Summary: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.
Chertov O, Ueda H, Xu L, Tani K, Murphy W, Wang J, et al
. Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. J Exp Med. 1997;186:739-47 pubmed
..NH2-terminal sequence of the protein revealed this to be identical to cathepsin G. The monocyte chemotactic activity of human cathepsin G was dose dependent with optimal concentration at 0...
Lehrer R, Barton A, Daher K, Harwig S, Ganz T, Selsted M. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989;84:553-61 pubmed
..Overall, these studies show that HNP-mediated bactericidal activity against E. coli ML-35 is associated with sequential permeabilization of the OM and IM, and that inner membrane permeabilization appears to be the lethal event. ..
Morandi E, Jagessar S, t Hart B, Gran B. EBV Infection Empowers Human B Cells for Autoimmunity: Role of Autophagy and Relevance to Multiple Sclerosis. J Immunol. 2017;199:435-448 pubmed publisher
..Although human MOG protein was degraded less in EBV-infected than in uninfected B cells, induction of cathepsin G
activity by EBV led to total degradation of the immunodominant peptides MOG35-55
Shibata F, Konishi K, Kato H, Komorita N, Al Mokdad M, Fujioka M, et al
. Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3. Eur J Biochem. 1995;231:306-11 pubmed
..CINC-2 alpha, CINC-2 beta and CINC-3 induced a comparable response to CINC-1 in the release of cathepsin G from rat neutrophils...
Alatrash G, Garber H, Zhang M, Sukhumalchandra P, Qiu Y, Jakher H, et al
. Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target. Leukemia. 2017;31:234-237 pubmed publisher
Morimoto Kamata R, Yui S. Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells. Cancer Sci. 2017;108:1574-1583 pubmed publisher
b>Cathepsin G (CG), a neutrophil serine protease, induces cell migration and multicellular aggregation of human breast cancer MCF-7 cells in a process that is dependent on E-cadherin and CG enzymatic activity...