parathyroid neoplasms

Summary

Summary: Tumors or cancer of the PARATHYROID GLANDS.

Top Publications

  1. Lu M, Berglund E, Larsson C, Höög A, Farnebo L, Bränström R. Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma. J Endocrinol. 2011;208:31-9 pubmed publisher
    ..Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway...
  2. Juhlin C, Haglund F, Obara T, Arnold A, Larsson C, Höög A. Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours. Virchows Arch. 2011;459:47-53 pubmed publisher
  3. Witteveen J, Hamdy N, Dekkers O, Kievit J, van Wezel T, Teh B, et al. Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma. Mod Pathol. 2011;24:688-97 pubmed publisher
    ..Notwithstanding, we demonstrate a significant added value of these markers as strong determinants of increased malignant potential and thus as negative prognostic markers in this malignancy...
  4. Schulte K, Gill A, Barczynski M, Karakas E, Miyauchi A, Knoefel W, et al. Classification of parathyroid cancer. Ann Surg Oncol. 2012;19:2620-8 pubmed publisher
  5. Boguszewski C, Bianchet L, Raskin S, Nomura L, Borba L, Cavalcanti T. Application of genetic testing to define the surgical approach in a sporadic case of multiple endocrine neoplasia type 1. Arq Bras Endocrinol Metabol. 2010;54:705-10 pubmed
    ..Pathology showed a PA and 3 normal parathyroid glands, without hyperplasia, despite the diagnosis of MEN 1. This case illustrates the role of genetic testing in defining the therapeutic approach for sporadic MEN 1...
  6. Bachar G, Mizrachi A, Hadar T, Feinmesser R, Shpitzer T. Role of parathyroid hormone monitoring during parathyroidectomy. Head Neck. 2011;33:1754-7 pubmed publisher
    ..The value of intraoperative parathyroid hormone (IOPTH) monitoring in parathyroidectomy has been previously debated...
  7. Schaapveld M, Jorna F, Aben K, Haak H, Plukker J, Links T. Incidence and prognosis of parathyroid gland carcinoma: a population-based study in The Netherlands estimating the preoperative diagnosis. Am J Surg. 2011;202:590-7 pubmed publisher
    ..Parathyroid carcinoma is a rare malignancy and generally is diagnosed after surgery for primary hyperparathyroidism. Lack of a preoperative diagnosis and ill-considered surgical planning with its impact on survival are ill-described...
  8. Varshney S, Bhadada S, Sachdeva N, Arya A, Saikia U, Behera A, et al. Methylation status of the CpG islands in vitamin D and calcium-sensing receptor gene promoters does not explain the reduced gene expressions in parathyroid adenomas. J Clin Endocrinol Metab. 2013;98:E1631-5 pubmed publisher
    ..We investigated whether epigenetic silencing is involved in the decreased expression of VDR and CASR...
  9. Svedlund J, Aurén M, Sundstrom M, Dralle H, Akerstrom G, Björklund P, et al. Aberrant WNT/?-catenin signaling in parathyroid carcinoma. Mol Cancer. 2010;9:294 pubmed publisher
    ..The molecular etiology of PC is poorly understood...

More Information

Publications62

  1. Sharretts J, Kebebew E, Simonds W. Parathyroid cancer. Semin Oncol. 2010;37:580-90 pubmed publisher
    ..Metastatic disease can be palliated with surgical debulking. Medical therapy with the calcimimetic cinacalcet and bisphosphonates can ameliorate hypercalcemia in patients with inoperable disease...
  2. Krvavica A, Kovacic M, Baraka I, Rudic M. Non-functioning parathyroid gland carcinoma: case report. Acta Clin Croat. 2011;50:233-7 pubmed
    ..Detailed immunohistochemical analysis is needed to distinguish it from other thyroid and parathyroid neoplasms and metastatic carcinoma. Surgical treatment is presently the best mode of therapy.
  3. Kotromanović Z, Birtić D, Vceva A, Medić D, Zubčić Z, Mihalj H, et al. Non-functional parathyroid gland carcinoma, a rare malignant tumor of the head and neck. Coll Antropol. 2012;36 Suppl 2:23-5 pubmed
    ..There have been 24 cases reported of this disease in the literature. The focus of our study is to present a case of this disease and to review the published literature to date...
