alternative pathway complement c3 convertase
Summary: A serine protease that is the complex of COMPLEMENT C3B and COMPLEMENT FACTOR BB. It cleaves multiple COMPLEMENT C3 into COMPLEMENT C3A (anaphylatoxin) and COMPLEMENT C3B in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY.
Katschke K, Stawicki S, Yin J, Steffek M, Xi H, Sturgeon L, et al
. Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement. J Biol Chem. 2009;284:10473-9 pubmed publisher
..This study for the first time demonstrates the structural basis for complement inhibition by a C3b-selective antibody and provides insights into the molecular mechanisms of alternative pathway complement activation. ..
Krishnan V, Ponnuraj K, Xu Y, Macon K, Volanakis J, Narayana S. The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb. Structure. 2009;17:611-9 pubmed publisher
..The similarly positioned CUB and slightly displaced C345c domains of CVF could play a vital role in the formation of C3 convertases by providing important primary binding sites for factor B. ..
Rooijakkers S, Wu J, Ruyken M, van Domselaar R, Planken K, Tzekou A, et al
. Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol. 2009;10:721-7 pubmed publisher
..Understanding the mechanistic basis of the central complement-activation step and microbial immune evasion strategies targeting this step will aid in the development of complement therapeutics. ..
Ricklin D, Tzekou A, Garcia B, Hammel M, McWhorter W, Sfyroera G, et al
. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J Immunol. 2009;183:2565-74 pubmed publisher
..Our findings provide an important insight into complement evasion strategies by S. aureus and may act as a base for further functional studies. ..
Torreira E, Tortajada A, Montes T, Rodriguez de Cordoba S, Llorca O. Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase. J Immunol. 2009;183:7347-51 pubmed publisher
..These data illustrate the coexistence of C3b-bound fB in closed and open conformations that either exist in equilibrium or represent structural transitions during the assembly of the C3bB proconvertase. ..
Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr C, Axelrod H, et al
. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Structure. 2010;18:537-47 pubmed publisher
..The WH domain is critical to CvfB function and contains a unique sequence motif. Thus CvfB represents a novel assembly of modules for binding RNA. ..
Agarwal S, Ferreira V, Cortes C, Pangburn M, Rice P, Ram S. An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. J Immunol. 2010;185:507-16 pubmed publisher
..meningitidis or N. gonorrhoeae but play a crucial role in augmenting AP-dependent C3 deposition on the bacteria through the "conventional" mechanism of stabilizing AP C3 convertases...
Fakhouri F, Roumenina L, Provot F, Sallée M, Caillard S, Couzi L, et al
. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol. 2010;21:859-67 pubmed publisher
..8% and 7.7%, respectively. Better understanding of complement dysregulation in pregnancy complications is essential, especially to guide development of pharmacologic agents to modulate this system. ..