cathepsin b

Summary

Summary: A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.

Top Publications

  1. Victor B, Anbalagan A, Mohamed M, Sloane B, Cavallo Medved D. Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion. Breast Cancer Res. 2011;13:R115 pubmed publisher
    ..Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC...
  2. Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, et al. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 2010;107:2497-502 pubmed publisher
    The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (-/-) mice has been suggested...
  3. Gopinathan A, DeNicola G, Frese K, Cook N, Karreth F, Mayerle J, et al. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut. 2012;61:877-84 pubmed publisher
    The lysosomal protease cathepsin B is upregulated in human pancreatic ductal adenocarcinoma (PDA) and represents a potential therapeutic target...
  4. Duewell P, Kono H, Rayner K, Sirois C, Vladimer G, Bauernfeind F, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464:1357-61 pubmed publisher
    ..induce acute inflammation, which is impaired in mice deficient in components of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules...
  5. Reichenbach G, Starzinski Powitz A, Sloane B, Doll M, Kippenberger S, Bernd A, et al. PPAR? agonist Wy14643 suppresses cathepsin B in human endothelial cells via transcriptional, post-transcriptional and post-translational mechanisms. Angiogenesis. 2013;16:223-33 pubmed publisher
    b>Cathepsin B has been shown to be important in angiogenesis; therefore, understanding its regulation in endothelial cells should provide fundamental information that will aid in the development of new treatment options...
  6. Lamore S, Wondrak G. UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts. J Photochem Photobiol B. 2013;123:1-12 pubmed publisher
    ..Recently, we have identified the thiol-dependent cysteine-protease cathepsin B as a novel UVA-target undergoing photo-oxidative inactivation upstream of autophagic-lysosomal dysfunction in ..
  7. Song G, Bailey D, Dunlap K, Burghardt R, Spencer T, Bazer F, et al. Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae. Biol Reprod. 2010;82:854-64 pubmed publisher
    ..Cysteine proteases and their inhibitors may also specifically modify proteins for successful utilization and fluid-phase transport across uterine, placental, and neonatal gut epithelia. ..
  8. Li C, Chen L, Wang J, Zhang L, Tang P, Zhai S, et al. Expression and clinical significance of cathepsin B and stefin A in laryngeal cancer. Oncol Rep. 2011;26:869-75 pubmed publisher
    The aim of this study was to investigate the roles of the cathepsin B cysteine protease and its endogenous inhibitor stefin A in laryngeal cancer...
  9. Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-? and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, ?-secretase activity. J Alzheimers Dis. 2011;26:387-408 pubmed publisher
    The cysteine protease cathepsin B is a potential drug target for reducing brain amyloid-? (A?) and improving memory in Alzheimer's disease (AD), as reduction of cathepsin B in transgenic mice expressing human wild-type amyloid-? protein ..

More Information

Publications62

  1. Ha S, Park S, Hattlmann C, Barr S, Kim S. Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells. Antiviral Res. 2012;93:175-84 pubmed publisher
    ..Here, we showed that macrophages or HEK293T cells treated with the cathepsin B (CTSB)-specific inhibitor CA-074Me or cells deficient in CTSB failed to release HIV-1 Gag pseudoparticles into ..
  2. Han Y, Li Z, Li B, Sun X, Zhu C, Ling X, et al. Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis. Parasitol Res. 2011;109:369-78 pubmed publisher
    ..Here, we reported the cloning and characterization of a cDNA encoding a cathepsin B (AcCPB) from Angiostrongylus cantonensis fourth-stage larvae cDNA library...
  3. Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012;72:1199-209 pubmed publisher
    ..cathepsin inhibitor stefin A is a suppressor of breast cancer metastasis to bone that is coexpressed with cathepsin B in bone metastases. In this study, we used the immunocompetent 4T1...