  4. Van Udelsman B, Udelsman R. Surgery in primary hyperparathyroidism: extensive personal experience. J Clin Densitom. 2013;16:54-9 pubmed publisher
    ..This article reviews our approach reflecting advances in preoperative localization, anesthetic techniques, and intraoperative management of patients undergoing parathyroidectomy for the treatment of PHPT...
  5. Frank Raue K, Haag C, Schulze E, Keuser R, Raue F, Dralle H, et al. CDC73-related hereditary hyperparathyroidism: five new mutations and the clinical spectrum. Eur J Endocrinol. 2011;165:477-83 pubmed publisher
    ..Disease-causing mutations have been localised in the tumour suppressor gene CDC73. There is limited information available on the mutations, and resulting phenotypes and long-term follow-up data are especially scarce...
  6. O Neal P, Mowschenson P, Connolly J, Hasselgren P. Large parathyroid tumors have an increased risk of atypia and carcinoma. Am J Surg. 2011;202:146-50 pubmed publisher
    ..Risk for atypia and carcinoma in large parathyroid tumors is not known. Atypia and carcinoma were determined in small (<2 g) and large (?2 g) tumors in patients undergoing parathyroidectomy for primary hyperparathyroidism...
  7. Thakker R. Multiple endocrine neoplasia type 1 (MEN1). Best Pract Res Clin Endocrinol Metab. 2010;24:355-70 pubmed publisher
    ..The majority of MEN1 mutations are likely to disrupt the interactions of Menin with other proteins and thereby alter critical events in cell cycle regulation and proliferation...
  8. Yi Y, Nowak N, Pacchia A, Morrison C. Chromosome 11 genomic changes in parathyroid adenoma and hyperplasia: array CGH, FISH, and tissue microarrays. Genes Chromosomes Cancer. 2008;47:639-48 pubmed publisher
    ..This genetic change was relatively independent of other chromosome 11 changes and present in slightly less than one-half of adenomas. 11q23 deletion along with relatively strong CCND1 expression was common in uremic hyperparathyroidism...
  9. Rodgers S, Hunter G, Hamberg L, Schellingerhout D, Doherty D, Ayers G, et al. Improved preoperative planning for directed parathyroidectomy with 4-dimensional computed tomography. Surgery. 2006;140:932-40; discussion 940-1 pubmed
    ..The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyroid glands before parathyroidectomy...
  10. Ippolito G, Palazzo F, Sebag F, De Micco C, Henry J. Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg. 2007;94:566-70 pubmed
    ..Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult. The aim of this study was to determine whether parathyroid cancer and APA have different operative findings and long-term outcomes...
  11. Tan G, Shiran M, Swaminathan M, Phang K, Rohaizak M. Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. Asian J Surg. 2007;30:286-9 pubmed
    ..We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia...
  12. Henry J. Reoperation for primary hyperparathyroidism: tips and tricks. Langenbecks Arch Surg. 2010;395:103-9 pubmed publisher
  13. Cetani F, Pardi E, Ambrogini E, Banti C, Viacava P, Borsari S, et al. Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment. J Endocrinol Invest. 2008;31:900-4 pubmed
    ..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type...
  14. Howell V, Gill A, Clarkson A, Nelson A, Dunne R, Delbridge L, et al. Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma. J Clin Endocrinol Metab. 2009;94:434-41 pubmed publisher
    ..However, because parafibromin is only involved in up to 70% of parathyroid carcinomas and loss of parafibromin immunoreactivity may not be observed in all cases of HRPT2 mutation, a complementary marker is needed...
  15. Montenegro F, Chammas M, Juliano A, Cernea C, Cordeiro A. Ethanol injection under ultrasound guidance to palliate unresectable parathyroid carcinoma. Arq Bras Endocrinol Metabol. 2008;52:707-11 pubmed
    ..Non-curative resection and pharmacological measures may be useful for palliation in cases with recurrent and metastatic disease. Palliative treatment with intra-neoplastic ethanol injection has not been reported yet...
  16. Ito Y, Kakudo K, Hirokawa M, Fukushima M, Tomoda C, Inoue H, et al. Clinical significance of extrathyroid extension to the parathyroid gland of papillary thyroid carcinoma. Endocr J. 2009;56:251-5 pubmed
    ..Since minimal extension did not affect patient prognosis in our series, it is suggested that extension to the parathyroid gland has little clinical significance in PTC...
