osteoradionecrosis

Summary

Summary: Necrosis of bone following radiation injury.

Top Publications

  1. Peleg M, Lopez E. The treatment of osteoradionecrosis of the mandible: the case for hyperbaric oxygen and bone graft reconstruction. J Oral Maxillofac Surg. 2006;64:956-60 pubmed
  2. Reuther T, Schuster T, Mende U, Kubler A. Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients--a report of a thirty year retrospective review. Int J Oral Maxillofac Surg. 2003;32:289-95 pubmed
    This retrospective study aimed to demonstrate the incidence and the aetiological factors involved in osteoradionecrosis (ORN) in a group of 830 head and neck tumour patients who received radiotherapy between 1969 and 1999...
  3. Freiberger J, Yoo D, De Lisle Dear G, McGraw T, Blakey G, Padilla Burgos R, et al. Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis. Int J Radiat Oncol Biol Phys. 2009;75:717-24 pubmed publisher
    To elucidate long-term outcomes in 65 consecutive patients meeting a uniform definition of mandibular osteoradionecrosis (ORN) treated with multimodality therapy including hyperbaric oxygen (HBO)...
  4. Lee J, Huh S, Oh D, Bae D. Osteoradionecrosis after three-dimensional conformal radiotherapy for recurrent cervical cancer presenting as a progressive osteolytic lesion. Ann Nucl Med. 2008;22:139-41 pubmed publisher
    b>Osteoradionecrosis (ORN) of the pelvic bone presenting as a progressive osteolytic lesion, following three-dimensional conformal radiotherapy (3DCRT) with concurrent chemotherapy, is a clinical diagnostic challenge that must be ..
  5. Hall V. Actinomyces--gathering evidence of human colonization and infection. Anaerobe. 2008;14:1-7 pubmed publisher
    ..is the recognition of actinomycosis as a major factor and indicator of poor prognosis in both infected osteoradionecrosis and bisphosphonate-associated osteonecrosis of the jaws...
  6. Mut M, Schiff D, Miller B, Shaffrey M, Larner J, Shaffrey C. Osteoradionecrosis mimicking metastatic epidural spinal cord compression. Neurology. 2005;64:396-7 pubmed
  7. Pitak Arnnop P, Sader R, Dhanuthai K, Masaratana P, Bertolus C, Chaine A, et al. Management of osteoradionecrosis of the jaws: an analysis of evidence. Eur J Surg Oncol. 2008;34:1123-34 pubmed publisher
    To review and discuss the management of jaw bone osteoradionecrosis (JORN) based on levels of evidence...
  8. Cheon Y, Lee M, Kim Y, Rah D, Lee W. Gluteal artery perforator flap: a viable alternative for sacral radiation ulcer and osteoradionecrosis. J Plast Reconstr Aesthet Surg. 2010;63:642-7 pubmed publisher
    ..of cancer; however, it may cause adverse effects to normal tissue such as radiation-induced ulcer and osteoradionecrosis. The few cases of conservative management that were reported had a limited value and unsatisfactory results...
  9. Hansen T, Kunkel M, Weber A, James Kirkpatrick C. Osteonecrosis of the jaws in patients treated with bisphosphonates - histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med. 2006;35:155-60 pubmed
    ..In the present study, we examined the histologic findings of these cases. As similarities between this disorder and infected osteoradionecrosis (IORN) are described, both lesions were compared.

More Information

Publications69

  1. King A, Griffith J, Abrigo J, Leung S, Yau F, Tse G, et al. Osteoradionecrosis of the upper cervical spine: MR imaging following radiotherapy for nasopharyngeal carcinoma. Eur J Radiol. 2010;73:629-35 pubmed publisher
    ..To document the MRI appearances of radiation-induced abnormalities in the cervical spine following treatment for nasopharyngeal carcinoma (NPC)...
  2. Katsura K, Sasai K, Sato K, Saito M, Hoshina H, Hayashi T. Relationship between oral health status and development of osteoradionecrosis of the mandible: a retrospective longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:731-8 pubmed publisher
    Oral health status is a risk factor for postradiation bone complications (also known as osteoradionecrosis [ORN]), and oral health care is an important element in the prevention of this condition...