  4. Feng Q, Cheng Y, Hu Y, Zhang H, Peng J, Zhang N. Qushi Huayu Decoction (?????) inhibits protein and gene expression of cathepsin B in HepG2 cells induced by free fatty acids. Chin J Integr Med. 2010;16:518-24 pubmed publisher
    To study the experimental efficacy of Qushi Huayu Decoction (?????,QHD) on, protein and gene expression of cathepsin B (ctsb) in HepG2 cells induced by free fatty acids (FFAs)...
  5. Balboula A, Yamanaka K, Sakatani M, Hegab A, Zaabel S, Takahashi M. Intracellular cathepsin B activity is inversely correlated with the quality and developmental competence of bovine preimplantation embryos. Mol Reprod Dev. 2010;77:1031-9 pubmed publisher
    ..In this study, we investigated (1) the role of intracellular cathepsin B expression and developmental competence as well as the quality of bovine preimplantation embryos, and (2) the ..
  6. Smooker P, Jayaraj R, Pike R, Spithill T. Cathepsin B proteases of flukes: the key to facilitating parasite control?. Trends Parasitol. 2010;26:506-14 pubmed publisher
    Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes) which are abundant in juvenile and immature flukes...
  7. Cantres Rosario Y, Plaud Valentin M, GERENA Y, Skolasky R, Wojna V, Melendez L. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013;27:347-56 pubmed publisher
    ..Our laboratory has shown increased secretion and neurotoxicity of cathepsin B from in-vitro HIV-infected monocyte-derived macrophages, and increased expression in postmortem brain tissue ..
  8. Wu D, Wang H, Li Z, Wang L, Zheng F, Jiang J, et al. Cathepsin B may be a potential biomarker in cervical cancer. Histol Histopathol. 2012;27:79-87 pubmed publisher
    b>Cathepsin B is a protease which is able to digest extracellular matrix. It is currently unknown whether cathepsin B plays a role in cervical cancer development and progression...
  9. Chi Y, Koo Y, Dai S, Ahn J, Yun D, Lee S, et al. N-glycosylation at non-canonical Asn-X-Cys sequence of an insect recombinant cathepsin B-like counter-defense protein. Comp Biochem Physiol B Biochem Mol Biol. 2010;156:40-7 pubmed publisher
    CmCatB, a cowpea bruchid cathepsin B-like cysteine protease, facilitates insects coping with dietary protease inhibitor challenge...
  10. Sripa J, Pinlaor P, Brindley P, Sripa B, Kaewkes S, Robinson M, et al. RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini. Parasitol Int. 2011;60:283-8 pubmed publisher
    ..same electroporation settings with double stranded RNA targeting an endogenous papain-like cysteine protease, cathepsin B. This manipulation resulted in a significant reduction in specific mRNA levels encoding cathepsin B, and a ..
  11. Tomoo K. Development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor. Curr Top Med Chem. 2010;10:696-707 pubmed
    ..To illustrate an approach to drug design, an example of structure-based design of a cathepsin B-specific inhibitor is described.
  12. Wu D, Li Z, Xu Y, Wang L, Ding L, Wu J, et al. [Clinical significance of cathepsin B expressions in cervical cancer in tissues]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1330-2 pubmed
    corrected] To investigate cathepsin B (CB) expression in squamous cervical carcinoma and its relationship to the clinical and pathological condition...
  13. Moreno M, Ball M, Rukhlova M, Slinn J, L abbe D, Iqbal U, et al. IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity. Neoplasia. 2013;15:554-67 pubmed
    ..both growth factor-induced EC tubulogenesis in Matrigel and the concomitant increases in intracellular cathepsin B (CatB) activity. In vitro assays confirmed CIBP-4 capacity to block recombinant CatB activity...
  14. Ni F, Wang Y, Zhang J, Yu L, Fang W, Luo D. Cathepsin B-like and hemoglobin-type cysteine proteases: stage-specific gene expression in Angiostrongy cantonensis. Exp Parasitol. 2012;131:433-41 pubmed publisher
    Three cysteine protease genes, cathepsin B-like enzyme gene 1, 2 (AC-cathB-1, AC-cathB-2) and hemoglobin-type cysteine protease gene (AC-hem) were isolated and described from Angiostrongylus cantonensis adult...