  17. Chen Q, Kaji H, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, et al. Trial to predict malignancy of affected parathyroid glands in primary hyperparathyroidism. Endocr J. 2003;50:527-34 pubmed
    ..In conclusion, radial BMD was lower in malignant group compared to benign one in pHPT. Serum levels of calcium, ALP and mid PTH were useful to predict malignancy of affected parathyroid glands in pHPT patients...
  18. Kung B, Winokur R, Cognetti D, O Hara B, Rosen D. Parathyroid carcinoma: a rare cause of primary hyperparathyroidism. Ear Nose Throat J. 2009;88:E10-3 pubmed
    ..Her ionized calcium levels fell from a high of 8.4 mg/dl preoperatively to 4.7 mg/dl. On final pathologic examination, the mass was confirmed to be a parathyroid carcinoma...
  19. Rubin M, Silverberg S, D Amour P, Brossard J, Rousseau L, Sliney J, et al. An N-terminal molecular form of parathyroid hormone (PTH) distinct from hPTH(1 84) is overproduced in parathyroid carcinoma. Clin Chem. 2007;53:1470-6 pubmed
    ..We investigated whether N-PTH is also overproduced in parathyroid cancer and whether N-PTH concentration is influenced by calcimimetic therapy...
  20. Kirkby Bott J, Lewis P, Harmer C, Smellie W. One stage treatment of parathyroid cancer. Eur J Surg Oncol. 2005;31:78-83 pubmed
    ..To review the methods of treating parathyroid cancer in our series and report successful use of intraoperative frozen section to enable one stage surgical management...
  21. Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, et al. First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma. Endocr J. 2010;57:287-92 pubmed
    ..Therefore, we concluded that PTH immunization was an effective treatment against hypercalcemia caused by metastatic parathyroid carcinomas that are unresponsive to conventional treatments...
  22. Björklund P, Akerstrom G, Westin G. An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 2007;4:e328 pubmed
    ..Mechanisms that may account for this activation have not been identified, except for a few cases of beta-catenin (CTNNB1) stabilizing mutation in pHPT tumors...
  23. Mezhir J, Melis M, Headley R, Pai R, Posner M, Kaplan E. Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resection. J Hepatobiliary Pancreat Surg. 2007;14:410-3 pubmed
    ..Our case highlights the importance of an aggressive approach to patients with metastatic parathyroid cancer, as well as the utility of intraoperative parathyroid hormone levels to confirm successful extirpation of disease...
  24. Hewitt K, Sharma P, Samowitz W, Hobbs M. Aberrant methylation of the HRPT2 gene in parathyroid carcinoma. Ann Otol Rhinol Laryngol. 2007;116:928-33 pubmed
    ..We used a methylation-specific polymerase chain reaction (MS-PCR) technique to investigate whether hypermethylation is one mechanism of HRPT2 gene inactivation in parathyroid tumors...
  25. Haven C, Howell V, Eilers P, Dunne R, Takahashi M, van Puijenbroek M, et al. Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype. Cancer Res. 2004;64:7405-11 pubmed
    ..These findings provide insights into the molecular pathways involved in parathyroid tumorigenesis and will contribute to a better understanding, diagnosis, and treatment of parathyroid tumors...
  26. Yoshida S. Intracranial metastatic parathyroid carcinoma: case report. Surg Neurol. 2006;65:81-3 pubmed
    ..A review of the literature revealed only 2 other cases of intracranial metastatic parathyroid carcinoma. We present here the case of cerebral metastases from parathyroid carcinoma that could be treated successfully...
  27. Perrier N, Edeiken B, Nunez R, Gayed I, Jimenez C, Busaidy N, et al. A novel nomenclature to classify parathyroid adenomas. World J Surg. 2009;33:412-6 pubmed publisher
    ..We developed a nomenclature that provides a precise means of communicating the most frequently encountered parathyroid adenoma locations...
  28. Rodgers S, Perrier N. Parathyroid carcinoma. Curr Opin Oncol. 2006;18:16-22 pubmed
    ..This article reviews current knowledge on the etiology, diagnosis and treatment of parathyroid carcinoma...
