neprilysin

Summary

Summary: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Top Publications

  1. Huang H, Bihaqi S, Cui L, Zawia N. In vitro Pb exposure disturbs the balance between A? production and elimination: the role of A?PP and neprilysin. Neurotoxicology. 2011;32:300-6 pubmed publisher
    ..b>Neprilysin (NEP), a rate-limiting catabolic peptidase is involved in A? metabolism in vivo...
  2. Standeven K, Hess K, Carter A, Rice G, Cordell P, Balmforth A, et al. Neprilysin, obesity and the metabolic syndrome. Int J Obes (Lond). 2011;35:1031-40 pubmed publisher
    b>Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism...
  3. Vardeny O, Tacheny T, Solomon S. First-in-class angiotensin receptor neprilysin inhibitor in heart failure. Clin Pharmacol Ther. 2013;94:445-8 pubmed publisher
    b>Neprilysin inhibitors augment the natriuretic peptide system by preventing the breakdown of atrial natriuretic peptide and B-type natriuretic peptide...
  4. Miners J, Barua N, Kehoe P, Gill S, Love S. A?-degrading enzymes: potential for treatment of Alzheimer disease. J Neuropathol Exp Neurol. 2011;70:944-59 pubmed publisher
    ..Several A?-degrading enzymes, including neprilysin (NEP), insulin-degrading enzyme, and endothelin-converting enzyme reduce A? levels and protect against cognitive ..
  5. Chambers J, Kuribayashi H, Ikeda S, Une Y. Distribution of neprilysin and deposit patterns of Abeta subtypes in the brains of aged squirrel monkeys (Saimiri sciureus). Amyloid. 2010;17:75-82 pubmed publisher
    ..of deposition of two Abeta subtypes (Abeta40 and Abeta42) and the distribution of the Abeta degrading enzyme neprilysin (NEP) in the brains of aged squirrel monkeys, a species known to develop CAA and SPs...
  6. Oba J, Nakahara T, Hayashida S, Kido M, Xie L, Takahara M, et al. Expression of CD10 predicts tumor progression and unfavorable prognosis in malignant melanoma. J Am Acad Dermatol. 2011;65:1152-60 pubmed publisher
    ..The major limitation was the small sample size. CD10 expression may serve as a progression marker and can predict unfavorable prognosis in patients with MM. ..
  7. Bauer C, Pardossi Piquard R, Dunys J, Roy M, Checler F. ?-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib. J Alzheimers Dis. 2011;27:511-20 pubmed publisher
    ..The ectopeptidase, neprilysin (NEP), has been reported as the major A?-degrading enzyme in mice and human brains...
  8. Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, et al. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci Rep. 2013;3:1472 pubmed publisher
    ..Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease A? in AD-model mice, but more efficient ..
  9. Miners J, Morris S, Love S, Kehoe P. Accumulation of insoluble amyloid-? in down's syndrome is associated with increased BACE-1 and neprilysin activities. J Alzheimers Dis. 2011;23:101-8 pubmed publisher
    ..disease (AD)-related increases in the activities of ?-secretase (BACE-1) and A?-degrading enzymes including neprilysin (NEP) and angiotensin-converting enzyme (ACE) in the frontal cortex...

More Information

Publications62

  1. Walker J, Pacoma R, Watson J, Ou W, Alves J, Mason D, et al. Enhanced proteolytic clearance of plasma A? by peripherally administered neprilysin does not result in reduced levels of brain A? in mice. J Neurosci. 2013;33:2457-64 pubmed publisher
    ..b>Neprilysin (NEP) is a zinc-dependent metalloprotease that is one of the key A?-degrading enzymes in the brain...
  2. Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki K, Oki K, et al. Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep. 2013;3:1197 pubmed publisher
    ..b>Neprilysin (NEP) is the most important A?-degrading enzyme in the brain...
  3. Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, et al. Localization of mature neprilysin in lipid rafts. J Neurosci Res. 2012;90:870-7 pubmed publisher
    ..Moreover, the ablation of cholesterol metabolism has been implicated in AD. Neprilysin (NEP), a neutral endopeptidase, is one of the major A?-degrading enzymes in the brain...
