suzuki J, Jin Z, Meoli D, Matoba T, Berk B. Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells. Circ Res. 2006;98:811-7 pubmed
    ..Previously we demonstrated that cyclophilin A (CyPA) is a secreted oxidative stress-induced factor (SOXF) that promotes inflammation, VSMC growth, and ..
  49. Flisiak R, Horban A, Gallay P, Bobardt M, Selvarajah S, Wiercinska Drapalo A, et al. The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology. 2008;47:817-26 pubmed publisher
    ..These are the first preliminary human data supporting the hypothesis that CypB may play an important role in hepatitis C virus replication and that Cyp inhibition is a valid target for the development of anti-hepatitis C drugs. ..
  50. Hanoulle X, Badillo A, Wieruszeski J, Verdegem D, Landrieu I, Bartenschlager R, et al. Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J Biol Chem. 2009;284:13589-601 pubmed publisher
    ..NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB. ..
  51. Waller H, Chatterji U, Gallay P, Parkinson T, Targett Adams P. The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A. J Virol Methods. 2010;165:202-10 pubmed publisher
    ..CsA inhibits isomerase activity of cellular-encoded cyclophilin proteins, of which cyclophilin A (CypA) in particular is required for HCV replication...
  52. Kaiser E, Kroll C, Ernst K, Schwan C, Popoff M, Fischer G, et al. Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90. Infect Immun. 2011;79:3913-21 pubmed publisher
    ..Moreover, CDTa and Ia, the enzyme component of iota-toxin, specifically bound to immobilized Hsp90 and cyclophilin A in vitro. In combination with our recently obtained data on the C2 toxin from C...
  53. Takapoo M, Chamseddine A, Bhalla R, Miller F. Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. Vascul Pharmacol. 2011;55:143-8 pubmed publisher
    ..In response to oxidative stress, smooth muscle cells (SMCs) secrete the pro-inflammatory immunomodulator cyclophilin A (CyPA)...
  54. Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012;424:647-50 pubmed publisher
    b>Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A...
  55. Luo C, Luo H, Zheng S, Gui C, Yue L, Yu C, et al. Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Biochem Biophys Res Commun. 2004;321:557-65 pubmed
    ..Protein-protein interaction analysis using bioinformatics tools indicated that SARS_NP may bind to human cyclophilin A (hCypA), and surface plasmon resonance (SPR) technology revealed this binding with the equilibrium ..
  56. Qi M, Aiken C. Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology. 2008;373:287-97 pubmed publisher
    ..role of virion-associated Nef in HIV-1 infection, we generated a fusion protein consisting of the host protein cyclophilin A (CypA) linked to the amino terminus of Nef...
  57. Newman R, Hall L, Kirmaier A, Pozzi L, Pery E, Farzan M, et al. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathog. 2008;4:e1000003 pubmed publisher
    ..Whether the formation of novel genes through alternative splicing has played a wider role in the evolution of the TRIM family remains to be investigated...
  58. Chatterji U, Bobardt M, Selvarajah S, Yang F, Tang H, Sakamoto N, et al. The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. J Biol Chem. 2009;284:16998-7005 pubmed publisher
    ..The study of the roles of Cyps in HCV replication should lead to the identification of new targets for the development of alternate anti-HCV therapies. ..
  59. Zhang B, Wang C, Wang Y, Fan C, Zhu P. [The role of CyPA in chemotaxis of neutrophil in rheumatoid arthritis and secretion of interleukin-8]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:423-5 pubmed
    ..CyPA could affect the chemotaxis of IL-8 in the neutrophil of RA patients' peripheral blood. The secretion of IL-8 is accelerated by CyPA on neutrophil of RA patients'peripheral blood. ..
  60. Tamesa M, Kuramitsu Y, Fujimoto M, Maeda N, Nagashima Y, Tanaka T, et al. Detection of autoantibodies against cyclophilin A and triosephosphate isomerase in sera from breast cancer patients by proteomic analysis. Electrophoresis. 2009;30:2168-81 pubmed publisher
    ..The matched protein spots on 2-DE gels were digested and used for LC-MS/MS analysis, and identified as cyclophilin A (peptidyl-prolyl cis-trans isomerase A), triosephosphate isomerase and ubiquitin-conjugating enzyme E2N...
  61. Satoh K, Shimokawa H, Berk B. Cyclophilin A: promising new target in cardiovascular therapy. Circ J. 2010;74:2249-56 pubmed
    b>Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer...
