cytochrome p450 family 4


Summary: A cytochrome P450 enzyme family that includes members which function in the metabolism of FATTY ACIDS, especially ARACHIDONIC ACIDS and their derivatives.

Top Publications

  1. Johnson J, Caudle K, Gong L, Whirl Carrillo M, Stein C, Scott S, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharmacol Ther. 2017;102:397-404 pubmed publisher
    ..In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry. ..
  2. Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, et al. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A. 2017;114:3181-3185 pubmed publisher
    ..Collectively, CYP4A14 plays an important role in the pathogenesis of both SS and NASH and may represent a potential therapeutic target for the treatment of NAFLD. ..
  3. Jinda W, Taylor T, Suzuki Y, Thongnoppakhun W, Limwongse C, Lertrit P, et al. Whole Exome Sequencing in Eight Thai Patients With Leber Congenital Amaurosis Reveals Mutations in the CTNNA1 and CYP4V2 Genes. Invest Ophthalmol Vis Sci. 2017;58:2413-2420 pubmed publisher
    ..The present study expands the spectrum of LCA-associated genes, which is a benefit for molecular diagnosis. The identification of mutations in the CTNNA1 and CYP4V2 genes requires further elucidation in larger cohorts with LCA. ..
  4. Alnabulsi A, Swan R, Cash B, Alnabulsi A, Murray G. The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance. Br J Cancer. 2017;116:1612-1620 pubmed publisher
    ..046). A significant and independent association has been identified between overall survival and the differential expression of CYP4A11 and CYP4F11 in the whole patient cohort and in mismatch repair-proficient tumours. ..
  5. Yi M, Shin J, Lee S. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. Toxicol Appl Pharmacol. 2017;330:100-106 pubmed publisher
    ..Further study is required to understand the role of CYP4V2 with regard to fat accumulation in the activated macrophage and atherosclerotic plaque development. ..
  6. Hirashima T, Miyata M, Ishihara K, Hasegawa T, Sugahara M, Ogino K, et al. Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations. Invest Ophthalmol Vis Sci. 2017;58:3871-3878 pubmed publisher
    ..The outer choroidal vascular narrowing might progress with the inner choroidal thinning in BCD, and the inner choroidal vasculature might be extinguished in advanced-stage BCD. Our findings may help to clarify the etiology of BCD. ..