  4. Miners J, Kehoe P, Love S. Neprilysin protects against cerebral amyloid angiopathy and A?-induced degeneration of cerebrovascular smooth muscle cells. Brain Pathol. 2011;21:594-605 pubmed publisher
    b>Neprilysin (NEP), which degrades amyloid-? (A?), is expressed by neurons and cerebrovascular smooth muscle cells (CVSMCs)...
  5. Siepmann M, Kumar S, Mayer G, Walter J. Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt. PLoS ONE. 2010;5: pubmed publisher
    b>Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction...
  6. Ichii M, Oritani K, Yokota T, Zhang Q, Garrett K, Kanakura Y, et al. The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage. PLoS ONE. 2010;5:e12954 pubmed publisher
    ..CD34(+) CD10(Hi) progenitors are obviously in the B lineage but may have progressed beyond the point where they can be expanded in culture. ..
  7. Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee D, et al. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J Neurosci. 2010;30:9651-8 pubmed publisher
    ..weekly infusions of the CD11b+ bone marrow cells transfected with a genetically engineered form of the protease neprilysin completely arrest amyloid deposition in an aggressively depositing transgenic model...
  8. Liu Y, Studzinski C, Beckett T, Murphy M, Klein R, Hersh L. Circulating neprilysin clears brain amyloid. Mol Cell Neurosci. 2010;45:101-7 pubmed publisher
    The use of the peptidase neprilysin (NEP) as a therapeutic for lowering brain amyloid burden is receiving increasing attention...
  9. Sexton T, Hitchcook L, Rodgers D, Bradley L, Hersh L. Active site mutations change the cleavage specificity of neprilysin. PLoS ONE. 2012;7:e32343 pubmed publisher
    b>Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides...
  10. Wayman C, Baxter D, Turner L, van der Graaf P, Naylor A. UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit. Br J Pharmacol. 2010;160:51-9 pubmed publisher
    ..This suggests that the endogenous neurotransmitter mediating genital blood flow is a substrate for NEP (most likely VIP). NEP inhibitors may restore sexual arousal in women adversely affected by female sexual arousal disorder. ..
  11. Maguer Satta V, Besancon R, Bachelard Cascales E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem Cells. 2011;29:389-96 pubmed publisher
    ..This highlights the importance of understanding the role of CD10 in cancer SC. We will review the characteristics, main functions, and mechanism of action of CD10. Finally, we will review its clinical use and involvement in cancer. ..
  12. Hafez D, Huang J, Huynh A, Valtierra S, Rockenstein E, Bruno A, et al. Neprilysin-2 is an important ?-amyloid degrading enzyme. Am J Pathol. 2011;178:306-12 pubmed publisher
    ..The A?-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors...
  13. Wick M, Buesing E, Wehling C, Loomis Z, Cool C, Zamora M, et al. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183:330-40 pubmed publisher
    Studies with genetically engineered mice showed that decreased expression of the transmembrane peptidase neprilysin (NEP) increases susceptibility to hypoxic pulmonary vascular remodeling and hypertension; in hypoxic wild-type mice, ..
  14. Wang Z, Yang D, Zhang X, Li T, Li J, Tang Y, et al. Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons. PLoS ONE. 2011;6:e19229 pubmed publisher
    ..A? metabolism is a dynamic process in the A? production and clearance that requires neprilysin (NEP) and other enzymes to degrade A?...
  15. Klein C, Patte Mensah C, Taleb O, Bourguignon J, Schmitt M, Bihel F, et al. The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction. Neuropharmacology. 2013;70:254-60 pubmed publisher
    ..and pharmacological approaches to demonstrate that low micromolar concentrations of KYNA strongly induce neprilysin (NEP) gene expression, protein level and enzymatic activity increase in human neuroblastoma SH-SY5Y cells...
  16. Morisaki N, Moriwaki S, Sugiyama Nakagiri Y, Haketa K, Takema Y, Imokawa G. Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. J Biol Chem. 2010;285:39819-27 pubmed publisher
    ..As there are similarities in the molecular weights and inhibitory profiles of HSF elastase and neprilysin (neutral endopeptidase 24...