  29. Sitges Serra A, Rosa P, Valero M, Membrilla E, Sancho J. Surgery for sporadic primary hyperparathyroidism: controversies and evidence-based approach. Langenbecks Arch Surg. 2008;393:239-44 pubmed publisher
    ..Small (<300 mg) adenomas continue to challenge preoperative imaging, and most of them will still require a bilateral exploration...
  30. Wilkins B, Lewis J. Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery. Head Neck Pathol. 2009;3:140-9 pubmed publisher
    ..While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors...
  31. Doherty G. Multiple endocrine neoplasia type 1. J Surg Oncol. 2005;89:143-50 pubmed
    ..Care of people with MEN-1 requires knowledge of the problems that may arise, and the best approaches to detect and care for the manifestations of this incurable, but manageable, disease...
  32. Adamek S, Libanský P, Nanka O, Sedy J, Pafko P. [Surgical therapy of primary hyperparathyroidism and it's complications. Experience with 453 patients]. Zentralbl Chir. 2005;130:109-13 pubmed
    ..5 % of patients. Postoperative hypercalcemia persisted in 1.2 % of patients. Recurrent hypercalcemia was present in 0.2 % of cases. In three cases (0.7 %), unilateral injury of recurrent laryngeal nerve was observed...
  33. Rosen J, Costouros N, Lorang D, Burns A, Alexander H, Skarulis M, et al. Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas. Ann Surg Oncol. 2005;12:412-6 pubmed
    ..The molecular pathways responsible for the variations in clinical severity of pHPT are unknown. We studied gene expression profiles in patients with SPAs and pHPT to determine associations between these changes and clinical parameters...
  34. Betea D, Bradwell A, Harvey T, Mead G, Schmidt Gayk H, Ghaye B, et al. Hormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma. J Clin Endocrinol Metab. 2004;89:3413-20 pubmed
    ..This is the first evidence that PTH immunization not only can improve clinical, hormonal, and biochemical measures in parathyroid carcinoma but also has an antitumor effect...
  35. Allendorf J, DiGorgi M, Spanknebel K, Inabnet W, Chabot J, LoGerfo P. 1112 consecutive bilateral neck explorations for primary hyperparathyroidism. World J Surg. 2007;31:2075-80 pubmed
    ..In this series we report a single surgeon's experience with bilateral neck exploration for primary hyperparathyroidism in an effort to establish benchmark outcomes from which to evaluate minimally invasive protocols...
  36. Silverberg S, Rubin M, Faiman C, Peacock M, Shoback D, Smallridge R, et al. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab. 2007;92:3803-8 pubmed
  37. Ahmad F, Strickland A, Wright G, Elabassy M, Kiruparan P, Bell P, et al. Laparoscopic microwave tissue ablation of hepatic metastasis from a parathyroid carcinoma. Eur J Surg Oncol. 2005;31:321-2 pubmed
  38. Pellegata N, Quintanilla Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, et al. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci U S A. 2006;103:15558-63 pubmed
    ..Our findings demonstrate that germ-line mutations in p27(Kip1) can predispose to the development of multiple endocrine tumors in both rats and humans...
  39. Chiu B, Sturgeon C, Angelos P. What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomy. Surgery. 2006;140:418-22 pubmed
    ..We hypothesized that nonlocalizing sestamibi scans would correlate with multigland disease and persistent primary hyperparathyroidism...
  40. Iwata T, Inoue K, Morita R, Mizuguchi S, Tsukioka T, Onoda N, et al. Functional large parathyroid carcinoma extending into the superior mediastinum. Ann Thorac Cardiovasc Surg. 2008;14:112-5 pubmed
    ..On the 8th postoperative day, the patient was discharged uneventfully with a decreased serum level of PTH (59.0 pg/mL), and no recurrent disease or exacerbation of hyperthyroidism was observed 36 months after surgery...
  41. Jacobson S, van Heerden J, Farley D, Grant C, Thompson G, Mullan B, et al. Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World J Surg. 2004;28:1127-31 pubmed
    ..Further experience with this surgical approach seems warranted to determine the overall cure rate, operative morbidity, and the sensitivity and specificity of preoperative localization studies...