  62. Han H, Peng J, Hong Y, Fu Z, Xu J, Lin J, et al. Molecular cloning and characterization of a cyclophilin A homologue from Schistosoma japonicum. Parasitol Res. 2012;111:807-17 pubmed publisher
    ..In the present study, Sj cyclophilin A (CyPA) was cloned, characterized, and subcloned into a prokaryotic expression vector to produce soluble ..
  63. Colgan J, Asmal M, Neagu M, Yu B, Schneidkraut J, Lee Y, et al. Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity. 2004;21:189-201 pubmed
    b>Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin...
  64. Semba S, Huebner K. Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression. Mol Cancer Res. 2006;4:529-38 pubmed
    ..proteins that exhibited 4-fold differences in expression on comparison of the two infected cell lysates, cyclophilin A, the intracellular reporter of the immunosuppressive drug cyclosporine A, showed a remarkably decreased ..
  65. Zhao C, Fang C, Tian X, Wang L, Yang P, Wen Y. Proteomic analysis of hepatitis B surface antigen positive transgenic mouse liver and decrease of cyclophilin A. J Med Virol. 2007;79:1478-84 pubmed
    ..Among these proteins, cyclophilin A (CypA), the major target for the potent immunosuppressive drug cyclosporin A, was found decreased in HBsAg ..
  66. Chatterji U, Bobardt M, Lim P, Gallay P. Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes. J Gen Virol. 2010;91:1189-93 pubmed publisher
    The mechanisms by which cyclophilin A (CypA) governs hepatitis C virus (HCV) replication remain unknown...
  67. Wang W, Yuan Y, Xue F, Liao X, Wang Q, Xiong J, et al. Extracellular cyclophilin A may be a potential target to protect against myocardial reperfusion injury. Med Hypotheses. 2011;77:734-8 pubmed publisher
    ..Recently, the extracellular cyclophilin A (CypA) has been showed to play an important role in initiation and development of inflammation by chemo ..
  68. Dear J, Simpson K, Nicolai M, Catterson J, Street J, Huizinga T, et al. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol. 2011;187:3347-52 pubmed publisher
    ..b>Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when released by cells...
  69. Obchoei S, Weakley S, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, et al. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011;10:102 pubmed publisher
    b>Cyclophilin A (CypA) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of CypA in liver fluke-associated cholangiocarcinoma (CCA) are not presently known...
  70. Yu G, Wan R, Hu Y, Ni J, Yin G, Xing M, et al. Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-?B pathway in experimental pancreatitis. Biochem Biophys Res Commun. 2014;444:75-80 pubmed publisher
    ..Recent studies have shown that Cyclophilin A (CypA) released from necrotic cells is involved in the pathogenesis of several inflammatory diseases...
  71. Li J, Chen J, Gui C, Zhang L, Qin Y, Xu Q, et al. Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. Bioorg Med Chem. 2006;14:2209-24 pubmed
    b>Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis-trans isomerases (PPIases), which can bind to cyclosporin A (CsA)...
  72. Diaz Griffero F, Vandegraaff N, Li Y, McGee Estrada K, Stremlau M, Welikala S, et al. Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology. 2006;351:404-19 pubmed
    ..TRIM5alpha with one encoding TRIMCyp, a fusion between the RING, B-box 2 and coiled-coil domains of TRIM5 and cyclophilin A. TRIMCyp restricts human immunodeficiency virus (HIV-1) infection by a mechanism dependent on the interaction ..
  73. Abdurahman S, Höglund S, Höglund A, Vahlne A. Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity. Retrovirology. 2007;4:19 pubmed
    ..Glu98, which is located on a surface of a flexible cyclophilin A binding loop is not involved in any intra-molecular contacts with other CA residues...
  74. Yang H, Chen J, Yang J, Qiao S, Zhao S, Yu L. Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal. Biochem Biophys Res Commun. 2007;361:763-7 pubmed
    b>Cyclophilin A (CypA), a peptidyl-prolyl cis-trans isomerase (PPIase), was originally identified as the intracellular receptor for cyclosporin A (CsA). Recently, correlations of CypA with tumor pathogenesis have been studied...
  75. Pushkarsky T, Yurchenko V, Laborico A, Bukrinsky M. CD147 stimulates HIV-1 infection in a signal-independent fashion. Biochem Biophys Res Commun. 2007;363:495-9 pubmed
    ..activation of extracellular-signal regulated kinase 1 and 2 (ERK1/2) in response to stimulation with cyclophilin A (CypA)...
  76. Lin T, Emerman M. Determinants of cyclophilin A-dependent TRIM5 alpha restriction against HIV-1. Virology. 2008;379:335-41 pubmed publisher
    ..The CA protein of HIV-1 also interacts with high affinity to the host protein cyclophilin A (CypA)...
