Summary: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.
- Sinden N, Baker M, Smith D, Kreft J, Dafforn T, Stockley R. Î±-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2015;308:L179-90 pubmed
- Land J, Abdulahad W, Arends S, Sanders J, Stegeman C, Heeringa P, et al. Prospective monitoring of in vitro produced PR3-ANCA does not improve relapse prediction in granulomatosis with polyangiitis. PLoS ONE. 2017;12:e0182549 pubmed publisher..While differences were observed for the serum ANCA titer in relapsing and non-relapsing patients, monitoring in vitro PR3-ANCA IgG production does not improve relapse prediction in GPA patients. ..
- Pearce F, Craven A, Merkel P, Luqmani R, Watts R. Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis. Rheumatology (Oxford). 2017;56:1962-1969 pubmed publisher..This study confirms the previously observed differential occurrence of MPO-AAV and PR3-AAV between different ethnic groups. ..
- de Joode A, Sanders J, PuÃ©chal X, Guillevin L, Hiemstra T, Flossmann O, et al. Long term azathioprine maintenance therapy in ANCA-associated vasculitis: combined results of long-term follow-up data. Rheumatology (Oxford). 2017;56:1894-1901 pubmed publisher..ANCA specificity has more effect on relapse-free survival than duration of maintenance therapy and should be used to tailor therapy individually. ..