  3. Chrcanovic B, Reher P, Sousa A, Harris M. Osteoradionecrosis of the jaws--a current overview--part 1: Physiopathology and risk and predisposing factors. Oral Maxillofac Surg. 2010;14:3-16 pubmed publisher
    ..paper is to explore the current theories about definition, classification, incidence and physiopathology of osteoradionecrosis (ORN) of the jaws...
  4. Chrcanovic B, Reher P, Sousa A, Harris M. Osteoradionecrosis of the jaws--a current overview--Part 2: dental management and therapeutic options for treatment. Oral Maxillofac Surg. 2010;14:81-95 pubmed publisher
    ..is to explore the current theories about pretreatment assessment and dental management of patients receiving head and neck radiotherapy, and the therapeutic options to treat osteoradionecrosis of the jaws, based on the literature review.
  5. Leonetti J, Marzo S, Zender C, Porter R, Melian E. Temporal bone osteoradionecrosis after surgery and radiotherapy for malignant parotid tumors. Otol Neurotol. 2010;31:656-9 pubmed
    To assess the incidence of osteoradionecrosis (ORN) of the temporal bone after surgery with radiotherapy for malignant parotid tumors.
  6. Nabil S, Samman N. Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review. Int J Oral Maxillofac Surg. 2011;40:229-43 pubmed publisher
    ..to answer the clinical question 'What are the incidence and the factors influencing the development of osteoradionecrosis after tooth extraction in irradiated patients?'...
  7. Teng M, Futran N. Osteoradionecrosis of the mandible. Curr Opin Otolaryngol Head Neck Surg. 2005;13:217-21 pubmed
    b>Osteoradionecrosis of the mandible is a serious complication of radiation therapy to the head and neck...
  8. Monnier Y, Broome M, Betz M, Bouferrache K, Ozsahin M, Jaques B. Mandibular osteoradionecrosis in squamous cell carcinoma of the oral cavity and oropharynx: incidence and risk factors. Otolaryngol Head Neck Surg. 2011;144:726-32 pubmed publisher
    Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in head and neck cancer patients...
  9. Wang P, Tu T, Liu K. Cystic brain necrosis and temporal bone osteoradionecrosis after radiotherapy and surgery in a patient of ear carcinoma. J Chin Med Assoc. 2004;67:487-91 pubmed
    ..We report the progressive radionecrosis of temporal lobe and cyst formation, which caused the neuropsychological symptoms 10 years after radiotherapy...
  10. Yoo J, Rosenthal D, Mitchell K, Ginsberg L. Osteoradionecrosis of the hyoid bone: imaging findings. AJNR Am J Neuroradiol. 2010;31:761-6 pubmed publisher
    ..Only a handful of cases in the hyoid bone are documented, all in the clinical literature. Our purpose is to present the clinical and imaging features of ORN involving the hyoid bone...
  11. Lim B, Pang K, Low W, Tan H. CSF otorrhea complicating temporal bone osteoradionecrosis in a patient with nasopharyngeal carcinoma. Ear Nose Throat J. 2005;84:39-40 pubmed
    ..performed a myringotomy and subsequently made a diagnosis of cerebrospinal fluid (CSF) leakage secondary to osteoradionecrosis of the temporal bone...
  12. Ahmed M, Hansen V, Harrington K, Nutting C. Reducing the risk of xerostomia and mandibular osteoradionecrosis: the potential benefits of intensity modulated radiotherapy in advanced oral cavity carcinoma. Med Dosim. 2009;34:217-24 pubmed publisher
    ..The magnitude of reductions in dose to the salivary glands and mandible are likely to translate into reduced incidence of xerostomia and osteoradionecrosis for patients with OCC.
  13. Hansen T, Kunkel M, Springer E, Walter C, Weber A, Siegel E, et al. Actinomycosis of the jaws--histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis. Virchows Arch. 2007;451:1009-17 pubmed
    Actinomycosis of the jaws is a rare disease, which has been recently described in patients with infected osteoradionecrosis (IORN) and bisphosphonate-associated osteonecrosis (BON)...