  77. Neagu M, Ziegler P, Pertel T, Strambio de Castillia C, Grütter C, Martinetti G, et al. Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 2009;119:3035-47 pubmed publisher
    ..of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infection...
  78. Satoh K, Nigro P, Berk B. Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal. 2010;12:675-82 pubmed publisher
    ..b>Cyclophilin A (CyPA) is a 20 kD chaperone protein that is secreted from vascular smooth muscle cells (VSMC) in response to ..
  79. Tribouillard Tanvier D, Carroll J, Moore R, Striebel J, Chesebro B. Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro. J Biol Chem. 2012;287:4628-39 pubmed publisher
    ..This stimulation was greatly reduced both by antibody to cyclophilin A (CyPA), a known mediator of inflammation in peripheral tissues, and by cyclosporine A, a CyPA inhibitor...
  80. Bell R, Winkler E, Singh I, Sagare A, Deane R, Wu Z, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012;485:512-6 pubmed publisher
    ..Using different APOE transgenic mice, including mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of APOE4 and lack of murine Apoe, but not APOE2 and APOE3, leads to BBB ..
  81. Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, et al. Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology. 2005;129:1031-41 pubmed
    ..The anti-HCV activity of cyclosporin A is mediated through a specific blockade of cyclophilins, and these molecules may constitute novel targets for anti-HCV therapeutics. ..
  82. Ghezzi P, Casagrande S, Massignan T, Basso M, Bellacchio E, Mollica L, et al. Redox regulation of cyclophilin A by glutathionylation. Proteomics. 2006;6:817-25 pubmed
    ..redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation...
  83. Weintraub N. Understanding abdominal aortic aneurysm. N Engl J Med. 2009;361:1114-6 pubmed publisher
  84. Bonfils C, Bec N, Larroque C, Del Rio M, Gongora C, Pugniere M, et al. Cyclophilin A as negative regulator of apoptosis by sequestering cytochrome c. Biochem Biophys Res Commun. 2010;393:325-30 pubmed publisher
    ..There are increasing evidence indicating that cyclophilin A is highly expressed in many tumors and cell lines where it exerts an anti-apoptotic function...
  85. Kim I, Kim H, Shin S, Kim Y, Lee D, Park K, et al. A cyclophilin A CPR1 overexpression enhances stress acquisition in Saccharomyces cerevisiae. Mol Cells. 2010;29:567-74 pubmed publisher
    ..We found the expression of cyclophilin A, Cpr1, changes in response to exposure to yeast Saccharomyces cerevisiae to abiotic stress conditions...
  86. Verdegem D, Badillo A, Wieruszeski J, Landrieu I, Leroy A, Bartenschlager R, et al. Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. J Biol Chem. 2011;286:20441-54 pubmed publisher
    ..inhibitors have been mapped into NS5A-D3, we also investigated the functional interaction between NS5A-D3 and cyclophilin A (CypA). CypA indeed interacts with NS5A-D3, and this interaction is completely abolished by cyclosporin A...
  87. Zhang M, Dai C, Zhu H, Chen S, Wu Y, Li Q, et al. Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. Mol Cell Biochem. 2011;357:387-95 pubmed publisher
    b>Cyclophilin A (CypA) is a member of peptidyl prolyl isomerases (PPIases), which catalyze the cis/trans isomerization of prolyl peptide bonds on the NH-terminal side of Pro residues in peptide chains...
  88. Yan J, Zang X, Chen R, Yuan W, Gong J, Wang C, et al. The clinical implications of increased cyclophilin A levels in patients with acute coronary syndromes. Clin Chim Acta. 2012;413:691-5 pubmed publisher
    b>Cyclophilin A is a secreted molecule that has a physiological and pathological role in cardiovascular diseases...
  89. von Hahn T, Schiene Fischer C, Van N, Pfaender S, Karavul B, Steinmann E, et al. Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication. Gastroenterology. 2012;143:439-47.e1 pubmed publisher
    Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development...
  90. Liu X, Zhao Z, Liu W. Insights into the roles of cyclophilin A during influenza virus infection. Viruses. 2013;5:182-91 pubmed publisher
    b>Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis...
  91. Li J, Zhang J, Chen J, Luo X, Zhu W, Shen J, et al. Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay. J Comb Chem. 2006;8:326-37 pubmed
    The discovery of cyclophilin A (CypA) inhibitor is now of special interest in the treatment of immunological disorders...
  92. Li Y, Li X, Stremlau M, Lee M, Sodroski J. Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection. J Virol. 2006;80:6738-44 pubmed
    ..A change in the cyclophilin A-binding loop of the HIV-1 capsid decreased TRIM5alpha(hu) R332P binding and allowed escape from restriction...