  15. Lopez Castejon G, Theaker J, Pelegrin P, Clifton A, Braddock M, Surprenant A. P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J Immunol. 2010;185:2611-9 pubmed publisher
    ..bone marrow-derived macrophages and found that ATP induced rapid release of the lysosomal cysteine proteases cathepsin B, K, L, and S and that was independent of the presence of the proinflammatory cytokines IL-1beta and IL-18...
  16. Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Vegran F, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013;19:57-64 pubmed publisher
    ..Chemotherapy-triggered IL-1? secretion relied on lysosomal permeabilization and the release of cathepsin B, which bound to Nlrp3 and drove caspase-1 activation...
  17. Martin S, Moffitt K, McDowell A, Greenan C, Bright Thomas R, Jones A, et al. Association of airway cathepsin B and S with inflammation in cystic fibrosis. Pediatr Pulmonol. 2010;45:860-8 pubmed publisher
    ..The aim of this study was to determine cathepsin B and S levels in cystic fibrosis (CF) sputum and to assess any relationship to recognized markers of ..
  18. Bien S, Rimmbach C, Neumann H, Niessen J, Reimer E, Ritter C, et al. Doxorubicin-induced cell death requires cathepsin B in HeLa cells. Biochem Pharmacol. 2010;80:1466-77 pubmed publisher
    The cysteine protease cathepsin B acts as a key player in apoptosis. Cathepsin B-mediated cell death is induced by various stimuli such as ischemia, bile acids or TNF?...
  19. Meister T, Niehues R, Hahn D, Domschke W, Sendler M, Lerch M, et al. Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis--without affecting disease severity. J Physiol Pharmacol. 2010;61:565-75 pubmed
    The lysosomal protease cathepsin B is thought to play a crucial role in the intracellular activation cascade of digestive proteases and in the initiation of acute pancreatitis...
  20. Wang X, Liu B, Tang B, Xiang J. Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix. J Exp Zool B Mol Dev Evol. 2011;316:306-12 pubmed publisher
    This study was designed to investigate the possible role of Meretrix meretrix cathepsin B (MmeCB) in embryonic and larval development. MmeCB mRNA expression profile was revealed by semi-quantitative RT-PCR...
  21. Morchang A, Panaampon J, Suttitheptumrong A, Yasamut U, Noisakran S, Yenchitsomanus P, et al. Role of cathepsin B in dengue virus-mediated apoptosis. Biochem Biophys Res Commun. 2013;438:20-5 pubmed publisher
    ..We show for the first time that DENV induces lysosomal membrane permeabilization. The resulting cytosolic cathepsin B and S contributed to apoptosis via caspase activation...
  22. Lalanne A, Moraga I, Hao Y, Pereira J, Alves N, Huntington N, et al. CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol. 2010;184:5678-85 pubmed publisher
    ..not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is ..
  23. Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, et al. A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS ONE. 2012;7:e32272 pubmed publisher
    b>Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling...
  24. Lee H, Kim C. Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia. Exp Mol Med. 2011;43:223-9 pubmed
    ..The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the transitional period from the canalicular to saccular ..
  25. Nouh M, Mohamed M, El Shinawi M, Shaalan M, Cavallo Medved D, Khaled H, et al. Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med. 2011;9:1 pubmed publisher
    Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. In non-IBC, the cysteine protease cathepsin B (CTSB) is known to be involved in cancer progression and invasion; however, very little is known about its role ..
  26. Welin A, Eklund D, Stendahl O, Lerm M. Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis. PLoS ONE. 2011;6:e20302 pubmed publisher
    ..and IL-1? release from infected cells, the cell death induced by Mtb was not dependent on caspase-1 or cathepsin B. It was, however, dependent on mycobacterial expression of ESAT-6...
  27. Sundelöf J, Sundstrom J, Hansson O, Eriksdotter Jonhagen M, Giedraitis V, Larsson A, et al. Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls. J Alzheimers Dis. 2010;22:1223-30 pubmed publisher
    b>Cathepsin B is suggested to be involved in amyloid-? (A?) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed...