  14. Hansen T, Wagner W, Kirkpatrick C, Kunkel M. Infected osteoradionecrosis of the mandible: follow-up study suggests deterioration in outcome for patients with Actinomyces-positive bone biopsies. Int J Oral Maxillofac Surg. 2006;35:1001-4 pubmed
    Infected osteoradionecrosis (IORN) is one of the major complications of oral cancer radiotherapy. Recent studies showed a high prevalence of Actinomyces in IORN...
  15. Kalantar Hormozi A, Khorvash B. Repair of skin covering osteoradionecrosis of the mandible with the fasciocutaneous supraclavicular artery island flap: case report. J Craniomaxillofac Surg. 2006;34:440-2 pubmed
    b>Osteoradionecrosis of the mandible is a serious complication following radiotherapy for head and neck cancer. Reconstructive procedures in the head and neck region use a wide range of flaps for defect closure...
  16. Chang E, Leon P, Hoffman W, Schmidt B. Quality of life for patients requiring surgical resection and reconstruction for mandibular osteoradionecrosis: 10-year experience at the University of California San Francisco. Head Neck. 2012;34:207-12 pubmed publisher
    Mandibular osteoradionecrosis is the most devastating complication after radiation therapy for head and neck malignancies. Quality of life (QOL) after surgical treatment is unclear.
  17. Buchbinder D, St Hilaire H. The use of free tissue transfer in advanced osteoradionecrosis of the mandible. J Oral Maxillofac Surg. 2006;64:961-4 pubmed
  18. Feltl D, Vosmik M, Jirasek M, Stahalova V, Kubes J. Symptomatic osteoradionecrosis of pelvic bones in patients with gynecological malignancies-result of a long-term follow-up. Int J Gynecol Cancer. 2006;16:478-83 pubmed
    ..Of the eligible 3155 patients, 15 developed symptomatic bone fracture caused by osteoradionecrosis, which makes an overall incidence of 0...
  19. Studer G, Studer S, Zwahlen R, Huguenin P, Gratz K, Lütolf U, et al. Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT). Strahlenther Onkol. 2006;182:283-8 pubmed
    b>Osteoradionecrosis (ON) of the mandible is a serious late complication of high-dose radiation therapy for tumors of the oropharynx and oral cavity...
  20. Støre G, Olsen I. Scanning and transmission electron microscopy demonstrates bacteria in osteoradionecrosis. Int J Oral Maxillofac Surg. 2005;34:777-81 pubmed
    According to the current concept of osteoradionecrosis such tissue has become hypoxic, hypovascular and hypocellular and it has previously failed to show any bacterial growth. By using a molecular method, i.e...
  21. Gomez D, Estilo C, Wolden S, Zelefsky M, Kraus D, Wong R, et al. Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulated radiation therapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011;81:e207-13 pubmed publisher
    b>Osteoradionecrosis (ORN) is a known complication of radiation therapy to the head and neck...
  22. Bagan J, Jimenez Y, Hernandez S, Murillo J, Díaz J, Poveda R, et al. Osteonecrosis of the jaws by intravenous bisphosphonates and osteoradionecrosis: a comparative study. Med Oral Patol Oral Cir Bucal. 2009;14:e616-9 pubmed
    We analyze the possible clinical differences between bone jaw exposed areas in ONJ (osteonecrosis of the jaws) and ORN (osteoradionecrosis).
  23. Oh H, Chambers M, Martin J, Lim H, Park H. Osteoradionecrosis of the mandible: treatment outcomes and factors influencing the progress of osteoradionecrosis. J Oral Maxillofac Surg. 2009;67:1378-86 pubmed publisher
    The present study was undertaken to evaluate our recent experience with mandibular osteoradionecrosis (ORN) and to identify factors that contribute to its progress.
  24. Chen H, Lin C, Jen Y, Juan C, Hsueh C, Lee J, et al. Ruptured internal carotid pseudoaneurysm in a nasopharyngeal carcinoma patient with skull base osteoradionecrosis. Otolaryngol Head Neck Surg. 2004;130:388-90 pubmed
  25. Wang L, Su Y, Liao G. Quality of life in osteoradionecrosis patients after mandible primary reconstruction with free fibula flap. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:162-8 pubmed publisher
    To evaluate the quality-of-life outcomes in osteoradionecrosis patients undergoing primary mandible reconstruction with free fibula flap, and to analyze the association between quality of life and demographic and medical characteristics ..
