cytochrome p450 family 26

Summary

Summary: A cytochrome P450 enzyme family whose members function in the metabolism of RETINOIC ACID. It includes RETINOIC ACID 4-HYDROXYLASE.

Top Publications

  1. El Shahawy M, Reibring C, Neben C, Hallberg K, Marangoni P, Harfe B, et al. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017;13:e1006914 pubmed publisher
    ..These findings reveal key functions for SHH and RA in cell fate specification in the lingual epithelium and aid in deciphering the molecular mechanisms that assign cell identity. ..
  2. Alonso S, Jones R, Ghiaur G. Retinoic acid, CYP26, and drug resistance in the stem cell niche. Exp Hematol. 2017;54:17-25 pubmed publisher
    ..Bypassing this gatekeeping mechanism holds promise for overcoming drug resistance and improving clinical outcomes in hematological malignancies and cancer in general. ..