  28. Chen W, Wang X, Li X, Lv X, Zhou C, Deng C, et al. Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis. Parasit Vectors. 2011;4:149 pubmed publisher
    ..The purpose of this study was to identify a cathepsin B of Clonorchis sinensis (CsCB) and to investigate its diagnostic value for human helminthiases.
  29. Hochdörffer K, Abu Ajaj K, Schäfer Obodozie C, Kratz F. Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix. J Med Chem. 2012;55:7502-15 pubmed publisher
    ..as a bone targeting ligand, doxorubicin as the anticancer agent, and either an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective release of doxorubicin at the site of action...
  30. Balboula A, Yamanaka K, Sakatani M, Kawahara M, Hegab A, Zaabel S, et al. Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation. Reproduction. 2013;146:407-17 pubmed publisher
    b>Cathepsin B was found to be correlated inversely with the quality of bovine oocytes and embryos...
  31. Mohamed M, Cavallo Medved D, Rudy D, Anbalagan A, Moin K, Sloane B. Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes. Cell Physiol Biochem. 2010;25:315-24 pubmed publisher
    ..that 231-CM increased U937: 1) proliferation; 2) expression, activity and secretion of the cysteine protease cathepsin B (CTSB); 3) secretion of matrix metalloproteinases (MMP)-2 and -9; and 4) secretion of interleukin-6 (IL-6) and ..
  32. Czibere L, Baur L, Wittmann A, Gemmeke K, Steiner A, Weber P, et al. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. PLoS ONE. 2011;6:e23604 pubmed publisher
    ..in the basal expression of 13 candidate genes, using tissue from the entire brain, including coronin 7 (Coro7), cathepsin B (Ctsb), muscleblind-like 1 (Mbnl1), metallothionein 1 (Mt1), solute carrier family 25 member 17 (Slc25a17), ..
  33. Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, et al. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene. 2011;30:54-64 pubmed publisher
    Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients...
  34. Tingaud Sequeira A, Carnevali O, Cerdà J. Cathepsin B differential expression and enzyme processing and activity during Fundulus heteroclitus embryogenesis. Comp Biochem Physiol A Mol Integr Physiol. 2011;158:221-8 pubmed publisher
    The role of lysosomal proteases such as cathepsin B (Ctsb) and one of the paralogs of cathepsin L (Ctsla) during yolk metabolism in fish oocytes is well established...
  35. Costa M, Batista P, Shida C, Robert C, Bisch P, Pascutti P. How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics. BMC Genomics. 2010;11 Suppl 5:S5 pubmed publisher
    b>Cathepsin B (catB) is a promising target for anti-cancer drug design due to its implication in several steps of tumorigenesis...
  36. Ludewig S, Kossner M, Schiller M, Baumann K, Schirmeister T. Enzyme kinetics and hit validation in fluorimetric protease assays. Curr Top Med Chem. 2010;10:368-82 pubmed
    ..in misleadingly strong inhibitors are scrutinized and exemplified for two different typical protease assays (cathepsin B, chymotrypsin)...
  37. Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012;1824:89-104 pubmed publisher
    ..Moreover, cathepsin B in secretory vesicles has been recently identified as a ?-secretase for production of neurotoxic ?- amyloid (A?)..
  38. Veeravalli K, Chetty C, Ponnala S, Gondi C, Lakka S, Fassett D, et al. MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice. PLoS ONE. 2010;5:e11583 pubmed publisher
    Involvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established...
  39. Rajamäki K, Lappalainen J, Öörni K, Välimäki E, Matikainen S, Kovanen P, et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE. 2010;5:e11765 pubmed publisher
    ..The crystals were shown to induce leakage of the lysosomal protease cathepsin B into the cytoplasm and inhibition of this enzyme reduced cholesterol crystal-induced IL-1beta secretion, ..