  26. Oh H, Chambers M, Garden A, Wong P, Martin J. Risk of osteoradionecrosis after extraction of impacted third molars in irradiated head and neck cancer patients. J Oral Maxillofac Surg. 2004;62:139-44 pubmed
    This study was performed to compare the risk of osteoradionecrosis (ORN) in head and neck cancer patients in whom 1 or more impacted third molars were extracted before radiotherapy with patients whose impacted third molars were left intact...
  27. Mendenhall W. Mandibular osteoradionecrosis. J Clin Oncol. 2004;22:4867-8 pubmed
  28. Scala M, Gipponi M, Mereu P, Strada P, Corvo R, Muraglia A, et al. Regeneration of mandibular osteoradionecrosis defect with platelet rich plasma gel. In Vivo. 2010;24:889-93 pubmed
    b>Osteoradionecrosis (ORN) of the mandible is a major complication of radiation therapy of head and neck cancer with a potential of occurrence ranging from 5 to 15% of the irradiated patients...
  29. Goldwaser B, Chuang S, Kaban L, August M. Risk factor assessment for the development of osteoradionecrosis. J Oral Maxillofac Surg. 2007;65:2311-6 pubmed
    b>Osteoradionecrosis (ORN) of the jaws has been extensively studied. However, controversy still exists regarding its etiology, risk factors, and the underlying mechanism of disease...
  30. Wreford Brown C, Hampson N. Hyperbaric oxygen treatment protocols for mandibular osteoradionecrosis. Undersea Hyperb Med. 2003;30:175-9 pubmed
    To determine hyperbaric oxygen (HBO2) treatment practices for osteoradionecrosis (ORN) of the mandible in North America, we surveyed hyperbaric facilities listed in the 1998 UHMS Chamber Directory. A survey response rate of 99...
  31. Xu J, Zheng Z, Fang D, Gao R, Liu Y, Fan Z, et al. Early-stage pathogenic sequence of jaw osteoradionecrosis in vivo. J Dent Res. 2012;91:702-8 pubmed publisher
    The mechanism underlying jaw osteoradionecrosis (ORN) is not fully understood, particularly in the early stages...
  32. Hirsch D, Bell R, Dierks E, Potter J, Potter B. Analysis of microvascular free flaps for reconstruction of advanced mandibular osteoradionecrosis: a retrospective cohort study. J Oral Maxillofac Surg. 2008;66:2545-56 pubmed publisher
    ..There is little data, however, indicating whether or not the presence of osteoradionecrosis (ORN) affects treatment outcome...
  33. Madrid C, Abarca M, Bouferrache K. Osteoradionecrosis: an update. Oral Oncol. 2010;46:471-4 pubmed publisher
    b>Osteoradionecrosis (ORN) of the mandible is the most serious and severe side effect of combined treatment of head and neck tumors...
  34. Hansen T, Kirkpatrick C, Walter C, Kunkel M. Increased numbers of osteoclasts expressing cysteine proteinase cathepsin K in patients with infected osteoradionecrosis and bisphosphonate-associated osteonecrosis--a paradoxical observation?. Virchows Arch. 2006;449:448-54 pubmed
    Erosion of the bone is a common problem in patients suffering from infected osteoradionecrosis (IORN) or bisphosphonate-associated osteonecrosis (BON)...
  35. Hansen T, Kunkel M, Kirkpatrick C, Weber A. Actinomyces in infected osteoradionecrosis--underestimated?. Hum Pathol. 2006;37:61-7 pubmed
    Infected osteoradionecrosis (IORN) is a severe complication of radiation therapy for head and neck cancer. Infected osteoradionecrosis can lead to fracture and often requires subsequent jaw resection...
