deubiquitinating enzymes


Summary: Enzymes that remove UBIQUITIN from a protein substrate, including POLYUBIQUITIN, or from other molecules.

Top Publications

  1. Tse W. Importance of deubiquitinases in zebrafish craniofacial development. Biochem Biophys Res Commun. 2017;487:813-819 pubmed publisher
    ..Lastly, we used uchl3 morphant as an example to show that our screening data could be useful for further functional studies. To summarize, we identified new craniofacial developmental role of 26 DUBs in the zebrafish. ..
  2. Bailey Elkin B, Knaap R, Kikkert M, Mark B. Structure and Function of Viral Deubiquitinating Enzymes. J Mol Biol. 2017;429:3441-3470 pubmed publisher
    ..Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs), which remove ubiquitin from cellular targets and depolymerize polyubiquitin chains...
  3. Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, et al. EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Nat Commun. 2018;9:758 pubmed publisher
    ..We further show that usp8 knockout zebrafish develops ciliopathy-related phenotypes including cystic kidney, suggesting that USP8 is a regulator of ciliogenesis in vertebrates. ..
  4. Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, et al. Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase. Biochem Pharmacol. 2017;137:29-50 pubmed publisher
    ..These systematic studies provided insights in the development of novel proteasome inhibitors for cancer treatment. ..
  5. Shang P, Misra S, Hause B, Fang Y. A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase. J Virol. 2017;91: pubmed publisher
    ..Our results provide insights into how a gain of function through genetic recombination, in particular cross-order recombination, may improve the ability of a virus to evade host immunity. ..
  6. Kattah M, Malynn B, Ma A. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol. 2017;429:3471-3485 pubmed publisher
    ..Here we review specific ubiquitin-modifying enzymes and ubiquitination events that orchestrate inflammatory responses, with an emphasis on the NLRP3 inflammasome. ..
  7. Hewings D, Flygare J, Bogyo M, Wertz I. Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights. FEBS J. 2017;284:1555-1576 pubmed publisher
    ..We will also review the diverse applications of the current probes, and discuss the need for new probe types to study emerging aspects of ubiquitin biology. ..
  8. Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed publisher
    ..Thus, our study reveals a key priming molecular event that is a prerequisite for NLRP3 inflammasome activation. Inhibiting NLRP3 phosphorylation could be an effective treatment for NLRP3-related diseases. ..
  9. Delley C, Müller A, Ziemski M, Weber Ban E. Prokaryotic Ubiquitin-Like Protein and Its Ligase/Deligase Enyzmes. J Mol Biol. 2017;429:3486-3499 pubmed publisher

More Information


  1. Kwon K, Oh S, Kim Y, Han T, Ahn J. Cooperative inhibition of RIP1-mediated NF-?B signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit. PLoS Pathog. 2017;13:e1006423 pubmed publisher
    ..Collectively, our data demonstrate that cytomegalovirus-encoded DUB and inactive R1 homolog target RIP1 and cooperatively inhibit RIP1-mediated NF-?B signaling at the late stages of HCMV infection. ..
  2. Kampmeyer C, Karakostova A, Schenstrøm S, Abildgaard A, Lauridsen A, Jourdain I, et al. The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem. 2017;292:15240-15253 pubmed publisher
    ..In conclusion, our results suggest that a cytosolic protein quality control pathway monitors folding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fission yeast. ..
  3. Puvar K, Zhou Y, Qiu J, Luo Z, Wirth M, Das C. Ubiquitin Chains Modified by the Bacterial Ligase SdeA Are Protected from Deubiquitinase Hydrolysis. Biochemistry. 2017;56:4762-4766 pubmed publisher
    ..Furthermore, this renders the ubiquitin chains unable to be processed by a variety of deubiquitinating enzymes. These observations broaden the scope of SdeA's modulatory functions during Legionella infection.
  4. Dyson O, Pagano J, Whitehurst C. The Translesion Polymerase Pol ? Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1. J Virol. 2017;91: pubmed publisher
    ..These findings help to establish how EBV enlists and manipulates cellular DNA repair factors during the viral lytic cycle, contributing to efficient infectious virion production. ..
  5. de Poot S, Tian G, Finley D. Meddling with Fate: The Proteasomal Deubiquitinating Enzymes. J Mol Biol. 2017;429:3525-3545 pubmed publisher
    Three deubiquitinating enzymes-Rpn11, Usp14, and Uch37-are associated with the proteasome regulatory particle...
  6. Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D. Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017;24:920-930 pubmed publisher
    ..Our work provides insights into the architecture, activity and regulation of USP30, which will aid drug design against this and related enzymes. ..
  7. Li X, Seidel C, Szerszen L, Lange J, Workman J, Abmayr S. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Genes Dev. 2017;31:1588-1600 pubmed publisher
    ..Furthermore, we found that the DUB module can bind to chromatin and regulate transcription independently of the HAT module. Our results suggest that the DUB module has functions within SAGA and independent functions. ..
  8. Mevissen T, Komander D. Mechanisms of Deubiquitinase Specificity and Regulation. Annu Rev Biochem. 2017;86:159-192 pubmed publisher
    ..We further discuss the many mechanisms of DUB regulation with a focus on those that modulate catalytic activity. Our review provides a framework to tackle lingering questions in DUB biology. ..
  9. Mazurkiewicz M, Hillert E, Wang X, Pellegrini P, Olofsson M, Selvaraju K, et al. Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition. Oncotarget. 2017;8:21115-21127 pubmed publisher
    ..We conclude that ALL cells are highly sensitive to the proteasome DUB inhibitor VLX1570 suggesting a novel therapeutic option for this disease. ..