  40. Chu S, Yang S, Tzang B, Hsieh Y, Lue K, Lu K. Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee. Clin Chim Acta. 2010;411:1788-92 pubmed publisher
    To relate the expression of the matrix degrading proteinase cathepsin B and its endogenous inhibitor cystatin C in the synovial fluid (SF) to the clinical and laboratory variables of joint inflammation in gouty arthritis of the knee...
  41. Chen W, Chen J, Jiao B, Lin W, Wu Y, Liu L, et al. Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion. J Virol. 2012;86:13533-41 pubmed publisher
    ..pulldown, coimmunoprecipitation, and a mammalian two-hybrid assay, HBSP was found to directly interact with cathepsin B (CTSB). Similar to HBSP knockdown, knocking down CTSB also reduced cell migration and invasion...
  42. Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012;131:2034-43 pubmed publisher
    ..S1P), promotes Ets1 nuclear expression and binding to the promoter region of matrix-degrading protease cathepsin B. Through confocal microscopy and flow cytometry, we found that AC overexpression promotes pericellular ..
  43. Gupta R, Rao Gogineni V, Nalla A, Chetty C, Klopfenstein J, Tsung A, et al. Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo. Int J Oncol. 2011;38:973-83 pubmed publisher
    ..Earlier studies have reported that proteases such as uPA, uPAR and cathepsin B play important roles in tumor progression...
  44. Lee Y, Chen S, Shyu L, Lee M, Wu T, Tsao S, et al. Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia. Clin Chim Acta. 2012;413:630-5 pubmed publisher
    We identified the relationship between plasma level changes of cathepsin B and cystatin C before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP)...
  45. El Fadili A, Zangger H, Desponds C, Gonzalez I, Zalila H, Schaff C, et al. Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. Cell Death Dis. 2010;1:e71 pubmed publisher
    ..of Z-VAD-FMK to Leishmania major metacaspase (LmjMCA), and identified cysteine proteinase C (LmjCPC), a cathepsin B-like (CPC) enzyme, as the Z-VAD-FMK binding enzyme...
  46. Sripa J, Brindley P, Sripa B, Loukas A, Kaewkes S, Laha T. Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. Parasitol Int. 2012;61:191-5 pubmed publisher
    A cathepsin B-like cysteine protease belonging to family C1 is abundantly expressed in the transcriptome and proteome of the carcinogenic liver fluke of humans, Opisthorchis viverrini...
  47. Hoegen T, Tremel N, Klein M, Angele B, Wagner H, Kirschning C, et al. The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. J Immunol. 2011;187:5440-51 pubmed publisher
    ..The latter depends on the release of ATP, lysosomal destabilization (but not disruption), and cathepsin B activation...
  48. Wang J, Xia Q, Chu K, Pan J, Sun L, Zeng B, et al. Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. J Neuropathol Exp Neurol. 2011;70:314-22 pubmed publisher
    ..The redistribution of the lysosomal enzyme cathepsin B after injury was inhibited by 3-MA administered before ischemia, suggesting that this might be another ..
  49. Gondi C, Rao J. Cathepsin B as a cancer target. Expert Opin Ther Targets. 2013;17:281-91 pubmed publisher
    b>Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans...
  50. Unciti Broceta J, Maceira J, Morales S, García Pérez A, Muñóz Torres M, Garcia Salcedo J. Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes. J Biol Chem. 2013;288:10548-57 pubmed publisher
    ..on endocytosis and vesicle traffic were visible within 3 h and can be attributed to inhibition of lysosomal cathepsin b-like protease activity...
  51. Luo C, Chen X, Yang R, Sun Y, Li Q, Bao H, et al. Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway. J Neurosci Res. 2010;88:2847-58 pubmed publisher
    ..We have previously reported that cathepsin B expression increased remarkably after traumatic brain injury (TBI)...
  52. Jin C, Flavell R. Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol. 2010;30:628-31 pubmed publisher
    ..Three signaling pathways involving potassium efflux, generation of reactive oxygen species, and cathepsin B release are discussed.
  53. Andl C, McCowan K, Allison G, Rustgi A. Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia. 2010;12:485-98 pubmed
    ..We also find that cathepsin B induction is necessary for fibroblast-mediated invasion...