  36. Nguyen M, Billington A, Habal M. Osteoradionecrosis of the skull after radiation therapy for invasive carcinoma. J Craniofac Surg. 2011;22:1677-81 pubmed publisher
    b>Osteoradionecrosis (ORN) of the skull is a rare but fatal complication of radiation therapy for the treatment of head and neck malignancies...
  37. Obinata K, Ohmori K, Tuchiya K, Nishioka T, Shirato H, Nakamura M. Clinical study of a spacer to help prevent osteoradionecrosis resulting from brachytherapy for tongue cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:246-50 pubmed
    We sought to describe a simple method to construct a spacer and to evaluate with the use of computed tomography the spacer's effectiveness in preventing osteoradionecrosis of the mandible.
  38. Xu J, Zheng Z, Fang D, Gao R, Liu Y, Fan Z, et al. Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in Swine. Cell Transplant. 2012;21:1679-86 pubmed publisher
    Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers...
  39. Nabil S, Samman N. Risk factors for osteoradionecrosis after head and neck radiation: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:54-69 pubmed publisher
    This systematic review aimed to answer the clinical question, "What is the current risk of developing osteoradionecrosis of the jaws among irradiated head and neck cancer patients?"
  40. Studer G, Gratz K, Glanzmann C. Osteoradionecrosis of the mandibula in patients treated with different fractionations. Strahlenther Onkol. 2004;180:233-40 pubmed
  41. Curi M, Oliveira dos Santos M, Feher O, Faria J, Rodrigues M, Kowalski L. Management of extensive osteoradionecrosis of the mandible with radical resection and immediate microvascular reconstruction. J Oral Maxillofac Surg. 2007;65:434-8 pubmed
    b>Osteoradionecrosis (ORN) is a severe and devastating late complication of radiotherapy in patients with head and neck cancer...
  42. Donovan D, Huynh T, Purdom E, Johnson R, Sniezek J. Osteoradionecrosis of the cervical spine resulting from radiotherapy for primary head and neck malignancies: operative and nonoperative management. Case report. J Neurosurg Spine. 2005;3:159-64 pubmed
    b>Osteoradionecrosis is a process of dysvascular bone necrosis and fibrous replacement following exposure to high doses of radiation...
  43. Huang X, Zheng Y, Zhang X, Mai H, Zeng L, Liu X, et al. Diagnosis and management of skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma. Laryngoscope. 2006;116:1626-31 pubmed
    The objective of this study was to investigate the diagnosis and management of skull base osteoradionecrosis (ORN) after radiotherapy for nasopharyngeal carcinoma (NPC).
  44. Tsai C, Hofstede T, Sturgis E, Garden A, Lindberg M, Wei Q, et al. Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2013;85:415-20 pubmed publisher
    To determine the association between radiation doses delivered to the mandible and the occurrence of osteoradionecrosis (ORN).
  45. Delanian S, Depondt J, Lefaix J. Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head Neck. 2005;27:114-23 pubmed
    b>Osteoradionecrosis (ORN) is a nonhealing wound of the bone that is difficult to manage. Is a treatment combining pentoxifylline (PTX) and tocopherol (vitamin E) boosted by clodronate effective in reversing this fibronecrotic process?
  46. Baumann D, Yu P, Hanasono M, Skoracki R. Free flap reconstruction of osteoradionecrosis of the mandible: a 10-year review and defect classification. Head Neck. 2011;33:800-7 pubmed publisher
    The purpose of this study was to evaluate outcomes of free flap reconstruction for advanced osteoradionecrosis (ORN) defects and develop an algorithm to guide surgical planning.
  47. Cohen M, Nishimura I, Tamplen M, Hokugo A, Beumer J, Steinberg M, et al. Animal model of radiogenic bone damage to study mandibular osteoradionecrosis. Am J Otolaryngol. 2011;32:291-300 pubmed publisher
    The objective of the study was to create an animal model to study mandibular osteoradionecrosis (ORN) using high-dose rate (HDR) brachytherapy.
  48. Delanian S, Chatel C, Porcher R, Depondt J, Lefaix J. Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys. 2011;80:832-9 pubmed publisher
    b>Osteoradionecrosis (ORN) is a nonhealing wound of the bone that is difficult to manage. Combined treatment with pentoxifylline and vitamin E reduces radiation-induced fibrosis and ORN with a good prognosis...