  17. Spencer B, Marr R, Gindi R, Potkar R, Michael S, Adame A, et al. Peripheral delivery of a CNS targeted, metalo-protease reduces a? toxicity in a mouse model of Alzheimer's disease. PLoS ONE. 2011;6:e16575 pubmed publisher
    ..We generated a lentivirus vector expressing the amyloid ?-degrading enzyme, neprilysin, fused to the ApoB transport domain and delivered this by intra-peritoneal injection to amyloid protein ..
  18. Fleischmann A, Rocha C, Saxer Sekulic N, Zlobec I, Sauter G, Thalmann G. High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death. Virchows Arch. 2011;458:741-8 pubmed publisher
    ..In conclusion, a high CD10 expression in prostate cancer predicts early death. This information is inherent in the primary tumors and in the lymph node metastases and might help to personalize patient management. ..
  19. Henderson S, Andersson C, Narwal R, Janson J, Goldschmidt T, Appelkvist P, et al. Sustained peripheral depletion of amyloid-? with a novel form of neprilysin does not affect central levels of amyloid-?. Brain. 2014;137:553-64 pubmed publisher
    ..Here we describe the use of an amyloid-? degrading enzyme, the endogenous metallopeptidase neprilysin, which is fused to albumin to extend plasma half-life and has been engineered to confer increased amyloid-? ..
  20. Morisaki N, Ohuchi A, Moriwaki S. The role of neprilysin in regulating the hair cycle. PLoS ONE. 2013;8:e55947 pubmed publisher
    ..Since our previous study identified skin fibroblast elastase as neprilysin (NEP), we examined the fluctuation of NEP enzyme activity and its expression during the synchronized hair cycle ..
  21. Maetzler W, Stoycheva V, Schmid B, Schulte C, Hauser A, Brockmann K, et al. Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-?42 levels in Lewy body disease. J Alzheimers Dis. 2010;22:933-8 pubmed publisher
    ..b>Neprilysin (NEP) is an A?-degrading protein found at presynaptic terminals and in body fluids...
  22. Wang S, Wang R, Chen L, Bennett D, Dickson D, Wang D. Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem. 2010;115:47-57 pubmed publisher
    ..The major A?-degrading enzymes are neprilysin (NEP), insulin-degrading enzyme (IDE), and endothelin-converting enzyme (ECE-1)...
  23. Masloub S, Abdel Azim A, Elhamid E. CD10 and osteopontin expression in dentigerous cyst and ameloblastoma. Diagn Pathol. 2011;6:44 pubmed publisher
    ..To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma...
  24. Erin N, Turker S, Elpek O, Yildirim B. Differential changes in Substance P, VIP as well as neprilysin levels in patients with gastritis or ulcer. Peptides. 2012;35:218-24 pubmed publisher
    ..Furthermore changes in neprilysin levels, which hydrolyse these neuropeptides, were determined...
  25. Nalivaeva N, Belyaev N, Lewis D, Pickles A, Makova N, Bagrova D, et al. Effect of sodium valproate administration on brain neprilysin expression and memory in rats. J Mol Neurosci. 2012;46:569-77 pubmed publisher
    ..In the healthy brain, a group of amyloid-degrading enzymes including neprilysin (NEP) maintain A? levels at physiologically low concentrations but, with age and under some pathological ..
  26. Holler C, Webb R, Laux A, Beckett T, Niedowicz D, Ahmed R, et al. BACE2 expression increases in human neurodegenerative disease. Am J Pathol. 2012;180:337-50 pubmed publisher
    ..A better understanding of the normal functions of BACE1 and BACE2, and how these change in different disease states, is essential for the future development of AD therapeutics. ..
  27. Keller P, Arendt L, Skibinski A, Logvinenko T, Klebba I, Dong S, et al. Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A. 2012;109:2772-7 pubmed publisher
    ..These findings identify normal cellular precursors to human breast cancers and reveal the existence of a population of cells with epidermal progenitor activity within adult human breast tissues. ..
