matrix metalloproteinase 8


Summary: A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.

Top Publications

  1. Giachino F, Loiacono M, Lucchiari M, Manzo M, Battista S, Saglio E, et al. Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department. Crit Care. 2013;17:R33 pubmed publisher
    ..Combination of plasma MMP8 and D-dimer at individually suboptimal cutoffs could safely rule out AAD in a substantial proportion of patients evaluated in the emergency department. ..
  2. Witkin S, Mendes Soares H, Linhares I, Jayaram A, Ledger W, Forney L. Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections. MBio. 2013;4: pubmed publisher
    ..Thus, isomers of lactic acid may function as signaling molecules that alter host gene expression and influence risk of infection-related preterm birth. ..
  3. Sorsa T, Gürsoy U, Nwhator S, Hernandez M, Tervahartiala T, Leppilahti J, et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70:142-63 pubmed publisher
  4. Elayyan J, Lee E, Gabay O, Smith C, Qiq O, Reich E, et al. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. FASEB J. 2017;31:3116-3125 pubmed publisher
    ..Elayyan, J., Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. ..
  5. An F, Du J, Cao Y, Shi J, Guo Y, Jin T, et al. MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population. Oncotarget. 2017;8:21561-21566 pubmed publisher
    ..05-1.98, P=0.022), and log-additive model (OR =1.40, 95% CI, 1.04-1.90, P=0.027). These results provide the first evidence that MMP8 SNP at the rs11225394 locus is associated with the increased risk of ONFH in Chinese Han population. ..
  6. Kim J, Jeong Y, Lee E, Park J, Seo H, Kim H. Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. Biochem Biophys Res Commun. 2017;493:879-886 pubmed publisher
    ..Collectively, the data suggested that M8I has a therapeutic potential in treating neurodegenerative diseases that are aggravated by systemic inflammation. ..
  7. Shlopov B, Lie W, Mainardi C, Cole A, Chubinskaya S, Hasty K. Osteoarthritic lesions: involvement of three different collagenases. Arthritis Rheum. 1997;40:2065-74 pubmed
    ..Retinoic acid, an agent which induces autodigestion of cartilage in vitro, stimulated only the expression of MMP-13. These findings suggest a key role of MMP-13 and MMP-8, as well as MMP-1 in osteoarthritis. ..
  8. Blackburn J, Brinckerhoff C. Wild-type versus mutant MMP-8 in melanoma: 'when you come to a fork in the road, take it'. Pigment Cell Melanoma Res. 2009;22:248-50 pubmed publisher
  9. Mattey D, Nixon N, Dawes P. Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Res Ther. 2012;14:R204 pubmed publisher
    ..This finding is consistent with increased activation of neutrophils in RA and identifies serum MMP-8 as a useful marker for increased risk of premature death. ..

More Information


  1. Dwivedi M, Bhagat A, Srivastava R, Jain A, Baghel K, Raj S. Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients Managed by Negative Pressure Wound Therapy or Conventional Wound Care: A Randomized Controlled Trial. J Wound Ostomy Continence Nurs. 2017;44:343-349 pubmed publisher
    ..The novel NPWT device used in this study reduced exudate production and enhanced the rate of formation of red granulation tissue. ..
  2. Shen T, Hsia T, Chao C, Chen W, Chen C, Chen W, et al. The Contribution of MMP-8 Promoter Polymorphisms in Lung Cancer. Anticancer Res. 2017;37:3563-3567 pubmed
    ..The polymorphisms MMP-8 C-799T, Val436Ala and Lys460Thr may not play a major role in mediating personal susceptibility to lung cancer in Taiwan. ..
  3. Karabencheva Christova T, Christov C, Fields G. Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies. Adv Protein Chem Struct Biol. 2017;109:1-24 pubmed publisher
    ..Ultimately, the MD simulation studies have complemented structural (NMR spectroscopy, X-ray crystallography) and kinetic analyses to provide a more detailed mechanistic view of MMP-catalyzed collagenolysis. ..
  4. Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al. Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017;196:494-501 pubmed publisher
    ..PERSEVERE-XP significantly improves on PERSEVERE and suggests a role for TP53-related cellular division, repair, and metabolism in the pathophysiology of septic shock. ..
  5. Aström P, Juurikka K, Hadler Olsen E, Svineng G, Cervigne N, Coletta R, et al. The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. Br J Cancer. 2017;117:1007-1016 pubmed publisher
    ..Together, low MMP-8 and high VEGF-C expression have strong independent prognostic value in OTSCC. ..
  6. Caria C, Gotardo E, Santos P, Acedo S, de Morais T, Ribeiro M, et al. Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipose during weight cycling in mice. Exp Cell Res. 2017;359:431-440 pubmed publisher
    ..Our results suggest that MMPs inhibition could be an interesting target to improve adipose tissue inflammation during WL and to support weight cyclers. ..