  49. Mendonça J, Juiz Lopez P. Regenerative facial reconstruction of terminal stage osteoradionecrosis and other advanced craniofacial diseases with adult cultured stem and progenitor cells. Plast Reconstr Surg. 2010;126:1699-709 pubmed publisher
  50. Wahl M. Osteoradionecrosis prevention myths. Int J Radiat Oncol Biol Phys. 2006;64:661-9 pubmed
    To critically analyze controversial osteoradionecrosis (ORN) prevention techniques, including preradiation extractions of healthy or restorable teeth and the use of prophylactic antibiotics or hyperbaric oxygen (HBO) treatments for ..
  51. Chopra S, Kamdar D, Ugur O, Chen G, Peshek B, Marunick M, et al. Factors predictive of severity of osteoradionecrosis of the mandible. Head Neck. 2011;33:1600-5 pubmed publisher
    An analysis of risk factors predictive of severe mandibular osteoradionecrosis (ORN) is needed to aid prophylaxis and management of this condition.
  52. Støre G, Eribe E, Olsen I. DNA-DNA hybridization demonstrates multiple bacteria in osteoradionecrosis. Int J Oral Maxillofac Surg. 2005;34:193-6 pubmed
    ..nucleatum. The results of this study indicate that bacteria, particularly anaerobes, may play a more fundamental role in the pathophysiology of osteoradionecrosis than being merely surface contaminants.
  53. Liu S, Chang J, Ng S, Chan S, Yen T. False positive fluorine-18 fluorodeoxy-D-glucose positron emission tomography finding caused by osteoradionecrosis in a nasopharyngeal carcinoma patient. Br J Radiol. 2004;77:257-60 pubmed
    ..Histopathological studies showed osteoradionecrosis of the debrided tissue and follow-up PET showed complete regression of the skull base lesion...
  54. Ang E, Black C, Irish J, Brown D, Gullane P, O Sullivan B, et al. Reconstructive options in the treatment of osteoradionecrosis of the craniomaxillofacial skeleton. Br J Plast Surg. 2003;56:92-9 pubmed
    b>Osteoradionecrosis (ORN) of the craniomaxillofacial skeleton is a serious and debilitating complication that can occur following radiation therapy in the head and neck...
  55. Delanian S, Lefaix J. Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. Br J Radiol. 2002;75:467-9 pubmed
    b>Osteoradionecrosis (ORN) is a late terminal sequela of irradiation that does not resolve spontaneously...
  56. Lee I, Koom W, Lee C, Kim Y, Yoo S, Keum K, et al. Risk factors and dose-effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients. Int J Radiat Oncol Biol Phys. 2009;75:1084-91 pubmed publisher
    To analyze risk factors and the dose-effect relationship for osteoradionecrosis (ORN) of the mandible after radiotherapy of oral and oropharyngeal cancers.
  57. Jacobson A, Buchbinder D, Hu K, Urken M. Paradigm shifts in the management of osteoradionecrosis of the mandible. Oral Oncol. 2010;46:795-801 pubmed publisher
    b>Osteoradionecrosis (ORN) of the mandible is a significant complication of radiation therapy for head and neck cancer...
  58. Studer G, Graetz K, Glanzmann C. In response to Dr. Merav A. Ben-David et al. ("Lack of osteoradionecrosis of the mandible after IMRT," Int J Radiat Oncol Biol Phys 2007:In Press). Int J Radiat Oncol Biol Phys. 2007;68:1583-4 pubmed
  59. Annane D, Depondt J, Aubert P, Villart M, Gehanno P, Gajdos P, et al. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol. 2004;22:4893-900 pubmed
    To determine the efficacy and safety of hyperbaric oxygen therapy (HBO) for overt mandibular osteoradionecrosis.
  60. Nason R, Chole R. Bacterial biofilms may explain chronicity in osteoradionecrosis of the temporal bone. Otol Neurotol. 2007;28:1026-8 pubmed
    To identify biofilm formation within a case of temporal bone osteoradionecrosis.