  42. Forsberg L, Björck E, Hashemi J, Zedenius J, Höög A, Farnebo L, et al. Distinction in gene expression profiles demonstrated in parathyroid adenomas by high-density oligoarray technology. Eur J Endocrinol. 2005;152:459-70 pubmed
    ..The results were then evaluated with respect to differences between adenomas and normal parathyroid tissue, and to the presence of loss of heterozygosity (LOH) in chromosomal region 11q13...
  43. Chen H, Pruhs Z, Starling J, Mack E. Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy. Surgery. 2005;138:583-7; discussion 587-90 pubmed
    ..However, several investigators report that these assays are not cost effective and do not improve outcomes significantly...
  44. Bjorklund P, Akerstrom G, Westin G. Activated beta-catenin in the novel human parathyroid tumor cell line sHPT-1. Biochem Biophys Res Commun. 2007;352:532-6 pubmed
    ..The Wnt/beta-catenin signalling pathway, and beta-catenin in particular, presents a potential therapeutic target for HPT...
  45. Kleinpeter K, Lovato J, Clark P, Wooldridge T, Norman E, Bergman S, et al. Is parathyroid carcinoma indeed a lethal disease?. Ann Surg Oncol. 2005;12:260-6 pubmed
    ..There is no current staging system. Our primary aim was to review the presentation, diagnosis, surgical treatment, and outcomes of patients, with the goal of assessing the incidence of death related to parathyroid carcinoma...
  46. Simonds W. Ruling out a suspect: the role of beta-catenin mutation in benign parathyroid neoplasia. J Clin Endocrinol Metab. 2007;92:1235-6 pubmed
  47. Tochio M, Takaki H, Yamakado K, Uraki J, Kashima M, Nakatsuka A, et al. A case report of 20 lung radiofrequency ablation sessions for 50 lung metastases from parathyroid carcinoma causing hyperparathyroidism. Cardiovasc Intervent Radiol. 2010;33:657-9 pubmed publisher
    ..Pulmonary resection was combined for lung hilum metastases. The patient is still alive 4 years after the initial RF session. He has received 20 RF sessions for 50 lung metastases during this period...
  48. Norenstedt S, Ekbom A, Brandt L, Zedenius J, Nilsson I. Postoperative mortality in parathyroid surgery in Sweden during five decades: improved outcome despite older patients. Eur J Endocrinol. 2009;160:295-9 pubmed publisher
    ..Our question was whether the risk of postoperative death has been affected by the increased proportion of elderly patients referred for parathyroid surgery...
  49. Schnatz P, Thaxton S. Parathyroidectomy in the third trimester of pregnancy. Obstet Gynecol Surv. 2005;60:672-82 pubmed
    ..Postponing surgery may be hazardous. Postoperative hypocalcemia is common but easily treated. Hyperparathyroidism should be considered a risk factor for preeclampsia...
  50. Szmuilowicz E, Utiger R. A case of parathyroid carcinoma with hypercalcemia responsive to cinacalcet therapy. Nat Clin Pract Endocrinol Metab. 2006;2:291-6; quiz 297 pubmed
    ..The patient was treated with intravenous saline, pamidronate, and zoledronic acid. He was referred to our hospital on day 35 for treatment of refractory hypercalcemia...
  51. Gao W, Ruan C, Zhang J, Liu H, Xu X, Sun Y, et al. Nonfunctional parathyroid carcinoma. J Cancer Res Clin Oncol. 2010;136:969-74 pubmed publisher
    ..We present a case of nonfunctioning PTC and review the literature in an effort to provide a better understanding of this rare disorder...
  52. Irvin G, Solorzano C, Carneiro D. Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome. World J Surg. 2004;28:1287-92 pubmed
    ..There was no statistical difference in the overall recurrence rates ( p = 0.23). The QPTH-guided parathyroidectomy identifies MGD and allows an improved success rate with the same low recurrence rate when compared to the results of BNE...
  53. Fernandez Ranvier G, Jensen K, Khanafshar E, Quivey J, Glastonbury C, Kebebew E, et al. Nonfunctioning parathyroid carcinoma: case report and review of literature. Endocr Pract. 2007;13:750-7 pubmed
    ..To report a case of nonfunctioning parathyroid carcinoma that was incidentally found during a thyroidectomy for multinodular goiter...