  28. Groubman M, Kamanina Y, Petrushanko I, Rubtsov A, Lopina O. Neutral endopeptidase neprilysin is copurified with Na,K-ATPase from rabbit outer medulla and hydrolyzes its ?-subunit. Biochemistry (Mosc). 2010;75:1281-4 pubmed
    ..chromatography/tandem mass spectrometry (LC/MS/MS) analysis showed that the neutral membrane-bound endopeptidase neprilysin is located in one protein band together with the Na,K-ATPase ?-subunit...
  29. Bachelard Cascales E, Chapellier M, Delay E, Pochon G, Voeltzel T, Puisieux A, et al. The CD10 enzyme is a key player to identify and regulate human mammary stem cells. Stem Cells. 2010;28:1081-8 pubmed publisher
    ..Taken together, our data suggest that integrin-mediated contact with the basement membrane and cleavage of signaling factors by CD10 are key elements in the niche that maintains the progenitor and stem cell pools in the mammary lineage. ..
  30. Hegde L, Yu C, Renner T, Thibodeaux H, Armstrong S, Park T, et al. Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat. J Cardiovasc Pharmacol. 2011;57:495-504 pubmed publisher
    Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy but cause high incidence of angioedema...
  31. Solomon S, Zile M, Pieske B, Voors A, Shah A, Kraigher Krainer E, et al. The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. Lancet. 2012;380:1387-95 pubmed publisher
    ..We assessed the efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), in patients with this disorder...
  32. Li Y, Wang J, Liu J, Liu F. A novel system for in vivo neprilysin gene delivery using a syringe electrode. J Neurosci Methods. 2010;193:226-31 pubmed publisher
    ..We focused on delivery of a plasmid encoding human neprilysin (hNEP), an enzyme implicated in the degradation of toxic amyloid-beta (Abeta) peptide, with potential ..
  33. Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, et al. Cell surface expression of the major amyloid-? peptide (A?)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1. J Biol Chem. 2012;287:29362-72 pubmed publisher
    b>Neprilysin is one of the major amyloid-? peptide (A?)-degrading enzymes, the expression of which declines in the brain during aging...
  34. McMurray J, Packer M, Desai A, Gong J, Lefkowitz M, Rizkala A, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine I. Eur J Heart Fail. 2013;15:1062-73 pubmed publisher
    ..The best understood of these mediators are the natriuretic peptides which are metabolized by the enzyme neprilysin. LCZ696 belongs to a new class of drugs, the angiotensin receptor neprilysin inhibitors (ARNIs), which both ..
  35. Barua N, Miners J, Bienemann A, Wyatt M, Welser K, Tabor A, et al. Convection-enhanced delivery of neprilysin: a novel amyloid-?-degrading therapeutic strategy. J Alzheimers Dis. 2012;32:43-56 pubmed
    ..Previous studies have demonstrated the therapeutic potential of viral vector-mediated neprilysin (NEP) gene therapy in mouse models of Alzheimer's disease (AD)...
  36. Hong Y, Beckett C, Belyaev N, Turner A. The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells. Int J Cancer. 2012;130:775-86 pubmed publisher
    The zinc metallopeptidase, neprilysin (NEP), is an endothelin-1 degrading enzyme whose expression is extensively downregulated in prostate cancer...
  37. Nalivaeva N, Fisk L, Belyaev N, Turner A. Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2008;5:212-24 pubmed
    ..These include, among others, neprilysin (NEP) and its homologue endothelin-converting enzyme (ECE), insulysin (IDE), angiotensin-converting enzyme (ACE) ..
  38. Huang J, Bruno A, Patel C, Huynh A, Philibert K, Glucksman M, et al. Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40. Neuroscience. 2008;155:258-62 pubmed publisher
    ..b>Neprilysin (NEP) is the best known target of T/P; however neprilysin knockout results in only modest Abeta increases ..
  39. Broccolini A, Gidaro T, De Cristofaro R, Morosetti R, Gliubizzi C, Ricci E, et al. Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscle. J Neurochem. 2008;105:971-81 pubmed publisher
    ..h-IBM muscle shows the abnormal accumulation of proteins including amyloid-beta (Abeta). Neprilysin (NEP), a metallopeptidase that cleaves Abeta, is characterized by the presence of several N-glycosylation sites, ..
  40. Thanawala V, Kadam V, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008;9:887-94 pubmed
    ..EIs possess the advantage that they lack the opioid side effects. This article reviews the mechanisms by which EIs act and elucidates the pathways involved. ..
  41. Miners J, Verbeek M, Rikkert M, Kehoe P, Love S. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods. 2008;167:229-36 pubmed
    b>Neprilysin, a zinc-metalloendopeptidase, has important roles in the physiology and pathology of many diseases such as hypertension, cancer and Alzheimer's disease...
  42. Pankow K, Wang Y, Gembardt F, Krause E, Sun X, Krause G, et al. Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide. Circ Res. 2007;101:875-82 pubmed
    ..that BNP, in contrast to the structurally related atrial and C-type natriuretic peptide, was not hydrolyzed by neprilysin (NEP)...
  43. Hara H, Oh hashi K, Yoneda S, Shimazawa M, Inatani M, Tanihara H, et al. Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. Mol Vis. 2006;12:977-82 pubmed
    ..In mammals, neprilysin is known to play a key role in these processes, and its inactivation can initiate cellular disorganization...
  44. Fryer R, Segreti J, Banfor P, Widomski D, Backes B, Lin C, et al. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. Br J Pharmacol. 2008;153:947-55 pubmed
    ..Thus, novel BME inhibitors must display no activity against APP to avoid angioedema risk due to high prevalence of ACE inhibitor therapy in patients with diabetes and cardiovascular disease. ..
  45. Six E, Bonhomme D, Monteiro M, Beldjord K, Jurkowska M, Cordier Garcia C, et al. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J Exp Med. 2007;204:3085-93 pubmed
    ..Moreover, they belong to the most immature thymocyte population. Collectively, these findings unravel the existence of a postnatal lymphoid-polarized population that is capable of migrating from the BM to the thymus. ..
  46. Eisele Y, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E. Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. Mol Biol Cell. 2007;18:3591-600 pubmed
    ..with the increase in AICD, Gleevec leads to elevated mRNA and protein levels of the Abeta-degrading enzyme neprilysin, a potential target gene of AICD-regulated transcription...
  47. Poblet E, Jimenez F. CD10 and CD34 in fetal and adult human hair follicles: dynamic changes in their immunohistochemical expression during embryogenesis and hair cycling. Br J Dermatol. 2008;159:646-52 pubmed publisher
    ..The distribution of the immunoreactivity to CD10 in the placode and CD34 in the dermal condensate suggests a role of these proteins in initial stages of hair formation. ..
  48. Walther T, Albrecht D, Becker M, Schubert M, Kouznetsova E, Wiesner B, et al. Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase. PLoS ONE. 2009;4:e4590 pubmed publisher
    Neutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation...
  49. Chen Y, Han T, Iqbal J, Irons R, Chan W, Zhu X, et al. Diffuse large B-cell lymphoma in Chinese patients: immunophenotypic and cytogenetic analyses of 124 cases. Am J Clin Pathol. 2010;133:305-13 pubmed publisher
    ..More interestingly, BCL2 expression was associated with gain of chromosome 3/3q in Chinese DLBCL cases, whereas this association was less significant in Western cases. ..
  50. Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, et al. Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era. Cancer Sci. 2009;100:1842-7 pubmed publisher
    ..001) and also in the R-CHOP group (P < 0.001). Results of improved survival with rituximab addition indicate that the relevance of previously recognized prognostic factors should be re-evaluated. ..
  51. Abramov E, Dolev I, Fogel H, Ciccotosto G, Ruff E, Slutsky I. Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci. 2009;12:1567-76 pubmed publisher
  52. Sanz E, Muñoz A N, Monserrat J, Van Den Rym A, Escoll P, Ranz I, et al. Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways. Proc Natl Acad Sci U S A. 2010;107:5925-30 pubmed publisher
    ..Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway. ..
  53. Zraika S, Aston Mourney K, Marek P, Hull R, Green P, Udayasankar J, et al. Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation. J Biol Chem. 2010;285:18177-83 pubmed publisher
    ..b>Neprilysin is a metallopeptidase known to degrade amyloid in Alzheimer disease...